Page last updated: 2024-08-03 03:31:01
gr 82334
Description
GR 82334: tachykinin NK-1 receptor antagonist [MeSH]
Cross-References
| ID Source | ID |
|---|
| PubMed CID | 16130972 |
| SCHEMBL ID | 7945525 |
| MeSH ID | M0211648 |
Synonyms (11)
| Synonym |
|---|
| physalaemin(1-11), d-pro(9)(spiro-gamma-lactam)leu(10)-trp(11)- |
| physalemin, 9-deglycine-10-((5s)-6-oxo-l-alpha-(2-methylpropyl)-1,7-diazaspiro(4.4)nonane-7-acetic acid)-11-l-tryptophanamide- |
| gr 82334 |
| 129623-01-4 |
| SCHEMBL7945525 |
| AKOS024456738 |
| DTXSID10156209 |
| gr 82334, >=95% |
| gr82334 |
| xadpnkfyxl w |
| l-tryptophanamide,5-oxo-l-prolyl-l-alanyl-l-a-aspartyl-l-prolyl-l-asparaginyl-l-lysyl-l-phenylalanyl-l-tyrosyl-(as,5s)-a-(2-methylpropyl)-6-oxo-1,7-diazaspiro[4.4]nonane-7-acetyl- |
Research
Studies (65)
| Timeframe | Studies, This Drug (%) | All Drugs % |
|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 43 (66.15) | 18.2507 |
| 2000's | 17 (26.15) | 29.6817 |
| 2010's | 5 (7.69) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
Study Types
| Publication Type | This drug (%) | All Drugs (%) |
|---|
| Trials | 0 (0.00%) | 5.53% |
| Reviews | 0 (0.00%) | 6.00% |
| Case Studies | 0 (0.00%) | 4.05% |
| Observational | 0 (0.00%) | 0.25% |
| Other | 65 (100.00%) | 84.16% |
| Substance | Studies | Classes | Roles | First Year | Last Year | Average Age | Relationship Strength | Trials | pre-1990 | 1990's | 2000's | 2010's | post-2020 |
|---|
| gamma-aminobutyric acid | | amino acid zwitterion;
gamma-amino acid;
monocarboxylic acid | human metabolite;
neurotransmitter;
Saccharomyces cerevisiae metabolite;
signalling molecule | 1995 | 1995 | 29.0 | low | 0 | 0 | 1 | 0 | 0 | 0 |
| pyridoxal phosphate | | methylpyridines;
monohydroxypyridine;
pyridinecarbaldehyde;
vitamin B6 phosphate | coenzyme;
cofactor;
EC 2.7.7.7 (DNA-directed DNA polymerase) inhibitor;
Escherichia coli metabolite;
human metabolite;
mouse metabolite;
Saccharomyces cerevisiae metabolite | 1999 | 2000 | 24.5 | low | 0 | 0 | 2 | 0 | 0 | 0 |
| 2-amino-5-phosphonovalerate | | non-proteinogenic alpha-amino acid | NMDA receptor antagonist | 1993 | 1994 | 30.5 | low | 0 | 0 | 2 | 0 | 0 | 0 |
| sk&f-38393 | | benzazepine;
catechols;
secondary amino compound | | 1997 | 1997 | 27.0 | low | 0 | 0 | 1 | 0 | 0 | 0 |
| 4-aminopyridine | | aminopyridine;
aromatic amine | avicide;
orphan drug;
potassium channel blocker | 1993 | 1997 | 29.0 | low | 0 | 0 | 2 | 0 | 0 | 0 |
| 7-nitroindazole | | | | 2004 | 2004 | 20.0 | low | 0 | 0 | 0 | 1 | 0 | 0 |
| bisindolylmaleimide i | | | | 2003 | 2003 | 21.0 | low | 0 | 0 | 0 | 1 | 0 | 0 |
| celecoxib | | organofluorine compound;
pyrazoles;
sulfonamide;
toluenes | cyclooxygenase 2 inhibitor;
geroprotector;
non-narcotic analgesic;
non-steroidal anti-inflammatory drug | 2004 | 2004 | 20.0 | low | 0 | 0 | 0 | 1 | 0 | 0 |
