Compounds > pentamorphone
Page last updated: 2024-11-11

pentamorphone

Description Research Excerpts Clinical Trials Roles Classes Pathways Study Profile Bioassays Related Drugs Related Conditions Protein Interactions Research Growth Market Indicators

Cross-References

ID SourceID
PubMed CID5464186
CHEMBL ID2107032
SCHEMBL ID120834
MeSH IDM0163428

Synonyms (30)

Synonym
pentamorphone
rx-77989
a-4492 ,
D05416
68616-83-1
pentamorphone (usan/inn)
rx77989
pentamorphona [inn-spanish]
mm4487b4mw ,
7,8-didehydro-4,5alpha-epoxy-3-hydroxy-17-methyl-14-(pentylamino)morphinan-6-one
unii-mm4487b4mw
morphinan-6-one, 7,8-didehydro-4,5-epoxy-3-hydroxy-17-methyl-14-(pentylamino)-, (5alpha)-
pentamorphona
pentamorphonum
pentamorphonum [inn-latin]
rx 77989
pentamorphone [usan:inn]
14b-n-pentylaminomorphinone
CHEMBL2107032
SCHEMBL120834
pentamorphone [inn]
morphinan-6-one, 7,8-didehydro-4,5-epoxy-3-hydroxy-17-methyl-14-(pentylamino)-, (5.alpha.)-
pentamorphone [usan]
pentamorphone [mart.]
(4r,4as,7ar,12br)-9-hydroxy-3-methyl-4a-(pentylamino)-2,3,4,4a-tetrahydro-1h-4,12-methanobenzofuro[3,2-e]isoquinolin-7(7ah)-one
Q7165029
DTXSID901018235
pentamorphone; rx 77989;a 4492
penomorphone
(4r,4as,7ar,12br)-9-hydroxy-3-methyl-4a-(pentylamino)-2,4,7a,13-tetrahydro-1h-4,12-methanobenzofuro[3,2-e]isoquinolin-7-one

Research Excerpts

Overview

Pentamorphone is a novel, potent opiate with rapid onset and short duration of action that has been reported to produce analgesia with limited depression of ventilation. It appears to be an analgesic with clinically tolerable side effects in the range 0.12 to 0.24 microgram.kg-1.

ExcerptReferenceRelevance
"Pentamorphone is a new, highly potent opioid reported to have minimal cardiovascular effects in humans and a high therapeutic index in animals. "( Pharmacodynamics of pentamorphone during coronary artery bypass grafting in humans.
Falinski, BA; Hug, CC; Klochany, A; Sebel, PS, 1992)		2.05
"Pentamorphone is a novel, potent opiate with rapid onset and short duration of action that has been reported to produce analgesia with limited depression of ventilation. "( Depression of ventilatory responses to hypoxia and hypercapnia after pentamorphone.
Afifi, MS; Camporesi, EM; Cohen, NA; Glass, PS; Shook, JE, 1990)		1.96
"Pentamorphone appears to be an analgesic with clinically tolerable side effects in the range 0.12 to 0.24 microgram.kg-1 that merits further evaluation under clinical conditions."( Evaluation of pentamorphone in humans: a new potent opiate.
Camporesi, EM; Glass, PS; Quill, T; Reves, JG; Shafron, D, 1989)		1.36
[information is derived through text-mining from research data collected from National Library of Medicine (NLM), extracted Dec-2023]

Research

Studies (8)

TimeframeStudies, This Drug (%)All Drugs %
pre-19902 (25.00)18.7374
1990's6 (75.00)18.2507
2000's0 (0.00)29.6817
2010's0 (0.00)24.3611
2020's0 (0.00)2.80
[information is prepared from research data collected from National Library of Medicine (NLM), extracted Dec-2023]

Market Indicators

Research Demand Index: 12.19

According to the monthly volume, diversity, and competition of internet searches for this compound, as well the volume and growth of publications, there is estimated to be weak demand-to-supply ratio for research on this compound.

