Compounds > mk-8825
Page last updated: 2024-11-13

mk-8825

Description Research Excerpts Clinical Trials Roles Classes Pathways Study Profile Bioassays Related Drugs Related Conditions Protein Interactions Research Growth Market Indicators

Cross-References

ID SourceID
PubMed CID56944164
CHEMBL ID2035983
MeSH IDM0577327

Synonyms (10)

Synonym
bdbm50385309
chembl2035983 ,
mk-8825
2-((8r)-8-(3,5-difluorophenyl)-8-methyl-10-oxo-6,9-diazaspiro94.5)dec-9-yl)-n-((6s)-2'-oxo-1',2',5,7-tetrahydrospiro[cyclopenta(b)pyridine-6,3'-pyrrolo(2,3-b)pyridin)-3-yl)acetamide
1380887-60-4
mk 8825
6,9-diazaspiro(4.5)decane-9-acetamide, 8-(3,5-difluorophenyl)-8-methyl-10-oxo-n-((3's)-1',2',5,7-tetrahydro-2'-oxospiro(6h-cyclopenta(b)pyridine-6,3'-(3h)pyrrolo(2,3-b)pyridin)-3-yl)-, (8r)-
2-((r)-8-(3,5-difluorophenyl)-8-methyl-10-oxo-6,9-diazaspiro[4.5]decan-9-yl)-n-((s)-2'-oxo-1',2',5,7-tetrahydrospiro[cyclopenta[b]pyridine-6,3'-pyrrolo[2,3-b]pyridin]-3-yl)acetamide
STARBLD0021910
PD085897
[information is derived through text-mining from research data collected from National Library of Medicine (NLM), extracted Dec-2023]

Protein Targets (10)

Inhibition Measurements

ProteinTaxonomyMeasurementAverageMin (ref.)Avg (ref.)Max (ref.)Bioassay(s)
Receptor activity-modifying protein 1Homo sapiens (human)Ki0.00030.00000.00030.0008AID665599; AID665636
Receptor activity-modifying protein 3Homo sapiens (human)Ki0.84500.59000.84501.1000AID665637; AID665639
Potassium voltage-gated channel subfamily E member 1Homo sapiens (human)IC50 (µMol)20.00000.12004.048010.0000AID665642
Calcitonin receptorHomo sapiens (human)Ki1.43350.00061.43353.2000AID665636; AID665637; AID665640
Voltage-dependent L-type calcium channel subunit alpha-1CHomo sapiens (human)IC50 (µMol)20.00000.00032.25459.6000AID665644
Sodium channel protein type 5 subunit alphaHomo sapiens (human)IC50 (µMol)20.00000.00033.64849.2000AID665643
Calcitonin gene-related peptide type 1 receptorHomo sapiens (human)IC50 (µMol)0.00030.00000.00510.0110AID665615; AID665616
Calcitonin gene-related peptide type 1 receptorHomo sapiens (human)Ki5.14750.00000.02820.5900AID665599; AID665611; AID665638; AID665639
Calcitonin gene-related peptide type 1 receptorMus musculus (house mouse)Ki0.01900.01900.01900.0190AID665614
[prepared from compound, protein, and bioassay information from National Library of Medicine (NLM), extracted Dec-2023]

Activation Measurements

ProteinTaxonomyMeasurementAverageMin (ref.)Avg (ref.)Max (ref.)Bioassay(s)
Calcitonin gene-related peptide type 1 receptorHomo sapiens (human)Kd0.00010.00010.00190.0037AID665617
[prepared from compound, protein, and bioassay information from National Library of Medicine (NLM), extracted Dec-2023]

Other Measurements

ProteinTaxonomyMeasurementAverageMin (ref.)Avg (ref.)Max (ref.)Bioassay(s)
Calcitonin gene-related peptide type 1 receptorHomo sapiens (human)Kb0.00020.00000.00010.0002AID665617
[prepared from compound, protein, and bioassay information from National Library of Medicine (NLM), extracted Dec-2023]

Biological Processes (120)