| thiorphan | | N-acyl-amino acid | | 1997 | 1997 | 27.0 | low | 0 | 0 | 1 | 0 | 0 | 0 |
| fenvalerate | | aromatic ether;
carboxylic ester;
monochlorobenzenes | pyrethroid ester acaricide;
pyrethroid ester insecticide | 2001 | 2001 | 23.0 | low | 0 | 0 | 0 | 1 | 0 | 0 |
| guanethidine | | azocanes;
guanidines | adrenergic antagonist;
antihypertensive agent;
sympatholytic agent | 1995 | 1995 | 29.0 | low | 0 | 0 | 1 | 0 | 0 | 0 |
| 1-(5-isoquinolinesulfonyl)-2-methylpiperazine | | isoquinolines;
N-sulfonylpiperazine | EC 2.7.11.13 (protein kinase C) inhibitor | 2009 | 2009 | 15.0 | low | 0 | 0 | 0 | 1 | 0 | 0 |
| haloperidol | | aromatic ketone;
hydroxypiperidine;
monochlorobenzenes;
organofluorine compound;
tertiary alcohol | antidyskinesia agent;
antiemetic;
dopaminergic antagonist;
first generation antipsychotic;
serotonergic antagonist | 1997 | 1997 | 27.0 | low | 0 | 0 | 1 | 0 | 0 | 0 |
| hexamethonium | | quaternary ammonium salt | | 1993 | 1993 | 31.0 | low | 0 | 0 | 1 | 0 | 0 | 0 |
| lidocaine | | benzenes;
monocarboxylic acid amide;
tertiary amino compound | anti-arrhythmia drug;
drug allergen;
environmental contaminant;
local anaesthetic;
xenobiotic | 1996 | 1996 | 28.0 | low | 0 | 0 | 1 | 0 | 0 | 0 |
| indomethacin | | aromatic ether;
indole-3-acetic acids;
monochlorobenzenes;
N-acylindole | analgesic;
drug metabolite;
EC 1.14.99.1 (prostaglandin-endoperoxide synthase) inhibitor;
environmental contaminant;
gout suppressant;
non-steroidal anti-inflammatory drug;
xenobiotic metabolite;
xenobiotic | 1995 | 2011 | 21.0 | low | 0 | 0 | 1 | 0 | 1 | 0 |
| isoproterenol | | catechols;
secondary alcohol;
secondary amino compound | beta-adrenergic agonist;
bronchodilator agent;
cardiotonic drug;
sympathomimetic agent | 1994 | 1994 | 30.0 | low | 0 | 0 | 1 | 0 | 0 | 0 |
| ketanserin | | aromatic ketone;
organofluorine compound;
piperidines;
quinazolines | alpha-adrenergic antagonist;
antihypertensive agent;
cardiovascular drug;
EC 3.4.21.26 (prolyl oligopeptidase) inhibitor;
serotonergic antagonist | 1997 | 1997 | 27.0 | low | 0 | 0 | 1 | 0 | 0 | 0 |
| mexiletine | | aromatic ether;
primary amino compound | anti-arrhythmia drug | 2001 | 2001 | 23.0 | low | 0 | 0 | 0 | 1 | 0 | 0 |
| nicardipine | | benzenes;
C-nitro compound;
diester;
dihydropyridine;
methyl ester;
tertiary amino compound | | 2003 | 2003 | 21.0 | low | 0 | 0 | 0 | 1 | 0 | 0 |
| nifedipine | | C-nitro compound;
dihydropyridine;
methyl ester | calcium channel blocker;
human metabolite;
tocolytic agent;
vasodilator agent | 1994 | 1995 | 29.5 | low | 0 | 0 | 2 | 0 | 0 | 0 |
| potassium chloride | | inorganic chloride;
inorganic potassium salt;
potassium salt | fertilizer | 1999 | 1999 | 25.0 | low | 0 | 0 | 1 | 0 | 0 | 0 |
| pyridoxal phosphate-6-azophenyl-2',4'-disulfonic acid | | arenesulfonic acid;
azobenzenes;
methylpyridines;
monohydroxypyridine;
organic phosphate;
