Compounds > brl 44408
Page last updated: 2024-09-25

brl 44408

Description

BRL 44408: has selectivity for adrenergic alpha-2A receptors; BRL 48962 is the R-enantiomer; BRL 48553 is the R-enantiomer [Medical Subject Headings (MeSH), National Library of Medicine, extracted Dec-2023]

Cross-References

ID SourceID
PubMed CID121850
CHEMBL ID216097
SCHEMBL ID7596949
MeSH IDM0195544

Synonyms (25)

Synonym
gtpl525
PDSP2_001727
PDSP1_001744
brl44408
NCGC00025023-02
2-((4,5-dihydro-1h-imidazol-2-yl)methyl)-2,3-dihydro-1-methyl-1h-isoindole
brl 44408
brl-44408
1h-isoindole, 2-((4,5-dihydro-1h-imidazol-2-yl)methyl)-2,3-dihydro-1-methyl-
2-(2h-(1-methyl-1,3-dihydroisoindole)methyl)-4,5-dihydroimidazole
CHEMBL216097
L000144
FT-0663603
2-(4,5-dihydro-1h-imidazol-2-ylmethyl)-1-methyl-1,3-dihydroisoindole
cas_121850
bdbm82520
nsc_121850
118343-19-4
zet7b198w2 ,
unii-zet7b198w2
SCHEMBL7596949
J-003739
2-[(4,5-dihydro-1h-imidazol-2-yl)methyl]-1-methyl-2,3-dihydro-1h-isoindole
DTXSID30922665
Q4836377

Protein Targets (4)

Potency Measurements

ProteinTaxonomyMeasurementAverage (µ)Min (ref.)Avg (ref.)Max (ref.)Bioassay(s)
RGS12Homo sapiens (human)Potency44.66840.794310.991425.1189AID2390
Microtubule-associated protein tauHomo sapiens (human)Potency31.62280.180013.557439.8107AID1460
regulator of G-protein signaling 4Homo sapiens (human)Potency1.68340.531815.435837.6858AID504845
euchromatic histone-lysine N-methyltransferase 2Homo sapiens (human)Potency22.38720.035520.977089.1251AID504332
[prepared from compound, protein, and bioassay information from National Library of Medicine (NLM), extracted Dec-2023]

Bioassays (8)

Assay IDTitleYearJournalArticle
AID1347154Primary screen GU AMC qHTS for Zika virus inhibitors2020Proceedings of the National Academy of Sciences of the United States of America, 12-08, Volume: 117, Issue:49
Therapeutic candidates for the Zika virus identified by a high-throughput screen for Zika protease inhibitors.
AID1508630Primary qHTS for small molecule stabilizers of the endoplasmic reticulum resident proteome: Secreted ER Calcium Modulated Protein (SERCaMP) assay2021Cell reports, 04-27, Volume: 35, Issue:4
A target-agnostic screen identifies approved drugs to stabilize the endoplasmic reticulum-resident proteome.
AID1346049Human alpha2A-adrenoceptor (Adrenoceptors)1994The Journal of pharmacology and experimental therapeutics, Dec, Volume: 271, Issue:3
The novel alpha-2 adrenergic radioligand [3H]-MK912 is alpha-2C selective among human alpha-2A, alpha-2B and alpha-2C adrenoceptors.
AID1346058Human alpha2B-adrenoceptor (Adrenoceptors)1994The Journal of pharmacology and experimental therapeutics, Dec, Volume: 271, Issue:3
The novel alpha-2 adrenergic radioligand [3H]-MK912 is alpha-2C selective among human alpha-2A, alpha-2B and alpha-2C adrenoceptors.
AID1346159Human alpha2C-adrenoceptor (Adrenoceptors)1994The Journal of pharmacology and experimental therapeutics, Dec, Volume: 271, Issue:3
The novel alpha-2 adrenergic radioligand [3H]-MK912 is alpha-2C selective among human alpha-2A, alpha-2B and alpha-2C adrenoceptors.
AID1346049Human alpha2A-adrenoceptor (Adrenoceptors)1989European journal of pharmacology, Sep-22, Volume: 168, Issue:3
Novel alpha 2-adrenoceptor antagonists show selectivity for alpha 2A- and alpha 2B-adrenoceptor subtypes.
AID274936Antagonist effect on compound A-induced antinociception in Swiss Albino mouse at 1 mg/kg, ip2006Journal of medicinal chemistry, Dec-28, Volume: 49, Issue:26
Arylpiperazinylalkylpyridazinones and analogues as potent and orally active antinociceptive agents: synthesis and studies on mechanism of action.
AID274933Antinociceptive activity in Swiss Albino mouse at 1 mg/kg, ip by abdominal constriction assay2006Journal of medicinal chemistry, Dec-28, Volume: 49, Issue:26
Arylpiperazinylalkylpyridazinones and analogues as potent and orally active antinociceptive agents: synthesis and studies on mechanism of action.
[information is prepared from bioassay data collected from National Library of Medicine (NLM), extracted Dec-2023]