Processvia Protein(s)Taxonomy
angiogenesisReceptor activity-modifying protein 1Homo sapiens (human)
calcium ion transportReceptor activity-modifying protein 1Homo sapiens (human)
intracellular protein transportReceptor activity-modifying protein 1Homo sapiens (human)
adenylate cyclase-activating G protein-coupled receptor signaling pathwayReceptor activity-modifying protein 1Homo sapiens (human)
regulation of G protein-coupled receptor signaling pathwayReceptor activity-modifying protein 1Homo sapiens (human)
protein transportReceptor activity-modifying protein 1Homo sapiens (human)
receptor internalizationReceptor activity-modifying protein 1Homo sapiens (human)
positive regulation of protein glycosylationReceptor activity-modifying protein 1Homo sapiens (human)
protein localization to plasma membraneReceptor activity-modifying protein 1Homo sapiens (human)
amylin receptor signaling pathwayReceptor activity-modifying protein 1Homo sapiens (human)
calcitonin gene-related peptide receptor signaling pathwayReceptor activity-modifying protein 1Homo sapiens (human)
G protein-coupled receptor signaling pathwayReceptor activity-modifying protein 1Homo sapiens (human)
cellular response to hormone stimulusReceptor activity-modifying protein 1Homo sapiens (human)
angiogenesisReceptor activity-modifying protein 2Homo sapiens (human)
vasculogenesisReceptor activity-modifying protein 2Homo sapiens (human)
sprouting angiogenesisReceptor activity-modifying protein 2Homo sapiens (human)
calcium ion transportReceptor activity-modifying protein 2Homo sapiens (human)
intracellular protein transportReceptor activity-modifying protein 2Homo sapiens (human)
adenylate cyclase-activating G protein-coupled receptor signaling pathwayReceptor activity-modifying protein 2Homo sapiens (human)
heart developmentReceptor activity-modifying protein 2Homo sapiens (human)
regulation of blood pressureReceptor activity-modifying protein 2Homo sapiens (human)
regulation of G protein-coupled receptor signaling pathwayReceptor activity-modifying protein 2Homo sapiens (human)
positive regulation of gene expressionReceptor activity-modifying protein 2Homo sapiens (human)
protein transportReceptor activity-modifying protein 2Homo sapiens (human)
receptor internalizationReceptor activity-modifying protein 2Homo sapiens (human)
adherens junction assemblyReceptor activity-modifying protein 2Homo sapiens (human)
cellular response to vascular endothelial growth factor stimulusReceptor activity-modifying protein 2Homo sapiens (human)
negative regulation of vascular permeabilityReceptor activity-modifying protein 2Homo sapiens (human)
positive regulation of angiogenesisReceptor activity-modifying protein 2Homo sapiens (human)
bicellular tight junction assemblyReceptor activity-modifying protein 2Homo sapiens (human)
basement membrane assemblyReceptor activity-modifying protein 2Homo sapiens (human)
protein localization to plasma membraneReceptor activity-modifying protein 2Homo sapiens (human)
vascular associated smooth muscle cell developmentReceptor activity-modifying protein 2Homo sapiens (human)
adrenomedullin receptor signaling pathwayReceptor activity-modifying protein 2Homo sapiens (human)
negative regulation of endothelial cell apoptotic processReceptor activity-modifying protein 2Homo sapiens (human)
positive regulation of vasculogenesisReceptor activity-modifying protein 2Homo sapiens (human)
cellular response to hormone stimulusReceptor activity-modifying protein 2Homo sapiens (human)
G protein-coupled receptor signaling pathwayReceptor activity-modifying protein 2Homo sapiens (human)
positive regulation of receptor recyclingReceptor activity-modifying protein 3Homo sapiens (human)
calcium ion transportReceptor activity-modifying protein 3Homo sapiens (human)
intracellular protein transportReceptor activity-modifying protein 3Homo sapiens (human)
adenylate cyclase-activating G protein-coupled receptor signaling pathwayReceptor activity-modifying protein 3Homo sapiens (human)
positive regulation of gene expressionReceptor activity-modifying protein 3Homo sapiens (human)
positive regulation of protein kinase A signalingReceptor activity-modifying protein 3Homo sapiens (human)
protein transportReceptor activity-modifying protein 3Homo sapiens (human)
receptor internalizationReceptor activity-modifying protein 3Homo sapiens (human)
cross-receptor inhibition within G protein-coupled receptor heterodimerReceptor activity-modifying protein 3Homo sapiens (human)
positive regulation of calcium-mediated signalingReceptor activity-modifying protein 3Homo sapiens (human)
positive regulation of phosphatidylinositol 3-kinase/protein kinase B signal transductionReceptor activity-modifying protein 3Homo sapiens (human)
positive regulation of ERK1 and ERK2 cascadeReceptor activity-modifying protein 3Homo sapiens (human)
cellular response to estradiol stimulusReceptor activity-modifying protein 3Homo sapiens (human)
protein localization to plasma membraneReceptor activity-modifying protein 3Homo sapiens (human)
G protein-coupled receptor signaling pathway involved in heart processReceptor activity-modifying protein 3Homo sapiens (human)
amylin receptor signaling pathwayReceptor activity-modifying protein 3Homo sapiens (human)
positive regulation of protein localization to plasma membraneReceptor activity-modifying protein 3Homo sapiens (human)
response to amyloid-betaReceptor activity-modifying protein 3Homo sapiens (human)
adrenomedullin receptor signaling pathwayReceptor activity-modifying protein 3Homo sapiens (human)
cellular response to hormone stimulusReceptor activity-modifying protein 3Homo sapiens (human)
G protein-coupled receptor signaling pathwayReceptor activity-modifying protein 3Homo sapiens (human)
epithelial cell maturationPotassium voltage-gated channel subfamily E member 1Homo sapiens (human)
sensory perception of soundPotassium voltage-gated channel subfamily E member 1Homo sapiens (human)
male gonad developmentPotassium voltage-gated channel subfamily E member 1Homo sapiens (human)
vestibular nucleus developmentPotassium voltage-gated channel subfamily E member 1Homo sapiens (human)
secretory granule organizationPotassium voltage-gated channel subfamily E member 1Homo sapiens (human)
regulation of ventricular cardiac muscle cell membrane repolarizationPotassium voltage-gated channel subfamily E member 1Homo sapiens (human)
cellular response to cAMPPotassium voltage-gated channel subfamily E member 1Homo sapiens (human)
cellular response to acidic pHPotassium voltage-gated channel subfamily E member 1Homo sapiens (human)
cellular response to light stimulusPotassium voltage-gated channel subfamily E member 1Homo sapiens (human)
potassium ion transmembrane transportPotassium voltage-gated channel subfamily E member 1Homo sapiens (human)
cardiac muscle cell action potential involved in contractionPotassium voltage-gated channel subfamily E member 1Homo sapiens (human)
cardiac muscle cell contractionPotassium voltage-gated channel subfamily E member 1Homo sapiens (human)
ventricular cardiac muscle cell action potentialPotassium voltage-gated channel subfamily E member 1Homo sapiens (human)
membrane repolarizationPotassium voltage-gated channel subfamily E member 1Homo sapiens (human)
membrane repolarization during action potentialPotassium voltage-gated channel subfamily E member 1Homo sapiens (human)
membrane repolarization during cardiac muscle cell action potentialPotassium voltage-gated channel subfamily E member 1Homo sapiens (human)
regulation of heart rate by cardiac conductionPotassium voltage-gated channel subfamily E member 1Homo sapiens (human)
negative regulation of protein targeting to membranePotassium voltage-gated channel subfamily E member 1Homo sapiens (human)
potassium ion export across plasma membranePotassium voltage-gated channel subfamily E member 1Homo sapiens (human)
membrane repolarization during ventricular cardiac muscle cell action potentialPotassium voltage-gated channel subfamily E member 1Homo sapiens (human)
regulation of potassium ion transmembrane transportPotassium voltage-gated channel subfamily E member 1Homo sapiens (human)
positive regulation of potassium ion transmembrane transportPotassium voltage-gated channel subfamily E member 1Homo sapiens (human)
regulation of delayed rectifier potassium channel activityPotassium voltage-gated channel subfamily E member 1Homo sapiens (human)
negative regulation of delayed rectifier potassium channel activityPotassium voltage-gated channel subfamily E member 1Homo sapiens (human)
activation of adenylate cyclase activityCalcitonin receptorHomo sapiens (human)
ossificationCalcitonin receptorHomo sapiens (human)
cell surface receptor signaling pathwayCalcitonin receptorHomo sapiens (human)
adenylate cyclase-activating G protein-coupled receptor signaling pathwayCalcitonin receptorHomo sapiens (human)
positive regulation of gene expressionCalcitonin receptorHomo sapiens (human)
positive regulation of protein kinase A signalingCalcitonin receptorHomo sapiens (human)
