| Assay ID | Title | Year | Journal | Article |
|---|
| AID290259 | Selectivity for kappa opioid receptor over mu opioid receptor expressed in CHO cells | 2007 | Bioorganic & medicinal chemistry letters, Mar-15, Volume: 17, Issue:6
| High-affinity carbamate analogues of morphinan at opioid receptors. |
| AID670111 | Displacement of [3H]-U69,593 from human kappa opioid receptor expressed in CHO cells after 60 mins by scintillation counting | 2012 | Journal of medicinal chemistry, Apr-26, Volume: 55, Issue:8
| Synthesis, binding affinity, and functional in vitro activity of 3-benzylaminomorphinan and 3-benzylaminomorphine ligands at opioid receptors. |
| AID149976 | Agonistic activity against kappa opioid receptor in Chinese hamster ovary membranes | 2004 | Journal of medicinal chemistry, Apr-08, Volume: 47, Issue:8
| 2-aminothiazole-derived opioids. Bioisosteric replacement of phenols. |
| AID1148433 | Narcotic antagonist activity in sc dosed mouse assessed as reversal of oxymorphone-induced straub tail response administered 10 mins before oxymorphone challenge | 1978 | Journal of medicinal chemistry, May, Volume: 21, Issue:5
| Analgesics and narcotic antagonists in the benzomorphan and 8-oxamorphinan series. 5. |
| AID592432 | Displacement of [3H]U69593 from human kappa opioid receptor expressed in CHO cells after 60 mins by scintillation counting | 2011 | Journal of medicinal chemistry, Mar-24, Volume: 54, Issue:6
| Aminothiazolomorphinans with mixed κ and μ opioid activity. |
| AID149121 | Binding affinity against opioid receptor kappa 1 using [3H]-U-69,593 as radioligand in guinea pig brain membranes. | 2004 | Journal of medicinal chemistry, Jan-01, Volume: 47, Issue:1
| 10-Ketomorphinan and 3-substituted-3-desoxymorphinan analogues as mixed kappa and micro opioid ligands: synthesis and biological evaluation of their binding affinity at opioid receptors. |
| AID149778 | Binding affinity against opioid receptor delta 1 using [3H]naltrindole as radioligand in guinea pig brain membranes. | 2004 | Journal of medicinal chemistry, Jan-01, Volume: 47, Issue:1
| 10-Ketomorphinan and 3-substituted-3-desoxymorphinan analogues as mixed kappa and micro opioid ligands: synthesis and biological evaluation of their binding affinity at opioid receptors. |
| AID149904 | Binding affinity towards Opioid receptor delta 1 in guinea pig brain membranes using [3H]naltrindole as radioligand | 2001 | Bioorganic & medicinal chemistry letters, Oct-22, Volume: 11, Issue:20
| Mixed kappa agonists and mu agonists/antagonists as potential pharmacotherapeutics for cocaine abuse: synthesis and opioid receptor binding affinity of N-substituted derivatives of morphinan. |
| AID259402 | Activity at human mu opioid receptor expressed in CHO cells by [35S]GTP-gamma-S binding assay | 2006 | Journal of medicinal chemistry, Jan-12, Volume: 49, Issue:1
| Synthesis and preliminary in vitro investigation of bivalent ligands containing homo- and heterodimeric pharmacophores at mu, delta, and kappa opioid receptors. |
| AID592434 | Antagonist activity at human kappa opioid receptor expressed in CHO cells assessed as increase in U50488-induced [35S]GTPgammaS binding by scintillation counting | 2011 | Journal of medicinal chemistry, Mar-24, Volume: 54, Issue:6
| Aminothiazolomorphinans with mixed κ and μ opioid activity. |
| AID1148435 | Narcotic antagonist activity in sc dosed mouse assessed as reversal of oxymorphone-induced narcosis | 1978 | Journal of medicinal chemistry, May, Volume: 21, Issue:5
| Analgesics and narcotic antagonists in the benzomorphan and 8-oxamorphinan series. 5. |
| AID296055 | Displacement of [3H]naltrindole from human delta opioid receptor expressed in CHO membrane | 2007 | Bioorganic & medicinal chemistry, Jun-15, Volume: 15, Issue:12
| In-vitro investigation of oxazol and urea analogues of morphinan at opioid receptors. |
