Page last updated: 2024-11-04

tazarotene and Pain

tazarotene has been researched along with Pain in 8 studies

tazarotene: a topical acetylenic retinoid; a topical kerytolytic
tazarotene : The ethyl ester of tazarotenic acid. A prodrug for tazarotenic acid, it is used for the treatment of psoriasis, acne, and sun-damaged skin.

Pain: An unpleasant sensation induced by noxious stimuli which are detected by NERVE ENDINGS of NOCICEPTIVE NEURONS.

Research Excerpts

ExcerptRelevanceReference
"Background: Tazarotene has been extensively studied in clinical trials and is widely used to treat acne vulgaris (acne)."9.30A Phase 2, Multicenter, Double-Blind, Randomized, Vehicle-Controlled Clinical Study to Compare the Safety and Efficacy of a Novel Tazarotene 0.045% Lotion and Tazarotene 0.1% Cream in the Treatment of Moderate-to-Severe Acne Vulgaris ( Green, LJ; Guenin, E; Harris, S; Kircik, LH; Martin, G; Pillai, R; Tanghetti, EA, 2019)
"Background: As current tazarotene formulations indicated for acne (0."7.96Novel Polymeric Lotion Formulation of Once-Daily Tazarotene (0.045%) for Moderate-to-Severe Acne: Pooled Phase 3 Analysis. ( Guenin, E; Harris, S; Lain, E; Loncaric, A; Pillai, R; Tanghetti, EA; Werschler, WP, 2020)
" Safety and treatment emergent adverse events (TEAEs) were evaluated throughout."6.90Efficacy, Safety, and Tolerability of a Halobetasol 0.01% /Tazarotene 0.045% Fixed Combination in the Treatment of Severe Localized Plaque Psoriasis: Post Hoc Analysis of Two Phase III Randomized Controlled Trials ( Israel, R; Lebwohl, MG; Lin, T; Stein Gold, L; Sugarman, JL, 2019)
"Background: Tazarotene has been extensively studied in clinical trials and is widely used to treat acne vulgaris (acne)."5.30A Phase 2, Multicenter, Double-Blind, Randomized, Vehicle-Controlled Clinical Study to Compare the Safety and Efficacy of a Novel Tazarotene 0.045% Lotion and Tazarotene 0.1% Cream in the Treatment of Moderate-to-Severe Acne Vulgaris ( Green, LJ; Guenin, E; Harris, S; Kircik, LH; Martin, G; Pillai, R; Tanghetti, EA, 2019)
"Background: As current tazarotene formulations indicated for acne (0."3.96Novel Polymeric Lotion Formulation of Once-Daily Tazarotene (0.045%) for Moderate-to-Severe Acne: Pooled Phase 3 Analysis. ( Guenin, E; Harris, S; Lain, E; Loncaric, A; Pillai, R; Tanghetti, EA; Werschler, WP, 2020)
" Safety and treatment emergent adverse events (TEAEs) were evaluated throughout."2.90Efficacy, Safety, and Tolerability of a Halobetasol 0.01% /Tazarotene 0.045% Fixed Combination in the Treatment of Severe Localized Plaque Psoriasis: Post Hoc Analysis of Two Phase III Randomized Controlled Trials ( Israel, R; Lebwohl, MG; Lin, T; Stein Gold, L; Sugarman, JL, 2019)
" Our purpose is to compare the rates of adverse events associated with different topical psoriasis treatments."2.42A systematic review of adverse effects associated with topical treatments for psoriasis. ( Bruner, CR; Feldman, SR; Fleischer, AB; Ventrapragada, M, 2003)

Research

Studies (8)

TimeframeStudies, this research(%)All Research%
pre-19900 (0.00)18.7374
1990's0 (0.00)18.2507
2000's2 (25.00)29.6817
2010's3 (37.50)24.3611
2020's3 (37.50)2.80

Authors

AuthorsStudies
Lebwohl, MG1
Sugarman, JL2
Stein Gold, L3
Lin, T3
Israel, R2
Elewski, B1
Draelos, Z1
Jacobson, A1
Tanghetti, EA3
Werschler, WP1
Lain, E1
Guenin, E2
Harris, S2
Loncaric, A1
Pillai, R3
He, C1
Jin, H1
Liu, X1
Hu, F1
Zhang, L2
Zhang, S1
He, Y1
Yang, X1
Chen, H1
Wang, X1
Ji, C1
Lv, C1
Miao, G1
Li, X2
Diao, Q1
Li, L1
Li, Y1
Wang, R1
Zhou, X1
Xia, X1
Yan, M1
Song, J1
Zhang, R1
Geng, L1
Zheng, M1
Lu, Q1
Lu, T1
Shi, Y1
Jing, H1
Zhang, X1
Shi, J1
Xia, J1
Gao, Y1
Wang, Y1
Weiss, J1
Bagel, J1
Yamauchi, PS1
Martin, G2
Kircik, LH1
Green, LJ1
Bruner, CR1
Feldman, SR1
Ventrapragada, M1
Fleischer, AB1
Waller, JM1
Wu, JJ1
Murase, JE1
Dyson, SW1
Kelly, KM1

Clinical Trials (3)