negative regulation of ossificationCalcitonin receptorHomo sapiens (human)
osteoclast differentiationCalcitonin receptorHomo sapiens (human)
cross-receptor inhibition within G protein-coupled receptor heterodimerCalcitonin receptorHomo sapiens (human)
regulation of mRNA stabilityCalcitonin receptorHomo sapiens (human)
positive regulation of calcium-mediated signalingCalcitonin receptorHomo sapiens (human)
response to glucocorticoidCalcitonin receptorHomo sapiens (human)
positive regulation of phosphatidylinositol 3-kinase/protein kinase B signal transductionCalcitonin receptorHomo sapiens (human)
positive regulation of ERK1 and ERK2 cascadeCalcitonin receptorHomo sapiens (human)
amylin receptor signaling pathwayCalcitonin receptorHomo sapiens (human)
response to amyloid-betaCalcitonin receptorHomo sapiens (human)
positive regulation of cytosolic calcium ion concentrationCalcitonin receptorHomo sapiens (human)
immune system developmentVoltage-dependent L-type calcium channel subunit alpha-1CHomo sapiens (human)
positive regulation of cytosolic calcium ion concentrationVoltage-dependent L-type calcium channel subunit alpha-1CHomo sapiens (human)
heart developmentVoltage-dependent L-type calcium channel subunit alpha-1CHomo sapiens (human)
regulation of cardiac muscle contraction by regulation of the release of sequestered calcium ionVoltage-dependent L-type calcium channel subunit alpha-1CHomo sapiens (human)
embryonic forelimb morphogenesisVoltage-dependent L-type calcium channel subunit alpha-1CHomo sapiens (human)
camera-type eye developmentVoltage-dependent L-type calcium channel subunit alpha-1CHomo sapiens (human)
positive regulation of adenylate cyclase activityVoltage-dependent L-type calcium channel subunit alpha-1CHomo sapiens (human)
positive regulation of muscle contractionVoltage-dependent L-type calcium channel subunit alpha-1CHomo sapiens (human)
calcium ion transport into cytosolVoltage-dependent L-type calcium channel subunit alpha-1CHomo sapiens (human)
cardiac conductionVoltage-dependent L-type calcium channel subunit alpha-1CHomo sapiens (human)
calcium ion transmembrane transport via high voltage-gated calcium channelVoltage-dependent L-type calcium channel subunit alpha-1CHomo sapiens (human)
calcium ion transmembrane transportVoltage-dependent L-type calcium channel subunit alpha-1CHomo sapiens (human)
cardiac muscle cell action potential involved in contractionVoltage-dependent L-type calcium channel subunit alpha-1CHomo sapiens (human)
membrane depolarization during cardiac muscle cell action potentialVoltage-dependent L-type calcium channel subunit alpha-1CHomo sapiens (human)
membrane depolarization during AV node cell action potentialVoltage-dependent L-type calcium channel subunit alpha-1CHomo sapiens (human)
cell communication by electrical coupling involved in cardiac conductionVoltage-dependent L-type calcium channel subunit alpha-1CHomo sapiens (human)
regulation of heart rate by cardiac conductionVoltage-dependent L-type calcium channel subunit alpha-1CHomo sapiens (human)
regulation of ventricular cardiac muscle cell action potentialVoltage-dependent L-type calcium channel subunit alpha-1CHomo sapiens (human)
membrane depolarization during atrial cardiac muscle cell action potentialVoltage-dependent L-type calcium channel subunit alpha-1CHomo sapiens (human)
calcium ion import across plasma membraneVoltage-dependent L-type calcium channel subunit alpha-1CHomo sapiens (human)
regulation of heart rateSodium channel protein type 5 subunit alphaHomo sapiens (human)
cardiac conduction system developmentSodium channel protein type 5 subunit alphaHomo sapiens (human)
cardiac ventricle developmentSodium channel protein type 5 subunit alphaHomo sapiens (human)
brainstem developmentSodium channel protein type 5 subunit alphaHomo sapiens (human)
sodium ion transportSodium channel protein type 5 subunit alphaHomo sapiens (human)
positive regulation of sodium ion transportSodium channel protein type 5 subunit alphaHomo sapiens (human)
response to denervation involved in regulation of muscle adaptationSodium channel protein type 5 subunit alphaHomo sapiens (human)
telencephalon developmentSodium channel protein type 5 subunit alphaHomo sapiens (human)
cerebellum developmentSodium channel protein type 5 subunit alphaHomo sapiens (human)
sodium ion transmembrane transportSodium channel protein type 5 subunit alphaHomo sapiens (human)
odontogenesis of dentin-containing toothSodium channel protein type 5 subunit alphaHomo sapiens (human)
positive regulation of action potentialSodium channel protein type 5 subunit alphaHomo sapiens (human)
positive regulation of epithelial cell proliferationSodium channel protein type 5 subunit alphaHomo sapiens (human)
membrane depolarizationSodium channel protein type 5 subunit alphaHomo sapiens (human)
cardiac muscle contractionSodium channel protein type 5 subunit alphaHomo sapiens (human)
regulation of ventricular cardiac muscle cell membrane repolarizationSodium channel protein type 5 subunit alphaHomo sapiens (human)
regulation of atrial cardiac muscle cell membrane depolarizationSodium channel protein type 5 subunit alphaHomo sapiens (human)
regulation of atrial cardiac muscle cell membrane repolarizationSodium channel protein type 5 subunit alphaHomo sapiens (human)
regulation of ventricular cardiac muscle cell membrane depolarizationSodium channel protein type 5 subunit alphaHomo sapiens (human)
cellular response to calcium ionSodium channel protein type 5 subunit alphaHomo sapiens (human)
cardiac muscle cell action potential involved in contractionSodium channel protein type 5 subunit alphaHomo sapiens (human)
regulation of cardiac muscle cell contractionSodium channel protein type 5 subunit alphaHomo sapiens (human)
ventricular cardiac muscle cell action potentialSodium channel protein type 5 subunit alphaHomo sapiens (human)
membrane depolarization during action potentialSodium channel protein type 5 subunit alphaHomo sapiens (human)
membrane depolarization during cardiac muscle cell action potentialSodium channel protein type 5 subunit alphaHomo sapiens (human)
atrial cardiac muscle cell action potentialSodium channel protein type 5 subunit alphaHomo sapiens (human)
SA node cell action potentialSodium channel protein type 5 subunit alphaHomo sapiens (human)
AV node cell action potentialSodium channel protein type 5 subunit alphaHomo sapiens (human)
bundle of His cell action potentialSodium channel protein type 5 subunit alphaHomo sapiens (human)
membrane depolarization during AV node cell action potentialSodium channel protein type 5 subunit alphaHomo sapiens (human)
membrane depolarization during SA node cell action potentialSodium channel protein type 5 subunit alphaHomo sapiens (human)
membrane depolarization during Purkinje myocyte cell action potentialSodium channel protein type 5 subunit alphaHomo sapiens (human)
membrane depolarization during bundle of His cell action potentialSodium channel protein type 5 subunit alphaHomo sapiens (human)
AV node cell to bundle of His cell communicationSodium channel protein type 5 subunit alphaHomo sapiens (human)
regulation of heart rate by cardiac conductionSodium channel protein type 5 subunit alphaHomo sapiens (human)
membrane depolarization during atrial cardiac muscle cell action potentialSodium channel protein type 5 subunit alphaHomo sapiens (human)
regulation of sodium ion transmembrane transportSodium channel protein type 5 subunit alphaHomo sapiens (human)
angiogenesisCalcitonin gene-related peptide type 1 receptorHomo sapiens (human)
calcium ion transportCalcitonin gene-related peptide type 1 receptorHomo sapiens (human)
cell surface receptor signaling pathwayCalcitonin gene-related peptide type 1 receptorHomo sapiens (human)
G protein-coupled receptor signaling pathway, coupled to cyclic nucleotide second messengerCalcitonin gene-related peptide type 1 receptorHomo sapiens (human)
adenylate cyclase-activating G protein-coupled receptor signaling pathwayCalcitonin gene-related peptide type 1 receptorHomo sapiens (human)
heart developmentCalcitonin gene-related peptide type 1 receptorHomo sapiens (human)
protein transportCalcitonin gene-related peptide type 1 receptorHomo sapiens (human)
receptor internalizationCalcitonin gene-related peptide type 1 receptorHomo sapiens (human)
cellular response to sucrose stimulusCalcitonin gene-related peptide type 1 receptorHomo sapiens (human)
positive regulation of vascular associated smooth muscle cell proliferationCalcitonin gene-related peptide type 1 receptorHomo sapiens (human)
calcitonin gene-related peptide receptor signaling pathwayCalcitonin gene-related peptide type 1 receptorHomo sapiens (human)
adrenomedullin receptor signaling pathwayCalcitonin gene-related peptide type 1 receptorHomo sapiens (human)
vascular associated smooth muscle cell proliferationCalcitonin gene-related peptide type 1 receptorHomo sapiens (human)
[Information is prepared from geneontology information from the June-17-2024 release]

