1-methyl-3-isobutylxanthine has been researched along with Pain in 4 studies
1-Methyl-3-isobutylxanthine: A potent cyclic nucleotide phosphodiesterase inhibitor; due to this action, the compound increases cyclic AMP and cyclic GMP in tissue and thereby activates CYCLIC NUCLEOTIDE-REGULATED PROTEIN KINASES
3-isobutyl-1-methylxanthine : An oxopurine that is xanthine which is substituted at positions 1 and 3 by methyl and isobutyl groups, respectively.
Pain: An unpleasant sensation induced by noxious stimuli which are detected by NERVE ENDINGS of NOCICEPTIVE NEURONS.
| Excerpt | Relevance | Reference |
|---|---|---|
| "Clonidine pretreatment did not significantly alter the effect of baclofen alone, but reversed the potentiation of the action of baclofen produced by both theophylline and isobutylmethylxanthine." | 1.27 | Clonidine reverses methylxanthine-induced potentiation of baclofen antinociception. ( Sawynok, J; Steardo, L, 1985) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 2 (50.00) | 18.7374 |
| 1990's | 1 (25.00) | 18.2507 |
| 2000's | 0 (0.00) | 29.6817 |
| 2010's | 1 (25.00) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Chłoń-Rzepa, G | 1 |
| Ślusarczyk, M | 1 |
| Jankowska, A | 1 |
| Gawalska, A | 1 |
| Bucki, A | 1 |
| Kołaczkowski, M | 1 |
| Świerczek, A | 1 |
| Pociecha, K | 1 |
| Wyska, E | 1 |
| Zygmunt, M | 1 |
| Kazek, G | 1 |
| Sałat, K | 1 |
| Pawłowski, M | 1 |
| Wang, Z | 1 |
| Bilsky, EJ | 1 |
| Wang, D | 1 |
| Porreca, F | 1 |
| Sadée, W | 1 |
| Duggan, AW | 1 |
| Griersmith, BT | 1 |
| Steardo, L | 1 |
| Sawynok, J | 1 |
4 other studies available for 1-methyl-3-isobutylxanthine and Pain
| Article | Year |
|---|---|
Novel amide derivatives of 1,3-dimethyl-2,6-dioxopurin-7-yl-alkylcarboxylic acids as multifunctional TRPA1 antagonists and PDE4/7 inhibitors: A new approach for the treatment of pain.
Topics: Amides; Analgesics; Animals; Cyclic Nucleotide Phosphodiesterases, Type 4; Cyclic Nucleotide Phospho | 2018 |
3-Isobutyl-1-methylxanthine inhibits basal mu-opioid receptor phosphorylation and reverses acute morphine tolerance and dependence in mice.
Topics: 1-Methyl-3-isobutylxanthine; Adenylyl Cyclases; Animals; Cells, Cultured; Cyclic AMP; Drug Tolerance | 1999 |
Methyl xanthines, adenosine 3',5'-cyclic monophosphate and the spinal transmission of nociceptive information.
Topics: 1-Methyl-3-isobutylxanthine; Animals; Cats; Cyclic AMP; Injections, Intravenous; Pain; Spinal Cord; | 1979 |
Clonidine reverses methylxanthine-induced potentiation of baclofen antinociception.
Topics: 1-Methyl-3-isobutylxanthine; Animals; Baclofen; Clonidine; Drug Interactions; Male; Neural Pathways; | 1985 |