pyridinecarbaldehyde | purinergic receptor P2X antagonist | 1999 | 2000 | 24.5 | low | 0 | 0 | 2 | 0 | 0 | 0 |
| proglumide | | benzamides;
dicarboxylic acid monoamide;
glutamine derivative;
racemate | anti-ulcer drug;
cholecystokinin antagonist;
cholinergic antagonist;
delta-opioid receptor agonist;
drug metabolite;
gastrointestinal drug;
opioid analgesic;
xenobiotic metabolite | 1993 | 1993 | 31.0 | low | 0 | 0 | 1 | 0 | 0 | 0 |
| ritanserin | | organofluorine compound;
piperidines;
thiazolopyrimidine | antidepressant;
antipsychotic agent;
anxiolytic drug;
dopaminergic antagonist;
EC 3.4.21.26 (prolyl oligopeptidase) inhibitor;
serotonergic antagonist | 1997 | 1997 | 27.0 | low | 0 | 0 | 1 | 0 | 0 | 0 |
| suramin | | naphthalenesulfonic acid;
phenylureas;
secondary carboxamide | angiogenesis inhibitor;
antinematodal drug;
antineoplastic agent;
apoptosis inhibitor;
EC 2.7.11.13 (protein kinase C) inhibitor;
GABA antagonist;
GABA-gated chloride channel antagonist;
purinergic receptor P2 antagonist;
ryanodine receptor agonist;
trypanocidal drug | 1995 | 2015 | 16.0 | low | 0 | 0 | 1 | 0 | 2 | 0 |
| urethane | | carbamate ester | fungal metabolite;
mutagen | 1996 | 1996 | 28.0 | low | 0 | 0 | 1 | 0 | 0 | 0 |
| corticosterone | | 11beta-hydroxy steroid;
20-oxo steroid;
21-hydroxy steroid;
3-oxo-Delta(4) steroid;
C21-steroid;
glucocorticoid;
primary alpha-hydroxy ketone | human metabolite;
mouse metabolite | 2007 | 2007 | 17.0 | low | 0 | 0 | 0 | 1 | 0 | 0 |
| carbachol | | ammonium salt;
carbamate ester | cardiotonic drug;
miotic;
muscarinic agonist;
nicotinic acetylcholine receptor agonist;
non-narcotic analgesic | 1993 | 1993 | 31.0 | low | 0 | 0 | 1 | 0 | 0 | 0 |
| lysine | | aspartate family amino acid;
L-alpha-amino acid zwitterion;
L-alpha-amino acid;
lysine;
organic molecular entity;
proteinogenic amino acid | algal metabolite;
anticonvulsant;
Escherichia coli metabolite;
human metabolite;
micronutrient;
mouse metabolite;
nutraceutical;
plant metabolite;
Saccharomyces cerevisiae metabolite | 2004 | 2004 | 20.0 | low | 0 | 0 | 0 | 1 | 0 | 0 |
| adenosine diphosphate | | adenosine 5'-phosphate;
purine ribonucleoside 5'-diphosphate | fundamental metabolite;
human metabolite | 1995 | 1995 | 29.0 | low | 0 | 0 | 1 | 0 | 0 | 0 |
| phenylephrine | | phenols;
phenylethanolamines;
secondary amino compound | alpha-adrenergic agonist;
cardiotonic drug;
mydriatic agent;
nasal decongestant;
protective agent;
sympathomimetic agent;
vasoconstrictor agent | 2001 | 2001 | 23.0 | low | 0 | 0 | 0 | 1 | 0 | 0 |
| arginine | | arginine;
glutamine family amino acid;
L-alpha-amino acid;
proteinogenic amino acid | biomarker;
Escherichia coli metabolite;
micronutrient;
mouse metabolite;
nutraceutical | 1995 | 1995 | 29.0 | low | 0 | 0 | 1 | 0 | 0 | 0 |
| quinoxalines | | mancude organic heterobicyclic parent;
naphthyridine;
ortho-fused heteroarene | | 2009 | 2009 | 15.0 | low | 0 | 0 | 0 | 1 | 0 | 0 |
