chloroquine has been researched along with Pain in 23 studies
Chloroquine: The prototypical antimalarial agent with a mechanism that is not well understood. It has also been used to treat rheumatoid arthritis, systemic lupus erythematosus, and in the systemic therapy of amebic liver abscesses.
chloroquine : An aminoquinoline that is quinoline which is substituted at position 4 by a [5-(diethylamino)pentan-2-yl]amino group at at position 7 by chlorine. It is used for the treatment of malaria, hepatic amoebiasis, lupus erythematosus, light-sensitive skin eruptions, and rheumatoid arthritis.
Pain: An unpleasant sensation induced by noxious stimuli which are detected by NERVE ENDINGS of NOCICEPTIVE NEURONS.
| Excerpt | Relevance | Reference |
|---|---|---|
| "Intrathecal application of morphine is among the most powerful methods used to treat severe chronic pain." | 3.79 | Itch and analgesia resulting from intrathecal application of morphine: contrasting effects on different populations of trigeminothalamic tract neurons. ( Giesler, GJ; Moser, HR, 2013) |
| " Moreover, similar to wild-type littermates, Nf1± mice developed inflammation-induced heat and mechanical hypersensitivity, capsaicin-induced nocifensive behavior, histamine-dependent or -independent scratching, and chronic constriction injury-induced cold allodynia." | 3.79 | Assessment of pain and itch behavior in a mouse model of neurofibromatosis type 1. ( Brenner, DS; Gereau, RW; Gutmann, DH; O'Brien, DE, 2013) |
| "Although itch and pain have many similarities, they are completely different in perceptual experience and behavioral response." | 1.91 | Microglia are involved in regulating histamine-dependent and non-dependent itch transmissions with distinguished signal pathways. ( Li, BM; Liu, Y; Liu, YU; Ma, CL; Mou, B; Pan, H; Peng, J; Xiong, MT; Yang, Y; Yun, X; Zhang, JY; Zhang, QR; Zhao, HX, 2023) |
| "Atopic dermatitis is often associated with increased pain." | 1.91 | Crisaborole Inhibits Itch and Pain by Preventing Neutrophil Infiltration in a Mouse Model of Atopic Dermatitis. ( Akiyama, T; Bystrom, L; Ishida, H; Markan, A; Pavlenko, D; Todurga Seven, Z; Verpile, R, 2023) |
| "Itch and pain are distinct unpleasant sensations that can be triggered from the same receptive fields in the skin, raising the question of how pruriception and nociception are coded and discriminated." | 1.56 | Differential Coding of Itch and Pain by a Subpopulation of Primary Afferent Neurons. ( Ase, AR; Ribeiro-da-Silva, A; Séguéla, P; Sharif, B, 2020) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 7 (30.43) | 18.7374 |
| 1990's | 0 (0.00) | 18.2507 |
| 2000's | 2 (8.70) | 29.6817 |
| 2010's | 7 (30.43) | 24.3611 |
| 2020's | 7 (30.43) | 2.80 |
| Authors | Studies |
|---|---|
| Yang, Y | 1 |
| Mou, B | 1 |
| Zhang, QR | 1 |
| Zhao, HX | 1 |
| Zhang, JY | 1 |
| Yun, X | 1 |
| Xiong, MT | 1 |
| Liu, Y | 1 |
| Liu, YU | 1 |
| Pan, H | 1 |
| Ma, CL | 1 |
| Li, BM | 1 |
| Peng, J | 1 |
| Funahashi, H | 1 |
| Pavlenko, D | 2 |
| Sakai, K | 1 |
| Verpile, R | 2 |
| Sanders, KM | 1 |
