| Substance | Relationship Strength | Studies | Trials | Classes | Roles |
|---|
7,8-dihydroxyflavone
7,8-dihydroxyflavone : A dihydroxyflavone that is flavone substituted by hydroxy groups at positions 7 and 8. A dihydroxyflavone that is flavone substituted by hydroxy groups at positions 7 and 8. A naturally occurring flavonoid produced by several plants, including the weed Tridax procumbens (coalbuttons or tridax daisy) and the tree Godmania aesculifolia, In animal models, it has shown efficacy against several diseases of the nervous system, including Alzheimer's, Parkinson's, and Huntington's. | 3.51 | 1 | 0 | dihydroxyflavone | antidepressant;
antineoplastic agent;
antioxidant;
plant metabolite;
tropomyosin-related kinase B receptor agonist |
glycyrrhetinic acid
[no description available] | 3.51 | 1 | 0 | cyclic terpene ketone;
hydroxy monocarboxylic acid;
pentacyclic triterpenoid | immunomodulator;
plant metabolite |
oleanolic acid
[no description available] | 3.51 | 1 | 0 | hydroxy monocarboxylic acid;
pentacyclic triterpenoid | plant metabolite |
etoposide
[no description available] | 3.17 | 1 | 0 | beta-D-glucoside;
furonaphthodioxole;
organic heterotetracyclic compound | antineoplastic agent;
DNA synthesis inhibitor |
ursolic acid
[no description available] | 2.05 | 1 | 0 | hydroxy monocarboxylic acid;
pentacyclic triterpenoid | geroprotector;
plant metabolite |
narciclasine
narciclasine: antitumor alkaloid from bulbs of Narcissus species | 3.51 | 1 | 0 | phenanthridines | metabolite |
Tormentic acid
tormentic acid: aglycone of Rosamultin | 2.05 | 1 | 0 | triterpenoid | metabolite |
isoalantolactone
isoalantolactone: RN given refers to (3aR-(3aalpha,4aalpha,8abeta,9aalpha))-isomer; structure. isoalantolactone : A sesquiterpene lactone of the eudesmanolide group. It has been isolated from Inula helenium. | 3.51 | 1 | 0 | eudesmane sesquiterpenoid;
sesquiterpene lactone | antifungal agent;
apoptosis inducer;
plant metabolite |
eburicoic acid
eburicoic acid: structure | 3.17 | 1 | 0 | | |
maslinic acid
(2Alpha,3beta)-2,3-dihydroxyolean-12-en-28-oic acid: from Luehea divaricata and Agrimonia eupatoria | 3.51 | 1 | 0 | dihydroxy monocarboxylic acid;
pentacyclic triterpenoid | anti-inflammatory agent;
antineoplastic agent;
antioxidant;
plant metabolite |
asperuloside
asperuloside : A iridoid monoterpenoid glycoside isolated from Galium verum. | 3.51 | 1 | 0 | acetate ester;
beta-D-glucoside;
gamma-lactone;
iridoid monoterpenoid;
monosaccharide derivative | metabolite |
uvaol
uvaol: from Vauquelinia corymbosa (Rosaceae) | 2.05 | 1 | 0 | triterpenoid | metabolite |
10-hydroxycamptothecin
[no description available] | 3.17 | 1 | 0 | pyranoindolizinoquinoline | |
diphyllin
diphyllin: extract of Cleistanthus collinus (Roxb), a highly poisonous plant; do not confuse with diphyllin or diphylline which is the main heading AMINOPHYLLINE; do not confuse with the theophylline derivative DYPHYLLINE | 3.51 | 1 | 0 | lignan | |
daidzin
daidzein 7-O-beta-D-glucoside : A glycosyloxyisoflavone that is daidzein attached to a beta-D-glucopyranosyl residue at position 7 via a glycosidic linkage. It is used in the treatment of alcohol dependency (antidipsotropic).. daidzin: a potent, selective, and reversible inhibitor of human mitochondrial aldehyde dehydrogenase | 2.1 | 1 | 0 | 7-hydroxyisoflavones 7-O-beta-D-glucoside;
hydroxyisoflavone;
monosaccharide derivative | plant metabolite |
tanshinone
tanshinone: from root of Salvia miltiorrhiza Bunge; RN given refers to tanshinone I; cardioprotective agent and neuroprotective agent | 3.51 | 1 | 0 | abietane diterpenoid | anticoronaviral agent |
celastrol