| pyrrolidonecarboxylic acid | | 5-oxoproline;
L-proline derivative;
non-proteinogenic L-alpha-amino acid | algal metabolite | 1993 | 1997 | 29.5 | low | 0 | 0 | 4 | 0 | 0 | 0 |
| quinuclidines | | quinuclidines;
saturated organic heterobicyclic parent | | 1997 | 2006 | 24.0 | low | 0 | 0 | 2 | 1 | 0 | 0 |
| indazoles | | indazole | | 2004 | 2004 | 20.0 | low | 0 | 0 | 0 | 1 | 0 | 0 |
| toluene 2,4-diisocyanate | | toluene meta-diisocyanate | allergen;
hapten | 1994 | 1994 | 30.0 | low | 0 | 0 | 1 | 0 | 0 | 0 |
| copper sulfate | | metal sulfate | emetic;
fertilizer;
sensitiser | 1999 | 1999 | 25.0 | low | 0 | 0 | 1 | 0 | 0 | 0 |
| substance p | | peptide | neurokinin-1 receptor agonist;
neurotransmitter;
vasodilator agent | 1993 | 2014 | 26.0 | medium | 0 | 0 | 27 | 9 | 1 | 0 |
| mezlocillin | | | | 2004 | 2004 | 20.0 | low | 0 | 0 | 0 | 1 | 0 | 0 |
| mifepristone | | 3-oxo-Delta(4) steroid;
acetylenic compound;
tertiary amino compound | abortifacient;
contraceptive drug;
hormone antagonist;
synthetic oral contraceptive | 2007 | 2007 | 17.0 | low | 0 | 0 | 0 | 1 | 0 | 0 |
| loxiglumide | | organic molecular entity | | 1993 | 1993 | 31.0 | low | 0 | 0 | 1 | 0 | 0 | 0 |
| mesulergine | | ergot alkaloid;
sulfamides | antiparkinson drug;
dopamine agonist;
serotonergic antagonist | 1997 | 1997 | 27.0 | low | 0 | 0 | 1 | 0 | 0 | 0 |
| nicotine | | 3-(1-methylpyrrolidin-2-yl)pyridine | anxiolytic drug;
biomarker;
immunomodulator;
mitogen;
neurotoxin;
nicotinic acetylcholine receptor agonist;
peripheral nervous system drug;
phytogenic insecticide;
plant metabolite;
psychotropic drug;
teratogenic agent;
xenobiotic | 1999 | 1999 | 25.0 | low | 0 | 0 | 1 | 0 | 0 | 0 |
| alpha,beta-methyleneadenosine 5'-triphosphate | | nucleoside triphosphate analogue | | 2010 | 2010 | 14.0 | low | 0 | 0 | 0 | 1 | 0 | 0 |
| cp 96345 | | | | 1994 | 2002 | 28.1 | low | 0 | 0 | 6 | 1 | 0 | 0 |
| 1-(2-(3-(4-methoxyphenyl)propoxy)-4-methoxyphenylethyl)-1h-imidazole | | ether;
imidazoles;
monomethoxybenzene | TRP channel blocker | 2003 | 2003 | 21.0 | low | 0 | 0 | 0 | 1 | 0 | 0 |
| sr 48968 | | | | 1994 | 1996 | 29.3 | low | 0 | 0 | 3 | 0 | 0 | 0 |
| fluorocitrate | | carbonyl compound | | 2004 | 2004 | 20.0 | low | 0 | 0 | 0 | 1 | 0 | 0 |
| 7,7-diphenyl-2-(1-imino-2-(2-methoxyphenyl)ethyl)perhydroisoindol-4-one | | | | 1993 | 2005 | 26.2 | low | 0 | 0 | 6 | 2 | 0 | 0 |
| fk 888 | | peptide | | 1994 | 1999 | 27.7 | low | 0 | 0 | 3 | 0 | 0 | 0 |
| senktide | | | | 1993 | 2000 | 28.0 | low | 0 | 0 | 6 | 0 | 0 | 0 |
| sr 140333 | | | | 1997 | 1997 | 27.0 | low | 0 | 0 | 2 | 0 | 0 | 0 |
| gr 73632 | | | | 1993 | 2000 | 28.8 | low | 0 | 0 | 6 | 0 | 0 | 0 |
| substance p, methyl ester- | | | | 1993 | 1993 | 31.0 | low | 0 | 0 | 1 | 0 | 0 | 0 |
| neurokinin a (4-10), beta-ala(8)- | | | | 1995 | 1995 | 29.0 | low | 0 | 0 | 1 | 0 | 0 | 0 |