Molecular Functions (40)

Processvia Protein(s)Taxonomy
calcitonin gene-related peptide receptor activityReceptor activity-modifying protein 1Homo sapiens (human)
protein bindingReceptor activity-modifying protein 1Homo sapiens (human)
amylin receptor activityReceptor activity-modifying protein 1Homo sapiens (human)
calcitonin gene-related peptide bindingReceptor activity-modifying protein 1Homo sapiens (human)
coreceptor activityReceptor activity-modifying protein 1Homo sapiens (human)
adrenomedullin receptor activityReceptor activity-modifying protein 2Homo sapiens (human)
protein bindingReceptor activity-modifying protein 2Homo sapiens (human)
coreceptor activityReceptor activity-modifying protein 2Homo sapiens (human)
adrenomedullin bindingReceptor activity-modifying protein 2Homo sapiens (human)
amyloid-beta bindingReceptor activity-modifying protein 3Homo sapiens (human)
adrenomedullin receptor activityReceptor activity-modifying protein 3Homo sapiens (human)
protein bindingReceptor activity-modifying protein 3Homo sapiens (human)
amylin receptor activityReceptor activity-modifying protein 3Homo sapiens (human)
coreceptor activityReceptor activity-modifying protein 3Homo sapiens (human)
voltage-gated potassium channel activityPotassium voltage-gated channel subfamily E member 1Homo sapiens (human)
delayed rectifier potassium channel activityPotassium voltage-gated channel subfamily E member 1Homo sapiens (human)
voltage-gated potassium channel activity involved in cardiac muscle cell action potential repolarizationPotassium voltage-gated channel subfamily E member 1Homo sapiens (human)
voltage-gated potassium channel activity involved in ventricular cardiac muscle cell action potential repolarizationPotassium voltage-gated channel subfamily E member 1Homo sapiens (human)
delayed rectifier potassium channel activityPotassium voltage-gated channel subfamily E member 1Homo sapiens (human)
protein bindingPotassium voltage-gated channel subfamily E member 1Homo sapiens (human)
potassium channel regulator activityPotassium voltage-gated channel subfamily E member 1Homo sapiens (human)
telethonin bindingPotassium voltage-gated channel subfamily E member 1Homo sapiens (human)
protein-containing complex bindingPotassium voltage-gated channel subfamily E member 1Homo sapiens (human)
transmembrane transporter bindingPotassium voltage-gated channel subfamily E member 1Homo sapiens (human)
calcitonin bindingCalcitonin receptorHomo sapiens (human)
amyloid-beta bindingCalcitonin receptorHomo sapiens (human)
calcitonin gene-related peptide receptor activityCalcitonin receptorHomo sapiens (human)
protein bindingCalcitonin receptorHomo sapiens (human)
calcitonin bindingCalcitonin receptorHomo sapiens (human)
amylin receptor activityCalcitonin receptorHomo sapiens (human)
calcitonin receptor activityCalcitonin receptorHomo sapiens (human)
high voltage-gated calcium channel activityVoltage-dependent L-type calcium channel subunit alpha-1CHomo sapiens (human)
voltage-gated calcium channel activity involved in cardiac muscle cell action potentialVoltage-dependent L-type calcium channel subunit alpha-1CHomo sapiens (human)
voltage-gated calcium channel activityVoltage-dependent L-type calcium channel subunit alpha-1CHomo sapiens (human)
protein bindingVoltage-dependent L-type calcium channel subunit alpha-1CHomo sapiens (human)
calmodulin bindingVoltage-dependent L-type calcium channel subunit alpha-1CHomo sapiens (human)
high voltage-gated calcium channel activityVoltage-dependent L-type calcium channel subunit alpha-1CHomo sapiens (human)
metal ion bindingVoltage-dependent L-type calcium channel subunit alpha-1CHomo sapiens (human)
alpha-actinin bindingVoltage-dependent L-type calcium channel subunit alpha-1CHomo sapiens (human)
voltage-gated calcium channel activity involved in cardiac muscle cell action potentialVoltage-dependent L-type calcium channel subunit alpha-1CHomo sapiens (human)
voltage-gated calcium channel activity involved in AV node cell action potentialVoltage-dependent L-type calcium channel subunit alpha-1CHomo sapiens (human)
voltage-gated sodium channel activitySodium channel protein type 5 subunit alphaHomo sapiens (human)
protein bindingSodium channel protein type 5 subunit alphaHomo sapiens (human)
calmodulin bindingSodium channel protein type 5 subunit alphaHomo sapiens (human)
fibroblast growth factor bindingSodium channel protein type 5 subunit alphaHomo sapiens (human)
enzyme bindingSodium channel protein type 5 subunit alphaHomo sapiens (human)
protein kinase bindingSodium channel protein type 5 subunit alphaHomo sapiens (human)
protein domain specific bindingSodium channel protein type 5 subunit alphaHomo sapiens (human)
ankyrin bindingSodium channel protein type 5 subunit alphaHomo sapiens (human)
ubiquitin protein ligase bindingSodium channel protein type 5 subunit alphaHomo sapiens (human)
transmembrane transporter bindingSodium channel protein type 5 subunit alphaHomo sapiens (human)
nitric-oxide synthase bindingSodium channel protein type 5 subunit alphaHomo sapiens (human)
voltage-gated sodium channel activity involved in cardiac muscle cell action potentialSodium channel protein type 5 subunit alphaHomo sapiens (human)
voltage-gated sodium channel activity involved in AV node cell action potentialSodium channel protein type 5 subunit alphaHomo sapiens (human)
voltage-gated sodium channel activity involved in bundle of His cell action potentialSodium channel protein type 5 subunit alphaHomo sapiens (human)
voltage-gated sodium channel activity involved in Purkinje myocyte action potentialSodium channel protein type 5 subunit alphaHomo sapiens (human)
voltage-gated sodium channel activity involved in SA node cell action potentialSodium channel protein type 5 subunit alphaHomo sapiens (human)
scaffold protein bindingSodium channel protein type 5 subunit alphaHomo sapiens (human)
adrenomedullin receptor activityCalcitonin gene-related peptide type 1 receptorHomo sapiens (human)
calcitonin gene-related peptide receptor activityCalcitonin gene-related peptide type 1 receptorHomo sapiens (human)
G protein-coupled receptor activityCalcitonin gene-related peptide type 1 receptorHomo sapiens (human)
calcitonin receptor activityCalcitonin gene-related peptide type 1 receptorHomo sapiens (human)
protein bindingCalcitonin gene-related peptide type 1 receptorHomo sapiens (human)
adrenomedullin bindingCalcitonin gene-related peptide type 1 receptorHomo sapiens (human)
[Information is prepared from geneontology information from the June-17-2024 release]