Research

Studies (82)

TimeframeStudies, This Drug (%)All Drugs %
pre-19901 (1.22)18.7374
1990's21 (25.61)18.2507
2000's39 (47.56)29.6817
2010's19 (23.17)24.3611
2020's2 (2.44)2.80
[information is prepared from research data collected from National Library of Medicine (NLM), extracted Dec-2023]

Study Types

Publication TypeThis drug (%)All Drugs (%)
Trials0 (0.00%)5.53%
Reviews0 (0.00%)6.00%
Case Studies0 (0.00%)4.05%
Observational0 (0.00%)0.25%
Other82 (100.00%)84.16%
[information is prepared from research data collected from National Library of Medicine (NLM), extracted Dec-2023]
SubstanceDescriptionRelationhip StrengthStudiesTrialsClassesRoles
oxymetazoline[no description available]medium40carboxamidine;
imidazolines;
phenols		alpha-adrenergic agonist;
nasal decongestant;
sympathomimetic agent;
vasoconstrictor agent
prazosin[no description available]medium170aromatic ether;
furans;
monocarboxylic acid amide;
piperazines;
quinazolines		alpha-adrenergic antagonist;
antihypertensive agent;
EC 3.4.21.26 (prolyl oligopeptidase) inhibitor
spiroxatrine[no description available]medium30imidazolidines
wb 4101[no description available]medium60aromatic ether;
benzodioxine;
secondary amino compound		alpha-adrenergic antagonist
yohimbine[no description available]medium230methyl 17-hydroxy-20xi-yohimban-16-carboxylatealpha-adrenergic antagonist;
dopamine receptor D2 antagonist;
serotonergic antagonist
rx 821002[no description available]medium80benzodioxine;
cyclic ketal;
imidazolines		alpha-adrenergic antagonist
rauwolscine[no description available]medium10methyl 17-hydroxy-20xi-yohimban-16-carboxylate
ar-c239[no description available]medium180piperazines
st 91[no description available]medium10substituted aniline
clonidine[no description available]medium240clonidine;
imidazoline
acetic acid[no description available]medium20monocarboxylic acidantimicrobial food preservative;
Daphnia magna metabolite;
food acidity regulator;
protic solvent
imiloxan[no description available]medium120benzodioxine
acridines[no description available]medium20acridines;
mancude organic heterotricyclic parent;
polycyclic heteroarene		genotoxin
jp-1302[no description available]medium20
sirolimus[no description available]medium10antibiotic antifungal drug;
cyclic acetal;
cyclic ketone;
ether;
macrolide lactam;
organic heterotricyclic compound;
secondary alcohol		antibacterial drug;
anticoronaviral agent;
antineoplastic agent;
bacterial metabolite;
geroprotector;
immunosuppressive agent;
mTOR inhibitor
dexmedetomidine[no description available]medium60medetomidinealpha-adrenergic agonist;
analgesic;
non-narcotic analgesic;
sedative
atipamezole[no description available]medium10
bupropion[no description available]medium10aromatic ketone;
monochlorobenzenes;
secondary amino compound		antidepressant;
environmental contaminant;
xenobiotic
guanfacine[no description available]medium30acetamides
phencyclidine[no description available]medium10benzenes;
piperidines		anaesthetic;
neurotoxin;
NMDA receptor antagonist;
psychotropic drug
haloperidol[no description available]medium10aromatic ketone;
hydroxypiperidine;
monochlorobenzenes;
organofluorine compound;
tertiary alcohol		antidyskinesia agent;
antiemetic;
dopaminergic antagonist;
first generation antipsychotic;
