morin and Pain

Morin displayed significant inhibition of chick chorioallantoic membrane (CAM) angiogenesis and was able to increase the endostatin level in human umbilical vein endothelial cells (HUVECs). Morin was shown to contain an in vivo anti-inflammatory activity using a carrageenan-induced air pouch model in mice. Antinociceptive activity of morin was also assessed using an acetic acid-induced writhing test in mice. Collectively, morin possesses antiangiogenic, in vivo anti-inflammatory, and antinociceptive activities.

Topics: Acetic Acid; Analgesics; Angiogenesis Inhibitors; Animals; Anti-Inflammatory Agents; Behavior, Animal; Carrageenan; Cell Line; Chick Embryo; Chorioallantoic Membrane; Disease Models, Animal; Endostatins; Endothelial Cells; Flavonoids; Humans; Inflammation; Maclura; Male; Mice; Mice, Inbred ICR; Pain; Phytotherapy; Plant Extracts; Psidium; Umbilical Veins