[no description available] | 3.51 | 1 | 0 | monocarboxylic acid;
pentacyclic triterpenoid | anti-inflammatory drug;
antineoplastic agent;
antioxidant;
EC 5.99.1.3 [DNA topoisomerase (ATP-hydrolysing)] inhibitor;
Hsp90 inhibitor;
metabolite |
glabridin
[no description available] | 3.51 | 1 | 0 | hydroxyisoflavans | antiplasmodial drug |
oleanolic acid 3-acetate
oleanolic acid 3-acetate: from Gardenia jasminoides; RN given for (3beta)-isomer | 2.1 | 1 | 0 | | |
sitosterol, (3beta)-isomer
sitosterol : A member of the class of phytosterols that is stigmast-5-ene substituted by a beta-hydroxy group at position 3.. Sobatum: tradename; active fraction of Solanum trilobatum; reduces side-effects of radiation-induced toxicity | 2.05 | 1 | 0 | 3beta-hydroxy-Delta(5)-steroid;
3beta-sterol;
C29-steroid;
phytosterols;
stigmastane sterol | anticholesteremic drug;
antioxidant;
mouse metabolite;
plant metabolite;
sterol methyltransferase inhibitor |
withaferin a
withaferin A : A withanolide that is 5,6:22,26-diepoxyergosta-2,24-diene-1,26-dione substituted by hydroxy groups at positions 4 and 27 (the 4beta,5beta,6beta,22R stereoisomer). Isolated from Physalis longifolia, it exhibits cytotoxic activity.. withaferin A: an antiestrogen and phytogenic antineoplastic agent isolated from leaves of Withania somnifera Dun.; structure | 3.51 | 1 | 0 | 27-hydroxy steroid;
4-hydroxy steroid;
delta-lactone;
enone;
epoxy steroid;
ergostanoid;
primary alcohol;
secondary alcohol;
withanolide | antineoplastic agent;
apoptosis inducer |
hyperforin
hyperforin : A cyclic terpene ketone that is a prenylated carbobicyclic acylphloroglucinol derivative produced by St. John's Wort, Hypericum perforatum.. hyperforin: a prenylated acylphloroglucinol derivative; antibiotic component of novoimanine; psychoactive agent in St. John's wort; Russian; structure; | 3.51 | 1 | 0 | | |
ononin
[no description available] | 2.1 | 1 | 0 | 4'-methoxyisoflavones;
7-hydroxyisoflavones 7-O-beta-D-glucoside;
monosaccharide derivative | plant metabolite |
acarbose
[no description available] | 2.08 | 1 | 0 | amino cyclitol;
glycoside | |
ganoderiol f
ganoderiol F: a ganoderma triterpene from Ganoderma amboinense; structure in first source | 3.87 | 3 | 0 | triterpenoid | |
methyl ursolate
methyl ursolate: structure in first source | 2.05 | 1 | 0 | | |
Ganodermanontriol
[no description available] | 3.58 | 2 | 0 | triterpenoid | metabolite |
formononetin
[no description available] | 3.68 | 2 | 0 | 4'-methoxyisoflavones;
7-hydroxyisoflavones | phytoestrogen;
plant metabolite |
luteolin
[no description available] | 2.1 | 1 | 0 | 3'-hydroxyflavonoid;
tetrahydroxyflavone | angiogenesis inhibitor;
anti-inflammatory agent;
antineoplastic agent;
apoptosis inducer;
c-Jun N-terminal kinase inhibitor;
EC 2.3.1.85 (fatty acid synthase) inhibitor;
immunomodulator;
nephroprotective agent;
plant metabolite;
radical scavenger;
vascular endothelial growth factor receptor antagonist |
7,3'-dihydroxy-4'-methoxyisoflavone
calycosin : A member of the class of 7-hydroxyisoflavones that is 7-hydroxyisoflavone which is substituted by an additional hydroxy group at the 3' position and a methoxy group at the 4' position.. 7,3'-dihydroxy-4'-methoxyisoflavone: isolated from Astragali radix; structure in first source | 2.1 | 1 | 0 | 4'-methoxyisoflavones;
7-hydroxyisoflavones | antioxidant;
metabolite |
luteolin-7-glucoside
luteolin 7-O-beta-D-glucoside : A glycosyloxyflavone that is luteolin substituted by a beta-D-glucopyranosyl moiety at position 7 via a glycosidic linkage.. luteolin-7-glucoside: has both antiasthmatic and antineoplastic activities; has 3C protease inhibitory activity; isolated from Ligustrum lucidum | 2.1 | 1 | 0 | beta-D-glucoside;