serotonergic antagonist
morphine[no description available]medium20morphinane alkaloid;
organic heteropentacyclic compound;
tertiary amino compound		anaesthetic;
drug allergen;
environmental contaminant;
geroprotector;
mu-opioid receptor agonist;
opioid analgesic;
plant metabolite;
vasodilator agent;
xenobiotic
imidazolidines[no description available]medium10azacycloalkane;
imidazolidines;
saturated organic heteromonocyclic parent
m-chlorophenylguanidine[no description available]medium10
brimonidine tartrate[no description available]medium80
mk 912[no description available]medium100
quinoxalines[no description available]medium80mancude organic heterobicyclic parent;
naphthyridine;
ortho-fused heteroarene
piperidines[no description available]medium10
am 251[no description available]medium10amidopiperidine;
carbohydrazide;
dichlorobenzene;
organoiodine compound;
pyrazoles		antidepressant;
antineoplastic agent;
apoptosis inducer;
CB1 receptor antagonist
3-(2-hydroxy-4-(1,1-dimethylheptyl)phenyl)-4-(3-hydroxypropyl)cyclohexanol[no description available]medium10alkylbenzene;
ring assembly
cocaine[no description available]medium30benzoate ester;
methyl ester;
tertiary amino compound;
tropane alkaloid		adrenergic uptake inhibitor;
central nervous system stimulant;
dopamine uptake inhibitor;
environmental contaminant;
local anaesthetic;
mouse metabolite;
plant metabolite;
serotonin uptake inhibitor;
sodium channel blocker;
sympathomimetic agent;
vasoconstrictor agent;
xenobiotic
cyclohexanol[no description available]medium10cyclohexanols;
secondary alcohol		solvent
idazoxan[no description available]medium80benzodioxine;
imidazolines		alpha-adrenergic antagonist
formaldehyde[no description available]medium10aldehyde;
one-carbon compound		allergen;
carcinogenic agent;
disinfectant;
EC 3.5.1.4 (amidase) inhibitor;
environmental contaminant;
Escherichia coli metabolite;
mouse metabolite;
Saccharomyces cerevisiae metabolite
fluorocitrate[no description available]medium10carbonyl compound
isoproterenol[no description available]medium10catechols;
secondary alcohol;
secondary amino compound		beta-adrenergic agonist;
bronchodilator agent;
cardiotonic drug;
sympathomimetic agent
clenbuterol[no description available]medium10amino alcohol;
dichlorobenzene;
ethanolamines;
primary arylamine;
secondary amino compound;
substituted aniline		beta-adrenergic agonist;
bronchodilator agent;
sympathomimetic agent
mocetinostat[no description available]medium10aminopyrimidine;
benzamides;
pyridines;
secondary amino compound;
secondary carboxamide;
substituted aniline		antineoplastic agent;
apoptosis inducer;
autophagy inducer;
cardioprotective agent;
EC 3.5.1.98 (histone deacetylase) inhibitor;
hepatotoxic agent
phenylephrine[no description available]medium70phenols;
phenylethanolamines;
secondary amino compound		alpha-adrenergic agonist;
cardiotonic drug;
mydriatic agent;
nasal decongestant;
protective agent;
sympathomimetic agent;
vasoconstrictor agent
n-methyl-3,4-methylenedioxyamphetamine[no description available]medium30amphetamines;
benzodioxoles		neurotoxin
ng-nitroarginine methyl ester[no description available]medium10alpha-amino acid ester;
L-arginine derivative;
methyl ester;
N-nitro compound		EC 1.14.13.39 (nitric oxide synthase) inhibitor