| AID296054 | Displacement of [3H]U69,593 from human kappa opioid receptor expressed in CHO membrane | 2007 | Bioorganic & medicinal chemistry, Jun-15, Volume: 15, Issue:12
| In-vitro investigation of oxazol and urea analogues of morphinan at opioid receptors. |
| AID235330 | Selectivity ratio of kappa opioid receptor to that of mu opioid receptor in guinea pig brain membranes | 2001 | Bioorganic & medicinal chemistry letters, Oct-22, Volume: 11, Issue:20
| Mixed kappa agonists and mu agonists/antagonists as potential pharmacotherapeutics for cocaine abuse: synthesis and opioid receptor binding affinity of N-substituted derivatives of morphinan. |
| AID229388 | Relative affinity for delta and kappa opioid receptors | 2004 | Journal of medicinal chemistry, Apr-08, Volume: 47, Issue:8
| 2-aminothiazole-derived opioids. Bioisosteric replacement of phenols. |
| AID148369 | Inhibitory activity against Opioid receptor delta 1 in chinese Hamster Ovary (CHO) cell membranes was determined using [3H]naltrindole radioligand | 2003 | Journal of medicinal chemistry, Nov-20, Volume: 46, Issue:24
| Design and synthesis of novel dimeric morphinan ligands for kappa and micro opioid receptors. |
| AID150824 | Inhibitory activity was determined in stimulating [35S]-GTP-gamma S binding mediated by the Opioid receptor mu 1 in chinese Hamster Ovary (CHO)membranes | 2003 | Journal of medicinal chemistry, Nov-20, Volume: 46, Issue:24
| Design and synthesis of novel dimeric morphinan ligands for kappa and micro opioid receptors. |
| AID259396 | Displacement of [3H]U69593 from human kappa opioid receptor expressed in CHO cells | 2006 | Journal of medicinal chemistry, Jan-12, Volume: 49, Issue:1
| Synthesis and preliminary in vitro investigation of bivalent ligands containing homo- and heterodimeric pharmacophores at mu, delta, and kappa opioid receptors. |
| AID259395 | Displacement of [3H]naltrindole from human delta opioid receptor expressed in CHO cells | 2006 | Journal of medicinal chemistry, Jan-12, Volume: 49, Issue:1
| Synthesis and preliminary in vitro investigation of bivalent ligands containing homo- and heterodimeric pharmacophores at mu, delta, and kappa opioid receptors. |
| AID592437 | Selectivity ratio of Ki for human mu opioid receptor to Ki for human kappa opioid receptor | 2011 | Journal of medicinal chemistry, Mar-24, Volume: 54, Issue:6
| Aminothiazolomorphinans with mixed κ and μ opioid activity. |
| AID235329 | Selectivity ratio of kappa opioid receptor to that of delta opioid receptor in guinea pig brain membranes | 2001 | Bioorganic & medicinal chemistry letters, Oct-22, Volume: 11, Issue:20
| Mixed kappa agonists and mu agonists/antagonists as potential pharmacotherapeutics for cocaine abuse: synthesis and opioid receptor binding affinity of N-substituted derivatives of morphinan. |
| AID670113 | Displacement of [3H]-naltrindole from human delta opioid receptor expressed in CHO cells after 3 hrs by scintillation counting | 2012 | Journal of medicinal chemistry, Apr-26, Volume: 55, Issue:8
| Synthesis, binding affinity, and functional in vitro activity of 3-benzylaminomorphinan and 3-benzylaminomorphine ligands at opioid receptors. |
| AID592436 | Displacement of [3H]Naltrindole from human delta opioid receptor expressed in CHO cells after 3 hrs by scintillation counting | 2011 | Journal of medicinal chemistry, Mar-24, Volume: 54, Issue:6
| Aminothiazolomorphinans with mixed κ and μ opioid activity. |
| AID296059 | Antagonist activity at human kappa opioid receptor expressed in CHO cells assessed as inhibition of U69,593-induced stimulation of [35S]GTP-gamma-S binding after 60 mins | 2007 | Bioorganic & medicinal chemistry, Jun-15, Volume: 15, Issue:12
| In-vitro investigation of oxazol and urea analogues of morphinan at opioid receptors. |
| AID259399 | Functional activity at human kappa opioid receptor expressed CHO cells by [35S]GTPgammaS binding assay | 2006 | Journal of medicinal chemistry, Jan-12, Volume: 49, Issue:1
