phenylalanine has been researched along with Pain in 45 studies
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 21 (46.67) | 18.7374 |
| 1990's | 9 (20.00) | 18.2507 |
| 2000's | 9 (20.00) | 29.6817 |
| 2010's | 6 (13.33) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Anderson, DJ; Baker, S; Gopalakrishnan, M; Honore, P; Jarvis, MF; Lee, CH; Lynch, JJ; McDonald, H; Mortell, KH; Nelson, SL; Sabet, R; Sarris, K | 1 |
| Bihani, G; Bodhankar, S; Dhaneshwar, S; Kusurkar, M | 1 |
| Becker, S; Ceko, M; Elfassy, NM; Leyton, M; Louis-Foster, M; Schweinhardt, P; Shir, Y | 1 |
| Baumkötter, J; Heitmann, H; Ploner, M; Schulz, E; Tiemann, L | 1 |
| Alevizou, A; Bozi, E; Gregoriou, S; Katoulis, A; Makris, M; Mantas, N; Rigopoulos, D; Soura, E | 1 |
| Acuña, MA; Benke, D; Burgos, CF; Corringer, PJ; Di Lio, A; Lara, CO; Moraga-Cid, G; Muñoz, B; Ralvenius, WT; Yévenes, GE; Zeilhofer, HU | 1 |
| Ariyoshi, Y; Kawabata, S; Kimura, Y; Maruhashi, A; Miyatake, S; Ono, K; Shimahara, M; Suzuki, M | 1 |
| Atula, T; Auterinen, I; Collan, J; Joensuu, H; Kankaanranta, L; Koivunoro, H; Kortesniemi, M; Kotiluoto, P; Kouri, M; Mäkitie, A; Minn, H; Revitzer, H; Saarilahti, K; Salli, E; Savolainen, S; Seppälä, T; Seppänen, M; Seren, T; Uusi-Simola, J; Välimäki, P | 1 |
| Allawi, J; Horrobin, DF; Loder, C | 1 |
| Besson, JM; Buritova, J; Fournié-Zaluski, MC; Le Guen, S; Roques, BP | 1 |
| Butkevich, IP; Makukhina, GV; Mikhaĭlenko, VA | 1 |
| Duggan, AW; Foong, FW; Zhao, ZQ | 1 |
| Marcus, R; Seltzer, S; Stoch, R | 1 |
| Johnston, MV; Singer, HS | 1 |
| Sicuteri, F | 2 |
| Ehrenpreis, S | 1 |
| D'Alessandro, R | 1 |
| Inoki, R; Kudo, T; Yonehara, N | 1 |
| Grecksch, G; Rüthrich, HL; Schmidt, R | 1 |
| Fournié-Zaluski, MC; Maldonado, R; Roques, BP; Turcaud, S; Valverde, O | 1 |
| Kaliuzhnyĭ, LV; Kozlov, AIu; Litvinova, SV | 1 |
| Derrien, M; Noble, F; Roques, BP | 1 |
| Besson, JM; Buritova, J; Fournié-Zaluski, MC; Honore, P; Roques, BP | 1 |
| Chover-Gonzalez, AJ; Fournié-Zaluski, MC; Gibert-Rahola, J; Lai-Kuen, R; Maldonado, R; Mico, JA; Ortega-Alvaro, A; Roques, BP | 1 |
| McCarty, MF; Russell, AL | 1 |
| Boucher, M; Coudoré-Civiale, MA; Eschalier, A; Fournié-Zaluski, MC; Méen, M; Roques, BP | 1 |
| Benavides, J; Fournié-Zaluski, MC; Nieto, MM; Noble, F; Roques, BP; Walker, J; Wilson, J | 1 |
| Brodzik-Bienkowska, A; Hruby, VJ; Kosson, D; Kosson, P; Lachwa-From, M; Lipkowski, AW; Misicka, A | 1 |
| Fernstrom, JD | 1 |
| Baamonde, A; Fournie-Zaluski, MC; Roques, BP; Ruiz-Gayo, M; Turcaud, S | 1 |
| Becker, A; Grecksch, G; Matthies, H | 1 |
| Hyodo, M; Ikeuchi, T; Kawachi, A; Kitade, T; Minamikawa, M; Morikawa, K; Odahara, Y; Sakai, T; Shinohara, S; Toyota, S | 2 |
| Nurmikko, T; Pertovaara, A; Pöntinen, PJ | 1 |
| Federici, F; Gerardi, AU; Morcellini, M | 1 |
| Dong, WK; Halpern, LM | 1 |
| Millinger, GS | 1 |
| Hoffman, J; Ramamurthy, S; Schoenfeld, L; Walsh, NE | 1 |
| Huffman, J; Ramamurthy, S; Schoenfeld, LS; Walsh, NE | 1 |
| Daines, GE; Mitchell, MJ; Thomas, BL | 1 |
| Sarne, Y; Segev, S; Urca, G | 1 |
| Tenen, SS | 2 |
| Gentz, J; Johansson, S; Lindblad, B; Lindstedt, S; Zetterström, R | 1 |
4 review(s) available for phenylalanine and Pain
| Article | Year |
|---|---|
Perspectives in the control of chronic pain by nutritional manipulation.