xylazine[no description available]medium301,3-thiazine;
methylbenzene;
secondary amino compound		alpha-adrenergic agonist;
analgesic;
emetic;
muscle relaxant;
sedative
nifedipine[no description available]medium10C-nitro compound;
dihydropyridine;
methyl ester		calcium channel blocker;
human metabolite;
tocolytic agent;
vasodilator agent
suramin[no description available]medium10naphthalenesulfonic acid;
phenylureas;
secondary carboxamide		angiogenesis inhibitor;
antinematodal drug;
antineoplastic agent;
apoptosis inhibitor;
EC 2.7.11.13 (protein kinase C) inhibitor;
GABA antagonist;
GABA-gated chloride channel antagonist;
purinergic receptor P2 antagonist;
ryanodine receptor agonist;
trypanocidal drug
thymine[no description available]medium10pyrimidine nucleobase;
pyrimidone		Escherichia coli metabolite;
human metabolite;
mouse metabolite
bmy 7378[no description available]medium20
rs 100329[no description available]medium10piperazines
cirazoline[no description available]medium20aromatic ether
transforming growth factor beta[no description available]medium10
ergotamine[no description available]medium10peptide ergot alkaloidalpha-adrenergic agonist;
mycotoxin;
non-narcotic analgesic;
oxytocic;
serotonergic agonist;
vasoconstrictor agent
brl 15572[no description available]medium10hydrochlorideprodrug;
serotonergic antagonist
2-piperidone[no description available]medium10delta-lactam;
piperidones		EC 1.2.1.88 (L-glutamate gamma-semialdehyde dehydrogenase) inhibitor
guanabenz[no description available]medium30dichlorobenzene
kampirone[no description available]medium10N-arylpiperazine
tolterodine tartrate[no description available]medium10tartrate salt
buspirone[no description available]medium10azaspiro compound;
N-alkylpiperazine;
N-arylpiperazine;
organic heteropolycyclic compound;
piperidones;
pyrimidines		anxiolytic drug;
EC 3.4.21.26 (prolyl oligopeptidase) inhibitor;
sedative;
serotonergic agonist
cromakalim[no description available]medium10
phenylpropanolamine[no description available]medium10amphetamines;
phenethylamine alkaloid		plant metabolite
potassium chloride[no description available]medium10inorganic chloride;
inorganic potassium salt;
potassium salt		fertilizer
reserpine[no description available]medium10alkaloid ester;
methyl ester;
yohimban alkaloid		adrenergic uptake inhibitor;
antihypertensive agent;
EC 3.4.21.26 (prolyl oligopeptidase) inhibitor;
environmental contaminant;
first generation antipsychotic;
plant metabolite;
xenobiotic
tetrodotoxin[no description available]medium20azatetracycloalkane;
oxatetracycloalkane;
quinazoline alkaloid		animal metabolite;
bacterial metabolite;
marine metabolite;
neurotoxin;
voltage-gated sodium channel blocker
racemetirosine[no description available]medium10
propranolol[no description available]medium10naphthalenes;
propanolamine;
secondary amine		anti-arrhythmia drug;
antihypertensive agent;
anxiolytic drug;
beta-adrenergic antagonist;
environmental contaminant;
human blood serum metabolite;
vasodilator agent;
xenobiotic
nan 190[no description available]medium10N-alkylpiperazine;
N-arylpiperazine;
phthalimides		serotonergic antagonist
3,4-methylenedioxyethamphetamine[no description available]medium10benzodioxoles;
secondary amino compound