| neurokinin a(4-10), tyr(5)-trp(6,8,9)-lys(10)- | | | | 1993 | 2004 | 26.6 | medium | 0 | 0 | 5 | 3 | 0 | 0 |
| l 703606 | | | | 2006 | 2006 | 18.0 | low | 0 | 0 | 0 | 1 | 0 | 0 |
| omega-n-methylarginine | | amino acid zwitterion;
arginine derivative;
guanidines;
L-arginine derivative;
non-proteinogenic L-alpha-amino acid | | 1997 | 1997 | 27.0 | low | 0 | 0 | 1 | 0 | 0 | 0 |
| substance p, pro(9)- | | | | 1994 | 1994 | 30.0 | low | 0 | 0 | 1 | 0 | 0 | 0 |
| substance p, sar(9)-met(o2)(11)- | | | | 1993 | 2010 | 25.9 | low | 0 | 0 | 7 | 3 | 0 | 0 |
| atropine | | | | 1993 | 1999 | 28.5 | low | 0 | 0 | 8 | 0 | 0 | 0 |
| bradykinin | | oligopeptide | human blood serum metabolite;
vasodilator agent | 1993 | 1996 | 30.0 | low | 0 | 0 | 3 | 0 | 0 | 0 |
| inositol 1,4,5-trisphosphate | | myo-inositol trisphosphate | mouse metabolite | 1996 | 1996 | 28.0 | low | 0 | 0 | 1 | 0 | 0 | 0 |
| nitroarginine | | guanidines;
L-arginine derivative;
N-nitro compound;
non-proteinogenic L-alpha-amino acid | | 1995 | 2000 | 26.7 | low | 0 | 0 | 3 | 0 | 0 | 0 |
| ryanodine | | | | 2003 | 2003 | 21.0 | low | 0 | 0 | 0 | 1 | 0 | 0 |
| devazepide | | 1,4-benzodiazepinone;
indolecarboxamide | antineoplastic agent;
apoptosis inducer;
cholecystokinin antagonist;
gastrointestinal drug | 1999 | 1999 | 25.0 | low | 0 | 0 | 1 | 0 | 0 | 0 |
| cocaine | | benzoate ester;
methyl ester;
tertiary amino compound;
tropane alkaloid | adrenergic uptake inhibitor;
central nervous system stimulant;
dopamine uptake inhibitor;
environmental contaminant;
local anaesthetic;
mouse metabolite;
plant metabolite;
serotonin uptake inhibitor;
sodium channel blocker;
sympathomimetic agent;
vasoconstrictor agent;
xenobiotic | 2005 | 2006 | 18.5 | low | 0 | 0 | 0 | 2 | 0 | 0 |
| tetragastrin | | peptidyl amide;
tetrapeptide | anxiogenic;
human metabolite | 1994 | 1994 | 30.0 | low | 0 | 0 | 1 | 0 | 0 | 0 |
| capsaicin | | capsaicinoid | non-narcotic analgesic;
TRPV1 agonist;
voltage-gated sodium channel blocker | 1992 | 2000 | 29.3 | low | 0 | 0 | 10 | 0 | 0 | 0 |
| neurokinin a (3-10), lysyl(3)-glycyl(8)-r-lactam-leucine(9)- | | | | 1993 | 2003 | 27.7 | medium | 0 | 0 | 2 | 1 | 0 | 0 |
| substance p (4-11), beta-ala(4)-sar(9)-met(02)(11)- | | | | 2006 | 2006 | 18.0 | high | 0 | 0 | 0 | 1 | 0 | 0 |
| 2,3-dioxo-6-nitro-7-sulfamoylbenzo(f)quinoxaline | | naphthalenes;
sulfonic acid derivative | | 2009 | 2009 | 15.0 | low | 0 | 0 | 0 | 1 | 0 | 0 |
| ovalbumin | | | | 2007 | 2007 | 17.0 | low | 0 | 0 | 0 | 1 | 0 | 0 |
| adp beta s | | | | 1995 | 1995 | 29.0 | low | 0 | 0 | 1 | 0 | 0 | 0 |
| cp 99994 | | | | 1995 | 1999 | 27.0 | low | 0 | 0 | 2 | 0 | 0 | 0 |
| neurokinin a | | | | 1993 | 2004 | 28.1 | low | 0 | 0 | 11 | 3 | 0 | 0 |
| kn 62 | | piperazines | | 2009 | 2009 | 15.0 | low | 0 | 0 | 0 | 1 | 0 | 0 |
| gr 94800 | | | | 1994 | 1995 | 29.5 | medium | 0 | 0 | 2 | 0 | 0 | 0 |