Topics: Animals; Antidepressive Agents; Brain; Chronic Disease; Humans; Leucine; Migraine Disorders; Neurotransmitter Agents; Pain; Phenylalanine; Rats; Sensory Thresholds; Serotonin; Tryptophan | 1981 |
Brain neurotransmitters and neuromodulators in pediatrics.
Topics: Attention Deficit Disorder with Hyperactivity; Autistic Disorder; Brain; Child; Endorphins; Enkephalins; Epilepsy; Humans; Movement Disorders; Neurotransmitter Agents; Pain; Phenylalanine; Psychotic Disorders; Receptors, Neurotransmitter | 1982 |
Effects on the diet on brain neurotransmitters.
Topics: Acetyl Coenzyme A; Acetylcholine; Animals; Brain; Catecholamines; Choline; Choline Deficiency; Diet; Dietary Proteins; Fatty Acids, Nonesterified; Hydroxyindoleacetic Acid; Insulin; Neurotransmitter Agents; Pain; Phenylalanine; Protein Binding; Rats; Serotonin; Serum Albumin; Tryptophan; Tyrosine; Tyrosine 3-Monooxygenase | 1977 |
Neutral amino acid therapy for the management of chronic pain.
Topics: Animals; Chronic Disease; Enkephalins; Humans; Pain; Phenylalanine; Serotonin; Transcutaneous Electric Nerve Stimulation; Tryptophan | 1986 |
6 trial(s) available for phenylalanine and Pain
| Article | Year |
|---|---|
A double-blind vehicle-controlled study of a preparation containing undecylenoyl phenylalanine 2% in the treatment of melasma in females.
Topics: Adult; Dermatologic Agents; Double-Blind Method; Erythema; Female; Humans; Lipopeptides; Melanosis; Middle Aged; Pain; Patient Satisfaction; Phenylalanine; Pruritus; Treatment Outcome | 2014 |
Boron neutron capture therapy in the treatment of locally recurred head-and-neck cancer: final analysis of a phase I/II trial.
Topics: Adult; Aged; Boron Compounds; Boron Neutron Capture Therapy; Carcinoma, Adenoid Cystic; Carcinoma, Squamous Cell; Confidence Intervals; Disease-Free Survival; Fatigue; Female; Head and Neck Neoplasms; Humans; Male; Middle Aged; Mouth Diseases; Mucositis; Neoplasm Recurrence, Local; Osteoradionecrosis; Pain; Phenylalanine; Prospective Studies; Radiotherapy Dosage; Sarcoma; Xerostomia | 2012 |
Treatment of multiple sclerosis with lofepramine, L-phenylalanine and vitamin B(12): mechanism of action and clinical importance: roles of the locus coeruleus and central noradrenergic systems.
