proglumide and Pain
proglumide has been researched along with Pain in 20 studies
Proglumide: A drug that exerts an inhibitory effect on gastric secretion and reduces gastrointestinal motility. It is used clinically in the drug therapy of gastrointestinal ulcers.
proglumide : A racemate composed of equal amounts of (R)- and (S)-proglumide. A non-selective CCK antagonist that was used primarily for treatment of stomach ulcers, but has been replaced by newer drugs.
N(2)-benzoyl-N,N-dipropyl-alpha-glutamine : A dicarboxylic acid monoamide obtained by formal condensation of the alpha-carboxy group of N-benzoylglutamic acid with dippropylamine.
Pain: An unpleasant sensation induced by noxious stimuli which are detected by NERVE ENDINGS of NOCICEPTIVE NEURONS.
Research Excerpts
| Excerpt | Relevance | Reference |
|---|---|---|
| "The therapeutic efficacy of a CCK-A receptor antagonist, loxiglumide, in patients with painful acute attacks of chronic pancreatitis was evaluated." | 9.10 | Clinical evaluation of oral administration of a cholecystokinin-A receptor antagonist (loxiglumide) to patients with acute, painful attacks of chronic pancreatitis: a multicenter dose-response study in Japan. ( Matsuno, S; Satake, K; Shiratori, K; Takeuchi, T, 2002) |
| "The analgesic efficacy of morphine is sometimes only partial in patients with chronic benign pain." | 9.08 | The cholecystokinin antagonist proglumide enhances the analgesic efficacy of morphine in humans with chronic benign pain. ( McCleane, GJ, 1998) |
| "The therapeutic efficacy of a CCK-A receptor antagonist, loxiglumide, in patients with painful acute attacks of chronic pancreatitis was evaluated." | 5.10 | Clinical evaluation of oral administration of a cholecystokinin-A receptor antagonist (loxiglumide) to patients with acute, painful attacks of chronic pancreatitis: a multicenter dose-response study in Japan. ( Matsuno, S; Satake, K; Shiratori, K; Takeuchi, T, 2002) |
| "The analgesic efficacy of morphine is sometimes only partial in patients with chronic benign pain." | 5.08 | The cholecystokinin antagonist proglumide enhances the analgesic efficacy of morphine in humans with chronic benign pain. ( McCleane, GJ, 1998) |
| " Mechanical allodynia elicited by burn injury was partially reversed by meloxicam (5 mg/kg), gabapentin (100 mg/kg) and oxycodone (3 and 10 mg/kg), while thermal allodynia and gait abnormalities were only significantly improved by amitriptyline (3 mg/kg) and oxycodone (10 mg/kg)." | 3.83 | Transcriptomic and behavioural characterisation of a mouse model of burn pain identify the cholecystokinin 2 receptor as an analgesic target. ( Deuis, JR; Lewis, RJ; Vetter, I; Yin, K, 2016) |
| "pretreatment with lorglumide (0." | 1.29 | Involvement of supraspinal and spinal CCK receptors in the modulation of antinociception induced by cold water swimming stress in the mouse. ( Kim, KW; Kim, YH; Kwon, SH; Min, BH; Song, DK; Suh, HW, 1996) |
Research
Studies (20)
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 8 (40.00) | 18.7374 |
| 1990's | 9 (45.00) | 18.2507 |
| 2000's | 2 (10.00) | 29.6817 |
| 2010's | 1 (5.00) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
Authors
| Authors | Studies |
|---|---|
| Yin, K | 1 |
| Deuis, JR | 1 |
| Lewis, RJ | 1 |
| Vetter, I | 1 |
| Shiratori, K | 1 |
| Takeuchi, T | 1 |
| Satake, K | 1 |
| Matsuno, S | 1 |
| Suh, HW | 1 |
| Song, DK | 1 |
| Kwon, SH | 1 |
| Kim, KW | 1 |
| Min, BH | 1 |
| Kim, YH | 1 |
| Bernstein, ZP | 1 |
| Yucht, S | 1 |
| Battista, E | 1 |
| Lema, M | 1 |
| Spaulding, MB | 1 |
| McCleane, GJ | 1 |
| Zarrindast, MR | 2 |
| Rezayat, M | 2 |
| Ghanipoor, N | 1 |
| Parvini, S | 1 |
| Feinle, C | 1 |
| Samiee, F | 1 |
| Suh, HH | 1 |
| Collins, KA | 1 |
| Tseng, LF | 1 |
| Wang, XJ | 2 |
| Wang, XH | 2 |
| Han, JS | 3 |
| Kellstein, DE | 1 |
| Price, DD | 2 |
| Mayer, DJ | 2 |
| Li, Y | 1 |
| Suberg, SN | 1 |
| Watkins, LR | 2 |
| Kubota, K | 2 |
| Sun, FY | 1 |
| Sugaya, K | 2 |
| Sunagane, N | 1 |
| Matsuda, I | 1 |
| Panerai, AE | 1 |
| Kinscheck, IB | 1 |
| Yang, HY | 1 |
| Tang, J | 1 |
| Iadarola, M | 1 |
| Panula, P | 1 |
| Costa, E | 1 |
| von der Gruen, A | 1 |
| Miller, J | 1 |
| Rafii, A | 1 |
| Price, C | 1 |
Reviews
1 review available for proglumide and Pain
| Article | Year |
|---|---|
Interaction of cholecystokinin and opioids in pain modulation.