| Synthesis and preliminary in vitro investigation of bivalent ligands containing homo- and heterodimeric pharmacophores at mu, delta, and kappa opioid receptors. |
| AID592438 | Selectivity ratio of Ki for human delta opioid receptor to Ki for human kappa opioid receptor | 2011 | Journal of medicinal chemistry, Mar-24, Volume: 54, Issue:6
| Aminothiazolomorphinans with mixed κ and μ opioid activity. |
| AID233831 | Selective inhibitory activity was determined against kappa & mu opioid receptor in chinese Hamster Ovary (CHO) cell membranes | 2003 | Journal of medicinal chemistry, Nov-20, Volume: 46, Issue:24
| Design and synthesis of novel dimeric morphinan ligands for kappa and micro opioid receptors. |
| AID296057 | Agonist activity at human kappa opioid receptor expressed in CHO cells assessed as stimulation of [35S]GTP-gamma-S binding relative to basal level after 60 mins | 2007 | Bioorganic & medicinal chemistry, Jun-15, Volume: 15, Issue:12
| In-vitro investigation of oxazol and urea analogues of morphinan at opioid receptors. |
| AID259394 | Displacement of [3H]DAMGO from human mu opioid receptor expressed in CHO cells | 2006 | Journal of medicinal chemistry, Jan-12, Volume: 49, Issue:1
| Synthesis and preliminary in vitro investigation of bivalent ligands containing homo- and heterodimeric pharmacophores at mu, delta, and kappa opioid receptors. |
| AID290256 | Displacement of [3H]DAMGO from human mu opioid receptors expressed in CHO cell membrane | 2007 | Bioorganic & medicinal chemistry letters, Mar-15, Volume: 17, Issue:6
| High-affinity carbamate analogues of morphinan at opioid receptors. |
| AID670117 | Selectivity index, ratio of inhibition of human mu opioid receptor to inhibition of human kappa opioid receptor | 2012 | Journal of medicinal chemistry, Apr-26, Volume: 55, Issue:8
| Synthesis, binding affinity, and functional in vitro activity of 3-benzylaminomorphinan and 3-benzylaminomorphine ligands at opioid receptors. |
| AID259398 | Selectivity for human kappa opioid receptor over delta opioid receptor | 2006 | Journal of medicinal chemistry, Jan-12, Volume: 49, Issue:1
| Synthesis and preliminary in vitro investigation of bivalent ligands containing homo- and heterodimeric pharmacophores at mu, delta, and kappa opioid receptors. |
| AID148351 | Percent maximal stimulation in [35S]-GTP-gamma S binding assay mediated by the Opioid receptor mu 1 in chinese Hamster Ovary (CHO)membranes | 2003 | Journal of medicinal chemistry, Nov-20, Volume: 46, Issue:24
| Design and synthesis of novel dimeric morphinan ligands for kappa and micro opioid receptors. |
| AID259400 | Activity at human kappa opioid receptor expressed in CHO cells by [35S]GTP-gamma-S binding assay | 2006 | Journal of medicinal chemistry, Jan-12, Volume: 49, Issue:1
| Synthesis and preliminary in vitro investigation of bivalent ligands containing homo- and heterodimeric pharmacophores at mu, delta, and kappa opioid receptors. |
| AID592435 | Displacement of [3H]DAMGO from human mu opioid receptor expressed in CHO cells after 60 mins by scintillation counting | 2011 | Journal of medicinal chemistry, Mar-24, Volume: 54, Issue:6
| Aminothiazolomorphinans with mixed κ and μ opioid activity. |
| AID670122 | Antagonist activity at human mu opioid receptor expressed in CHO cells assessed as inhibition of DAMGO-induced [33S]GTPgammaS binding after 60 mins by scintillation counting relative to control | 2012 | Journal of medicinal chemistry, Apr-26, Volume: 55, Issue:8
| Synthesis, binding affinity, and functional in vitro activity of 3-benzylaminomorphinan and 3-benzylaminomorphine ligands at opioid receptors. |
| AID235164 | Selectivity ratio expressed as Ki of delta opioid receptor to that of mu opioid receptor. | 2004 | Journal of medicinal chemistry, Jan-01, Volume: 47, Issue:1
