saccharin and Pain
saccharin has been researched along with Pain in 18 studies
Saccharin: Flavoring agent and non-nutritive sweetener.
saccharin : A 1,2-benzisothiazole having a keto-group at the 3-position and two oxo substituents at the 1-position. It is used as an artificial sweetening agent.
Pain: An unpleasant sensation induced by noxious stimuli which are detected by NERVE ENDINGS of NOCICEPTIVE NEURONS.
Research Excerpts
| Excerpt | Relevance | Reference |
|---|---|---|
| "This study aim to examine the hypothesis that repetitive painful stimuli during infancy will alter pain sensitivity and impair learning and memory during adulthood and that saccharin will prevent this through its analgesic effect." | 8.02 | Saccharin and naltrexone prevent increased pain sensitivity and impaired long-term memory induced by repetitive neonatal noxious stimulation: role of BDNF and enkephalin. ( Alazzani, M; Alhusban, AY; Alzoubi, KH; Bawaane, A; Khabour, OF; Nuseir, KQ, 2021) |
| " We therefore investigated the effects of a commercially available artificial sweetener (10 parts cyclamate and 1 part saccharin), glycine (sweet amino acid) or breast milk in reducing reaction to pain as compared with a placebo." | 5.09 | Artificial sweetener reduces nociceptive reaction in term newborn infants. ( Baumgartner, R; Bucher, HU; Bucher, N; Fauchère, JC; Seiler, M, 2000) |
| "This study aim to examine the hypothesis that repetitive painful stimuli during infancy will alter pain sensitivity and impair learning and memory during adulthood and that saccharin will prevent this through its analgesic effect." | 4.02 | Saccharin and naltrexone prevent increased pain sensitivity and impaired long-term memory induced by repetitive neonatal noxious stimulation: role of BDNF and enkephalin. ( Alazzani, M; Alhusban, AY; Alzoubi, KH; Bawaane, A; Khabour, OF; Nuseir, KQ, 2021) |
| "Chronic pain is a multidimensional experience that not only includes changes in nociception but also impairments in emotional and cognitive functions, not often taken into account in preclinical research." | 1.40 | Monoarthritis-induced emotional and cognitive impairments in rats are sensitive to low systemic doses or intra-amygdala injections of morphine. ( Ardid, D; Etienne, M; Grégoire, S; Marchand, F; Wattiez, AS, 2014) |
| " In addition, relative to both the chow only and saccharin conditions, chronic intake of the sucrose solution access significantly augmented morphine's antinociceptive properties." | 1.31 | Modulation of morphine-induced antinociception by palatable solutions in male and female rats. ( Homoleski, B; Kanarek, RB, 2000) |
| " The present results suggest that long-term intake of palatable nutritive solutions curbs tolerance to morphine-induced antinociception, whereas long-term intake of a nonnutritive, sweet saccharin solution does not." | 1.30 | Tolerance to morphine-induced antinociception is decreased by chronic sucrose or polycose intake. ( D'Anci, KE, 1999) |
| "Morphine (3." | 1.27 | Tolerance to morphine analgesia from brief exposure to a palatable solution. ( Green, KF; Klein, SP, 1988) |
Research
Studies (18)
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 5 (27.78) | 18.7374 |
| 1990's | 2 (11.11) | 18.2507 |
| 2000's | 5 (27.78) | 29.6817 |
| 2010's | 5 (27.78) | 24.3611 |
| 2020's | 1 (5.56) | 2.80 |
Authors
| Authors | Studies |
|---|---|
| Nuseir, KQ | 1 |
| Alzoubi, KH | 1 |
| Alhusban, AY | 1 |
| Alazzani, M | 1 |
| Bawaane, A | 1 |
| Khabour, OF | 1 |
| Lin, JY | 2 |
| Arthurs, J | 1 |
| Reilly, S | 2 |
| Nizhnikov, ME | 1 |
| Kozlov, AP | 1 |
| Kramskaya, TA | 1 |
| Varlinskaya, EI | 1 |
| Spear, NE | 1 |
| Grégoire, S | 1 |
| Wattiez, AS | 1 |
| Etienne, M | 1 |
| Marchand, F | 1 |
| Ardid, D | 1 |
| Refsgaard, LK | 1 |
| Hoffmann-Petersen, J | 1 |
| Sahlholt, M | 1 |
| Pickering, DS | 1 |
| Andreasen, JT | 1 |
| Roman, C | 1 |
| St Andre, J | 1 |
| Suri, M | 1 |
| Jain, S | 1 |
| Mathur, R | 1 |
| Bergmann, F | 2 |
| Cohen, E | 2 |
| Lieblich, I | 2 |
| Le Magnen, J | 1 |
| Marfaing-Jallat, P | 1 |
| Miceli, D | 1 |
| Devos, M | 1 |
| Riley, AL | 1 |
| Zellner, DA | 1 |
| Duncan, HJ | 1 |
| Ganchrow, JR | 1 |
| Blass, EM | 1 |
| D'Anci, KE | 1 |
| McNally, GP | 1 |
| Westbrook, RF | 1 |
| Irie, M | 1 |
| Asami, S | 1 |
| Nagata, S | 1 |
| Miyata, M | 1 |
| Kasai, H | 1 |
| Kanarek, RB | 1 |
| Homoleski, B | 1 |
| Bucher, HU | 1 |
| Baumgartner, R | 1 |
| Bucher, N | 1 |
| Seiler, M | 1 |
| Fauchère, JC | 1 |
| Calcagnetti, DJ | 1 |
| Holtzman, SG | 1 |
| Klein, SP | 1 |
| Green, KF | 1 |
Reviews
1 review available for saccharin and Pain
| Article | Year |
|---|---|
The role of endorphins in animal learning and behavior.