glycosyloxyflavone;
monosaccharide derivative;
trihydroxyflavone | antioxidant;
plant metabolite |
apigetrin
apigenin 7-O-beta-D-glucoside : A glycosyloxyflavone that is apigenin substituted by a beta-D-glucopyranosyl moiety at position 7 via a glycosidic linkage.. apigetrin: structure given in first source | 2.1 | 1 | 0 | beta-D-glucoside;
dihydroxyflavone;
glycosyloxyflavone;
monosaccharide derivative | antibacterial agent;
metabolite;
non-steroidal anti-inflammatory drug |
butein
[no description available] | 3.51 | 1 | 0 | chalcones;
polyphenol | antineoplastic agent;
antioxidant;
EC 1.1.1.21 (aldehyde reductase) inhibitor;
geroprotector;
hypoglycemic agent;
plant metabolite;
radiosensitizing agent;
tyrosine kinase inhibitor |
3',4',7-trihydroxyisoflavone
3',4',7-trihydroxyisoflavone : A 7-hydroxyisoflavone that is daidzein substituted by a hydroxy group at position 3'.. 3',4',7-trihydroxyisoflavone: from Streptomyces sp OH-1049; structure given in first source | 3.51 | 1 | 0 | 7-hydroxyisoflavones | antineoplastic agent;
EC 1.3.1.22 [3-oxo-5alpha-steroid 4-dehydrogenase (NADP(+))] inhibitor;
metabolite |
corylin
corylin: from Psoralea corylifolia (Leguminosae), has osteoblastic proliferation stimulating activity; structure in first source | 3.51 | 1 | 0 | | |
calycosin-7-o-beta-d-glucopyranoside
calycosin-7-O-beta-D-glucoside: from Radix Astragali. calycosin-7-O-beta-D-glucoside : A glycosyloxyisoflavone that is calycosin substituted by a beta-D-glucopyranosyl residue at position at 7 via a glycosidic linkage. | 2.1 | 1 | 0 | 4'-methoxyisoflavones;
7-hydroxyisoflavones 7-O-beta-D-glucoside;
hydroxyisoflavone;
monosaccharide derivative | |
spd-304
SPD-304: structure in first source | 2.1 | 1 | 0 | | |
poricoic acid g
poricoic acid G : A tricyclic triterpenoid isolated from Poria cocos.. poricoic acid G: from Poria cocos (Polyporaceae); structure in first source | 3.17 | 1 | 0 | dicarboxylic acid;
secondary alcohol;
tricyclic triterpenoid | fungal metabolite |
3,8-dihydroxy-6h-dibenzo(b,d)pyran-6-one
3,8-dihydroxy-6H-dibenzo(b,d)pyran-6-one: metabolite of ellagic acid | 3.51 | 1 | 0 | coumarins | geroprotector |
panduratin a
panduratin A: isolated from Kaempferia pandurata; structure in first source | 3.51 | 1 | 0 | diarylheptanoid | metabolite |
corosolic acid
[no description available] | 2.05 | 1 | 0 | triterpenoid | metabolite |
polyporenic acid c
[no description available] | 3.17 | 1 | 0 | | |
lipstatin
lipstatin: isolated from Streptomyces toxytricini; inhibitor of pancreatic lipase; structure given in first source | 3.51 | 1 | 0 | | |
11-keto-boswellic acid
[no description available] | 2.05 | 1 | 0 | | |
acetyl-11-ketoboswellic acid
acetyl-11-ketoboswellic acid: a 5-lipoxygenase inhibitor; structure given in first source | 2.05 | 1 | 0 | triterpenoid | |
diosgenin glucoside
diosgenin glucoside: RN given refers to (3beta,25R)-isomer; structure given in first source. diosgenin 3-O-beta-D-glucoside : A sterol 3-beta-D-glucoside having diosgenin as the sterol component. | 2.1 | 1 | 0 | hexacyclic triterpenoid;
monosaccharide derivative;
spiroketal;
sterol 3-beta-D-glucoside | metabolite |
trametenolic acid b
trametenolic acid B: from Trametes lactinea; structure in first source | 3.17 | 1 | 0 | triterpenoid | |
ganodermadiol
ganodermadiol: isolated from Ganoderma lucidum; structure given in first source. ganoderol B : A tetracyclic triterpenoid that is lanosta-7,9(11),24-triene which is substituted by hydroxy groups at positions 3 and 27. It has been isolated from several Ganoderma species. | 3.58 | 2 | 0 | 3beta-sterol;
