Page last updated: 2024-11-02

papaverine and Pain

papaverine has been researched along with Pain in 35 studies

Papaverine: An alkaloid found in opium but not closely related to the other opium alkaloids in its structure or pharmacological actions. It is a direct-acting smooth muscle relaxant used in the treatment of impotence and as a vasodilator, especially for cerebral vasodilation. The mechanism of its pharmacological actions is not clear, but it apparently can inhibit phosphodiesterases and it may have direct actions on calcium channels.
papaverine : A benzylisoquinoline alkaloid that is isoquinoline substituted by methoxy groups at positions 6 and 7 and a 3,4-dimethoxybenzyl group at position 1. It has been isolated from Papaver somniferum.

Pain: An unpleasant sensation induced by noxious stimuli which are detected by NERVE ENDINGS of NOCICEPTIVE NEURONS.

Research Excerpts

ExcerptRelevanceReference
"The aim of our work is to evaluate the efficacy of intracavernous sodium nitroprusside (SNP) in management of erectile dysfunction (ED) in a clinical comparative study with papaverine/phentolamine in ED patients."9.11Intracavernous sodium nitroprusside (SNP) versus papaverine/phentolamine in erectile dysfunction: a comparative study of short-term efficacy and side-effects. ( Abdelsalam, W; Atteya, A; Elnashaar, A; Gadallah, A; Shamloul, R; Zohdy, W, 2005)
"In an attempt to determine whether penile pain associated with intracorporeal injections could be due to the acidity of the medication, we performed a randomized study comparing the incidence of penile pain following intracorporeal injections with or without the addition of sodium bicarbonate to the intracorporeal medications."9.07Sodium bicarbonate alleviates penile pain induced by intracavernous injections for erectile dysfunction. ( Moriel, EZ; Rajfer, J, 1993)
"The efficacy of papaverine, and a combination of papaverine and phentolamine as a pharmacological treatment of impotence was compared in a double-blind, crossover trial."9.06Treatment of impotence by intrapenile injections. A comparison of papaverine versus papaverine and phentolamine: a double-blind, crossover trial. ( Carati, CJ; Earle, CM; Keogh, EJ; Lord, DJ; Tulloch, GS; Watters, GR; Wisniewski, ZS, 1989)
" The aim of the present study was to investigate whether papaverine, a novel RAGE inhibitor, could suppress inflammatory pain in mice after several time points, which was induced by the injection of complete Freund's adjuvant (CFA)."8.02Antinociceptive activity of the novel RAGE inhibitor, papaverine, in a mouse model of chronic inflammatory pain. ( Nakamura, T; Sato, A; Takahashi, Y; Takasawa, R; Takeuchi, K; Tanuma, SI; Ukai, S; Yoshizawa, K, 2021)
" In the IBS subjects, pain severity, as well as the sensory response to rectal balloon distention and rectal and sigmoid motility, were studied at baseline and after two weeks therapy with either oral buscopan (20 mg three times a day, n=37), a buscopan suppository (30 mg once daily, n=21), oral drotaverine (80 mg three times a day, n=30), calcium gluconate tablets (one three times a day, n=16) as a control for oral agents, or calendula suppository (once daily, n=14) as a control for those who received a suppository."5.14Interactions between symptoms and motor and visceral sensory responses of irritable bowel syndrome patients to spasmolytics (antispasmodics). ( Dzhanayev, YA; Golovenko, OV; Khalif, IL; Makarchuk, PA; Podmarenkova, LF; Quigley, EM, 2009)
"The aim of our work is to evaluate the efficacy of intracavernous sodium nitroprusside (SNP) in management of erectile dysfunction (ED) in a clinical comparative study with papaverine/phentolamine in ED patients."5.11Intracavernous sodium nitroprusside (SNP) versus papaverine/phentolamine in erectile dysfunction: a comparative study of short-term efficacy and side-effects. ( Abdelsalam, W; Atteya, A; Elnashaar, A; Gadallah, A; Shamloul, R; Zohdy, W, 2005)
"A study comparing intracorporeal injection of prostaglandin E1 (one-drug solution) and papaverine plus prostaglandin E1 (2-drug solution) for treatment of impotence."5.08Papaverine plus prostaglandin E1 versus prostaglandin E1 alone for intracorporeal injection therapy. ( Zaher, TF, 1998)
"Transurethral alprostadil therapy is an effective therapeutic option for patients with erectile dysfunction and may even "rescue" some patients who have failed prior intracavernous injection therapy."5.08Transurethral alprostadil as therapy for patients who withdrew from or failed prior intracavernous injection therapy. ( Engel, JD; McVary, KT, 1998)
"In an attempt to determine whether penile pain associated with intracorporeal injections could be due to the acidity of the medication, we performed a randomized study comparing the incidence of penile pain following intracorporeal injections with or without the addition of sodium bicarbonate to the intracorporeal medications."5.07Sodium bicarbonate alleviates penile pain induced by intracavernous injections for erectile dysfunction. ( Moriel, EZ; Rajfer, J, 1993)
"The efficacy of papaverine, and a combination of papaverine and phentolamine as a pharmacological treatment of impotence was compared in a double-blind, crossover trial."5.06Treatment of impotence by intrapenile injections. A comparison of papaverine versus papaverine and phentolamine: a double-blind, crossover trial. ( Carati, CJ; Earle, CM; Keogh, EJ; Lord, DJ; Tulloch, GS; Watters, GR; Wisniewski, ZS, 1989)
" The aim of the present study was to investigate whether papaverine, a novel RAGE inhibitor, could suppress inflammatory pain in mice after several time points, which was induced by the injection of complete Freund's adjuvant (CFA)."4.02Antinociceptive activity of the novel RAGE inhibitor, papaverine, in a mouse model of chronic inflammatory pain. ( Nakamura, T; Sato, A; Takahashi, Y; Takasawa, R; Takeuchi, K; Tanuma, SI; Ukai, S; Yoshizawa, K, 2021)
"A total of 78 patients 17 to 84 years old reported their experience via questionnaire with the papaverine-phentolamine injection technique for impotence."3.67Intracavernous self-injection for impotence: a long-term therapeutic option? Experience in 78 patients. ( Bruskewitz, RC; Feyzi, J; Gasser, TC; Girdley, FM; Graversen, PH, 1988)

