Page last updated: 2024-11-04

saccharin and Pain

saccharin has been researched along with Pain in 18 studies

Saccharin: Flavoring agent and non-nutritive sweetener.
saccharin : A 1,2-benzisothiazole having a keto-group at the 3-position and two oxo substituents at the 1-position. It is used as an artificial sweetening agent.

Pain: An unpleasant sensation induced by noxious stimuli which are detected by NERVE ENDINGS of NOCICEPTIVE NEURONS.

Research Excerpts

ExcerptRelevanceReference
"This study aim to examine the hypothesis that repetitive painful stimuli during infancy will alter pain sensitivity and impair learning and memory during adulthood and that saccharin will prevent this through its analgesic effect."8.02Saccharin and naltrexone prevent increased pain sensitivity and impaired long-term memory induced by repetitive neonatal noxious stimulation: role of BDNF and enkephalin. ( Alazzani, M; Alhusban, AY; Alzoubi, KH; Bawaane, A; Khabour, OF; Nuseir, KQ, 2021)
" We therefore investigated the effects of a commercially available artificial sweetener (10 parts cyclamate and 1 part saccharin), glycine (sweet amino acid) or breast milk in reducing reaction to pain as compared with a placebo."5.09Artificial sweetener reduces nociceptive reaction in term newborn infants. ( Baumgartner, R; Bucher, HU; Bucher, N; Fauchère, JC; Seiler, M, 2000)
"This study aim to examine the hypothesis that repetitive painful stimuli during infancy will alter pain sensitivity and impair learning and memory during adulthood and that saccharin will prevent this through its analgesic effect."4.02Saccharin and naltrexone prevent increased pain sensitivity and impaired long-term memory induced by repetitive neonatal noxious stimulation: role of BDNF and enkephalin. ( Alazzani, M; Alhusban, AY; Alzoubi, KH; Bawaane, A; Khabour, OF; Nuseir, KQ, 2021)
"Chronic pain is a multidimensional experience that not only includes changes in nociception but also impairments in emotional and cognitive functions, not often taken into account in preclinical research."1.40Monoarthritis-induced emotional and cognitive impairments in rats are sensitive to low systemic doses or intra-amygdala injections of morphine. ( Ardid, D; Etienne, M; Grégoire, S; Marchand, F; Wattiez, AS, 2014)
" In addition, relative to both the chow only and saccharin conditions, chronic intake of the sucrose solution access significantly augmented morphine's antinociceptive properties."1.31Modulation of morphine-induced antinociception by palatable solutions in male and female rats. ( Homoleski, B; Kanarek, RB, 2000)
" The present results suggest that long-term intake of palatable nutritive solutions curbs tolerance to morphine-induced antinociception, whereas long-term intake of a nonnutritive, sweet saccharin solution does not."1.30Tolerance to morphine-induced antinociception is decreased by chronic sucrose or polycose intake. ( D'Anci, KE, 1999)
"Morphine (3."1.27Tolerance to morphine analgesia from brief exposure to a palatable solution. ( Green, KF; Klein, SP, 1988)

Research

Studies (18)

TimeframeStudies, this research(%)All Research%
pre-19905 (27.78)18.7374
1990's2 (11.11)18.2507
2000's5 (27.78)29.6817
2010's5 (27.78)24.3611
2020's1 (5.56)2.80

Authors

AuthorsStudies
Nuseir, KQ1
Alzoubi, KH1
Alhusban, AY1
Alazzani, M1
Bawaane, A1
Khabour, OF1
Lin, JY2
Arthurs, J1
Reilly, S2
Nizhnikov, ME1
Kozlov, AP1
Kramskaya, TA1
Varlinskaya, EI1
Spear, NE1
Grégoire, S1
Wattiez, AS1
Etienne, M1
Marchand, F1
Ardid, D1
Refsgaard, LK1
Hoffmann-Petersen, J1
Sahlholt, M1
Pickering, DS1
Andreasen, JT1
Roman, C1
St Andre, J1
Suri, M1
Jain, S1
Mathur, R1
Bergmann, F2
Cohen, E2
Lieblich, I2
Le Magnen, J1
Marfaing-Jallat, P1
Miceli, D1
Devos, M1
Riley, AL1
Zellner, DA1
Duncan, HJ1
Ganchrow, JR1
Blass, EM1
D'Anci, KE1
McNally, GP1
Westbrook, RF1
Irie, M1
Asami, S1
Nagata, S1
Miyata, M1
Kasai, H1
Kanarek, RB1
Homoleski, B1
Bucher, HU1
Baumgartner, R1
Bucher, N1
Seiler, M1
Fauchère, JC1
Calcagnetti, DJ1
Holtzman, SG1
Klein, SP1
Green, KF1

Reviews

1 review available for saccharin and Pain

ArticleYear
The role of endorphins in animal learning and behavior.
    Neuroscience and biobehavioral reviews, 1980,Spring, Volume: 4, Issue:1

    Topics: Adrenocorticotropic Hormone; Animals; Avoidance Learning; Behavior, Animal; Conditioning, Classical;

1980

Trials

1 trial available for saccharin and Pain

ArticleYear
Artificial sweetener reduces nociceptive reaction in term newborn infants.
    Early human development, 2000, Volume: 59, Issue:1

    Topics: Analgesics; Crying; Cyclamates; Female; Glycine; Heart Rate; Humans; Infant, Newborn; Male; Milk, Hu