Ceullar Components (36)

Processvia Protein(s)Taxonomy
plasma membraneReceptor activity-modifying protein 1Homo sapiens (human)
plasma membraneReceptor activity-modifying protein 1Homo sapiens (human)
cell surfaceReceptor activity-modifying protein 1Homo sapiens (human)
receptor complexReceptor activity-modifying protein 1Homo sapiens (human)
CGRP receptor complexReceptor activity-modifying protein 1Homo sapiens (human)
cell surfaceReceptor activity-modifying protein 1Homo sapiens (human)
plasma membraneReceptor activity-modifying protein 2Homo sapiens (human)
cytoplasmReceptor activity-modifying protein 2Homo sapiens (human)
lysosomeReceptor activity-modifying protein 2Homo sapiens (human)
plasma membraneReceptor activity-modifying protein 2Homo sapiens (human)
clathrin-coated pitReceptor activity-modifying protein 2Homo sapiens (human)
cell surfaceReceptor activity-modifying protein 2Homo sapiens (human)
receptor complexReceptor activity-modifying protein 2Homo sapiens (human)
adrenomedullin receptor complexReceptor activity-modifying protein 2Homo sapiens (human)
cell surfaceReceptor activity-modifying protein 2Homo sapiens (human)
lysosomeReceptor activity-modifying protein 3Homo sapiens (human)
plasma membraneReceptor activity-modifying protein 3Homo sapiens (human)
plasma membraneReceptor activity-modifying protein 3Homo sapiens (human)
cell surfaceReceptor activity-modifying protein 3Homo sapiens (human)
receptor complexReceptor activity-modifying protein 3Homo sapiens (human)
amylin receptor complex 3Receptor activity-modifying protein 3Homo sapiens (human)
adrenomedullin receptor complexReceptor activity-modifying protein 3Homo sapiens (human)
cell surfaceReceptor activity-modifying protein 3Homo sapiens (human)
voltage-gated potassium channel complexPotassium voltage-gated channel subfamily E member 1Homo sapiens (human)
lysosomePotassium voltage-gated channel subfamily E member 1Homo sapiens (human)
plasma membranePotassium voltage-gated channel subfamily E member 1Homo sapiens (human)
cell surfacePotassium voltage-gated channel subfamily E member 1Homo sapiens (human)
apical plasma membranePotassium voltage-gated channel subfamily E member 1Homo sapiens (human)
Z discPotassium voltage-gated channel subfamily E member 1Homo sapiens (human)
membrane raftPotassium voltage-gated channel subfamily E member 1Homo sapiens (human)
acrosomal vesicleCalcitonin receptorHomo sapiens (human)
plasma membraneCalcitonin receptorHomo sapiens (human)
ciliumCalcitonin receptorHomo sapiens (human)
amylin receptor complex 1Calcitonin receptorHomo sapiens (human)
amylin receptor complex 2Calcitonin receptorHomo sapiens (human)
amylin receptor complex 3Calcitonin receptorHomo sapiens (human)
plasma membraneCalcitonin receptorHomo sapiens (human)
axonCalcitonin receptorHomo sapiens (human)
cytoplasmVoltage-dependent L-type calcium channel subunit alpha-1CHomo sapiens (human)
plasma membraneVoltage-dependent L-type calcium channel subunit alpha-1CHomo sapiens (human)
postsynaptic densityVoltage-dependent L-type calcium channel subunit alpha-1CHomo sapiens (human)
membraneVoltage-dependent L-type calcium channel subunit alpha-1CHomo sapiens (human)
Z discVoltage-dependent L-type calcium channel subunit alpha-1CHomo sapiens (human)
dendriteVoltage-dependent L-type calcium channel subunit alpha-1CHomo sapiens (human)
perikaryonVoltage-dependent L-type calcium channel subunit alpha-1CHomo sapiens (human)
postsynaptic density membraneVoltage-dependent L-type calcium channel subunit alpha-1CHomo sapiens (human)
L-type voltage-gated calcium channel complexVoltage-dependent L-type calcium channel subunit alpha-1CHomo sapiens (human)
voltage-gated calcium channel complexVoltage-dependent L-type calcium channel subunit alpha-1CHomo sapiens (human)
caveolaSodium channel protein type 5 subunit alphaHomo sapiens (human)
nucleoplasmSodium channel protein type 5 subunit alphaHomo sapiens (human)
nucleolusSodium channel protein type 5 subunit alphaHomo sapiens (human)
endoplasmic reticulumSodium channel protein type 5 subunit alphaHomo sapiens (human)
plasma membraneSodium channel protein type 5 subunit alphaHomo sapiens (human)
caveolaSodium channel protein type 5 subunit alphaHomo sapiens (human)
cell surfaceSodium channel protein type 5 subunit alphaHomo sapiens (human)
intercalated discSodium channel protein type 5 subunit alphaHomo sapiens (human)
membraneSodium channel protein type 5 subunit alphaHomo sapiens (human)
lateral plasma membraneSodium channel protein type 5 subunit alphaHomo sapiens (human)
Z discSodium channel protein type 5 subunit alphaHomo sapiens (human)
T-tubuleSodium channel protein type 5 subunit alphaHomo sapiens (human)
sarcolemmaSodium channel protein type 5 subunit alphaHomo sapiens (human)
perinuclear region of cytoplasmSodium channel protein type 5 subunit alphaHomo sapiens (human)
voltage-gated sodium channel complexSodium channel protein type 5 subunit alphaHomo sapiens (human)
plasma membraneCalcitonin gene-related peptide type 1 receptorHomo sapiens (human)
cytoplasmCalcitonin gene-related peptide type 1 receptorHomo sapiens (human)
lysosomeCalcitonin gene-related peptide type 1 receptorHomo sapiens (human)
endosomeCalcitonin gene-related peptide type 1 receptorHomo sapiens (human)
endoplasmic reticulumCalcitonin gene-related peptide type 1 receptorHomo sapiens (human)
plasma membraneCalcitonin gene-related peptide type 1 receptorHomo sapiens (human)
adrenomedullin receptor complexCalcitonin gene-related peptide type 1 receptorHomo sapiens (human)
CGRP receptor complexCalcitonin gene-related peptide type 1 receptorHomo sapiens (human)
plasma membraneCalcitonin gene-related peptide type 1 receptorHomo sapiens (human)
[Information is prepared from geneontology information from the June-17-2024 release]