Research

Studies (35)

TimeframeStudies, this research(%)All Research%
pre-199021 (60.00)18.7374
1990's5 (14.29)18.2507
2000's7 (20.00)29.6817
2010's1 (2.86)24.3611
2020's1 (2.86)2.80

Authors

AuthorsStudies
Yoshizawa, K1
Takeuchi, K1
Nakamura, T1
Ukai, S1
Takahashi, Y1
Sato, A1
Takasawa, R1
Tanuma, SI1
Nelson, CJ1
Hsiao, W1
Balk, E1
Narus, J1
Tal, R1
Bennett, NE1
Mulhall, JP1
Osman, F1
Buller, N1
Steeds, R1
Khalif, IL1
Quigley, EM1
Makarchuk, PA1
Golovenko, OV1
Podmarenkova, LF1
Dzhanayev, YA1
Kruuse, C1
Thomsen, LL1
Jacobsen, TB1
Olesen, J1
MERCIER, F1
MARINACCE, P1
RICHAUD, L1
STOLL, P1
MACRIS, SG1
GRAVENSTEIN, JS1
REICHLE, CW1
BEECHER, HK1
HAKANSSON, B1
DIGGS, LW1
WILLIAMS, DL1
MUFSON, I1
Ukhal', MI1
Melenevskiĭ, DA1
Lane, BR1
Lane, BZ1
Ausmundson, SJ1
Butler, RS1
Zippe, CD1
Jones, JS1
Lakin, MM1
Shamloul, R1
Atteya, A1
Elnashaar, A1
Gadallah, A1
Zohdy, W1
Abdelsalam, W1
Juan, H1
Seewann, S1
Barta, O1
Temesi, M1
Varró, J1
Zaĭtsev, AA1
Ignatov, IuD1
Dmitriev, AV1
Moriel, EZ1
Rajfer, J1
Zaher, TF1
Engel, JD1
McVary, KT1
Aikawa, N1
Ohmori, K1
Baniel, J1
Israilov, S1
Engelstein, D1
Shmueli, J1
Segenreich, E1
Livne, PM1
Bányász, T1
Karpiák, I1
Kocián, J1
Kociánová, J1
Gelin, LE1
Pallan, T1
Wulkan, IA1
Flores, L1
Chaudhry, MR1
Gintautas, J1
Abadir, AR1
Keogh, EJ1
Watters, GR1
Earle, CM1
Carati, CJ1
Wisniewski, ZS1
Tulloch, GS1
Lord, DJ1
Girdley, FM1
Bruskewitz, RC1
Feyzi, J1
Graversen, PH1
Gasser, TC1
Jönsson, PE1
Olsson, AM1
Petersson, BA1
Johansson, K1
Zoli, I1
Baroncini, S1
Cornia, GL1
Donato, S1
Minore, G1
Pigini, G1
Pretolani, E1
Kocher, R1
Rohrer, G1
Votcal, BE1
Lozinskij, LG1
Schnell, U1
Nakanishi, M1
Imamura, H1
Maruyama, Y1
Taira, N1
Nakayama, K1
Hashimoto, K1