primary allylic alcohol;
tetracyclic triterpenoid | antiviral agent;
fungal metabolite;
hepatoprotective agent |
astragaloside IV
[no description available] | 3.68 | 2 | 0 | pentacyclic triterpenoid;
triterpenoid saponin | anti-inflammatory agent;
antioxidant;
EC 4.2.1.1 (carbonic anhydrase) inhibitor;
neuroprotective agent;
plant metabolite;
pro-angiogenic agent |
lucidenic acid a
lucidenic acid A: isolated from fruiting bodies of Ganoderma lucidum; structure in first source | 3.17 | 1 | 0 | triterpenoid | |
lucidenic acid n
lucidenic acid N: from the dried fruiting bodies of Ganoderma lucidum (polyporaceae); structure in first source. lucidenic acid N : A tetracyclic triterpenoid that is 25,26,27-trinorlanost-8-en-24-oic acid substituted by hydroxy groups at positions 3 and 7 and oxo groups at positions 11 and 15 respectively (the 3beta,5alpha,7beta stereoisomer). Isolated from the fruiting bodies of Ganoderma lucidum, it exhibits cytotoxicity against tumour cells. | 2.46 | 2 | 0 | cyclic terpene ketone;
dioxo monocarboxylic acid;
secondary alcohol;
tetracyclic triterpenoid | antineoplastic agent;
EC 3.1.1.8 (cholinesterase) inhibitor;
metabolite |
methyl lucidenate f
methyl lucidenate F: from the dried fruiting bodies of Ganoderma lucidum (polyporaceae); structure in first source | 2.46 | 2 | 0 | triterpenoid | |
ganoderic acid t
ganoderic acid T: down-regulates expression of both MMP-2 and MMP-9; isolated from Ganoderma lucidum; structure in first source | 3.17 | 1 | 0 | | |
ganoderic acid f
ganoderic acid F: isolated from Ganoderma lucidum; structure in first source | 3.59 | 2 | 0 | triterpenoid | |
inotodiol
inotodiol: structure in first source | 3.17 | 1 | 0 | | |
3,7-dioxolanosta-8,24-dien-26-oic acid
[no description available] | 4.13 | 2 | 0 | | |
ganoderic acid c2
ganoderic acid C2: from the fruiting body of Ganoderma; structure in first source | 4.8 | 5 | 0 | triterpenoid | |
ganoderic acid y
ganoderic acid Y: has antiviral activity; isolated from Ganoderma lucidum; structure in first source | 4.13 | 2 | 0 | triterpenoid | |
7-oxo-ganoderic acid z
7-oxo-ganoderic acid Z: from the mushroom Ganoderma lucidum; structure in first source | 3.17 | 1 | 0 | | |
acetic acid
Acetic Acid: Product of the oxidation of ethanol and of the destructive distillation of wood. It is used locally, occasionally internally, as a counterirritant and also as a reagent. (Stedman, 26th ed). acetic acid : A simple monocarboxylic acid containing two carbons. | 1.99 | 1 | 0 | monocarboxylic acid | antimicrobial food preservative;
Daphnia magna metabolite;
food acidity regulator;
protic solvent |
glycine
[no description available] | 7.31 | 1 | 0 | alpha-amino acid;
amino acid zwitterion;
proteinogenic amino acid;
serine family amino acid | EC 2.1.2.1 (glycine hydroxymethyltransferase) inhibitor;
fundamental metabolite;
hepatoprotective agent;
micronutrient;
neurotransmitter;
NMDA receptor agonist;
nutraceutical |
aspirin
Aspirin: The prototypical analgesic used in the treatment of mild to moderate pain. It has anti-inflammatory and antipyretic properties and acts as an inhibitor of cyclooxygenase which results in the inhibition of the biosynthesis of prostaglandins. Aspirin also inhibits platelet aggregation and is used in the prevention of arterial and venous thrombosis. (From Martindale, The Extra Pharmacopoeia, 30th ed, p5). acetylsalicylate : A benzoate that is the conjugate base of acetylsalicylic acid, arising from deprotonation of the carboxy group.. acetylsalicylic acid : A member of the class of benzoic acids that is salicylic acid in which the hydrogen that is attached to the phenolic hydroxy group has been replaced by an acetoxy group. A non-steroidal anti-inflammatory drug with cyclooxygenase inhibitor activity. | 1.99 | 1 | 0 | benzoic acids;
