Page last updated: 2024-11-03

proglumide and Pain

proglumide has been researched along with Pain in 20 studies

Proglumide: A drug that exerts an inhibitory effect on gastric secretion and reduces gastrointestinal motility. It is used clinically in the drug therapy of gastrointestinal ulcers.
proglumide : A racemate composed of equal amounts of (R)- and (S)-proglumide. A non-selective CCK antagonist that was used primarily for treatment of stomach ulcers, but has been replaced by newer drugs.
N(2)-benzoyl-N,N-dipropyl-alpha-glutamine : A dicarboxylic acid monoamide obtained by formal condensation of the alpha-carboxy group of N-benzoylglutamic acid with dippropylamine.

Pain: An unpleasant sensation induced by noxious stimuli which are detected by NERVE ENDINGS of NOCICEPTIVE NEURONS.

Research Excerpts

ExcerptRelevanceReference
"The therapeutic efficacy of a CCK-A receptor antagonist, loxiglumide, in patients with painful acute attacks of chronic pancreatitis was evaluated."9.10Clinical evaluation of oral administration of a cholecystokinin-A receptor antagonist (loxiglumide) to patients with acute, painful attacks of chronic pancreatitis: a multicenter dose-response study in Japan. ( Matsuno, S; Satake, K; Shiratori, K; Takeuchi, T, 2002)
"The analgesic efficacy of morphine is sometimes only partial in patients with chronic benign pain."9.08The cholecystokinin antagonist proglumide enhances the analgesic efficacy of morphine in humans with chronic benign pain. ( McCleane, GJ, 1998)
"The therapeutic efficacy of a CCK-A receptor antagonist, loxiglumide, in patients with painful acute attacks of chronic pancreatitis was evaluated."5.10Clinical evaluation of oral administration of a cholecystokinin-A receptor antagonist (loxiglumide) to patients with acute, painful attacks of chronic pancreatitis: a multicenter dose-response study in Japan. ( Matsuno, S; Satake, K; Shiratori, K; Takeuchi, T, 2002)
"The analgesic efficacy of morphine is sometimes only partial in patients with chronic benign pain."5.08The cholecystokinin antagonist proglumide enhances the analgesic efficacy of morphine in humans with chronic benign pain. ( McCleane, GJ, 1998)
" Mechanical allodynia elicited by burn injury was partially reversed by meloxicam (5 mg/kg), gabapentin (100 mg/kg) and oxycodone (3 and 10 mg/kg), while thermal allodynia and gait abnormalities were only significantly improved by amitriptyline (3 mg/kg) and oxycodone (10 mg/kg)."3.83Transcriptomic and behavioural characterisation of a mouse model of burn pain identify the cholecystokinin 2 receptor as an analgesic target. ( Deuis, JR; Lewis, RJ; Vetter, I; Yin, K, 2016)
"pretreatment with lorglumide (0."1.29Involvement of supraspinal and spinal CCK receptors in the modulation of antinociception induced by cold water swimming stress in the mouse. ( Kim, KW; Kim, YH; Kwon, SH; Min, BH; Song, DK; Suh, HW, 1996)

Research

Studies (20)

TimeframeStudies, this research(%)All Research%
pre-19908 (40.00)18.7374
1990's9 (45.00)18.2507
2000's2 (10.00)29.6817
2010's1 (5.00)24.3611
2020's0 (0.00)2.80

Authors

AuthorsStudies
Yin, K1
Deuis, JR1
Lewis, RJ1
Vetter, I1
Shiratori, K1
Takeuchi, T1
Satake, K1
Matsuno, S1
Suh, HW1
Song, DK1
Kwon, SH1
Kim, KW1
Min, BH1
Kim, YH1
Bernstein, ZP1
Yucht, S1
Battista, E1
Lema, M1
Spaulding, MB1
McCleane, GJ1
Zarrindast, MR2
Rezayat, M2
Ghanipoor, N1
Parvini, S1
Feinle, C1
Samiee, F1
Suh, HH1
Collins, KA1
Tseng, LF1
Wang, XJ2
Wang, XH2
Han, JS3
Kellstein, DE1
Price, DD2
Mayer, DJ2
Li, Y1
Suberg, SN1
Watkins, LR2
Kubota, K2
Sun, FY1
Sugaya, K2
Sunagane, N1
Matsuda, I1
Panerai, AE1
Kinscheck, IB1
Yang, HY1
Tang, J1
Iadarola, M1
Panula, P1
Costa, E1
von der Gruen, A1
Miller, J1
Rafii, A1
Price, C1

Reviews

1 review available for proglumide and Pain

ArticleYear
Interaction of cholecystokinin and opioids in pain modulation.
    Pain and headache, 1987, Volume: 9

    Topics: Analgesia; Animals; Cholecystokinin; Endorphins; Narcotics; Pain; Proglumide; Rats; Receptors, Opioi

1987

Trials

3 trials available for proglumide and Pain

ArticleYear
Clinical evaluation of oral administration of a cholecystokinin-A receptor antagonist (loxiglumide) to patients with acute, painful attacks of chronic pancreatitis: a multicenter dose-response study in Japan.
    Pancreas, 2002, Volume: 25, Issue:1

    Topics: Acute Disease; Administration, Oral; Adult; Amylases; Chronic Disease; Female; Hormone Antagonists;

2002
Proglumide as a morphine adjunct in cancer pain management.
    Journal of pain and symptom management, 1998, Volume: 15, Issue:5

    Topics: Analgesics, Opioid; Cross-Over Studies; Double-Blind Method; Drug Synergism; Drug Therapy, Combinati

1998
The cholecystokinin antagonist proglumide enhances the analgesic efficacy of morphine in humans with chronic benign pain.
    Anesthesia and analgesia, 1998, Volume: 87, Issue:5

