n-dodecyl-l-lysine-amide and Pain

n-dodecyl-l-lysine-amide has been researched along with Pain* in 1 studies

Other Studies

1 other study(ies) available for n-dodecyl-l-lysine-amide and Pain

Article	Year
Phenyl isoxazole voltage-gated sodium channel blockers: structure and activity relationship. Bioorganic & medicinal chemistry letters, 2011, Jul-01, Volume: 21, Issue:13 Blocking of certain sodium channels is considered to be an attractive mechanism to treat chronic pain conditions. Phenyl isoxazole carbamate 1 was identified as a potent and selective Na(V)1.7 blocker. Structural analogues of 1, both carbamates, ureas and amides, were proven to be useful in establishing the structure-activity relationship and improving ADME related properties. Amide 24 showed a good overall in vitro profile, that translated well to rat in vivo PK. Topics: Administration, Oral; Animals; Carbamates; Humans; Infusion Pumps; Inhibitory Concentration 50; Isoxazoles; Molecular Structure; Pain; Rats; Sodium Channel Blockers; Structure-Activity Relationship	2011

Article

Year

Phenyl isoxazole voltage-gated sodium channel blockers: structure and activity relationship.

Bioorganic & medicinal chemistry letters, 2011, Jul-01, Volume: 21, Issue:13

Blocking of certain sodium channels is considered to be an attractive mechanism to treat chronic pain conditions. Phenyl isoxazole carbamate 1 was identified as a potent and selective Na(V)1.7 blocker. Structural analogues of 1, both carbamates, ureas and amides, were proven to be useful in establishing the structure-activity relationship and improving ADME related properties. Amide 24 showed a good overall in vitro profile, that translated well to rat in vivo PK.

Topics: Administration, Oral; Animals; Carbamates; Humans; Infusion Pumps; Inhibitory Concentration 50; Isoxazoles; Molecular Structure; Pain; Rats; Sodium Channel Blockers; Structure-Activity Relationship

2011