phenyl acetates;
salicylates | anticoagulant;
antipyretic;
cyclooxygenase 1 inhibitor;
cyclooxygenase 2 inhibitor;
drug allergen;
EC 1.1.1.188 (prostaglandin-F synthase) inhibitor;
geroprotector;
non-narcotic analgesic;
non-steroidal anti-inflammatory drug;
plant activator;
platelet aggregation inhibitor;
prostaglandin antagonist;
teratogenic agent |
valproic acid
Valproic Acid: A fatty acid with anticonvulsant and anti-manic properties that is used in the treatment of EPILEPSY and BIPOLAR DISORDER. The mechanisms of its therapeutic actions are not well understood. It may act by increasing GAMMA-AMINOBUTYRIC ACID levels in the brain or by altering the properties of VOLTAGE-GATED SODIUM CHANNELS.. valproic acid : A branched-chain saturated fatty acid that comprises of a propyl substituent on a pentanoic acid stem. | 2.41 | 1 | 0 | branched-chain fatty acid;
branched-chain saturated fatty acid | anticonvulsant;
antimanic drug;
EC 3.5.1.98 (histone deacetylase) inhibitor;
GABA agent;
neuroprotective agent;
psychotropic drug;
teratogenic agent |
pentylenetetrazole
Pentylenetetrazole: A pharmaceutical agent that displays activity as a central nervous system and respiratory stimulant. It is considered a non-competitive GAMMA-AMINOBUTYRIC ACID antagonist. Pentylenetetrazole has been used experimentally to study seizure phenomenon and to identify pharmaceuticals that may control seizure susceptibility.. pentetrazol : An organic heterobicyclic compound that is 1H-tetrazole in which the hydrogens at positions 1 and 5 are replaced by a pentane-1,5-diyl group. A central and respiratory stimulant, it was formerly used for the treatment of cough and other respiratory tract disorders, cardiovascular disorders including hypotension, and pruritis. | 7.41 | 1 | 0 | organic heterobicyclic compound;
organonitrogen heterocyclic compound | |
uridine diphosphate
Uridine Diphosphate: A uracil nucleotide containing a pyrophosphate group esterified to C5 of the sugar moiety. | 2.17 | 1 | 0 | pyrimidine ribonucleoside 5'-diphosphate;
uridine 5'-phosphate | Escherichia coli metabolite;
mouse metabolite |
lactose
Lactose: A disaccharide of GLUCOSE and GALACTOSE in human and cow milk. It is used in pharmacy for tablets, in medicine as a nutrient, and in industry.. lactose : A glycosylglucose disaccharide, found most notably in milk, that consists of D-galactose and D-glucose fragments bonded through a beta-1->4 glycosidic linkage. The glucose fragment can be in either the alpha- or beta-pyranose form, whereas the galactose fragment can only have the beta-pyranose form.. beta-lactose : The beta-anomer of lactose. | 2.05 | 1 | 0 | lactose | |
azacitidine
Azacitidine: A pyrimidine analogue that inhibits DNA methyltransferase, impairing DNA methylation. It is also an antimetabolite of cytidine, incorporated primarily into RNA. Azacytidine has been used as an antineoplastic agent.. 5-azacytidine : An N-glycosyl-1,3,5-triazine that is 4-amino-1,3,5-triazin-2(1H)-one substituted by a beta-D-ribofuranosyl residue via an N-glycosidic linkage. An antineoplastic agent, it is used in the treatment of myeloid leukaemia. | 2.25 | 1 | 0 | N-glycosyl-1,3,5-triazine;
nucleoside analogue | antineoplastic agent |
malondialdehyde
malonaldehyde : A dialdehyde that is propane substituted by two oxo groups at the terminal carbon atoms respectively. A biomarker of oxidative damage to lipids caused by smoking, it exists in vivo mainly in the enol form.. Malondialdehyde: The dialdehyde of malonic acid. | 2.66 | 2 | 0 | dialdehyde | biomarker |