Topics: Analgesia; Animals; Cholecystokinin; Endorphins; Narcotics; Pain; Proglumide; Rats; Receptors, Opioi | 1987 |
Trials
3 trials available for proglumide and Pain
| Article | Year |
|---|---|
Clinical evaluation of oral administration of a cholecystokinin-A receptor antagonist (loxiglumide) to patients with acute, painful attacks of chronic pancreatitis: a multicenter dose-response study in Japan.
Topics: Acute Disease; Administration, Oral; Adult; Amylases; Chronic Disease; Female; Hormone Antagonists; | 2002 |
Proglumide as a morphine adjunct in cancer pain management.
Topics: Analgesics, Opioid; Cross-Over Studies; Double-Blind Method; Drug Synergism; Drug Therapy, Combinati | 1998 |
The cholecystokinin antagonist proglumide enhances the analgesic efficacy of morphine in humans with chronic benign pain.
Topics: Adult; Aged; Aged, 80 and over; Analgesics, Opioid; Cholecystokinin; Chronic Disease; Cross-Over Stu | 1998 |
Other Studies
16 other studies available for proglumide and Pain
| Article | Year |
|---|---|
Transcriptomic and behavioural characterisation of a mouse model of burn pain identify the cholecystokinin 2 receptor as an analgesic target.
Topics: Amines; Amitriptyline; Animals; Cyclohexanecarboxylic Acids; Disease Models, Animal; Gabapentin; Gai | 2016 |
Involvement of supraspinal and spinal CCK receptors in the modulation of antinociception induced by cold water swimming stress in the mouse.
Topics: Animals; Brain; Cold Temperature; Hormone Antagonists; Indoles; Injections, Intraventricular; Inject | 1996 |
Interactions between antinociception induced by cholecystokinin antagonists and GABA agonists in the tail-flick test.
Topics: Animals; Baclofen; Benzodiazepinones; Devazepide; Dose-Response Relationship, Drug; Drug Interaction | 1998 |
Role of intestinal chemoreception in the induction of gastrointestinal sensations.
Topics: Adult; Anesthetics, Local; Catheterization; Chemoreceptor Cells; Duodenum; Female; Hormone Antagonis | 1998 |
Antinociceptive effect of intracerebroventricular administration of cholecystokinin antagonist in nerve-ligated mice.
Topics: Analgesics, Opioid; Animals; Anti-Ulcer Agents; Ceruletide; Dose-Response Relationship, Drug; Drug I | 2000 |
Intrathecal cholecystokinin octapeptide attenuates the antinociception and release of immunoreactive Met-enkephalin induced by intraventricular beta-endorphin in the rat.
Topics: Animals; beta-Endorphin; Depression, Chemical; Enkephalin, Methionine; Injections, Intraventricular; | 1992 |
Cholecystokinin octapeptide antagonized opioid analgesia mediated by mu- and kappa- but not delta-receptors in the spinal cord of the rat.
Topics: Animals; Dose-Response Relationship, Drug; Dynorphins; Endorphins; Enkephalin, D-Penicillamine (2,5) | 1990 |
[Cholecystokinin octapeptide (CCK-8) antagonized analgesia mediated by mu and kappa opioid receptors].
Topics: Analgesics; Animals; Dynorphins; Endorphins; Injections, Spinal; Male; Pain; Peptide Fragments; Prog | 1990 |
Cholecystokinin and its antagonist lorglumide respectively attenuate and facilitate morphine-induced inhibition of C-fiber evoked discharges of dorsal horn nociceptive neurons.
Topics: Animals; Cholecystokinin; Electric Stimulation; Evoked Potentials; Male; Morphine; Nerve Fibers; Neu | 1991 |
Cholecystokinin-octapeptide antagonizes morphine analgesia in periaqueductal gray of the rat.
Topics: Analgesia; Animals; Dose-Response Relationship, Drug; Male; Morphine; Pain; Periaqueductal Gray; Pro | 1989 |
Reversal of antinociceptive effect of caerulein by benzodiazepine.
Topics: Analgesics; Animals; Anti-Anxiety Agents; Benzodiazepines; Ceruletide; Dose-Response Relationship, D | 1986 |
Possible involvement of the CCK receptor in the benzodiazepine antagonism to CCK in the mouse brain.
Topics: Animals; Anti-Anxiety Agents; Benzodiazepines; Brain; Cholecystokinin; Eating; Male; Mice; Mice, Inb | 1987 |
[Potentiation concept in pharmacology].
Topics: 5-Hydroxytryptophan; Animals; Baclofen; Clomipramine; Diazepam; Drug Synergism; Drug Therapy, Combin | 1988 |
Potentiation of morphine analgesia by the cholecystokinin antagonist proglumide.
Topics: Analgesia; Animals; Cholecystokinin; Dose-Response Relationship, Drug; Drug Synergism; Glutamine; In | 1985 |
Are Phe-Met-Arg-Phe-NH2 immunoreactive peptides endacoids modulating opiate antinociception?
Topics: Animals; Bivalvia; Brain Chemistry; Cattle; FMRFamide; Immunoenzyme Techniques; Male; Medulla Oblong | 1985 |
Potentiation of systemic morphine analgesia in humans by proglumide, a cholecystokinin antagonist.
Topics: Adult; Cholecystokinin; Dose-Response Relationship, Drug; Double-Blind Method; Drug Synergism; Gluta | 1985 |