| tetrodotoxin | | azatetracycloalkane;
oxatetracycloalkane;
quinazoline alkaloid | animal metabolite;
bacterial metabolite;
marine metabolite;
neurotoxin;
voltage-gated sodium channel blocker | 1993 | 2001 | 28.0 | low | 0 | 0 | 4 | 1 | 0 | 0 |
| dizocilpine maleate | | maleate salt;
tetracyclic antidepressant | anaesthetic;
anticonvulsant;
neuroprotective agent;
nicotinic antagonist;
NMDA receptor antagonist | 2001 | 2004 | 21.5 | low | 0 | 0 | 0 | 2 | 0 | 0 |
| cyclo(gln-trp-phe-gly-leu-met) | | | | 1993 | 1995 | 30.0 | low | 0 | 0 | 2 | 0 | 0 | 0 |
| ergoline | | diamine;
ergoline alkaloid;
indole alkaloid fundamental parent;
indole alkaloid;
organic heterotetracyclic compound | | 1997 | 1997 | 27.0 | low | 0 | 0 | 1 | 0 | 0 | 0 |
| win 51708 | | | | 1997 | 2011 | 20.0 | low | 0 | 0 | 1 | 0 | 1 | 0 |
| sr 142801 | | | | 1997 | 2000 | 25.3 | low | 0 | 0 | 3 | 0 | 0 | 0 |
| (2s,3s)-2-phenyl-3-((5-trifluoromethoxy-2-methoxy)benzylamino)piperidine | | | | 1999 | 1999 | 25.0 | low | 0 | 0 | 1 | 0 | 0 | 0 |
| sincalide | | oligopeptide | | 2000 | 2000 | 24.0 | low | 0 | 0 | 1 | 0 | 0 | 0 |
| men 11420 | | | | 1997 | 2001 | 25.0 | low | 0 | 0 | 2 | 1 | 0 | 0 |
| eledoisin | | peptide | | 2004 | 2004 | 20.0 | low | 0 | 0 | 0 | 1 | 0 | 0 |
| bufokinin | | | | 2004 | 2004 | 20.0 | medium | 0 | 0 | 0 | 1 | 0 | 0 |
| physalaemin | | | | 1992 | 2015 | 25.2 | high | 0 | 0 | 45 | 16 | 4 | 0 |
| cholecystokinin | | | | 1999 | 1999 | 25.0 | low | 0 | 0 | 1 | 0 | 0 | 0 |
| iberiotoxin | | | | 2003 | 2003 | 21.0 | low | 0 | 0 | 0 | 1 | 0 | 0 |
| septide | | | | 1993 | 1997 | 29.5 | low | 0 | 0 | 4 | 0 | 0 | 0 |
| gr 71251 | | | | 1995 | 1995 | 29.0 | low | 0 | 0 | 1 | 0 | 0 | 0 |
| piperidines | | | | 1994 | 2000 | 27.2 | low | 0 | 0 | 10 | 0 | 0 | 0 |
| vasoactive intestinal peptide | | | | 2000 | 2006 | 21.0 | low | 0 | 0 | 1 | 1 | 0 | 0 |
| pyrethrins | | | | 2001 | 2001 | 23.0 | low | 0 | 0 | 0 | 1 | 0 | 0 |
| tan 67 | | | | 1999 | 1999 | 25.0 | low | 0 | 0 | 1 | 0 | 0 | 0 |
Characterization of receptors for two Xenopus gastrointestinal tachykinin peptides in their species of origin.Naunyn-Schmiedeberg's archives of pharmacology, , Volume: 370, Issue:1, 2004
Substance P release in the feline nucleus tractus solitarius during ergoreceptor but not baroreceptor afferent signaling.Brain research, , Jul-19, Volume: 944, Issue:1-2, 2002
Effect of tachykinins on ascending and descending reflex pathway in rat small intestine.Acta pharmacologica Sinica, , Volume: 23, Issue:4, 2002
Evidence of a peripheral role of neurokinins in detrusor hyperreflexia: a further study of selective tachykinin antagonists in chronic spinal injured rats.The Journal of urology, , Volume: 165, Issue:5, 2001
Evidence for the involvement of ATP, but not of VIP/PACAP or nitric oxide, in the excitatory effect of capsaicin in the small intestine.European journal of pharmacology, , Mar-31, Volume: 392, Issue:3, 2000