| 10-Ketomorphinan and 3-substituted-3-desoxymorphinan analogues as mixed kappa and micro opioid ligands: synthesis and biological evaluation of their binding affinity at opioid receptors. |
| AID290264 | Agonist activity at human mu opioid receptor expressed in CHO cells assessed as maximal stimulation of [35S]GTP-gamma-S binding | 2007 | Bioorganic & medicinal chemistry letters, Mar-15, Volume: 17, Issue:6
| High-affinity carbamate analogues of morphinan at opioid receptors. |
| AID445097 | Displacement of [3H]naltrindole from human delta opioid receptor expressed in CHO cells | 2010 | Journal of medicinal chemistry, Jan-14, Volume: 53, Issue:1
| Synthesis and opioid receptor binding affinities of 2-substituted and 3-aminomorphinans: ligands for mu, kappa, and delta opioid receptors. |
| AID445098 | Selectivity ratio of Ki for human kappa opioid receptor to Ki for human mu opioid receptor | 2010 | Journal of medicinal chemistry, Jan-14, Volume: 53, Issue:1
| Synthesis and opioid receptor binding affinities of 2-substituted and 3-aminomorphinans: ligands for mu, kappa, and delta opioid receptors. |
| AID290257 | Displacement of [3H]U-69593 from human kappa opioid receptors expressed in CHO cell membrane | 2007 | Bioorganic & medicinal chemistry letters, Mar-15, Volume: 17, Issue:6
| High-affinity carbamate analogues of morphinan at opioid receptors. |
| AID670123 | Agonist activity at human kappa opioid receptor expressed in CHO cells assessed as stimulation of [33S]GTPgammaS binding after 60 mins by scintillation counting | 2012 | Journal of medicinal chemistry, Apr-26, Volume: 55, Issue:8
| Synthesis, binding affinity, and functional in vitro activity of 3-benzylaminomorphinan and 3-benzylaminomorphine ligands at opioid receptors. |
| AID296058 | Agonist activity at human kappa opioid receptor expressed in CHO cells assessed as stimulation of [35S]GTP-gamma-S binding after 60 mins | 2007 | Bioorganic & medicinal chemistry, Jun-15, Volume: 15, Issue:12
| In-vitro investigation of oxazol and urea analogues of morphinan at opioid receptors. |
| AID296060 | Agonist activity at human mu opioid receptor expressed in CHO cells assessed as stimulation of [35S]GTP-gamma-S binding relative to basal level after 60 mins | 2007 | Bioorganic & medicinal chemistry, Jun-15, Volume: 15, Issue:12
| In-vitro investigation of oxazol and urea analogues of morphinan at opioid receptors. |
| AID592442 | Antagonist activity at human mu opioid receptor expressed in CHO cells assessed as inhibition of DAMGO-induced [35S]GTPgammaS binding by scintillation counting | 2011 | Journal of medicinal chemistry, Mar-24, Volume: 54, Issue:6
| Aminothiazolomorphinans with mixed κ and μ opioid activity. |
| AID233830 | Selective inhibitory activity was determined against kappa & delta opioid receptor in chinese Hamster Ovary (CHO) cell membranes | 2003 | Journal of medicinal chemistry, Nov-20, Volume: 46, Issue:24
| Design and synthesis of novel dimeric morphinan ligands for kappa and micro opioid receptors. |
| AID147944 | Inhibition of [3H]naltrindole binding to opioid receptor delta 1 of Chinese hamster ovary membrane | 2004 | Journal of medicinal chemistry, Apr-08, Volume: 47, Issue:8
| 2-aminothiazole-derived opioids. Bioisosteric replacement of phenols. |
| AID149977 | Binding ability against kappa opioid receptor by stimulating the [35S]GTP-gamma-S, radioligand in Chinese hamster ovary membranes | 2004 | Journal of medicinal chemistry, Apr-08, Volume: 47, Issue:8
| 2-aminothiazole-derived opioids. Bioisosteric replacement of phenols. |
| AID148327 | Binding ability against Opioid receptor mu 1 by stimulating the [35S]GTP-gamma-S radioligand in Chinese hamster ovary membranes | 2004 | Journal of medicinal chemistry, Apr-08, Volume: 47, Issue:8
| 2-aminothiazole-derived opioids. Bioisosteric replacement of phenols. |
| AID149994 | Inhibitory activity in stimulating [35S]-GTP-gamma S binding mediated by the Opioid receptor kappa 1 in chinese Hamster Ovary (CHO) cell membranes was determined | 2003 | Journal of medicinal chemistry, Nov-20, Volume: 46, Issue:24