| Akiyama, T | 2 |
| Todurga Seven, Z | 1 |
| Bystrom, L | 1 |
| Markan, A | 1 |
| Ishida, H | 1 |
| Ganchingco, JRC | 1 |
| Fukuyama, T | 1 |
| Yoder, JA | 1 |
| Bäumer, W | 1 |
| Alvaro, CG | 1 |
| Braz, JM | 2 |
| Bernstein, M | 1 |
| Hamel, KA | 1 |
| Craik, V | 1 |
| Yamanaka, H | 1 |
| Basbaum, AI | 2 |
| Sharif, B | 1 |
| Ase, AR | 1 |
| Ribeiro-da-Silva, A | 1 |
| Séguéla, P | 1 |
| Chang, YJ | 1 |
| Liu, KS | 1 |
| Wang, JJ | 1 |
| Hung, CH | 1 |
| Chen, YW | 1 |
| Wercberger, R | 1 |
| Weinrich, JA | 1 |
| Cao, LF | 1 |
| Si, M | 1 |
| Huang, Y | 1 |
| Chen, LH | 1 |
| Peng, XY | 1 |
| Qin, YQ | 1 |
| Liu, TT | 1 |
| Zhou, Y | 1 |
| Liu, T | 1 |
| Luo, WF | 1 |
| Lipshetz, B | 1 |
| Khasabov, SG | 1 |
| Truong, H | 1 |
| Netoff, TI | 1 |
| Simone, DA | 1 |
| Giesler, GJ | 2 |
| Moser, HR | 1 |
| O'Brien, DE | 1 |
| Brenner, DS | 1 |
| Gutmann, DH | 1 |
| Gereau, RW | 1 |
| Xu, Y | 1 |
| Lopes, C | 1 |
| Wende, H | 1 |
| Guo, Z | 1 |
| Cheng, L | 1 |
| Birchmeier, C | 1 |
| Ma, Q | 1 |
| Bandell, M | 1 |
| Patapoutian, A | 1 |
| McCoy, ES | 1 |
| Taylor-Blake, B | 1 |
| Zylka, MJ | 1 |
| Noskov, SM | 1 |
| Snigireva, AV | 1 |
| Dolgova, LN | 1 |
| Somova, MA | 1 |
| Polyakov, DP | 1 |
| BUTTERWORTH, RF | 1 |
| VERDU, R | 1 |
| LITTLE, AS | 1 |
| BELL, HE | 1 |
| Amaku, EO | 1 |
| Haddock, DR | 1 |
| Bonotey-Ahulu, FI | 1 |
| Janosi, M | 1 |
| Ankra-Badu, G | 1 |
| Reid, HA | 1 |
| Cifarelli, PS | 1 |
| Kitridou, RC | 1 |
| Solomon, SD | 1 |
1 review available for chloroquine and Pain
| Article | Year |
|---|---|
The patient with rheumatoid arthritis.
Topics: Activities of Daily Living; Arthritis, Rheumatoid; Bursitis; Chloroquine; Diagnosis, Differential; F | 1971 |
2 trials available for chloroquine and Pain
| Article | Year |
|---|---|
The use of homeopathic preparation Vozraston in the therapy of patients with rheumatoid arthritis.
Topics: Anti-Inflammatory Agents, Non-Steroidal; Antirheumatic Agents; Arthritis, Rheumatoid; Chloroquine; H | 2003 |
Thrombosis in sickle-cell pain crises? Controlled trial of ancrod (Arvin) in young adults.
Topics: Acetaminophen; Adolescent; Adult; Ampicillin; Anemia, Sickle Cell; Child; Chloroquine; Female; Fetal | 1973 |
20 other studies available for chloroquine and Pain
| Article | Year |
|---|---|
Microglia are involved in regulating histamine-dependent and non-dependent itch transmissions with distinguished signal pathways.
Topics: Animals; Chloroquine; Histamine; Mice; Mice, Transgenic; Microglia; Pain; Pruritus; Signal Transduct | 2023 |
Dynorphinergic Projections from the Central Amygdala to the Parabrachial Nucleus Regulate Itch.
Topics: Animals; Central Amygdaloid Nucleus; Chloroquine; Mice; Neurons; Pain; Parabrachial Nucleus; Pruritu | 2023 |
Crisaborole Inhibits Itch and Pain by Preventing Neutrophil Infiltration in a Mouse Model of Atopic Dermatitis.
Topics: Animals; Calcium; Capsaicin; Chloroquine; Dermatitis, Atopic; Disease Models, Animal; Histamine; Neu | 2023 |
Calcium imaging of primary canine sensory neurons: Small-diameter neurons responsive to pruritogens and algogens.