Bioassays (47)

Assay IDTitleYearJournalArticle
AID665635Volume of distribution at steady state in mouse at 2 mg/kg, iv2012Bioorganic & medicinal chemistry letters, Jun-15, Volume: 22, Issue:12
MK-8825: a potent and selective CGRP receptor antagonist with good oral activity in rats.
AID665601Fraction unbound in rat plasma2012Bioorganic & medicinal chemistry letters, Jun-15, Volume: 22, Issue:12
MK-8825: a potent and selective CGRP receptor antagonist with good oral activity in rats.
AID665611Displacement of [125I]CGRP from CGRP receptor in human SK-N-MC cells after 3 hrs2012Bioorganic & medicinal chemistry letters, Jun-15, Volume: 22, Issue:12
MK-8825: a potent and selective CGRP receptor antagonist with good oral activity in rats.
AID665623Oral bioavailability in mouse at 10 mg/kg2012Bioorganic & medicinal chemistry letters, Jun-15, Volume: 22, Issue:12
MK-8825: a potent and selective CGRP receptor antagonist with good oral activity in rats.
AID665633Volume of distribution at steady state in dog at 0.5 mg/kg, iv2012Bioorganic & medicinal chemistry letters, Jun-15, Volume: 22, Issue:12
MK-8825: a potent and selective CGRP receptor antagonist with good oral activity in rats.
AID665626Half life in monkey at 0.5 mg/kg, iv2012Bioorganic & medicinal chemistry letters, Jun-15, Volume: 22, Issue:12
MK-8825: a potent and selective CGRP receptor antagonist with good oral activity in rats.
AID665602Displacement of [125I]CGRP from CGRP receptor in dog brain membrane after 3 hrs2012Bioorganic & medicinal chemistry letters, Jun-15, Volume: 22, Issue:12
MK-8825: a potent and selective CGRP receptor antagonist with good oral activity in rats.
AID665638Displacement of [125I]adrenomedullin from human AM1 receptor expressed in HEK293 cells2012Bioorganic & medicinal chemistry letters, Jun-15, Volume: 22, Issue:12
MK-8825: a potent and selective CGRP receptor antagonist with good oral activity in rats.
AID665631Clearance in mouse at 2 mg/kg, iv2012Bioorganic & medicinal chemistry letters, Jun-15, Volume: 22, Issue:12
MK-8825: a potent and selective CGRP receptor antagonist with good oral activity in rats.
AID665617Antagonist activity at human CGRP receptor expressed in HEK293 cells assessed as inhibition of CGRP-induced cAMP response after 5 mins relative to control2012Bioorganic & medicinal chemistry letters, Jun-15, Volume: 22, Issue:12
MK-8825: a potent and selective CGRP receptor antagonist with good oral activity in rats.
AID665622Oral bioavailability in monkey at 20 mg/kg2012Bioorganic & medicinal chemistry letters, Jun-15, Volume: 22, Issue:12
MK-8825: a potent and selective CGRP receptor antagonist with good oral activity in rats.
AID665616Antagonist activity at human CGRP receptor expressed in HEK293 cells assessed as inhibition of CGRP-induced cAMP response after 5 mins in the presence of 50% human serum2012Bioorganic & medicinal chemistry letters, Jun-15, Volume: 22, Issue:12
MK-8825: a potent and selective CGRP receptor antagonist with good oral activity in rats.
AID665606Fraction unbound in monkey plasma2012Bioorganic & medicinal chemistry letters, Jun-15, Volume: 22, Issue:12
MK-8825: a potent and selective CGRP receptor antagonist with good oral activity in rats.
AID665607Ratio of compound to MK-3207 fraction unbound in rat plasma2012Bioorganic & medicinal chemistry letters, Jun-15, Volume: 22, Issue:12
MK-8825: a potent and selective CGRP receptor antagonist with good oral activity in rats.
AID665615Antagonist activity at human CGRP receptor expressed in HEK293 cells assessed as inhibition of CGRP-induced cAMP response after 5 mins in the absence of human serum2012Bioorganic & medicinal chemistry letters, Jun-15, Volume: 22, Issue:12
MK-8825: a potent and selective CGRP receptor antagonist with good oral activity in rats.
AID665624Half life in rat at 2 mg/kg, iv2012Bioorganic & medicinal chemistry letters, Jun-15, Volume: 22, Issue:12
MK-8825: a potent and selective CGRP receptor antagonist with good oral activity in rats.
AID665621Oral bioavailability in monkey at 2 mg/kg2012Bioorganic & medicinal chemistry letters, Jun-15, Volume: 22, Issue:12
MK-8825: a potent and selective CGRP receptor antagonist with good oral activity in rats.
AID665636Displacement of [125I]amylin from human AMY1 receptor expressed in COS7 cells after 3 hrs2012Bioorganic & medicinal chemistry letters, Jun-15, Volume: 22, Issue:12
MK-8825: a potent and selective CGRP receptor antagonist with good oral activity in rats.
AID665619Oral bioavailability in rat at 50 mg/kg2012Bioorganic & medicinal chemistry letters, Jun-15, Volume: 22, Issue:12
MK-8825: a potent and selective CGRP receptor antagonist with good oral activity in rats.
AID665625Half life in dog at 0.5 mg/kg, iv2012Bioorganic & medicinal chemistry letters, Jun-15, Volume: 22, Issue:12
MK-8825: a potent and selective CGRP receptor antagonist with good oral activity in rats.
AID665614Displacement of [125I]CGRP from mouse CGRP receptor2012Bioorganic & medicinal chemistry letters, Jun-15, Volume: 22, Issue:12
MK-8825: a potent and selective CGRP receptor antagonist with good oral activity in rats.
AID665600Displacement of [125I]CGRP from CGRP receptor in rat brain membrane after 3 hrs2012Bioorganic & medicinal chemistry letters, Jun-15, Volume: 22, Issue:12
MK-8825: a potent and selective CGRP receptor antagonist with good oral activity in rats.
AID665634Volume of distribution at steady state in monkey at 0.5 mg/kg, iv2012Bioorganic & medicinal chemistry letters, Jun-15, Volume: 22, Issue:12
MK-8825: a potent and selective CGRP receptor antagonist with good oral activity in rats.
AID665618Oral bioavailability in rat at 5 mg/kg2012Bioorganic & medicinal chemistry letters, Jun-15, Volume: 22, Issue:12