| Design and synthesis of novel dimeric morphinan ligands for kappa and micro opioid receptors. |
| AID259397 | Selectivity for human kappa opioid receptor over mu opioid receptor | 2006 | Journal of medicinal chemistry, Jan-12, Volume: 49, Issue:1
| Synthesis and preliminary in vitro investigation of bivalent ligands containing homo- and heterodimeric pharmacophores at mu, delta, and kappa opioid receptors. |
| AID592373 | Agonist activity at human kappa opioid receptor expressed in CHO cells assessed as [35S]GTPgammaS binding by scintillation counting relative to control | 2011 | Journal of medicinal chemistry, Mar-24, Volume: 54, Issue:6
| Aminothiazolomorphinans with mixed κ and μ opioid activity. |
| AID296061 | Agonist activity at human mu opioid receptor expressed in CHO cells assessed as stimulation of [35S]GTP-gamma-S binding after 60 mins | 2007 | Bioorganic & medicinal chemistry, Jun-15, Volume: 15, Issue:12
| In-vitro investigation of oxazol and urea analogues of morphinan at opioid receptors. |
| AID290258 | Displacement of [3H]naltrindole from human delta opioid receptors expressed in CHO cell membrane | 2007 | Bioorganic & medicinal chemistry letters, Mar-15, Volume: 17, Issue:6
| High-affinity carbamate analogues of morphinan at opioid receptors. |
| AID150827 | Maximal percent inhibitory activity was determined in stimulating [35S]-GTP-gamma S binding mediated by the Opioid receptor mu 1 in chinese Hamster Ovary (CHO) cell membranes | 2003 | Journal of medicinal chemistry, Nov-20, Volume: 46, Issue:24
| Design and synthesis of novel dimeric morphinan ligands for kappa and micro opioid receptors. |
| AID148158 | Maximal percent inhibitory activity in stimulating [35S]-GTP-gamma S binding mediated by the Opioid receptor kappa 1 in chinese Hamster Ovary (CHO) cell membranes; Not Tested | 2003 | Journal of medicinal chemistry, Nov-20, Volume: 46, Issue:24
| Design and synthesis of novel dimeric morphinan ligands for kappa and micro opioid receptors. |
| AID592441 | Agonist activity at human mu opioid receptor expressed in CHO cells assessed as [35S]GTPgammaS binding by scintillation counting relative to control | 2011 | Journal of medicinal chemistry, Mar-24, Volume: 54, Issue:6
| Aminothiazolomorphinans with mixed κ and μ opioid activity. |
| AID445096 | Displacement of [3H]U69593 from human kappa opioid receptor expressed in CHO cells | 2010 | Journal of medicinal chemistry, Jan-14, Volume: 53, Issue:1
| Synthesis and opioid receptor binding affinities of 2-substituted and 3-aminomorphinans: ligands for mu, kappa, and delta opioid receptors. |
| AID296053 | Displacement of [3H]DAMGO from human mu opioid receptor expressed in CHO membrane | 2007 | Bioorganic & medicinal chemistry, Jun-15, Volume: 15, Issue:12
| In-vitro investigation of oxazol and urea analogues of morphinan at opioid receptors. |
| AID149270 | Binding affinity towards Opioid receptor kappa 1 by displacing the radioligand [3H]U-69593 from guinea pig brain membrane | 2000 | Journal of medicinal chemistry, Jan-13, Volume: 43, Issue:1
| Synthesis and opioid receptor affinity of morphinan and benzomorphan derivatives: mixed kappa agonists and mu agonists/antagonists as potential pharmacotherapeutics for cocaine dependence. |
| AID290263 | Antagonist activity against [35S]GTP-gamma-S binding from human kappa opioid receptors expressed in CHO cell membrane | 2007 | Bioorganic & medicinal chemistry letters, Mar-15, Volume: 17, Issue:6
| High-affinity carbamate analogues of morphinan at opioid receptors. |
| AID592433 | Agonist activity at human kappa opioid receptor expressed in CHO cells assessed as [35S]GTPgammaS binding by scintillation counting | 2011 | Journal of medicinal chemistry, Mar-24, Volume: 54, Issue:6
| Aminothiazolomorphinans with mixed κ and μ opioid activity. |