CCK-mediated response in the activation of 5-HT receptor types in the guinea-pig ileum.Journal of physiology and biochemistry, , Volume: 55, Issue:2, 1999
Involvement of endogenous tachykinins and CGRP in the motor responses produced by capsaicin in the guinea-pig common bile duct.Naunyn-Schmiedeberg's archives of pharmacology, , Volume: 360, Issue:3, 1999
Sequential activation of the triple excitatory transmission to the circular muscle of guinea-pig colon.Neuroscience, , Volume: 79, Issue:1, 1997
Tachykinin NK1 and NK2 receptors mediate non-adrenergic non-cholinergic excitatory neuromuscular transmission in the human ileum.Neuropeptides, , Volume: 31, Issue:3, 1997
Pharmacological characterization of tachykinin NK2 receptors on isolated human urinary bladder, prostatic urethra and prostate.The Journal of pharmacology and experimental therapeutics, , Volume: 277, Issue:2, 1996
Evidence that tachykinin NK1 and NK2 receptors mediate non-adrenergic non-cholinergic excitation and contraction in the circular muscle of guinea-pig duodenum.British journal of pharmacology, , Volume: 115, Issue:2, 1995
Specialization of tachykinin NK1 and NK2 receptors in producing fast and slow atropine-resistant neurotransmission to the circular muscle of the guinea-pig colon.Neuroscience, , Volume: 63, Issue:4, 1994
Highly potent substance P antagonists substituted with beta-phenyl- or beta-benzyl-proline at position 10.European journal of pharmacology, , Jun-13, Volume: 258, Issue:3, 1994
A further analysis of the contraction induced by activation of cholecystokinin A receptors in guinea pig isolated ileum longitudinal muscle-myenteric plexus.The Journal of pharmacology and experimental therapeutics, , Volume: 270, Issue:2, 1994
Ascending enteric reflex contraction: roles of acetylcholine and tachykinins in relation to distension and propagation of excitation.The Journal of pharmacology and experimental therapeutics, , Volume: 264, Issue:1, 1993
Spinal effects of selective NK-1 and NK-2 receptor antagonists on bladder motility in anesthetized rats.Regulatory peptides, , Jul-02, Volume: 46, Issue:1-2, 1993
Neuromodulation mediated by neurokinin-1 subtype receptors in adult rabbit airways.The American journal of physiology, , Volume: 265, Issue:3 Pt 1, 1993
Evidence against a peripheral role of tachykinins in the initiation of micturition reflex in rats.The Journal of pharmacology and experimental therapeutics, , Volume: 264, Issue:3, 1993
Effect of the NK-1 receptor antagonist GR 82,334 on reflexly-induced bladder contractions.Life sciences, , Volume: 51, Issue:26, 1992
The function of P2X3 receptor and NK1 receptor antagonists on cyclophosphamide-induced cystitis in rats.World journal of urology, , Volume: 32, Issue:1, 2014