MK-8825: a potent and selective CGRP receptor antagonist with good oral activity in rats.
AID665645Ratio of compound to MK-3207 clearance in rat2012Bioorganic & medicinal chemistry letters, Jun-15, Volume: 22, Issue:12
MK-8825: a potent and selective CGRP receptor antagonist with good oral activity in rats.
AID665610Aqueous solubility of the compound in citrate buffer at pH 22012Bioorganic & medicinal chemistry letters, Jun-15, Volume: 22, Issue:12
MK-8825: a potent and selective CGRP receptor antagonist with good oral activity in rats.
AID665639Displacement of [125I]adrenomedullin from human AM2 receptor expressed in HEK293 cells2012Bioorganic & medicinal chemistry letters, Jun-15, Volume: 22, Issue:12
MK-8825: a potent and selective CGRP receptor antagonist with good oral activity in rats.
AID665613Displacement of [125I]CGRP from rabbit CGRP receptor2012Bioorganic & medicinal chemistry letters, Jun-15, Volume: 22, Issue:12
MK-8825: a potent and selective CGRP receptor antagonist with good oral activity in rats.
AID665632Volume of distribution at steady state in rat at 2 mg/kg, iv2012Bioorganic & medicinal chemistry letters, Jun-15, Volume: 22, Issue:12
MK-8825: a potent and selective CGRP receptor antagonist with good oral activity in rats.
AID665627Half life in mouse at 2 mg/kg, iv2012Bioorganic & medicinal chemistry letters, Jun-15, Volume: 22, Issue:12
MK-8825: a potent and selective CGRP receptor antagonist with good oral activity in rats.
AID665608Aqueous solubility of the compound in phosphate buffer at pH 72012Bioorganic & medicinal chemistry letters, Jun-15, Volume: 22, Issue:12
MK-8825: a potent and selective CGRP receptor antagonist with good oral activity in rats.
AID665599Displacement of [125I]CGRP from human recombinant CALCRL/RAMP1 receptor expressed in HEK293 cells after 3 hrs2012Bioorganic & medicinal chemistry letters, Jun-15, Volume: 22, Issue:12
MK-8825: a potent and selective CGRP receptor antagonist with good oral activity in rats.
AID665637Displacement of [125I]amylin from human AMY3 receptor expressed in COS7 cells after 3 hrs2012Bioorganic & medicinal chemistry letters, Jun-15, Volume: 22, Issue:12
MK-8825: a potent and selective CGRP receptor antagonist with good oral activity in rats.
AID665609Aqueous solubility of the compound in citrate buffer at pH 42012Bioorganic & medicinal chemistry letters, Jun-15, Volume: 22, Issue:12
MK-8825: a potent and selective CGRP receptor antagonist with good oral activity in rats.
AID665603Antimigraine activity in iv dosed rat assessed as inhibition of capsaicin-induced dermal vasodilation administered 10 mins post capsaicin-challenge measured after 20 mins by laser doppler scanning2012Bioorganic & medicinal chemistry letters, Jun-15, Volume: 22, Issue:12
MK-8825: a potent and selective CGRP receptor antagonist with good oral activity in rats.
AID665620Oral bioavailability in dog at 2 mg/kg2012Bioorganic & medicinal chemistry letters, Jun-15, Volume: 22, Issue:12
MK-8825: a potent and selective CGRP receptor antagonist with good oral activity in rats.
AID665641Inhibition of Ikr ion channel by voltage clamp assay2012Bioorganic & medicinal chemistry letters, Jun-15, Volume: 22, Issue:12
MK-8825: a potent and selective CGRP receptor antagonist with good oral activity in rats.
AID665629Clearance in dog at 0.5 mg/kg, iv2012Bioorganic & medicinal chemistry letters, Jun-15, Volume: 22, Issue:12
MK-8825: a potent and selective CGRP receptor antagonist with good oral activity in rats.
AID665644Inhibition of CaV1.2 ion channel by voltage clamp assay2012Bioorganic & medicinal chemistry letters, Jun-15, Volume: 22, Issue:12
MK-8825: a potent and selective CGRP receptor antagonist with good oral activity in rats.
AID665642Inhibition of Iks ion channel by voltage clamp assay2012Bioorganic & medicinal chemistry letters, Jun-15, Volume: 22, Issue:12
MK-8825: a potent and selective CGRP receptor antagonist with good oral activity in rats.
AID665640Displacement of [125I]calcitonin from human CT receptor expressed in HEK293 cells2012Bioorganic & medicinal chemistry letters, Jun-15, Volume: 22, Issue:12
MK-8825: a potent and selective CGRP receptor antagonist with good oral activity in rats.
AID665630Clearance in monkey at 0.5 mg/kg, iv2012Bioorganic & medicinal chemistry letters, Jun-15, Volume: 22, Issue:12
MK-8825: a potent and selective CGRP receptor antagonist with good oral activity in rats.
AID665604Fraction unbound in human plasma2012Bioorganic & medicinal chemistry letters, Jun-15, Volume: 22, Issue:12
MK-8825: a potent and selective CGRP receptor antagonist with good oral activity in rats.
AID665628Clearance in rat at 2 mg/kg, iv2012Bioorganic & medicinal chemistry letters, Jun-15, Volume: 22, Issue:12
MK-8825: a potent and selective CGRP receptor antagonist with good oral activity in rats.
AID665612Displacement of [125I]CGRP from CGRP receptor in rhesus monkey cerebellum after 3 hrs2012Bioorganic & medicinal chemistry letters, Jun-15, Volume: 22, Issue:12
MK-8825: a potent and selective CGRP receptor antagonist with good oral activity in rats.
AID665643Inhibition of NaV1.5 ion channel by voltage clamp assay2012Bioorganic & medicinal chemistry letters, Jun-15, Volume: 22, Issue:12
MK-8825: a potent and selective CGRP receptor antagonist with good oral activity in rats.
AID665605Fraction unbound in dog plasma2012Bioorganic & medicinal chemistry letters, Jun-15, Volume: 22, Issue:12
MK-8825: a potent and selective CGRP receptor antagonist with good oral activity in rats.
[information is prepared from bioassay data collected from National Library of Medicine (NLM), extracted Dec-2023]