3,4-methylenedioxyamphetamine[no description available]medium10benzodioxoles
capsaicin[no description available]medium10capsaicinoidnon-narcotic analgesic;
TRPV1 agonist;
voltage-gated sodium channel blocker
azepexole[no description available]medium20
carbachol[no description available]medium10ammonium salt;
carbamate ester		cardiotonic drug;
miotic;
muscarinic agonist;
nicotinic acetylcholine receptor agonist;
non-narcotic analgesic
mifepristone[no description available]medium103-oxo-Delta(4) steroid;
acetylenic compound;
tertiary amino compound		abortifacient;
contraceptive drug;
hormone antagonist;
synthetic oral contraceptive
6-cyano-7-nitroquinoxaline-2,3-dione[no description available]medium10quinoxaline derivative
corticosterone[no description available]medium1011beta-hydroxy steroid;
20-oxo steroid;
21-hydroxy steroid;
3-oxo-Delta(4) steroid;
C21-steroid;
glucocorticoid;
primary alpha-hydroxy ketone		human metabolite;
mouse metabolite
gamma-aminobutyric acid[no description available]medium10amino acid zwitterion;
gamma-amino acid;
monocarboxylic acid		human metabolite;
neurotransmitter;
Saccharomyces cerevisiae metabolite;
signalling molecule
pituitrin[no description available]medium10
carbocyanines[no description available]medium10cyanine dye;
organic iodide salt		fluorochrome
calcimycin[no description available]medium10benzoxazole
sk&f 104856[no description available]medium20
brl 41992[no description available]medium50
guanoxabenz[no description available]medium10
edetic acid[no description available]medium10ethylenediamine derivative;
polyamino carboxylic acid;
tetracarboxylic acid		anticoagulant;
antidote;
chelator;
copper chelator;
geroprotector
guanylyl imidodiphosphate[no description available]medium10nucleoside triphosphate analogue
medetomidine[no description available]medium30imidazoles
nordefrin[no description available]medium10catecholamine
dihydroxyphenylalanine[no description available]medium10hydroxyphenylalanine;
non-proteinogenic alpha-amino acid;
tyrosine derivative		human metabolite
mirtazapine[no description available]medium10benzazepine;
tetracyclic antidepressant		alpha-adrenergic antagonist;
anxiolytic drug;
H1-receptor antagonist;
histamine antagonist;
oneirogen;
serotonergic antagonist
eedq[no description available]medium10
mianserin[no description available]medium10dibenzoazepineadrenergic uptake inhibitor;
alpha-adrenergic antagonist;
antidepressant;
EC 3.4.21.26 (prolyl oligopeptidase) inhibitor;
geroprotector;
H1-receptor antagonist;
histamine agonist;
sedative;
serotonergic antagonist
dimethylphenylpiperazinium iodide[no description available]medium10N-arylpiperazine;
organic iodide salt;
piperazinium salt;
quaternary ammonium salt		nicotinic acetylcholine receptor agonist
berberine[no description available]medium20alkaloid antibiotic;
berberine alkaloid;
botanical anti-fungal agent;
organic heteropentacyclic compound		antilipemic drug;
antineoplastic agent;
antioxidant;
EC 1.1.1.141 [15-hydroxyprostaglandin dehydrogenase (NAD(+))] inhibitor;
EC 1.1.1.21 (aldehyde reductase) inhibitor;
EC 1.13.11.52 (indoleamine 2,3-dioxygenase) inhibitor;
EC 1.21.3.3 (reticuline oxidase) inhibitor;
EC 2.1.1.116 [3'-hydroxy-N-methyl-(S)-coclaurine 4'-O-methyltransferase] inhibitor;
EC 2.1.1.122 [(S)-tetrahydroprotoberberine N-methyltransferase] inhibitor;