Topics: Animals; Cadaver; Calcium Radioisotopes; Capsaicin; Cattle; Cells, Cultured; Chloroquine; Dogs; Gang | 2019 |
Hippocalcin-like 4, a neural calcium sensor, has a limited contribution to pain and itch processing.
Topics: Animals; Behavior Rating Scale; Behavior, Animal; Chloroquine; Gene Knockout Techniques; Histamine; | 2020 |
Differential Coding of Itch and Pain by a Subpopulation of Primary Afferent Neurons.
Topics: Adenosine Triphosphate; Animals; Channelrhodopsins; Chloroquine; Ganglia, Spinal; Gastrin-Releasing | 2020 |
Chloroquine for prolonged skin analgesia in rats.
Topics: Analgesia; Anesthetics, Local; Animals; Bupivacaine; Chloroquine; Dose-Response Relationship, Drug; | 2020 |
Pain and itch processing by subpopulations of molecularly diverse spinal and trigeminal projection neurons.
Topics: Animals; Chloroquine; Female; Gene Expression Regulation; Male; Mice, Inbred C57BL; Neurons; Pain; P | 2021 |
Long-term anti-itch effect of botulinum neurotoxin A is associated with downregulation of TRPV1 and TRPA1 in the dorsal root ganglia in mice.
Topics: Acetone; Animals; Botulinum Toxins, Type A; Chloroquine; Chronic Disease; Disease Models, Animal; Do | 2017 |
Responses of thalamic neurons to itch- and pain-producing stimuli in rats.
Topics: Action Potentials; Animals; Antipruritics; beta-Alanine; Capsaicin; Chloroquine; Histamine; Injectio | 2018 |
Itch and analgesia resulting from intrathecal application of morphine: contrasting effects on different populations of trigeminothalamic tract neurons.
Topics: Action Potentials; Analgesics, Opioid; Animals; Antirheumatic Agents; Chloroquine; Electric Stimulat | 2013 |
Assessment of pain and itch behavior in a mouse model of neurofibromatosis type 1.
Topics: Animals; Capsaicin; Chloroquine; Constriction; Disease Models, Animal; Functional Laterality; Histam | 2013 |
Ontogeny of excitatory spinal neurons processing distinct somatic sensory modalities.
Topics: Animals; Animals, Newborn; Capsaicin; Cell Count; Chloroquine; Embryo, Mammalian; Ganglia, Spinal; G | 2013 |
Itching for insight.
Topics: Animals; Antimalarials; Chloroquine; Humans; Pain; Pruritus; Sensory Receptor Cells; Skin | 2009 |
CGRPα-expressing sensory neurons respond to stimuli that evoke sensations of pain and itch.
Topics: Animals; Brain; Calcitonin Gene-Related Peptide; Capsaicin; Cells, Cultured; Chloroquine; Female; Ga | 2012 |
The burning skin syndrome: treatment with hydroxychloroquine.
Topics: Chloroquine; Dermatology; Humans; Hydroxychloroquine; Musculoskeletal Diseases; Pain; Paresthesia; S | 1960 |
[THE TREATMENT OF RHEUMATOID ARTHRITIS WITH CHLOROQUINE. EVALUATION OF THE IMPROVEMENT OBTAINED ON THE BASIS OF "MEASUREMENT" OF PAIN].
Topics: Arthritis; Arthritis, Rheumatoid; Chloroquine; Humans; Pain | 1963 |
PAINFUL SUBCUTANEOUS HEMORRHAGES OF THE EXTREMITIES WITH UNUSUAL REACTION TO INJECTED DEOXYRIBONUCLEIC ACID.
Topics: Adolescent; Chloroquine; DNA; Drug Therapy; Hematoma; Hydroxychloroquine; Injections; Knee; Pain; Pr | 1964 |
Nivaquine and urethral pain.
Topics: Adult; Chloroquine; Humans; Male; Middle Aged; Pain; Urethra | 1976 |
The liver in acute amebic colitis.
Topics: Acute Disease; Adult; Amebiasis; Biopsy; Chloroquine; Complement Fixation Tests; Diarrhea; Dysentery | 1969 |