MetricThis Compound (vs All)
Research Demand Index12.19 (24.57)
Research Supply Index2.56 (2.92)
Research Growth Index4.76 (4.65)
Search Engine Demand Index0.00 (26.88)
Search Engine Supply Index0.00 (0.95)

This Compound (12.19)

All Compounds (24.57)

Study Types

Publication TypeThis drug (%)All Drugs (%)
Trials4 (50.00%)5.53%
Reviews0 (0.00%)6.00%
Case Studies0 (0.00%)4.05%
Observational0 (0.00%)0.25%
Other4 (50.00%)84.16%
[information is prepared from research data collected from National Library of Medicine (NLM), extracted Dec-2023]
SubstanceRelationship StrengthStudiesTrialsClassesRoles
nitrous oxide
Nitrous Oxide: Nitrogen oxide (N2O). A colorless, odorless gas that is used as an anesthetic and analgesic. High concentrations cause a narcotic effect and may replace oxygen, causing death by asphyxia. It is also used as a food aerosol in the preparation of whipping cream.. dinitrogen oxide : A nitrogen oxide consisting of linear unsymmetrical molecules with formula N2O. While it is the most used gaseous anaesthetic in the world, its major commercial use, due to its solubility under pressure in vegetable fats combined with its non-toxicity in low concentrations, is as an aerosol spray propellant and aerating agent for canisters of 'whipped' cream.		1.9710gas molecular entity;
nitrogen oxide		analgesic;
bacterial metabolite;
food packaging gas;
food propellant;
general anaesthetic;
greenhouse gas;
inhalation anaesthetic;
NMDA receptor antagonist;
raising agent;
refrigerant;
vasodilator agent
fentanyl
Fentanyl: A potent narcotic analgesic, abuse of which leads to habituation or addiction. It is primarily a mu-opioid agonist. Fentanyl is also used as an adjunct to general anesthetics, and as an anesthetic for induction and maintenance. (From Martindale, The Extra Pharmacopoeia, 30th ed, p1078). fentanyl : A monocarboxylic acid amide resulting from the formal condensation of the aryl amino group of N-phenyl-1-(2-phenylethyl)piperidin-4-amine with propanoic acid.		4.6132anilide;
monocarboxylic acid amide;
piperidines		adjuvant;
anaesthesia adjuvant;
anaesthetic;
intravenous anaesthetic;
mu-opioid receptor agonist;
opioid analgesic
isoflurane
Isoflurane: A stable, non-explosive inhalation anesthetic, relatively free from significant side effects.		3.3711organofluorine compoundinhalation anaesthetic
hydromorphone
Hydromorphone: An opioid analgesic made from MORPHINE and used mainly as an analgesic. It has a shorter duration of action than morphine.. hydromorphone : A morphinane alkaloid that is a hydrogenated ketone derivative of morphine. A semi-synthetic drug, it is a centrally acting pain medication of the opioid class.		6.0484morphinane alkaloid;
organic heteropentacyclic compound		mu-opioid receptor agonist;
opioid analgesic
morphine
Meconium: The thick green-to-black mucilaginous material found in the intestines of a full-term fetus. It consists of secretions of the INTESTINAL GLANDS; BILE PIGMENTS; FATTY ACIDS; AMNIOTIC FLUID; and intrauterine debris. It constitutes the first stools passed by a newborn.		6.9710morphinane alkaloid;
organic heteropentacyclic compound;
tertiary amino compound		anaesthetic;
drug allergen;
environmental contaminant;
geroprotector;
mu-opioid receptor agonist;
opioid analgesic;
plant metabolite;
vasodilator agent;
xenobiotic
ConditionIndicatedRelationship StrengthStudiesTrials
Acute Post-operative Pain
[description not available]		04.3322
Pain, Postoperative
Pain during the period after surgery.		04.3322
Anoxemia
[description not available]		03.3611
Hypercapnia
A clinical manifestation of abnormal increase in the amount of carbon dioxide in arterial blood.		08.3611
Hypoxia
Sub-optimal OXYGEN levels in the ambient air of living organisms.		08.3611
Sensitivity and Specificity
Binary classification measures to assess test results. Sensitivity or recall rate is the proportion of true positives. Specificity is the probability of correctly determining the absence of a condition. (From Last, Dictionary of Epidemiology, 2d ed)		01.9710
Ache
[description not available]		03.3611
Pain
An unpleasant sensation induced by noxious stimuli which are detected by NERVE ENDINGS of NOCICEPTIVE NEURONS.		03.3611