Topics: Adrenergic Fibers; Adrenergic Uptake Inhibitors; Antidepressive Agents; Chronic Disease; Double-Blind Method; Drug Therapy, Combination; Fatigue Syndrome, Chronic; Humans; Locus Coeruleus; Lofepramine; Methylation; Multiple Sclerosis; Norepinephrine; Pain; Phenylalanine; Severity of Illness Index; Stroke; Stroke Rehabilitation; Tegmentum Mesencephali; Treatment Outcome; Vitamin B 12 | 2002 |
Studies on the enhanced effect of acupuncture analgesia and acupuncture anesthesia by D-phenylalanine (2nd report)--schedule of administration and clinical effects in low back pain and tooth extraction.
Topics: Acupuncture Analgesia; Administration, Oral; Adult; Back Pain; Drug Administration Schedule; Electroacupuncture; Female; Humans; Male; Middle Aged; Pain; Phenylalanine; Placebos; Premedication; Tooth Extraction | 1990 |
Analgesic effectiveness of D-phenylalanine in chronic pain patients.
Topics: Animals; Chronic Disease; Clinical Trials as Topic; Double-Blind Method; Enkephalins; Female; Humans; Male; Mice; Middle Aged; Nociceptors; Pain; Phenylalanine; Random Allocation; Rats | 1986 |
Effect of L-tryptophan and phenylalanine on burning pain threshold.
Topics: Adult; Burns; Double-Blind Method; Female; Humans; Pain; Phenylalanine; Random Allocation; Sensory Thresholds; Tryptophan | 1987 |
35 other study(ies) available for phenylalanine and Pain
| Article | Year |
|---|---|
Structure-activity relationships of alpha-amino acid ligands for the alpha2delta subunit of voltage-gated calcium channels.
Topics: Amino Acids; Animals; Benzene; Calcium Channel Blockers; Calcium Channels; Ligands; Molecular Structure; Pain; Protein Subunits; Rats; Structure-Activity Relationship | 2006 |
Carrier-linked mutual prodrugs of biphenylacetic acid as a promising alternative to bioprecursor fenbufen: design, kinetics, and pharmacological studies.
Topics: Administration, Oral; Analgesics; Animals; Anti-Inflammatory Agents, Non-Steroidal; Arthritis, Experimental; Arthritis, Rheumatoid; Disease Models, Animal; Drug Liberation; Female; Glycine; Humans; Inflammation; Male; Pain; Phenylacetates; Phenylalanine; Phenylbutyrates; Prodrugs; Rats; Rats, Wistar | 2014 |
Dopamine and pain sensitivity: neither sulpiride nor acute phenylalanine and tyrosine depletion have effects on thermal pain sensations in healthy volunteers.
Topics: Adolescent; Adult; Affect; Anxiety; Dopamine; Dopamine D2 Receptor Antagonists; Female; Healthy Volunteers; Humans; Male; Pain; Pain Perception; Pain Threshold; Phenylalanine; Presynaptic Terminals; Receptors, Dopamine D2; Sulpiride; Thermosensing; Tyrosine; Young Adult | 2013 |
Dopamine precursor depletion influences pain affect rather than pain sensation.
Topics: Adult; Dopamine; Electroencephalography; Healthy Volunteers; Humans; Male; Pain; Pain Perception; Pain Threshold; Phenylalanine; Synaptic Transmission; Tyrosine; Young Adult | 2014 |
Phosphorylation state-dependent modulation of spinal glycine receptors alleviates inflammatory pain.
Topics: Allosteric Site; Animals; Female; HEK293 Cells; Humans; Hyperalgesia; Inflammation; Inflammation Mediators; Male; Mice; Mice, Inbred C57BL; Mice, Transgenic; Models, Molecular; Neurons; Pain; Pain Management; Phenols; Phenylalanine; Phosphorylation; Protein Conformation; Receptors, Glycine; Recombinant Proteins; Spinal Cord | 2016 |
Boron neutron capture therapy for recurrent oral cancer and metastasis of cervical lymph node.
Topics: Adult; Aged; Aged, 80 and over; Boron Compounds; Boron Neutron Capture Therapy; Female; Fluorine Radioisotopes; Humans; Lymphatic Metastasis; Male; Middle Aged; Mouth Neoplasms; Neck; Neoplasm Recurrence, Local; Pain; Phenylalanine; Positron-Emission Tomography; Quality of Life; Radiation-Sensitizing Agents; Radiopharmaceuticals; Tomography, X-Ray Computed | 2009 |
Antinociceptive effects of RB101(S), a complete inhibitor of enkephalin-catabolizing enzymes, are enhanced by (+)-HA966, a functional NMDA receptor antagonist: a c-Fos study in the rat spinal cord.