Topics: Adrenocorticotropic Hormone; Animals; Avoidance Learning; Behavior, Animal; Conditioning, Classical; | 1980 |
Trials
1 trial available for saccharin and Pain
| Article | Year |
|---|---|
Artificial sweetener reduces nociceptive reaction in term newborn infants.
Topics: Analgesics; Crying; Cyclamates; Female; Glycine; Heart Rate; Humans; Infant, Newborn; Male; Milk, Hu | 2000 |
Other Studies
16 other studies available for saccharin and Pain
| Article | Year |
|---|---|
Saccharin and naltrexone prevent increased pain sensitivity and impaired long-term memory induced by repetitive neonatal noxious stimulation: role of BDNF and enkephalin.
Topics: Analgesics; Animals; Animals, Newborn; Brain-Derived Neurotrophic Factor; Enkephalins; Hippocampus; | 2021 |
Reduced palatability in pain-induced conditioned taste aversions.
Topics: Animals; Avoidance Learning; Conditioning, Classical; Feeding Behavior; Gallamine Triethiodide; Male | 2013 |
Central effects of ethanol interact with endogenous mu-opioid activity to control isolation-induced analgesia in maternally separated infant rats.
Topics: Animals; Central Nervous System Depressants; Drinking Behavior; Drinking Water; Ethanol; Female; Gro | 2014 |
Monoarthritis-induced emotional and cognitive impairments in rats are sensitive to low systemic doses or intra-amygdala injections of morphine.
Topics: Analgesics, Opioid; Animals; Arthritis, Experimental; Basolateral Nuclear Complex; Cognition; Cognit | 2014 |
Modelling affective pain in mice: Effects of inflammatory hypersensitivity on place escape/avoidance behaviour, anxiety and hedonic state.
Topics: Analysis of Variance; Animals; Anxiety Disorders; Avoidance Learning; Disease Models, Animal; Female | 2016 |
Taste, olfactory and trigeminal neophobia in rats with forebrain lesions.
Topics: Amygdala; Animals; Avoidance Learning; Capsaicin; Cerebral Cortex; Denervation; Disease Models, Anim | 2009 |
Pattern of biphasic response to various noxious stimuli in rats ingesting sucrose ad libitum.
Topics: Animals; Blood Glucose; Drinking; Eating; Male; Pain; Pain Measurement; Pain Threshold; Rats; Rats, | 2010 |
Biphasic effects of chronic saccharin intake on pain responses of healthy and diabetic rats of two genetically selected strains.
Topics: Analgesia; Animals; Diabetes Mellitus, Experimental; Drug Tolerance; Female; Morphine; Pain; Rats; S | 1984 |
Pain modulating and reward systems: a single brain mechanism?
Topics: Animals; Brain; Glucose; Naloxone; Pain; Quinine; Rats; Receptors, Opioid; Reward; Saccharin; Taste | 1980 |
Morphine tolerance in genetically selected rats induced by chronically elevated saccharin intake.
Topics: Animals; Drug Tolerance; Endorphins; Morphine; Pain; Rats; Saccharin; Stress, Physiological | 1983 |
Tolerance to morphine-induced antinociception is decreased by chronic sucrose or polycose intake.
Topics: Analgesics, Opioid; Animals; Body Weight; Drug Tolerance; Eating; Glucans; Male; Morphine; Pain; Rat | 1999 |
Acute exposure to saccharin reduces morphine analgesia in the the rat: evidence for involvement of N-methyl-D-aspartate and peripheral opioid receptors.
Topics: Analgesia; Analgesics, Opioid; Animals; Dizocilpine Maleate; Dose-Response Relationship, Drug; Excit | 2000 |
Classical conditioning of oxidative DNA damage in rats.
Topics: 8-Hydroxy-2'-Deoxyguanosine; Animals; Avoidance Learning; Carcinogens; Conditioning, Classical; Deox | 2000 |
Modulation of morphine-induced antinociception by palatable solutions in male and female rats.
Topics: Analgesics, Opioid; Animals; Body Weight; Diet; Female; Food-Drug Interactions; Male; Morphine; Pain | 2000 |
Intake of sweet water attenuates restraint-stress-induced potentiation of morphine analgesia in rats.
Topics: Analgesia; Animals; Dose-Response Relationship, Drug; Drinking; Drug Synergism; Glucose; Morphine; P | 1992 |
Tolerance to morphine analgesia from brief exposure to a palatable solution.
Topics: Animals; Drug Tolerance; Female; Glucose; Morphine; Pain; Rats; Rats, Inbred Strains; Saccharin; Tas | 1988 |