EC 2.7.11.10 (IkappaB kinase) inhibitor;
EC 3.1.1.4 (phospholipase A2) inhibitor;
EC 3.1.1.7 (acetylcholinesterase) inhibitor;
EC 3.1.1.8 (cholinesterase) inhibitor;
EC 3.1.3.48 (protein-tyrosine-phosphatase) inhibitor;
EC 3.4.14.5 (dipeptidyl-peptidase IV) inhibitor;
EC 3.4.21.26 (prolyl oligopeptidase) inhibitor;
geroprotector;
hypoglycemic agent;
metabolite;
potassium channel blocker
7,8-(methylenedioxy)-14-hydroxyberbane[no description available]medium20
vasoactive intestinal peptide[no description available]medium10
8-hydroxy-2-(di-n-propylamino)tetralin[no description available]medium10phenols;
tertiary amino compound;
tetralins		serotonergic antagonist
raclopride[no description available]medium10salicylamides
gr 127935[no description available]medium201,2,4-oxadiazole;
benzamides;
N-alkylpiperazine;
N-arylpiperazine
oxadiazoles[no description available]medium20
cgs 15855a[no description available]medium10
clorgyline[no description available]medium10aromatic ether;
dichlorobenzene;
terminal acetylenic compound;
tertiary amino compound		antidepressant;
EC 1.4.3.4 (monoamine oxidase) inhibitor
desipramine[no description available]medium30dibenzoazepine;
secondary amino compound		adrenergic uptake inhibitor;
alpha-adrenergic antagonist;
antidepressant;
cholinergic antagonist;
drug allergen;
EC 3.1.4.12 (sphingomyelin phosphodiesterase) inhibitor;
EC 3.4.21.26 (prolyl oligopeptidase) inhibitor;
H1-receptor antagonist;
serotonin uptake inhibitor
tramadol[no description available]medium102-[(dimethylamino)methyl]-1-(3-methoxyphenyl)cyclohexanoladrenergic uptake inhibitor;
antitussive;
capsaicin receptor antagonist;
delta-opioid receptor agonist;
kappa-opioid receptor agonist;
metabolite;
mu-opioid receptor agonist;
muscarinic antagonist;
nicotinic antagonist;
NMDA receptor antagonist;
opioid analgesic;
serotonergic antagonist;
serotonin uptake inhibitor
amitriptyline[no description available]medium10carbotricyclic compound;
tertiary amine		adrenergic uptake inhibitor;
antidepressant;
environmental contaminant;
tropomyosin-related kinase B receptor agonist;
xenobiotic
imipramine[no description available]medium10dibenzoazepineadrenergic uptake inhibitor;
antidepressant;
EC 3.4.21.26 (prolyl oligopeptidase) inhibitor
naloxone[no description available]medium10morphinane alkaloid;
organic heteropentacyclic compound;
tertiary alcohol		antidote to opioid poisoning;
central nervous system depressant;
mu-opioid receptor antagonist
cgp 35348[no description available]medium10
sumatriptan[no description available]medium10sulfonamide;
tryptamines		serotonergic agonist;
vasoconstrictor agent
5-carboxamidotryptamine[no description available]medium10tryptamines
mesulergine[no description available]medium10ergot alkaloid;
sulfamides		antiparkinson drug;
dopamine agonist;
serotonergic antagonist
sk&f 104078[no description available]medium20benzazepine
ergoline[no description available]medium10diamine;
ergoline alkaloid;
indole alkaloid fundamental parent;
indole alkaloid;
organic heterotetracyclic compound
prednisone[no description available]medium1011-oxo steroid;
17alpha-hydroxy steroid;
20-oxo steroid;
21-hydroxy steroid;
3-oxo-Delta(1),Delta(4)-steroid;
C21-steroid;
glucocorticoid;
