15-hydroperoxy-5-8-11-13-eicosatetraenoic-acid and Pain

15-hydroperoxy-5-8-11-13-eicosatetraenoic-acid has been researched along with Pain* in 1 studies

Other Studies

1 other study(ies) available for 15-hydroperoxy-5-8-11-13-eicosatetraenoic-acid and Pain

ArticleYear
Involvement of spinal lipoxygenase metabolites in hyperalgesia and opioid tolerance.
    European journal of pharmacology, 2004, Apr-26, Volume: 491, Issue:1

    This study investigated role of spinal lipoxygenase metabolites in induction of hyperalgesia and development of opioid analgesic tolerance. In the rat, nociception was measured using formalin and tail-flick tests. Intrathecal administration of leukotriene receptor agonist (LTB4) augmented the second phase of the formalin response and marginally increased sensitivity to acute thermal stimulation in the tail-flick test, responses suppressed by 6-(6-(3R-hydroxy-1E,5Z-undecadien-1-yl)-2-pyridinyl)-1,5S-hexanediol (U75302), a leukotriene BLT receptor antagonist. Treatment with 15-hydroxyperoxyeicosatetranoic acid (HPETE) increased phase II formalin activity, but had no effect on tail-flick responses. 12-HPETE failed to produce an effect in either nociceptive test. In the second part of this study, chronic spinal morphine for 5 days produced progressive decline in morphine antinociception and loss in analgesic potency. These effects were attenuated by co-administration of morphine with selective and nonselective lipoxygenase inhibitors. These results suggest involvement of lipoxygenase metabolites in both pain modulation and induction of opioid tolerance at the spinal level.

    Topics: Analgesics, Opioid; Animals; Benzoquinones; Dose-Response Relationship, Drug; Drug Tolerance; Flavanones; Formaldehyde; Hindlimb; Hyperalgesia; Injections, Spinal; Leukotriene B4; Leukotrienes; Lipid Peroxides; Lipoxygenase; Lipoxygenase Inhibitors; Male; Masoprocol; Morphine; Pain; Pain Measurement; Rats; Rats, Sprague-Dawley; Spinal Cord; Time Factors

2004