Proteins > Potassium voltage-gated channel subfamily KQT member 2
Page last updated: 2024-08-07 17:33:13
Potassium voltage-gated channel subfamily KQT member 2
A voltage-gated potassium channel subunit KCNQ2 that is encoded in the genome of mouse. [OMA:Q9Z351, PRO:DNx]
Synonyms
KQT-like 2;
Potassium channel subunit alpha KvLQT2;
Voltage-gated potassium channel subunit Kv7.2
Research
Bioassay Publications (3)
| Timeframe | Studies on this Protein(%) | All Drugs % |
|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 0 (0.00) | 18.2507 |
| 2000's | 2 (66.67) | 29.6817 |
| 2010's | 1 (33.33) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
Compounds (1)
Drugs with Activation Measurements
| Drug | Taxonomy | Measurement | Average (mM) | Bioassay(s) | Publication(s) |
|---|
| ezogabine | Mus musculus (house mouse) | EC50 | 1.3000 | 3 | 3 |
Discovery of (S,E)-3-(2-fluorophenyl)-N-(1-(3-(pyridin-3-yloxy)phenyl)ethyl)-acrylamide as a potent and efficacious KCNQ2 (Kv7.2) opener for the treatment of neuropathic pain.Bioorganic & medicinal chemistry letters, , Nov-15, Volume: 23, Issue:22, 2013
(S,E)-N-[1-(3-heteroarylphenyl)ethyl]-3-(2-fluorophenyl)acrylamides: synthesis and KCNQ2 potassium channel opener activity.Bioorganic & medicinal chemistry letters, , Jan-17, Volume: 15, Issue:2, 2005
(S)-N-[1-(4-cyclopropylmethyl-3,4-dihydro-2H-benzo[1,4]oxazin-6-yl)-ethyl]-3-(2-fluoro-phenyl)-acrylamide is a potent and efficacious KCNQ2 opener which inhibits induced hyperexcitability of rat hippocampal neurons.Bioorganic & medicinal chemistry letters, , Apr-19, Volume: 14, Issue:8, 2004