| AID290261 | Agonist activity at human opioid kappa receptor expressed in CHO cells assessed as maximal stimulation of [35S]GTP-gamma-S binding relative to control | 2007 | Bioorganic & medicinal chemistry letters, Mar-15, Volume: 17, Issue:6
| High-affinity carbamate analogues of morphinan at opioid receptors. |
| AID445095 | Displacement of [3H]DAMGO from human mu opioid receptor expressed in CHO cells | 2010 | Journal of medicinal chemistry, Jan-14, Volume: 53, Issue:1
| Synthesis and opioid receptor binding affinities of 2-substituted and 3-aminomorphinans: ligands for mu, kappa, and delta opioid receptors. |
| AID296062 | Antagonist activity at human mu opioid receptor expressed in CHO cells assessed as inhibition of DAMGO-induced [35S]GTPgammaS binding after 60 mins | 2007 | Bioorganic & medicinal chemistry, Jun-15, Volume: 15, Issue:12
| In-vitro investigation of oxazol and urea analogues of morphinan at opioid receptors. |
| AID148326 | Agonistic activity against Opioid receptor mu 1 in Chinese hamster ovary membranes | 2004 | Journal of medicinal chemistry, Apr-08, Volume: 47, Issue:8
| 2-aminothiazole-derived opioids. Bioisosteric replacement of phenols. |
| AID148734 | Selectivity kappa/delta | 2000 | Journal of medicinal chemistry, Jan-13, Volume: 43, Issue:1
| Synthesis and opioid receptor affinity of morphinan and benzomorphan derivatives: mixed kappa agonists and mu agonists/antagonists as potential pharmacotherapeutics for cocaine dependence. |
| AID259401 | Functional activity at human mu opioid receptor expressed in CHO cells by [35S]GTP-gamma-S binding assay | 2006 | Journal of medicinal chemistry, Jan-12, Volume: 49, Issue:1
| Synthesis and preliminary in vitro investigation of bivalent ligands containing homo- and heterodimeric pharmacophores at mu, delta, and kappa opioid receptors. |
| AID147851 | Percent maximal stimulation in stimulating [35S]-GTP-gamma S binding mediated by the Opioid receptor kappa 1 in chinese Hamster Ovary (CHO) cell membranes was determined | 2003 | Journal of medicinal chemistry, Nov-20, Volume: 46, Issue:24
| Design and synthesis of novel dimeric morphinan ligands for kappa and micro opioid receptors. |
| AID445099 | Selectivity ratio of Ki for human delta opioid receptor to Ki for human mu opioid receptor | 2010 | Journal of medicinal chemistry, Jan-14, Volume: 53, Issue:1
| Synthesis and opioid receptor binding affinities of 2-substituted and 3-aminomorphinans: ligands for mu, kappa, and delta opioid receptors. |
| AID139099 | Analgesic Potency was tested against mice | 1990 | Journal of medicinal chemistry, Oct, Volume: 33, Issue:10
| A Free-Wilson/Fujita-Ban analysis and prediction of the analgesic potency of some 3-hydroxy- and 3-methoxy-N-alkylmorphinan-6-one opioids. |
| AID149272 | Binding affinity towards Opioid receptor kappa 1 in guinea pig brain membranes using [3H]U-69593 as radioligand | 2001 | Bioorganic & medicinal chemistry letters, Oct-22, Volume: 11, Issue:20
| Mixed kappa agonists and mu agonists/antagonists as potential pharmacotherapeutics for cocaine abuse: synthesis and opioid receptor binding affinity of N-substituted derivatives of morphinan. |
| AID670118 | Selectivity index, ratio of inhibition of human delta opioid receptor to inhibition of human kappa opioid receptor | 2012 | Journal of medicinal chemistry, Apr-26, Volume: 55, Issue:8
| Synthesis, binding affinity, and functional in vitro activity of 3-benzylaminomorphinan and 3-benzylaminomorphine ligands at opioid receptors. |
| AID290265 | Antagonist activity at human mu opioid receptor expressed in CHO cells assessed as DAMGO-stimulated [35S]GTP-gamma-S binding | 2007 | Bioorganic & medicinal chemistry letters, Mar-15, Volume: 17, Issue:6
| High-affinity carbamate analogues of morphinan at opioid receptors. |
