Page last updated: 2024-12-11

harpagide

Description Research Excerpts Clinical Trials Roles Classes Pathways Study Profile Bioassays Related Drugs Related Conditions Protein Interactions Research Growth

Description

harpagide: from S. African plant Harpagophytum procumbens DC [Medical Subject Headings (MeSH), National Library of Medicine, extracted Dec-2023]

FloraRankFlora DefinitionFamilyFamily Definition
HarpagophytumgenusA plant genus of the family PEDALIACEAE. Members contain harpagoside.[MeSH]PedaliaceaeThe sesame family of the order Lamiales that are mainly herbs and shrubs growing in warm regions.[MeSH]
Harpagophytum procumbensspeciesSpecies of Harpagophytum. Common name Devil's Claw is also a common name of some PROBOSCIDEA PLANT species.[MeSH]PedaliaceaeThe sesame family of the order Lamiales that are mainly herbs and shrubs growing in warm regions.[MeSH]

Cross-References

ID SourceID
PubMed CID101286236
MeSH IDM0103254

Synonyms (1)

Synonym
harpagide

Research Excerpts

Pharmacokinetics

8-O-acetylharpagide and harpagide in plasma were determined by LC-MS/MS method at different time points. All pharmacokinetic parameters were estimated by non-compartmental analysis.

ExcerptReferenceRelevance
" Concentrations of 8-O-acetylharpagide and harpagide in plasma were determined by LC-MS/MS method at different time points and all pharmacokinetic parameters were estimated by non-compartmental analysis."( Pharmacokinetics of 8-O-acetylharpagide and harpagide after oral administration of Ajuga decumbens Thunb extract in rats.
He, R; Li, J; Li, P; Lu, Y; Peng, B; Wen, B; Xu, Q, 2013
)
0.39
" Pharmacokinetic parameters of both glycosides were essentially the same except Tmax when dosed as the extract or pure forms."( Pharmacokinetics of 8-O-acetylharpagide and harpagide after oral administration of Ajuga decumbens Thunb extract in rats.
He, R; Li, J; Li, P; Lu, Y; Peng, B; Wen, B; Xu, Q, 2013
)
0.39
"8-O-acetylharpagide was metabolized to harpagide, which affected the pharmacokinetic profiles of harpagide when dosed as the extract."( Pharmacokinetics of 8-O-acetylharpagide and harpagide after oral administration of Ajuga decumbens Thunb extract in rats.
He, R; Li, J; Li, P; Lu, Y; Peng, B; Wen, B; Xu, Q, 2013
)
0.39
" The method was successfully applied to the pharmacokinetic study of catalpol and harpagide after oral administration of Zeng-Ye-Decoction to normal and diabetic rats, respectively."( Validated LC-MS method for simultaneous quantitation of catalpol and harpagide in rat plasma: application to a comparative pharmacokinetic study in normal and diabetic rats after oral administration of Zeng-Ye-Decoction.
Bi, K; Chen, X; Feng, Y; Ju, P; Liu, Z; Peng, Y; Zhang, L, 2013
)
0.39
" Concentrations of 8-O-acetylharpagide and harpagide in plasma were determined by LC-MS/MS method at different time points and all pharmacokinetic parameters were estimated by non-compartment analysis."( [Pharmacokinetics of 8-O-acetylharpagide and harpagide after oral administration of Ajuga decumbens extract in beagle dog].
Li, JR; Wen, BY, 2013
)
0.39
"In this paper, absorption and pharmacokinetic study of Radix Rehmanniae was studied by liquid chromatography coupled with mass spectrometry method after oral administration to rats."( [Absorption and pharmacokinetics of radix rehmanniae in rats].
Ma, YM; Shi, R; Tan, ZD; Wang, TM; Zhong, J, 2013
)
0.39
" This method was successfully applied to the pharmacokinetic and tissue distribution studies of Aucubin, Ajugol and Catalpol in rat."( Pharmacokinetics and tissue distribution of Aucubin, Ajugol and Catalpol in rats using a validated simultaneous LC-ESI-MS/MS assay.
Li, X; Liu, M; Ma, B; Wang, C; Wu, X; Wu, Z; Xue, B; Zhang, Q; Zhu, J, 2015
)
0.42

Dosage Studied

ExcerptRelevanceReference
" Pharmacokinetic parameters of both glycosides were essentially the same except Tmax when dosed as the extract or pure forms."( Pharmacokinetics of 8-O-acetylharpagide and harpagide after oral administration of Ajuga decumbens Thunb extract in rats.
He, R; Li, J; Li, P; Lu, Y; Peng, B; Wen, B; Xu, Q, 2013
)
0.39
"8-O-acetylharpagide was metabolized to harpagide, which affected the pharmacokinetic profiles of harpagide when dosed as the extract."( Pharmacokinetics of 8-O-acetylharpagide and harpagide after oral administration of Ajuga decumbens Thunb extract in rats.
He, R; Li, J; Li, P; Lu, Y; Peng, B; Wen, B; Xu, Q, 2013
)
0.39
[information is derived through text-mining from research data collected from National Library of Medicine (NLM), extracted Dec-2023]

Research

Studies (48)

TimeframeStudies, This Drug (%)All Drugs %
pre-19902 (4.17)18.7374
1990's1 (2.08)18.2507
2000's11 (22.92)29.6817
2010's25 (52.08)24.3611
2020's9 (18.75)2.80
[information is prepared from research data collected from National Library of Medicine (NLM), extracted Dec-2023]

Study Types

Publication TypeThis drug (%)All Drugs (%)
Trials0 (0.00%)5.53%
Reviews1 (2.00%)6.00%
Case Studies0 (0.00%)4.05%
Observational0 (0.00%)0.25%
Other49 (98.00%)84.16%
[information is prepared from research data collected from National Library of Medicine (NLM), extracted Dec-2023]