2000

Other Studies

16 other studies available for saccharin and Pain

ArticleYear
Saccharin and naltrexone prevent increased pain sensitivity and impaired long-term memory induced by repetitive neonatal noxious stimulation: role of BDNF and enkephalin.
    Naunyn-Schmiedeberg's archives of pharmacology, 2021, Volume: 394, Issue:8

    Topics: Analgesics; Animals; Animals, Newborn; Brain-Derived Neurotrophic Factor; Enkephalins; Hippocampus;

2021
Reduced palatability in pain-induced conditioned taste aversions.
    Physiology & behavior, 2013, Jul-02, Volume: 119

    Topics: Animals; Avoidance Learning; Conditioning, Classical; Feeding Behavior; Gallamine Triethiodide; Male

2013
Central effects of ethanol interact with endogenous mu-opioid activity to control isolation-induced analgesia in maternally separated infant rats.
    Behavioural brain research, 2014, Mar-01, Volume: 260

    Topics: Animals; Central Nervous System Depressants; Drinking Behavior; Drinking Water; Ethanol; Female; Gro

2014
Monoarthritis-induced emotional and cognitive impairments in rats are sensitive to low systemic doses or intra-amygdala injections of morphine.
    European journal of pharmacology, 2014, Jul-15, Volume: 735

    Topics: Analgesics, Opioid; Animals; Arthritis, Experimental; Basolateral Nuclear Complex; Cognition; Cognit

2014
Modelling affective pain in mice: Effects of inflammatory hypersensitivity on place escape/avoidance behaviour, anxiety and hedonic state.
    Journal of neuroscience methods, 2016, Mar-15, Volume: 262

    Topics: Analysis of Variance; Animals; Anxiety Disorders; Avoidance Learning; Disease Models, Animal; Female

2016
Taste, olfactory and trigeminal neophobia in rats with forebrain lesions.
    Brain research, 2009, Jan-28, Volume: 1251

    Topics: Amygdala; Animals; Avoidance Learning; Capsaicin; Cerebral Cortex; Denervation; Disease Models, Anim

2009
Pattern of biphasic response to various noxious stimuli in rats ingesting sucrose ad libitum.
    Physiology & behavior, 2010, Sep-01, Volume: 101, Issue:2

    Topics: Animals; Blood Glucose; Drinking; Eating; Male; Pain; Pain Measurement; Pain Threshold; Rats; Rats,

2010
Biphasic effects of chronic saccharin intake on pain responses of healthy and diabetic rats of two genetically selected strains.
    Psychopharmacology, 1984, Volume: 82, Issue:3

    Topics: Analgesia; Animals; Diabetes Mellitus, Experimental; Drug Tolerance; Female; Morphine; Pain; Rats; S

1984
Pain modulating and reward systems: a single brain mechanism?
    Pharmacology, biochemistry, and behavior, 1980, Volume: 12, Issue:5

    Topics: Animals; Brain; Glucose; Naloxone; Pain; Quinine; Rats; Receptors, Opioid; Reward; Saccharin; Taste

1980
Morphine tolerance in genetically selected rats induced by chronically elevated saccharin intake.
    Science (New York, N.Y.), 1983, Aug-26, Volume: 221, Issue:4613

    Topics: Animals; Drug Tolerance; Endorphins; Morphine; Pain; Rats; Saccharin; Stress, Physiological

1983
Tolerance to morphine-induced antinociception is decreased by chronic sucrose or polycose intake.
    Pharmacology, biochemistry, and behavior, 1999, Volume: 63, Issue:1

    Topics: Analgesics, Opioid; Animals; Body Weight; Drug Tolerance; Eating; Glucans; Male; Morphine; Pain; Rat

1999
Acute exposure to saccharin reduces morphine analgesia in the the rat: evidence for involvement of N-methyl-D-aspartate and peripheral opioid receptors.
    Psychopharmacology, 2000, Volume: 149, Issue:1

    Topics: Analgesia; Analgesics, Opioid; Animals; Dizocilpine Maleate; Dose-Response Relationship, Drug; Excit

2000
Classical conditioning of oxidative DNA damage in rats.
    Neuroscience letters, 2000, Jul-07, Volume: 288, Issue:1

    Topics: 8-Hydroxy-2'-Deoxyguanosine; Animals; Avoidance Learning; Carcinogens; Conditioning, Classical; Deox

2000
Modulation of morphine-induced antinociception by palatable solutions in male and female rats.
    Pharmacology, biochemistry, and behavior, 2000, Volume: 66, Issue:3

    Topics: Analgesics, Opioid; Animals; Body Weight; Diet; Female; Food-Drug Interactions; Male; Morphine; Pain

2000
Intake of sweet water attenuates restraint-stress-induced potentiation of morphine analgesia in rats.
    Brain research bulletin, 1992, Volume: 29, Issue:6

    Topics: Analgesia; Animals; Dose-Response Relationship, Drug; Drinking; Drug Synergism; Glucose; Morphine; P

1992
Tolerance to morphine analgesia from brief exposure to a palatable solution.
    Brain research bulletin, 1988, Volume: 21, Issue:6

    Topics: Animals; Drug Tolerance; Female; Glucose; Morphine; Pain; Rats; Rats, Inbred Strains; Saccharin; Tas

1988