| AID148341 | Inhibitory activity in stimulating [35S]-GTP-gamma S binding mediated by the Opioid receptor mu 1 in chinese Hamster Ovary (CHO) cell membranes was determined | 2003 | Journal of medicinal chemistry, Nov-20, Volume: 46, Issue:24
| Design and synthesis of novel dimeric morphinan ligands for kappa and micro opioid receptors. |
| AID148036 | Binding affinity towards Opioid receptor mu 1 in guinea pig brain membranes using [3H]DAMGO as radioligand | 2001 | Bioorganic & medicinal chemistry letters, Oct-22, Volume: 11, Issue:20
| Mixed kappa agonists and mu agonists/antagonists as potential pharmacotherapeutics for cocaine abuse: synthesis and opioid receptor binding affinity of N-substituted derivatives of morphinan. |
| AID670110 | Displacement of [3H]-DAMGO from human mu opioid receptor expressed in CHO cells after 60 mins by scintillation counting | 2012 | Journal of medicinal chemistry, Apr-26, Volume: 55, Issue:8
| Synthesis, binding affinity, and functional in vitro activity of 3-benzylaminomorphinan and 3-benzylaminomorphine ligands at opioid receptors. |
| AID670119 | Agonist activity at human mu opioid receptor expressed in CHO cells assessed as stimulation of [33S]GTPgammaS binding after 60 mins by scintillation counting | 2012 | Journal of medicinal chemistry, Apr-26, Volume: 55, Issue:8
| Synthesis, binding affinity, and functional in vitro activity of 3-benzylaminomorphinan and 3-benzylaminomorphine ligands at opioid receptors. |
| AID151001 | Inhibitory activity against Opioid receptor mu 1 in chinese Hamster Ovary (CHO) cells membranes was determined using [3H]-DAMGO radioligand | 2003 | Journal of medicinal chemistry, Nov-20, Volume: 46, Issue:24
| Design and synthesis of novel dimeric morphinan ligands for kappa and micro opioid receptors. |
| AID235163 | Selectivity ratio expressed as Ki of delta opioid receptor to that of kappa opioid receptor. | 2004 | Journal of medicinal chemistry, Jan-01, Volume: 47, Issue:1
| 10-Ketomorphinan and 3-substituted-3-desoxymorphinan analogues as mixed kappa and micro opioid ligands: synthesis and biological evaluation of their binding affinity at opioid receptors. |
| AID229399 | Relative affinity for mu and kappa opioid receptors | 2004 | Journal of medicinal chemistry, Apr-08, Volume: 47, Issue:8
| 2-aminothiazole-derived opioids. Bioisosteric replacement of phenols. |
| AID148034 | Binding affinity towards Opioid receptor mu 1 by displacing the radioligand [3H]DAMGO from guinea pig brain membrane | 2000 | Journal of medicinal chemistry, Jan-13, Volume: 43, Issue:1
| Synthesis and opioid receptor affinity of morphinan and benzomorphan derivatives: mixed kappa agonists and mu agonists/antagonists as potential pharmacotherapeutics for cocaine dependence. |
| AID290262 | Agonist activity at huma kappa opioid receptor expressed in CHO cells assessed as U50488-stimulated of [35S]GTP-gamma-S binding | 2007 | Bioorganic & medicinal chemistry letters, Mar-15, Volume: 17, Issue:6
| High-affinity carbamate analogues of morphinan at opioid receptors. |
| AID290260 | Selectivity for kappa opioid receptor over delta opioid receptor | 2007 | Bioorganic & medicinal chemistry letters, Mar-15, Volume: 17, Issue:6
| High-affinity carbamate analogues of morphinan at opioid receptors. |
| AID148149 | Inhibitory activity against Opioid receptor kappa 1 in chinese Hamster Ovary (CHO) cell membranes was determined using [3H]U-69593 radioligand | 2003 | Journal of medicinal chemistry, Nov-20, Volume: 46, Issue:24
| Design and synthesis of novel dimeric morphinan ligands for kappa and micro opioid receptors. |
| AID670124 | Agonist activity at human kappa opioid receptor expressed in CHO cells assessed as stimulation of [33S]GTPgammaS binding after 60 mins by scintillation counting relative to control | 2012 | Journal of medicinal chemistry, Apr-26, Volume: 55, Issue:8
| Synthesis, binding affinity, and functional in vitro activity of 3-benzylaminomorphinan and 3-benzylaminomorphine ligands at opioid receptors. |