Topics: Analgesics; Animals; Carrageenan; Disulfides; Drug Therapy, Combination; Enkephalins; Enzyme Inhibitors; Excitatory Amino Acid Antagonists; Immunohistochemistry; Inflammation; Male; Naloxone; Narcotic Antagonists; Pain; Phenylalanine; Proto-Oncogene Proteins c-fos; Pyrrolidinones; Rats; Rats, Sprague-Dawley; Receptors, N-Methyl-D-Aspartate; Spinal Cord | 2003 |
[Antinociceptive properties of the 5-HT3 receptor antagonist in the model of inflammatory pain in rats of different age with prenatal deficit of serotonine and under stress].
Topics: Aging; Analgesics; Animals; Female; Inflammation; Male; Ondansetron; Pain; Phenylalanine; Pregnancy; Prenatal Exposure Delayed Effects; Rats; Rats, Wistar; Receptors, Serotonin, 5-HT3; Serotonin; Serotonin 5-HT3 Receptor Antagonists; Serotonin Antagonists; Stress, Physiological | 2007 |
Lack of interaction between methionine enkephalin and D-phenylalanine on nociceptive and non-nociceptive responses of dorsal horn neurones of the cat.
Topics: Analgesia; Animals; Cats; Drug Interactions; Enkephalin, Methionine; Naloxone; Neurons; Pain; Phenylalanine; Receptors, Opioid; Reflex; Spinal Cord | 1984 |
Enkephalinase inhibition relieves pain syndromes of central dysnociception (migraine and related headache).
Topics: Acute Disease; Adult; Animals; Aprotinin; Bradykinin; Captopril; Drug Therapy, Combination; Ergotamine; Female; Guinea Pigs; Headache; Humans; Hypertension; Male; Mice; Middle Aged; Migraine Disorders; Neprilysin; Pain; Phenylalanine; Proline; Protease Inhibitors | 1981 |
D-phenylalanine and other enkephalinase inhibitors as pharmacological agents: implications for some important therapeutic application.
Topics: Acupuncture Therapy; Animals; Drug Tolerance; Enkephalin, Methionine; Enkephalins; Humans; Morphine; Morphine Dependence; Neprilysin; Nociceptors; Pain; Phenylalanine; Protease Inhibitors; Receptors, Opioid | 1982 |
d-Phenylalanine does not affect nociceptive, flexion reflex thresholds in normal humans.
Topics: Double-Blind Method; Endorphins; Humans; Pain; Phenylalanine; Reflex | 1983 |
Synthesis and release of endorphins in trigeminal sensory nuclear complex induced by tooth pulp stimulation in the rat.
Topics: Animals; Cycloheximide; Dental Pulp; Electric Stimulation; Endorphins; Male; Pain; Phenylalanine; Rats; Rats, Inbred Strains; Trigeminal Nuclei | 1982 |
Phe1-substituted beta-casomorphin-5 analogues with analgesic activity.
Topics: Amino Acid Sequence; Analgesics; Animals; Disease Models, Animal; Drug Tolerance; Endorphins; Male; Molecular Sequence Data; Morphine; Pain; Peptide Fragments; Phenylalanine; Rats; Rats, Wistar; Vocalization, Animal | 1994 |
Antinociceptive response induced by mixed inhibitors of enkephalin catabolism in peripheral inflammation.
Topics: Analgesics; Animals; Disulfides; Enkephalins; Hydroxamic Acids; Inflammation; Injections, Intraventricular; Male; Morphine; Naloxone; Narcotic Antagonists; Neprilysin; Pain; Pain Measurement; Phenylalanine; Quaternary Ammonium Compounds; Rats; Rats, Sprague-Dawley | 1994 |
[The enkephalinase mechanisms of the resistance and tolerance to the analgesic effect of morphine in rats. Differences in the effects of the action of D-phenylalanine in morphine-sensitive, morphine-tolerant and morphine-resistant rats].
