metyrapone has been researched along with Pain in 4 studies
Metyrapone: An inhibitor of the enzyme STEROID 11-BETA-MONOOXYGENASE. It is used as a test of the feedback hypothalamic-pituitary mechanism in the diagnosis of CUSHING SYNDROME.
metyrapone : An aromatic ketone that is 3,3-dimethylbutan-2-one in which the methyl groups at positions 1 and 4 are replaced by pyridin-3-yl groups. A steroid 11beta-monooxygenase (EC 1.14.15.4) inhibitor, it is used in the diagnosis of adrenal insufficiency.
Pain: An unpleasant sensation induced by noxious stimuli which are detected by NERVE ENDINGS of NOCICEPTIVE NEURONS.
| Excerpt | Relevance | Reference |
|---|---|---|
| "We previously reported that morphine fails to produce analgesic tolerance when administered in the presence of formalin-induced pain, which may be related to activity of the hypothalamic-pituitary-adrenal axis." | 7.69 | The role of corticosterone in the blockade of tolerance to morphine analgesia by formalin-induced pain in the rat. ( Nores, WL; Olson, RD; Soignier, RD; Vaccarino, AL, 1997) |
| "We previously reported that morphine fails to produce analgesic tolerance when administered in the presence of formalin-induced pain, which may be related to activity of the hypothalamic-pituitary-adrenal axis." | 3.69 | The role of corticosterone in the blockade of tolerance to morphine analgesia by formalin-induced pain in the rat. ( Nores, WL; Olson, RD; Soignier, RD; Vaccarino, AL, 1997) |
| "Propranolol is a non-selective β adrenergic receptor blocker which antagonises the anti-inflammatory effect of non-steroidal anti-inflammatory drugs via the β1 and β2 adrenergic receptors." | 1.37 | Effects of epinephrine and cortisol on the analgesic activity of metyrosine in rats. ( Akcay, F; Albayrak, Y; Karatay, S; Polat, B; Saglam, MB; Suleyman, H; Uslu, T; Yildirim, K, 2011) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 2 (50.00) | 18.7374 |
| 1990's | 1 (25.00) | 18.2507 |
| 2000's | 0 (0.00) | 29.6817 |
| 2010's | 1 (25.00) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Albayrak, Y | 1 |
| Saglam, MB | 1 |
| Yildirim, K | 1 |
| Karatay, S | 1 |
| Polat, B | 1 |
| Uslu, T | 1 |
| Suleyman, H | 1 |
| Akcay, F | 1 |
| Mousa, S | 1 |
| Miller, CH | 1 |
| Couri, D | 1 |
| Vaccarino, AL | 1 |
| Nores, WL | 1 |
| Soignier, RD | 1 |
| Olson, RD | 1 |
| Dedov, II | 1 |
4 other studies available for metyrapone and Pain
| Article | Year |
|---|---|
Effects of epinephrine and cortisol on the analgesic activity of metyrosine in rats.
Topics: Adrenergic beta-Antagonists; alpha-Methyltyrosine; Analgesics; Animals; Carrageenan; Chromatography, | 2011 |
Corticosteroid modulation and stress-induced analgesia in rats.
Topics: Adrenal Cortex Hormones; Animals; Cold Temperature; Dexamethasone; Male; Metyrapone; Pain; Rats; Rat | 1981 |
The role of corticosterone in the blockade of tolerance to morphine analgesia by formalin-induced pain in the rat.
Topics: Animals; Corticosterone; Drug Tolerance; Formaldehyde; Male; Metyrapone; Morphine; Narcotics; Pain; | 1997 |
[Medial eminence of the neurohypophysis in extreme conditions].
Topics: Animals; Epinephrine; Inclusion Bodies; Male; Metyrapone; Microscopy, Electron; Nerve Endings; Pain; | 1972 |