propentofylline has been researched along with Pain in 9 studies
Pain: An unpleasant sensation induced by noxious stimuli which are detected by NERVE ENDINGS of NOCICEPTIVE NEURONS.
| Excerpt | Relevance | Reference |
|---|---|---|
| "Propentofylline is a unique methylxanthine with clear cyclic AMP, phosphodiesterase, and adenosine actions, including enhanced synaptic adenosine signaling." | 6.47 | Propentofylline: glial modulation, neuroprotection, and alleviation of chronic pain. ( De Leo, J; Sweitzer, S, 2011) |
| " Intrathecal treatment with propentofylline (PPF, 10 mM) for 7 consecutive days immediately after spinal injury attenuated the development of mechanical allodynia and thermal hyperalgesia in both hind limbs in a dose-related reduction compared to vehicle treatments (* P<0." | 3.75 | Remote astrocytic and microglial activation modulates neuronal hyperexcitability and below-level neuropathic pain after spinal injury in rat. ( Gwak, YS; Hulsebosch, CE, 2009) |
| "Propentofylline is a unique methylxanthine with clear cyclic AMP, phosphodiesterase, and adenosine actions, including enhanced synaptic adenosine signaling." | 2.47 | Propentofylline: glial modulation, neuroprotection, and alleviation of chronic pain. ( De Leo, J; Sweitzer, S, 2011) |
| "Propentofylline is a phosphodiesterase inhibitor that has been shown to attenuate the onset of morphine tolerance when administered intrathecally to rats." | 1.33 | Systemic administration of propentofylline does not attenuate morphine tolerance in non-injured rodents. ( Forsayeth, JR; Johnson, KW; Samuels, I; Shumilla, JA, 2005) |
| "treatment with etorphine, but not morphine, produced a significant increase in protein levels of G protein-coupled receptor kinase 2, dynamin II, beta-arrestin 2 and phosphorylated-conventional protein kinase C in membranes of the mouse spinal cord, suggesting that the etorphine-induced mu-opioid receptor desensitization may result from G protein-coupled receptor kinase 2/dynaminII/beta-arrestin2-dependent phosphorylation of mu-opioid receptors." | 1.33 | mu-Opioid receptor internalization-dependent and -independent mechanisms of the development of tolerance to mu-opioid receptor agonists: Comparison between etorphine and morphine. ( Miyatake, M; Nakamura, A; Narita, M; Niikura, K; Suzuki, M; Suzuki, T; Yajima, Y, 2006) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 0 (0.00) | 18.2507 |
| 2000's | 6 (66.67) | 29.6817 |
| 2010's | 3 (33.33) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Gwak, YS | 2 |
| Hulsebosch, CE | 2 |
| Constandil, L | 3 |
| Hernández, A | 3 |
| Pelissier, T | 2 |
| Arriagada, O | 2 |
| Espinoza, K | 1 |
| Burgos, H | 1 |
| Laurido, C | 3 |
| Sweitzer, S | 1 |
| De Leo, J | 1 |
| Yao, M | 1 |
| Chang, XY | 1 |
| Chu, YX | 1 |
| Yang, JP | 1 |
| Wang, LN | 1 |
| Cao, HQ | 1 |
| Liu, MJ | 1 |
| Xu, QN | 1 |
| Morales, F | 1 |
| Shumilla, JA | 1 |
| Samuels, I | 1 |
| Johnson, KW | 1 |
| Forsayeth, JR | 1 |
| Narita, M | 2 |
| Suzuki, M | 1 |
| Niikura, K | 1 |
| Nakamura, A | 1 |
| Miyatake, M | 1 |
| Yajima, Y | 1 |
| Suzuki, T | 1 |
| Barra, R | 1 |
| Soto-Moyano, R | 1 |
| Crown, ED | 1 |
| Unabia, GC | 1 |
1 review available for propentofylline and Pain
| Article | Year |
|---|---|
Propentofylline: glial modulation, neuroprotection, and alleviation of chronic pain.
Topics: Animals; Chronic Disease; Drug Tolerance; Humans; Morphine; Neuroglia; Neuroprotective Agents; Pain; | 2011 |
8 other studies available for propentofylline and Pain
| Article | Year |
|---|---|
Remote astrocytic and microglial activation modulates neuronal hyperexcitability and below-level neuropathic pain after spinal injury in rat.
Topics: Action Potentials; Animals; Astrocytes; Dose-Response Relationship, Drug; Glial Fibrillary Acidic Pr | 2009 |
Effect of interleukin-1beta on spinal cord nociceptive transmission of normal and monoarthritic rats after disruption of glial function.
Topics: Adjuvants, Immunologic; Animals; Arthritis, Experimental; Arthritis, Rheumatoid; Electric Stimulatio | 2009 |
Antiallodynic effects of propentofylline Elicited by interrupting spinal glial function in a rat model of bone cancer pain.
Topics: Animals; Bone Neoplasms; Cytokines; Disease Models, Animal; Female; Neuroglia; Pain; Rats; Rats, Spr | 2011 |
Antinociceptive interaction of (±)-CPP and propentofylline in monoarthritic rats.
Topics: Animals; Arthritis, Experimental; Dose-Response Relationship, Drug; Drug Synergism; Drug Therapy, Co | 2012 |
Systemic administration of propentofylline does not attenuate morphine tolerance in non-injured rodents.
Topics: Analgesia; Animals; Dose-Response Relationship, Drug; Drug Interactions; Drug Tolerance; Injections, | 2005 |
mu-Opioid receptor internalization-dependent and -independent mechanisms of the development of tolerance to mu-opioid receptor agonists: Comparison between etorphine and morphine.
Topics: Animals; Dose-Response Relationship, Drug; Drug Tolerance; Enkephalin, Ala(2)-MePhe(4)-Gly(5)-; Etor | 2006 |
Effects of interleukin-1beta on spinal cord nociceptive transmission in intact and propentofylline-treated rats.
Topics: Animals; Dose-Response Relationship, Drug; Injections, Intraperitoneal; Interleukin-1beta; Nerve Fib | 2007 |
Propentofylline attenuates allodynia, glial activation and modulates GABAergic tone after spinal cord injury in the rat.
Topics: Animals; gamma-Aminobutyric Acid; Male; Neuroglia; Pain; Rats; Rats, Sprague-Dawley; Spinal Cord Inj | 2008 |