primary alpha-hydroxy ketone;
tertiary alpha-hydroxy ketone		adrenergic agent;
anti-inflammatory drug;
antineoplastic agent;
immunosuppressive agent;
prodrug
5-methylurapidil[no description available]medium10
chlorphenamidine[no description available]medium10
amitraz[no description available]medium10formamidines;
tertiary amino compound		acaricide;
environmental contaminant;
insecticide;
xenobiotic
flesinoxan[no description available]medium10
bicuculline[no description available]medium10benzylisoquinoline alkaloid;
isoquinoline alkaloid;
isoquinolines		agrochemical;
central nervous system stimulant;
GABA-gated chloride channel antagonist;
GABAA receptor antagonist;
neurotoxin
rs 79948-197[no description available]medium10
ConditionIndicatedRelationship StrengthStudiesTrials
Abdominal Migraine0low10
Abdominal Pain0low10
Ache0low50
Acute Confusional Migraine0low10
Acute Kidney Failure0low10
Acute Kidney Injury0low10
Acute Kidney Insufficiency0low10
Acute Lung Injury0low20
Acute Renal Failure0low10
Acute Renal Injury0low10
Acute Renal Insufficiency0low10
Age-Related Memory Disorders0low10
Aging0low10
Allodynia0low10
Allodynia, Mechanical0low10
Allodynia, Tactile0low10
Allodynia, Thermal0low10
Anesthesia0low30
Anochlesia0low10
Anxiety0low10
Blood Poisoning0low30
Blood Pressure, Low0low10
Bloodstream Infection0low30
Bradykinesia0low10
Brain Damage, Chronic0low10
Brain Ischemia0low10
Catalepsy0low10
Cerea Flexibilitas0low10
Cerebral Ischemia0low10
Cervical Migraine Syndrome0low10
Chronic Encephalopathy0low10
Cirrhosis0low10
Cocaine Abuse0low10
Cocaine Addiction0low10
Cocaine Dependence0low10
Cocaine-Related Disorders0low10
Cognitive Decline0low10
Cognitive Dysfunction0low10
Cognitive Impairments0low10
Cold Fingers, Hereditary0low10
Colicky Pain0low10
Colitis0low10
Colitis, Mucous0low10
Colon, Irritable0low10
Congenital Zika Syndrome0low10
Congenital Zika Virus Infection0low10
Cumulative Trauma Disorders0low10
Decerebrate Posturing0low20
Decerebrate State0low20
Decorticate Rigidity0low20
Decorticate State0low20
Dementia Praecox0low10
Depression0low10
Disease Models, Animal0low70
Encephalopathy, Chronic0low10
Encephalopathy, Ischemic0low10
Fever0low20
Fever, Zika0low10
Fibrosis0low10
Flexibility, Waxy0low10
Headache, Migraine0low10
Hemicrania Migraine0low10
Hyperalgesia0low10
Hyperalgesia, Mechanical0low10
Hyperalgesia, Primary0low10
Hyperalgesia, Secondary0low10
Hyperalgesia, Tactile0low10
Hyperalgesia, Thermal0low10
Hyperalgesic Sensations0low10
Hyperalgia0low10
Hyperalgia, Mechanical0low10
Hyperalgia, Primary0low10
Hyperalgia, Secondary0low10
Hypodynamia0low10
Hypokinesia0low10
Hypokinesia, Antiorthostatic0low10
Hypotension0low10
Hypotension, Vascular0low10
Inadequate Sleep0low10
Inflammation0low40
Injuries0low10
Injuries and Wounds0low10
Injuries, Wounds0low10
Injury, Ischemia-Reperfusion0low10
Injury, Reperfusion0low10
Injury, Repetition Strain0low10
Innate Inflammatory Response0low40
Insufficient Sleep0low10
Insufficient Sleep Syndrome0low10
Irritable Bowel Syndrome0low10
Ischemia-Reperfusion Injury0low10
Ischemia, Cerebral0low10
Ischemic Encephalopathy0low10
Kidney Failure, Acute0low10
Kidney Insufficiency, Acute0low10
Lesion of Sciatic Nerve0low20
Low Blood Pressure0low10
Lung Injury, Acute0low20
Mechanical Allodynia0low10