Topics: Analgesia; Animals; Dose-Response Relationship, Drug; Drug Resistance; Drug Tolerance; Male; Morphine; Neprilysin; Pain; Phenylalanine; Rats; Rats, Wistar; Time Factors | 1993 |
Modulation of opioid antinociception by CCK at the supraspinal level: evidence of regulatory mechanisms between CCK and enkephalin systems in the control of pain.
Topics: Amino Acid Sequence; Analgesics; Animals; Cholecystokinin; Disulfides; Endorphins; Enkephalin, Ala(2)-MePhe(4)-Gly(5)-; Enkephalins; Injections, Intraventricular; Male; Mice; Molecular Sequence Data; Oligopeptides; Pain; Pain Measurement; Peptide Fragments; Phenylalanine; Sincalide; Spinal Cord | 1993 |
Antinociceptive effects of RB101, a complete inhibitor of enkephalin-catabolizing enzymes, are enhanced by a cholecystokinin type B receptor antagonist, as revealed by noxiously evoked spinal c-Fos expression in rats.
Topics: Analgesics; Animals; Benzodiazepinones; Devazepide; Disulfides; Dose-Response Relationship, Drug; Edema; Enzyme Inhibitors; Indoles; Male; Meglumine; Pain; Phenylalanine; Proto-Oncogene Proteins c-fos; Rats; Rats, Sprague-Dawley; Receptor, Cholecystokinin B; Receptors, Cholecystokinin; Spinal Cord | 1997 |
Antinociception produced by the peptidase inhibitor, RB 101, in rats with adrenal medullary transplant into the spinal cord.
Topics: Adrenal Medulla; Adrenergic alpha-Antagonists; Analysis of Variance; Animals; Disulfides; Injections, Intravenous; Male; Naloxone; Narcotic Antagonists; Pain; Phentolamine; Phenylalanine; Protease Inhibitors; Rats; Rats, Wistar; Spinal Cord; Subarachnoid Space; Transplantation, Autologous | 1998 |
DL-phenylalanine markedly potentiates opiate analgesia - an example of nutrient/pharmaceutical up-regulation of the endogenous analgesia system.
Topics: Analgesia; Analgesics, Opioid; Drug Synergism; Humans; Models, Neurological; Neural Pathways; Pain; Phenylalanine; Up-Regulation | 2000 |
Enhancement of the effects of a complete inhibitor of enkephalin-catabolizing enzymes, RB 101, by a cholecystokinin-B receptor antagonist in diabetic rats.
Topics: Aminopeptidases; Animals; Diabetes Mellitus, Experimental; Disulfides; Drug Synergism; Indoles; Male; Meglumine; Naloxone; Naltrexone; Neprilysin; Pain; Pain Measurement; Phenylalanine; Pressure; Rats; Rats, Sprague-Dawley; Receptor, Cholecystokinin B; Receptors, Cholecystokinin; Time Factors; Vocalization, Animal; Weight Loss | 2001 |
Facilitation of enkephalins catabolism inhibitor-induced antinociception by drugs classically used in pain management.
Topics: Analgesics; Analgesics, Opioid; Animals; Anti-Inflammatory Agents, Non-Steroidal; Arthritis, Experimental; Disulfides; Enkephalins; Enzyme Inhibitors; Formaldehyde; Injections, Intravenous; Injections, Subcutaneous; Male; Mice; Morphine; Neprilysin; Pain; Pain Measurement; Phenylalanine; Pressure; Rats; Rats, Sprague-Dawley; Reaction Time | 2001 |
Biological properties of a new fluorescent biphalin fragment analogue.
Topics: Analgesia; Analgesics; Animals; Dansyl Compounds; Enkephalins; Fluorescent Dyes; Male; Pain; Phenylalanine; Rats; Rats, Wistar; Receptors, Opioid, delta; Receptors, Opioid, mu | 2002 |
Hypothesis: migraine, a central biochemical dysnociception.