| AID148328 | Inhibition of [3H]-DAMGO binding to Opioid receptor mu 1 of Chinese hamster ovary membrane | 2004 | Journal of medicinal chemistry, Apr-08, Volume: 47, Issue:8
| 2-aminothiazole-derived opioids. Bioisosteric replacement of phenols. |
| AID1148432 | Analgesic activity in sc dosed mouse assessed as phenylquinone-induced writhing measured for 10 mins | 1978 | Journal of medicinal chemistry, May, Volume: 21, Issue:5
| Analgesics and narcotic antagonists in the benzomorphan and 8-oxamorphinan series. 5. |
| AID147903 | Binding affinity against opioid receptor mu 1 using [3H]DAMGO as radioligand in guinea pig brain membranes. | 2004 | Journal of medicinal chemistry, Jan-01, Volume: 47, Issue:1
| 10-Ketomorphinan and 3-substituted-3-desoxymorphinan analogues as mixed kappa and micro opioid ligands: synthesis and biological evaluation of their binding affinity at opioid receptors. |
| AID592444 | Antagonist activity at human mu opioid receptor expressed in CHO cells assessed as inhibition of DAMGO-induced [35S]GTPgammaS binding by scintillation counting relative to control | 2011 | Journal of medicinal chemistry, Mar-24, Volume: 54, Issue:6
| Aminothiazolomorphinans with mixed κ and μ opioid activity. |
| AID670121 | Antagonist activity at human mu opioid receptor expressed in CHO cells assessed as inhibition of DAMGO-induced [33S]GTPgammaS binding after 60 mins by scintillation counting | 2012 | Journal of medicinal chemistry, Apr-26, Volume: 55, Issue:8
| Synthesis, binding affinity, and functional in vitro activity of 3-benzylaminomorphinan and 3-benzylaminomorphine ligands at opioid receptors. |
| AID149902 | Binding affinity towards Opioid receptor delta 1 by displacing the radioligand [3H]naltrindole from guinea pig brain membrane | 2000 | Journal of medicinal chemistry, Jan-13, Volume: 43, Issue:1
| Synthesis and opioid receptor affinity of morphinan and benzomorphan derivatives: mixed kappa agonists and mu agonists/antagonists as potential pharmacotherapeutics for cocaine dependence. |
| AID1148434 | Analgesic activity in sc dosed rat assessed as phenylquinone-induced writhing measured for 10 mins | 1978 | Journal of medicinal chemistry, May, Volume: 21, Issue:5
| Analgesics and narcotic antagonists in the benzomorphan and 8-oxamorphinan series. 5. |
| AID670120 | Agonist activity at human mu opioid receptor expressed in CHO cells assessed as stimulation of [33S]GTPgammaS binding after 60 mins by scintillation counting relative to control | 2012 | Journal of medicinal chemistry, Apr-26, Volume: 55, Issue:8
| Synthesis, binding affinity, and functional in vitro activity of 3-benzylaminomorphinan and 3-benzylaminomorphine ligands at opioid receptors. |
| AID592439 | Agonist activity at human mu opioid receptor expressed in CHO cells assessed as [35S]GTPgammaS binding by scintillation counting | 2011 | Journal of medicinal chemistry, Mar-24, Volume: 54, Issue:6
| Aminothiazolomorphinans with mixed κ and μ opioid activity. |
| AID148735 | Selectivity kappa/mu | 2000 | Journal of medicinal chemistry, Jan-13, Volume: 43, Issue:1
| Synthesis and opioid receptor affinity of morphinan and benzomorphan derivatives: mixed kappa agonists and mu agonists/antagonists as potential pharmacotherapeutics for cocaine dependence. |
| AID1148436 | Antagonist activity in rat assessed as morphine-induced analgesia by hot plate tail flick test | 1978 | Journal of medicinal chemistry, May, Volume: 21, Issue:5
| Analgesics and narcotic antagonists in the benzomorphan and 8-oxamorphinan series. 5. |
| AID149978 | Inhibition of [3H]U-69593 binding to Opioid receptor kappa 1 of Chinese hamster ovary membrane | 2004 | Journal of medicinal chemistry, Apr-08, Volume: 47, Issue:8
| 2-aminothiazole-derived opioids. Bioisosteric replacement of phenols. |
| [information is prepared from bioassay data collected from National Library of Medicine (NLM), extracted Dec-2023] |