deuterium
Deuterium: The stable isotope of hydrogen. It has one neutron and one proton in the nucleus. | 2.05 | 1 | 0 | dihydrogen | |
glucose, (beta-d)-isomer
(1->3)-beta-D-glucan : A beta-D-glucan in which the glucose units are connected by (1->3) linkages.. (1->4)-beta-D-glucan : A beta-D-glucan in which the glucose units are connected by (1->4) linkages.. beta-D-glucose : D-Glucopyranose with beta configuration at the anomeric centre. | 2.21 | 1 | 0 | D-glucopyranose | epitope;
mouse metabolite |
tangeretin
tangeretin: structure given in first source; from citrus plants; inhibits invasion of MO4 mouse cells into embryonic chick heart in vitro. pentamethoxyflavone : A methoxyflavone that is flavone substituted by a five methoxy groups.. tangeretin : A pentamethoxyflavone flavone with methoxy groups at positions 4', 5, 6 , 7 and 8. | 2.11 | 1 | 0 | pentamethoxyflavone | antineoplastic agent;
plant metabolite |
methyl phenylglycine
methyl phenylglycine: RN given refers to parent cpd without isomeric designation | 2.31 | 1 | 0 | | |
limonin
[no description available] | 2.11 | 1 | 0 | epoxide;
furans;
hexacyclic triterpenoid;
lactone;
limonoid;
organic heterohexacyclic compound | inhibitor;
metabolite;
volatile oil component |
lanosterol
[no description available] | 5.47 | 54 | 0 | 14alpha-methyl steroid;
3beta-sterol;
tetracyclic triterpenoid | bacterial metabolite;
human metabolite;
mouse metabolite;
plant metabolite;
Saccharomyces cerevisiae metabolite |
gingerol
gingerol: an active ingredient in GINGER along with SHOGAOL. a nonvolatile methoxy phenyl decanone. gingerol : A beta-hydroxy ketone that is 5-hydroxydecan-3-one substituted by a 4-hydroxy-3-methoxyphenyl moiety at position 1; believed to inhibit adipogenesis. It is a constituent of fresh ginger. | 2.11 | 1 | 0 | beta-hydroxy ketone;
guaiacols | antineoplastic agent;
plant metabolite |
ergosterol
[no description available] | 2.04 | 1 | 0 | 3beta-hydroxy-Delta(5)-steroid;
3beta-sterol;
ergostanoid;
phytosterols | fungal metabolite;
Saccharomyces cerevisiae metabolite |
decitabine
[no description available] | 2.25 | 1 | 0 | 2'-deoxyribonucleoside | |
ganoderiol f
ganoderiol F: a ganoderma triterpene from Ganoderma amboinense; structure in first source | 2.05 | 1 | 0 | triterpenoid | |
squalene
Addavax: an oil-water nanoemulsion and adjuvant containing squalene, Tween 80, and sorbitane trioleate | 2.31 | 1 | 0 | triterpene | human metabolite;
mouse metabolite;
plant metabolite;
Saccharomyces cerevisiae metabolite |
sesquiterpenes
[no description available] | 2.11 | 1 | 0 | | |
ovalbumin
Ovalbumin: An albumin obtained from the white of eggs. It is a member of the serpin superfamily. | 2.31 | 1 | 0 | | |
osteoprotegerin
Osteoprotegerin: A secreted member of the TNF receptor superfamily that negatively regulates osteoclastogenesis. It is a soluble decoy receptor of RANK LIGAND that inhibits both CELL DIFFERENTIATION and function of OSTEOCLASTS by inhibiting the interaction between RANK LIGAND and RECEPTOR ACTIVATOR OF NUCLEAR FACTOR-KAPPA B. | 2.41 | 1 | 0 | long-chain fatty acid | |
ergosterol-5,8-peroxide
ergosterol peroxide : An ergostanoid that is ergosta-6,22-dien-3-ol with a peroxy group between positions 5 and 8 (the 3beta,5alpha,8alpha,22E stereoisomer). Isolated from Ganoderma lucidum and Cordyceps sinensis, it exhibits antimycobacterial, trypanocidal and antineoplastic activities.. ergosterol-5,8-peroxide: also inhibits sulfatase; isolated from fungus Cercospora kikuchii; structure given in first source | 2.04 | 1 | 0 | 3beta-sterol;