Topics: Adult; Animals; Apomorphine; Circadian Rhythm; Dopamine; Female; Fever; Headache; Humans; Levodopa; Lysergic Acid Diethylamide; Male; Migraine Disorders; Nervous System; Norepinephrine; Pain; Perceptual Disorders; Phenylalanine; Psilocybin; Rats; Reserpine; Serotonin; Sleep; Somatosensory Cortex; Synaptic Transmission | 1976 |
In vivo occupation of mouse brain opioid receptors by endogenous enkephalins: blockade of enkephalin degrading enzymes by RB 101 inhibits [3H]diprenorphine binding.
Topics: Analgesics; Animals; Brain; Cell Membrane; Diprenorphine; Disulfides; Enkephalins; Hot Temperature; Kinetics; Male; Mice; Mice, Inbred Strains; Neprilysin; Pain; Phenylalanine; Receptors, Opioid; Stress, Psychological; Tritium | 1992 |
Modulation of the antinociceptive effect of morphine by casomorphin derivatives.
Topics: Amino Acid Sequence; Animals; Drug Interactions; Endorphins; Enkephalin, Leucine-2-Alanine; Male; Mice; Mice, Inbred ICR; Molecular Sequence Data; Morphine; Pain; Phenylalanine; Proline; Stereoisomerism; Structure-Activity Relationship | 1991 |
Attenuation of tourniquet-induced pain in man by D-phenylalanine, a putative inhibitor of enkephalin degradation.
Topics: Adult; Arm; Double-Blind Method; Enkephalins; Female; Humans; Ischemia; Male; Middle Aged; Pain; Phenylalanine; Pressure; Tourniquets | 1987 |
Studies on the enhanced effect of acupuncture analgesia and acupuncture anesthesia by D-phenylalanine (first report)--effect on pain threshold and inhibition by naloxone.
Topics: Acupuncture Therapy; Adult; Analgesia; Anesthesia; Double-Blind Method; Female; Humans; Male; Naloxone; Pain; Phenylalanine; Placebos; Receptors, Opioid; Sensory Thresholds | 1988 |
[Cortico-thalamic potentials evoked by phenylalanine in pain. Experimental research].
Topics: Animals; Cerebral Cortex; Evoked Potentials; Female; Male; Pain; Phenylalanine; Rats; Thalamus | 1987 |
D-phenylalanine: a putative enkephalinase inhibitor studied in a primate acute pain model.
Topics: Animals; Aspirin; Avoidance Learning; Carboxypeptidases; Drug Interactions; Isomerism; Macaca fascicularis; Male; Morphine; Naloxone; Neprilysin; Pain; Phenylalanine; Protease Inhibitors; Sensory Thresholds; Tolmetin | 1986 |
D-phenylalanine was not found to exhibit opiate receptor mediated analgesia in monkeys.
Topics: Analgesics; Animals; Humans; Pain; Phenylalanine | 1986 |
Footshock-induced analgesia: its opioid nature depends on the strain of rat.
Topics: Analgesia; Animals; Electroshock; Endorphins; Foot; Naloxone; Pain; Periaqueductal Gray; Phenylalanine; Rats; Rats, Inbred Strains; Rats, Inbred WKY; Species Specificity | 1985 |
The effects of p-chlorophenylalanine, a serotonin depletor, on avoidance acquisition, pain sensitivity and related behavior in the rat.
Topics: Animals; Avoidance Learning; Brain; Conditioning, Psychological; Drinking; Electroshock; Escape Reaction; Habits; Humans; Locomotion; Motor Activity; Pain; Phenylalanine; Psychopharmacology; Rats; Reinforcement, Psychology; Serotonin | 1967 |
Antagonism of the analgesic effect of morphine and other drugs by p-chlorophenylalanine, a serotonin depletor.
Topics: Analgesia; Animals; Brain; Codeine; Dextropropoxyphene; Electroshock; Male; Methadone; Morphine; Pain; Phenylalanine; Rats; Serotonin; Serotonin Antagonists | 1968 |
Exertion of delta-aminolevulinic acid in hereditary tyrosinemia.
Topics: Abdomen; Adolescent; Amino Acid Metabolism, Inborn Errors; Amino Acids; Child; Creatinine; Feces; Female; Humans; Leg; Levulinic Acids; Male; Pain; Paresis; Phenylalanine; Porphyrins; Pyrroles; Tritium; Tyrosine | 1969 |