Research

Studies (8)

TimeframeStudies, This Drug (%)All Drugs %
pre-19900 (0.00)18.7374
1990's0 (0.00)18.2507
2000's0 (0.00)29.6817
2010's8 (100.00)24.3611
2020's0 (0.00)2.80
[information is prepared from research data collected from National Library of Medicine (NLM), extracted Dec-2023]

Market Indicators

Research Demand Index: 17.40

According to the monthly volume, diversity, and competition of internet searches for this compound, as well the volume and growth of publications, there is estimated to be moderate demand-to-supply ratio for research on this compound.

MetricThis Compound (vs All)
Research Demand Index17.40 (24.57)
Research Supply Index2.20 (2.92)
Research Growth Index4.51 (4.65)
Search Engine Demand Index15.26 (26.88)
Search Engine Supply Index3.00 (0.95)

This Compound (17.40)

All Compounds (24.57)

Study Types

Publication TypeThis drug (%)All Drugs (%)
Trials0 (0.00%)5.53%
Reviews0 (0.00%)6.00%
Case Studies0 (0.00%)4.05%
Observational0 (0.00%)0.25%
Other8 (100.00%)84.16%
[information is prepared from research data collected from National Library of Medicine (NLM), extracted Dec-2023]
SubstanceRelationship StrengthStudiesTrialsClassesRoles
nitroglycerin
Nitroglycerin: A volatile vasodilator which relieves ANGINA PECTORIS by stimulating GUANYLATE CYCLASE and lowering cytosolic calcium. It is also sometimes used for TOCOLYSIS and explosives.. nitroglycerol : A nitrate ester that is glycerol in which nitro group(s) replace the hydrogen(s) attached to one or more of the hydroxy groups.. nitroglycerin : A nitroglycerol that is glycerol in which the hydrogen atoms of all three hydroxy groups are replaced by nitro groups. It acts as a prodrug, releasing nitric oxide to open blood vessels and so alleviate heart pain.		7.4920nitroglycerolexplosive;
muscle relaxant;
nitric oxide donor;
prodrug;
tocolytic agent;
vasodilator agent;
xenobiotic
sumatriptan
Sumatriptan: A serotonin agonist that acts selectively at 5HT1 receptors. It is used in the treatment of MIGRAINE DISORDERS.. sumatriptan : A sulfonamide that consists of N,N-dimethyltryptamine bearing an additional (N-methylsulfamoyl)methyl substituent at position 5. Selective agonist for a vascular 5-HT1 receptor subtype (probably a member of the 5-HT1D family). Used (in the form of its succinate salt) for the acute treatment of migraine with or without aura in adults.		2.1310sulfonamide;
tryptamines		serotonergic agonist;
vasoconstrictor agent
mustard gas
Mustard Gas: Severe irritant and vesicant of skin, eyes, and lungs. It may cause blindness and lethal lung edema and was formerly used as a war gas. The substance has been proposed as a cytostatic and for treatment of psoriasis. It has been listed as a known carcinogen in the Fourth Annual Report on Carcinogens (NTP-85-002, 1985) (Merck, 11th ed).. bis(2-chloroethyl) sulfide : An ethyl sulfide that is diethyl sulfide in which a hydrogen from each of the terminal methyl groups is replaced by a chlorine. It is a powerful vesicant regulated under the Chemical Weapons Convention.		2.1710ethyl sulfide;
organochlorine compound		alkylating agent;
carcinogenic agent;
vesicant
2-chloroethyl ethyl sulfide
[no description available]		2.1710
hc 030031
2-(1,3-dimethyl-2,6-dioxo-1,2,3,6-tetrahydro-7H-purin-7-yl)-N-(4-isopropylphenyl)acetamide: a TRPA1 channel blocker		2.1710
telcagepant
telcagepant: structure in first source		2.0710
mk 3207
[no description available]		2.0710
ConditionIndicatedRelationship StrengthStudiesTrials
Disease Models, Animal
Naturally-occurring or experimentally-induced animal diseases with pathological processes analogous to human diseases.		05.4470
Abdominal Migraine
[description not available]		02.7830
Migraine Disorders
A class of disabling primary headache disorders, characterized by recurrent unilateral pulsatile headaches. The two major subtypes are common migraine (without aura) and classic migraine (with aura or neurological symptoms). (International Classification of Headache Disorders, 2nd ed. Cephalalgia 2004: suppl 1)		02.7830
Ache
[description not available]		02.2110
Pain
An unpleasant sensation induced by noxious stimuli which are detected by NERVE ENDINGS of NOCICEPTIVE NEURONS.		07.2110
Bleb
[description not available]		02.1710
Dermatoses
[description not available]		02.1710
Skin Diseases
Diseases involving the DERMIS or EPIDERMIS.		02.1710
Allodynia
[description not available]		08.7230
Lesion of Sciatic Nerve
[description not available]		03.0310
Nerve Pain
[description not available]		03.0310
Neuralgia
Intense or aching pain that occurs along the course or distribution of a peripheral or cranial nerve.		03.0310
Craniofacial Pain
[description not available]		04.9740
Facial Pain
Pain in the facial region including orofacial pain and craniofacial pain. Associated conditions include local inflammatory and neoplastic disorders and neuralgic syndromes involving the trigeminal, facial, and glossopharyngeal nerves. Conditions which feature recurrent or persistent facial pain as the primary manifestation of disease are referred to as FACIAL PAIN SYNDROMES.		04.9740
Encephalopathy, Traumatic
[description not available]		02.1310
Actinic Reticuloid Syndrome
[description not available]		02.1310
Brain Injuries, Traumatic
A form of acquired brain injury which occurs when a sudden trauma causes damage to the brain.		02.1310