    Topics: Adult; Aged; Aged, 80 and over; Analgesics, Opioid; Cholecystokinin; Chronic Disease; Cross-Over Stu

1998

Other Studies

16 other studies available for proglumide and Pain

ArticleYear
Transcriptomic and behavioural characterisation of a mouse model of burn pain identify the cholecystokinin 2 receptor as an analgesic target.
    Molecular pain, 2016, Volume: 12

    Topics: Amines; Amitriptyline; Animals; Cyclohexanecarboxylic Acids; Disease Models, Animal; Gabapentin; Gai

2016
Involvement of supraspinal and spinal CCK receptors in the modulation of antinociception induced by cold water swimming stress in the mouse.
    Neuropeptides, 1996, Volume: 30, Issue:4

    Topics: Animals; Brain; Cold Temperature; Hormone Antagonists; Indoles; Injections, Intraventricular; Inject

1996
Interactions between antinociception induced by cholecystokinin antagonists and GABA agonists in the tail-flick test.
    Pharmacology & toxicology, 1998, Volume: 83, Issue:4

    Topics: Animals; Baclofen; Benzodiazepinones; Devazepide; Dose-Response Relationship, Drug; Drug Interaction

1998
Role of intestinal chemoreception in the induction of gastrointestinal sensations.
    DTW. Deutsche tierarztliche Wochenschrift, 1998, Volume: 105, Issue:12

    Topics: Adult; Anesthetics, Local; Catheterization; Chemoreceptor Cells; Duodenum; Female; Hormone Antagonis

1998
Antinociceptive effect of intracerebroventricular administration of cholecystokinin antagonist in nerve-ligated mice.
    Pharmacology & toxicology, 2000, Volume: 87, Issue:4

    Topics: Analgesics, Opioid; Animals; Anti-Ulcer Agents; Ceruletide; Dose-Response Relationship, Drug; Drug I

2000
Intrathecal cholecystokinin octapeptide attenuates the antinociception and release of immunoreactive Met-enkephalin induced by intraventricular beta-endorphin in the rat.
    Neuropeptides, 1992, Volume: 21, Issue:3

    Topics: Animals; beta-Endorphin; Depression, Chemical; Enkephalin, Methionine; Injections, Intraventricular;

1992
Cholecystokinin octapeptide antagonized opioid analgesia mediated by mu- and kappa- but not delta-receptors in the spinal cord of the rat.
    Brain research, 1990, Jul-16, Volume: 523, Issue:1

    Topics: Animals; Dose-Response Relationship, Drug; Dynorphins; Endorphins; Enkephalin, D-Penicillamine (2,5)

1990
[Cholecystokinin octapeptide (CCK-8) antagonized analgesia mediated by mu and kappa opioid receptors].
    Sheng li xue bao : [Acta physiologica Sinica], 1990, Volume: 42, Issue:3

    Topics: Analgesics; Animals; Dynorphins; Endorphins; Injections, Spinal; Male; Pain; Peptide Fragments; Prog

1990
Cholecystokinin and its antagonist lorglumide respectively attenuate and facilitate morphine-induced inhibition of C-fiber evoked discharges of dorsal horn nociceptive neurons.
    Brain research, 1991, Feb-01, Volume: 540, Issue:1-2

    Topics: Animals; Cholecystokinin; Electric Stimulation; Evoked Potentials; Male; Morphine; Nerve Fibers; Neu

1991
Cholecystokinin-octapeptide antagonizes morphine analgesia in periaqueductal gray of the rat.
    Brain research, 1989, Feb-20, Volume: 480, Issue:1-2

    Topics: Analgesia; Animals; Dose-Response Relationship, Drug; Male; Morphine; Pain; Periaqueductal Gray; Pro

1989
Reversal of antinociceptive effect of caerulein by benzodiazepine.
    Journal of pharmacobio-dynamics, 1986, Volume: 9, Issue:4

    Topics: Analgesics; Animals; Anti-Anxiety Agents; Benzodiazepines; Ceruletide; Dose-Response Relationship, D

1986
Possible involvement of the CCK receptor in the benzodiazepine antagonism to CCK in the mouse brain.
    Japanese journal of pharmacology, 1987, Volume: 43, Issue:1

    Topics: Animals; Anti-Anxiety Agents; Benzodiazepines; Brain; Cholecystokinin; Eating; Male; Mice; Mice, Inb

1987
[Potentiation concept in pharmacology].
    Minerva anestesiologica, 1988, Volume: 54, Issue:4

    Topics: 5-Hydroxytryptophan; Animals; Baclofen; Clomipramine; Diazepam; Drug Synergism; Drug Therapy, Combin

1988
Potentiation of morphine analgesia by the cholecystokinin antagonist proglumide.
    Brain research, 1985, Feb-18, Volume: 327, Issue:1-2

    Topics: Analgesia; Animals; Cholecystokinin; Dose-Response Relationship, Drug; Drug Synergism; Glutamine; In

1985
Are Phe-Met-Arg-Phe-NH2 immunoreactive peptides endacoids modulating opiate antinociception?
    Progress in clinical and biological research, 1985, Volume: 192

    Topics: Animals; Bivalvia; Brain Chemistry; Cattle; FMRFamide; Immunoenzyme Techniques; Male; Medulla Oblong

1985
Potentiation of systemic morphine analgesia in humans by proglumide, a cholecystokinin antagonist.
    Anesthesia and analgesia, 1985, Volume: 64, Issue:8

    Topics: Adult; Cholecystokinin; Dose-Response Relationship, Drug; Double-Blind Method; Drug Synergism; Gluta

1985