Intrathecal administration of the common carboxyl-terminal decapeptide in endokinin A and endokinin B evokes scratching behavior and thermal hyperalgesia in the rat.Neuroscience letters, , Dec-27, Volume: 410, Issue:3, 2006
Involvement of spinal neurokinins, excitatory amino acids, proinflammatory cytokines, nitric oxide and prostanoids in pain facilitation induced by Phoneutria nigriventer spider venom.Brain research, , Sep-17, Volume: 1021, Issue:1, 2004
Nociception and allodynia/hyperalgesia induced by intrathecal administration of fenvalerate.Japanese journal of pharmacology, , Volume: 86, Issue:3, 2001
Electrocorticographic desynchronization after application of visceral and somatic noxious stimuli in urethane-anesthetized rats: effect of intrathecal administration of tachykinin (NK 1 or NK 2) receptor antagonists.The Journal of pharmacology and experimental therapeutics, , Volume: 276, Issue:1, 1996
Pharmacological characterization of GR82334, a tachykinin NK1 receptor antagonist, in the isolated spinal cord of the neonatal rat.European journal of pharmacology, , Jul-25, Volume: 281, Issue:1, 1995
Intra-articular administration of tachykinin NK₁ receptor antagonists reduces hyperalgesia and cartilage destruction in the inflammatory joint in rats with adjuvant-induced arthritis.European journal of pharmacology, , Oct-01, Volume: 668, Issue:1-2, 2011
Intrathecal administration of the common carboxyl-terminal decapeptide in endokinin A and endokinin B evokes scratching behavior and thermal hyperalgesia in the rat.Neuroscience letters, , Dec-27, Volume: 410, Issue:3, 2006
Involvement of spinal neurokinins, excitatory amino acids, proinflammatory cytokines, nitric oxide and prostanoids in pain facilitation induced by Phoneutria nigriventer spider venom.Brain research, , Sep-17, Volume: 1021, Issue:1, 2004
Nociception and allodynia/hyperalgesia induced by intrathecal administration of fenvalerate.Japanese journal of pharmacology, , Volume: 86, Issue:3, 2001
The modulatory effect of (+)-TAN-67 on the antinociceptive effects of the nociceptin/orphanin FQ in mice.European journal of pharmacology, , Nov-03, Volume: 383, Issue:3, 1999
The function of P2X3 receptor and NK1 receptor antagonists on cyclophosphamide-induced cystitis in rats.World journal of urology, , Volume: 32, Issue:1, 2014
Intrathecal administration of the common carboxyl-terminal decapeptide in endokinin A and endokinin B evokes scratching behavior and thermal hyperalgesia in the rat.Neuroscience letters, , Dec-27, Volume: 410, Issue:3, 2006
Involvement of spinal neurokinins, excitatory amino acids, proinflammatory cytokines, nitric oxide and prostanoids in pain facilitation induced by Phoneutria nigriventer spider venom.Brain research, , Sep-17, Volume: 1021, Issue:1, 2004
Nociception and allodynia/hyperalgesia induced by intrathecal administration of fenvalerate.Japanese journal of pharmacology, , Volume: 86, Issue:3, 2001
Dosage (1)