Trial Overview

TrialPhaseEnrollmentStudy TypeStart DateStatus
Efficacy of Excimer Laser Combined With Either Topical Tazarotene or Topical Betamethasone Valerate Versus Excimer Laser Alone in Treatment of Localized Chronic Plaque Psoriasis; Clinical and Dermoscopic Study[NCT05555797]Phase 430 participants (Anticipated)Interventional2022-10-30Not yet recruiting
Investigator-Initiated, Open Label Trial of a Combination of Halobetasol Propionate 0.01% Andtazarotene 0.045% Lotion (Duobrii®) for Plaque Type Psoriasis of the Hands and/or Feet[NCT04720105]Phase 422 participants (Actual)Interventional2020-11-19Completed
Spray® and Vectical Ointment® in the Treatment of Plaque Psoriasis[NCT01205880]Phase 412 participants (Actual)Interventional2009-12-31Completed
[information is prepared from clinicaltrials.gov, extracted Sep-2024]

Trial Outcomes

Dermatology Quality of Life Index (DLQI)

Patient-reported outcomes evaluated by Dermatology Quality of Life Index (DLQI). DLQi is a 10-item questionnaire, each question is scored from 0 to 3, giving a possible score range from 0 (meaning no impact of skin disease on quality of life) to 30 (meaning maximum impact on quality of life). Higher score indicates poorer health outcome. (NCT04720105)
Timeframe: Baseline and Week 24

Interventionscore on a scale (Mean)
BaselineWeek 24
Participants With Plaque Type Psoriasis6.244.94

Numerical Rating Scale (NRS)

Treatment satisfaction evaluated by a Numerical Rating Scale (NRS). Full scale from 0 to 10, higher score indicates poorer health outcome. (NCT04720105)
Timeframe: Baseline and Week 24

Interventionscore on a scale (Mean)
BaselineWeek 24
Participants With Plaque Type Psoriasis1.351.29

Palmoplantar Physician Global Assessment (ppPGA)

Number of participants achieving Palmoplantar Physician Global Assessment (ppPGA) of 0 (clear) or 1 (almost clear/minimal) after 24 weeks of treatment. The ppPGA is based on the Investigators Global Assessment (IGA) modified version 11, specifically applied to the hands and/or feet: 0 (clear), 1 (almost clear/minimal), 2 (mild), 3 (moderate), 4 (marked/moderate-to-severe), 5 (severe) (NCT04720105)
Timeframe: Baseline and Week 24

Interventionscore on a scale (Mean)
BaselineWeek 24
Participants With Plaque Type Psoriasis3.472.24

Reviews

2 reviews available for tazarotene and Pain

ArticleYear
Safety and Efficacy of a Fixed Combination Halobetasol and Tazarotene Lotion in the Treatment of Moderate-to-Severe Plaque Psoriasis: A Pooled Analysis of Two Phase 3 Studies.
    Journal of drugs in dermatology : JDD, 2018, Aug-01, Volume: 17, Issue:8

    Topics: Clinical Trials, Phase III as Topic; Clobetasol; Dermatitis; Dermatologic Agents; Drug Combinations;

2018
A systematic review of adverse effects associated with topical treatments for psoriasis.
    Dermatology online journal, 2003, Volume: 9, Issue:1

    Topics: Administration, Topical; Adrenal Cortex Hormones; Anthralin; Calcitriol; Coal Tar; Dermatologic Agen

2003

Trials

3 trials available for tazarotene and Pain

ArticleYear
Efficacy, Safety, and Tolerability of a Halobetasol 0.01% /Tazarotene 0.045% Fixed Combination in the Treatment of Severe Localized Plaque Psoriasis: Post Hoc Analysis of Two Phase III Randomized Controlled Trials
    Journal of drugs in dermatology : JDD, 2019, Oct-01, Volume: 18, Issue:10

    Topics: Adult; Clobetasol; Dermatitis, Contact; Dermatologic Agents; Double-Blind Method; Drug Combinations;

2019
Halobetasol 0.01%/Tazarotene 0.045% Lotion for Moderate-to-Severe Psoriasis: Pooled Phase 3 Analysis of Males and Females.
    Journal of drugs in dermatology : JDD, 2020, May-01, Volume: 19, Issue:5

    Topics: Adult; Aged; Clobetasol; Dermatitis, Contact; Double-Blind Method; Drug Combinations; Female; Humans

2020
A Phase 2, Multicenter, Double-Blind, Randomized, Vehicle-Controlled Clinical Study to Compare the Safety and Efficacy of a Novel Tazarotene 0.045% Lotion and Tazarotene 0.1% Cream in the Treatment of Moderate-to-Severe Acne Vulgaris
    Journal of drugs in dermatology : JDD, 2019, Jun-01, Volume: 18, Issue:6

    Topics: Acne Vulgaris; Adolescent; Adult; Dose-Response Relationship, Drug; Double-Blind Method; Emulsions;

2019

Other Studies

3 other studies available for tazarotene and Pain

ArticleYear
Novel Polymeric Lotion Formulation of Once-Daily Tazarotene (0.045%) for Moderate-to-Severe Acne: Pooled Phase 3 Analysis.
    Journal of drugs in dermatology : JDD, 2020, 03-01, Volume: 19, Issue:3

    Topics: Acne Vulgaris; Adolescent; Adult; Aged; Child; Clinical Trials, Phase III as Topic; Double-Blind Met

2020
Tazarotene/Betamethasone Dipropionate Cream in Patients with Plaque Psoriasis: Results of a Prospective, Multicenter, Observational Study.
    Dermatology (Basel, Switzerland), 2021, Volume: 237, Issue:4

    Topics: Administration, Cutaneous; Adult; Anti-Inflammatory Agents; Betamethasone; Dermatologic Agents; Drug

2021
Chronically painful right thumb with pustules and onycholysis. Diagnosis: acrodermatitis continua of Hallopeau.
    Clinical and experimental dermatology, 2007, Volume: 32, Issue:5

    Topics: Acrodermatitis; Aged; Chronic Disease; Dermatologic Agents; Diagnosis, Differential; Female; Humans;

2007