ergostanoid;
organic peroxide;
phytosterols | antimycobacterial drug;
antineoplastic agent;
metabolite;
trypanocidal drug |
zerumbone
zerumbone : A sesquiterpenoid and cyclic ketone that is (1E,4E,8E)-alpha-humulene which is substituted by an oxo group at the carbon atom attached to two double bonds. It is obtained by steam distillation from a type of edible ginger, Zingiber zerumbet Smith, grown particularly in southeast Asia.. zerumbone: RN given for (E,E,E)-isomer; structure in first source | 2.11 | 1 | 0 | cyclic ketone;
sesquiterpenoid | anti-inflammatory agent;
glioma-associated oncogene inhibitor;
plant metabolite |
beta-escin
[no description available] | 2.31 | 1 | 0 | | |
mocetinostat
mocetinostat : A benzamide obtained by formal condensation of the carboxy group of 4-({[4-(pyridin-3-yl)pyrimidin-2-yl]amino}methyl)benzoic acid with one of the amino groups of benzene-1,2-diamine. It is an orally active and isotype-selective HDAC inhibitor which exhibits antitumour activity (IC50 = 0.15, 0.29, 1.66 and 0.59 muM for HDAC1, HDAC2, HDAC3 and HDAC11).. mocetinostat: undergoing phase II clinical trials for treatment of cancer | 2.25 | 1 | 0 | aminopyrimidine;
benzamides;
pyridines;
secondary amino compound;
secondary carboxamide;
substituted aniline | antineoplastic agent;
apoptosis inducer;
autophagy inducer;
cardioprotective agent;
EC 3.5.1.98 (histone deacetylase) inhibitor;
hepatotoxic agent |
ganoderic acid f
ganoderic acid F: isolated from Ganoderma lucidum; structure in first source | 2.94 | 4 | 0 | triterpenoid | |
interleukin-8
Interleukin-8: A member of the CXC chemokine family that plays a role in the regulation of the acute inflammatory response. It is secreted by variety of cell types and induces CHEMOTAXIS of NEUTROPHILS and other inflammatory cells. | 2.03 | 1 | 0 | | |
transforming growth factor beta
Transforming Growth Factor beta: A factor synthesized in a wide variety of tissues. It acts synergistically with TGF-alpha in inducing phenotypic transformation and can also act as a negative autocrine growth factor. TGF-beta has a potential role in embryonal development, cellular differentiation, hormone secretion, and immune function. TGF-beta is found mostly as homodimer forms of separate gene products TGF-beta1, TGF-beta2 or TGF-beta3. Heterodimers composed of TGF-beta1 and 2 (TGF-beta1.2) or of TGF-beta2 and 3 (TGF-beta2.3) have been isolated. The TGF-beta proteins are synthesized as precursor proteins. | 2.25 | 1 | 0 | | |
ganoderic acid c2
ganoderic acid C2: from the fruiting body of Ganoderma; structure in first source | 2.05 | 1 | 0 | triterpenoid | |
3,7-dioxolanosta-8,24-dien-26-oic acid
3,7-dioxolanosta-8,24-dien-26-oic acid: isolated from the mushroom Ganoderma lucidum | 2.57 | 2 | 0 | | |
cyclin d1
Cyclin D1: Protein encoded by the bcl-1 gene which plays a critical role in regulating the cell cycle. Overexpression of cyclin D1 is the result of bcl-1 rearrangement, a t(11;14) translocation, and is implicated in various neoplasms. | 2.21 | 1 | 0 | | |
ganoderic acid
ganoderic acid: from the fruiting body of Ganoderma; structure in first source | 3.01 | 2 | 0 | | |
ganoderic acid d
ganoderic acid D: isolated from Ganoderma lucidum; structure in first source | 2.06 | 1 | 0 | | |
ganoderic acid h
ganoderic acid H: isolated from Ganoderma lucidum; structure in first source | 3.13 | 5 | 0 | | |
ganoderic acid b
ganoderic acid B: from Ganoderma lucidum in different places and stages by means of HPLC. The results show that contents of ganoderic acid B from different cultured places have differnces, different stages have effect on the amount too. | 2.06 | 1 | 0 | | |