Mechanical Hyperalgesia0low10
Memory Deficits0low10
Memory Disorder, Semantic0low10
Memory Disorder, Spatial0low10
Memory Disorders0low10
Memory Disorders, Age-Related0low10
Memory Loss0low10
Mental Deterioration0low10
Migraine0low10
Migraine Disorders0low10
Migraine Headache0low10
Migraine Variant0low10
Mild Cognitive Impairment0low10
Mild Neurocognitive Disorder0low10
Muscle Contraction0low50
Neuralgia-Neuritis, Sciatic Nerve0low20
Neuroblastoma0low10
Overuse Injury0low10
Overuse Syndrome0low10
Pain0low50
Pain, Burning0low50
Pain, Crushing0low50
Pain, Migratory0low50
Pain, Radiating0low50
Pain, Splitting0low50
Poisoning, Blood0low30
Pregnancy0low30
Pyaemia0low30
Pyemia0low30
Pyohemia0low30
Pyrexia0low20
Raynaud Disease0low10
Raynaud Phenomenon0low10
Raynaud's Disease0low10
REM Sleep Deprivation0low10
Renal Failure, Acute0low10
Renal Insufficiency, Acute0low10
Reperfusion Damage0low10
Reperfusion Injury0low10
Repetition Strain Injury0low10
Repetitive Motion Disorders0low10
Repetitive Strain Injury0low10
Repetitive Stress Injury0low10
Research-Related Injuries0low10
Retention Disorders, Cognitive0low10
Rigidity, Decerebrate0low20
Rigidity, Decorticate0low20
Schizophrenia0low10
Schizophrenic Disorders0low10
Sciatic Nerve Diseases0low20
Sciatic Nerve Palsy0low20
Sciatic Neuritis0low20
Sciatic Neuropathy0low20
Scleroderma, Systemic0low10
Sclerosis, Systemic0low10
Semantic Memory Disorder0low10
Sepsis0low30
Septicemia0low30
Severe Sepsis0low30
Sick Headache0low10
Sleep Debt0low10
Sleep Deprivation0low10
Sleep Fragmentation0low10
Sleep Insufficiency0low10
Spatial Memory Disorder0low10
Status Migrainosus0low10
Strain Injury, Repetition0low10
Suffering, Physical0low50
Systemic Scleroderma0low10
Systemic Sclerosis0low10
Tachyarrhythmia0low10
Tachycardia0low10
Tactile Allodynia0low10
Tendinitis0low10
Tendinopathy0low10
Tendinosis0low10
Tendonitis0low10
Tendonopathy0low10
Tendonosis0low10
Thermal Allodynia0low10
Trauma0low10
Trauma Disorders, Cumulative0low10
Vascular Hypotension0low10
Visceral Pain0low10
Wounds0low10
Wounds and Injuries0low10
Wounds and Injury0low10
Wounds, Injury0low10
Zika Fever0low10
Zika Virus Disease0low10
Zika Virus Infection0low10
ZikV Infection0low10

Research Highlights

Pharmacokinetics (1)

ArticleYear
Spatiotemporal interaction of alpha(2) autoreceptors and noradrenaline transporters in the rat locus coeruleus: implications for volume transmission.
Journal of neurochemistry, Volume: 74, Issue: 6		2000
[information is derived through text-mining from research data collected from National Library of Medicine (NLM), extracted Dec-2023]

Bioavailability (1)

ArticleYear
Role of alpha 2-adrenoceptors in the regulation of intestinal water transport.
British journal of pharmacology, Volume: 120, Issue: 5		1997
[information is derived through text-mining from research data collected from National Library of Medicine (NLM), extracted Dec-2023]

Dosage (1)

ArticleYear
Preclinical characterization of BRL 44408: antidepressant- and analgesic-like activity through selective alpha2A-adrenoceptor antagonism.
The international journal of neuropsychopharmacology, Volume: 13, Issue: 9		2010
[information is derived through text-mining from research data collected from National Library of Medicine (NLM), extracted Dec-2023]