Clinical Trials (1)

Trial Overview

TrialPhaseEnrollmentStudy TypeStart DateStatus
Efficacy of Tramadol Hcl in the Treatment of Renal Colic[NCT00310908]Phase 4100 participants (Anticipated)Interventional2006-09-30Completed
[information is prepared from clinicaltrials.gov, extracted Sep-2024]

Trials

13 trials available for papaverine and Pain

ArticleYear
Interactions between symptoms and motor and visceral sensory responses of irritable bowel syndrome patients to spasmolytics (antispasmodics).
    Journal of gastrointestinal and liver diseases : JGLD, 2009, Volume: 18, Issue:1

    Topics: Administration, Oral; Administration, Rectal; Adult; Butylscopolammonium Bromide; Calcium Gluconate;

2009
The phosphodiesterase 5 inhibitor sildenafil has no effect on cerebral blood flow or blood velocity, but nevertheless induces headache in healthy subjects.
    Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism, 2002, Volume: 22, Issue:9

    Topics: 3',5'-Cyclic-GMP Phosphodiesterases; Adult; Brain; Cerebral Arteries; Cerebrovascular Circulation; C

2002
[Using prostaglandin inhibitor dicloberl in patients with ureteral calculi].
    Likars'ka sprava, 2004, Issue:2

    Topics: Adult; Aged; Analgesics, Opioid; Diclofenac; Drug Therapy, Combination; Female; Humans; Male; Middle

2004
Intracavernous sodium nitroprusside (SNP) versus papaverine/phentolamine in erectile dysfunction: a comparative study of short-term efficacy and side-effects.
    The journal of sexual medicine, 2005, Volume: 2, Issue:1

    Topics: Adrenergic alpha-Antagonists; Adult; Drug Therapy, Combination; Erectile Dysfunction; Humans; Inject

2005
Sodium bicarbonate alleviates penile pain induced by intracavernous injections for erectile dysfunction.
    The Journal of urology, 1993, Volume: 149, Issue:5 Pt 2

    Topics: Adult; Aged; Alprostadil; Bicarbonates; Double-Blind Method; Drug Combinations; Erectile Dysfunction

1993
Papaverine plus prostaglandin E1 versus prostaglandin E1 alone for intracorporeal injection therapy.
    International urology and nephrology, 1998, Volume: 30, Issue:2

    Topics: Adult; Aged; Alprostadil; Drug Therapy, Combination; Erectile Dysfunction; Humans; Injections; Middl

1998
Transurethral alprostadil as therapy for patients who withdrew from or failed prior intracavernous injection therapy.
    Urology, 1998, Volume: 51, Issue:5

    Topics: Administration, Topical; Adrenergic alpha-Antagonists; Adult; Aged; Aged, 80 and over; Alprostadil;

1998
Three-year outcome of a progressive treatment program for erectile dysfunction with intracavernous injections of vasoactive drugs.
    Urology, 2000, Oct-01, Volume: 56, Issue:4

    Topics: Adult; Aged; Aged, 80 and over; Alprostadil; Drug Therapy, Combination; Erectile Dysfunction; Follow

2000
[Clinical experiences with preparation Hylakombun in gastroenterology].
    Wiener medizinische Wochenschrift. Supplement, 1975, Volume: 25

    Topics: Adult; Aged; Clinical Trials as Topic; Constipation; