| Assay ID | Title | Year | Journal | Article |
|---|
| AID1347154 | Primary screen GU AMC qHTS for Zika virus inhibitors | 2020 | Proceedings of the National Academy of Sciences of the United States of America, 12-08, Volume: 117, Issue:49
| Therapeutic candidates for the Zika virus identified by a high-throughput screen for Zika protease inhibitors. |
| AID1508630 | Primary qHTS for small molecule stabilizers of the endoplasmic reticulum resident proteome: Secreted ER Calcium Modulated Protein (SERCaMP) assay | 2021 | Cell reports, 04-27, Volume: 35, Issue:4
| A target-agnostic screen identifies approved drugs to stabilize the endoplasmic reticulum-resident proteome. |
| AID738302 | Antiproliferative activity against human MCF7 cells transfected with human sigma1 receptor after 48 hrs by MTT assay | 2013 | Bioorganic & medicinal chemistry, Apr-01, Volume: 21, Issue:7
| Investigation of σ receptors agonist/antagonist activity through N-(6-methoxytetralin-1-yl)- and N-(6-methoxynaphthalen-1-yl)alkyl derivatives of polymethylpiperidines. |
| AID1877932 | Displacement of [3H]-(+)-pentazocine from Dunkin-Hartley guinea pig brain cortex Sigma 1 receptor incubated for 150 mins by liquid scintillation counting analysis | 2022 | European journal of medicinal chemistry, Feb-15, Volume: 230 | Dual Sigma-1 receptor antagonists and hydrogen sulfide-releasing compounds for pain treatment: Design, synthesis, and pharmacological evaluation. |
| AID701161 | Displacement of [3H]di-o-tolylguanidine from sigma 2 receptor in guinea pig brain membranes after 120 mins by scintillation counter | 2012 | Journal of medicinal chemistry, Oct-11, Volume: 55, Issue:19
| Synthesis and biological evaluation of the 1-arylpyrazole class of σ(1) receptor antagonists: identification of 4-{2-[5-methyl-1-(naphthalen-2-yl)-1H-pyrazol-3-yloxy]ethyl}morpholine (S1RA, E-52862). |
| AID204443 | Ability to displace [3H](+)-pentazocine at sigma receptor in guinea pig brain membrane was determined | 1993 | Journal of medicinal chemistry, Aug-06, Volume: 36, Issue:16
| Synthesis and evaluation of conformationally restricted N-[2-(3,4-dichlorophenyl)ethyl]-N-methyl-2-(1-pyrrolidinyl)ethylamines at sigma receptors. 2. Piperazines, bicyclic amines, bridged bicyclic amines, and miscellaneous compounds. |
| AID1877941 | Antinociceptive activity in wild type CD1 mouse model of capsaicin-induced mechanical hypersensitivity assessed as reduction in mechanical hypersensitivity at 20 mg/kg, sc in presence of Sigma 1-receptor agonist PRE-084 | 2022 | European journal of medicinal chemistry, Feb-15, Volume: 230 | Dual Sigma-1 receptor antagonists and hydrogen sulfide-releasing compounds for pain treatment: Design, synthesis, and pharmacological evaluation. |
| AID1363638 | Antiallodynic activity in in CD1 mouse model of capsaicin-induced mechanical allodynia assessed as effect on paw withdrawal latency time at 2 to 64 mg/kg, sc administered 30 mins before capsaicin addition and measured at 30 secs intervals | 2018 | Journal of medicinal chemistry, 11-08, Volume: 61, Issue:21
| Synthesis, Receptor Affinity, and Antiallodynic Activity of Spirocyclic σ Receptor Ligands with Exocyclic Amino Moiety. |
| AID1363646 | Antiallodynic activity in in CD1 mouse model of capsaicin-induced mechanical allodynia assessed as effect on paw withdrawal latency time at 4 to 64 mg/kg, sc administered 30 mins before capsaicin addition and measured at 30 secs intervals | 2018 | Journal of medicinal chemistry, 11-08, Volume: 61, Issue:21
| Synthesis, Receptor Affinity, and Antiallodynic Activity of Spirocyclic σ Receptor Ligands with Exocyclic Amino Moiety. |
| AID701162 | Displacement of [3H](+)pentazocine from human sigma 1 receptor transfected in HEK293 cell membranes after 120 mins by scintillation counter | 2012 | Journal of medicinal chemistry, Oct-11, Volume: 55, Issue:19
| Synthesis and biological evaluation of the 1-arylpyrazole class of σ(1) receptor antagonists: identification of 4-{2-[5-methyl-1-(naphthalen-2-yl)-1H-pyrazol-3-yloxy]ethyl}morpholine (S1RA, E-52862). |
| AID738303 | Antiproliferative activity against human MCF7 cells after 48 hrs by MTT assay | 2013 | Bioorganic & medicinal chemistry, Apr-01, Volume: 21, Issue:7
| Investigation of σ receptors agonist/antagonist activity through N-(6-methoxytetralin-1-yl)- and N-(6-methoxynaphthalen-1-yl)alkyl derivatives of polymethylpiperidines. |
| AID1877931 | Displacement of [3H]-DTG from Sprague-Dawley rat liver Sigma 2 receptor incubated for 120 mins in presence of [3H]-(+)-pentazocine by liquid scintillation counting analysis | 2022 | European journal of medicinal chemistry, Feb-15, Volume: 230 | Dual Sigma-1 receptor antagonists and hydrogen sulfide-releasing compounds for pain treatment: Design, synthesis, and pharmacological evaluation. |
| AID1597415 | Antiallodynic activity in CD-1 mouse model of capsaicin-induced mechanical allodynia assessed as increase in paw withdrawal threshold at 32 mg/kg, sc administered 30 mins before capsaicin addition and measured after 15 mins by von-Frey test | | | |
| AID1877939 | Antinociceptive activity in sc dosed wild type CD1 mouse model of capsaicin-induced mechanical hypersensitivity assessed as reduction in mechanical hypersensitivity | 2022 | European journal of medicinal chemistry, Feb-15, Volume: 230 | Dual Sigma-1 receptor antagonists and hydrogen sulfide-releasing compounds for pain treatment: Design, synthesis, and pharmacological evaluation. |
| [information is prepared from bioassay data collected from National Library of Medicine (NLM), extracted Dec-2023] |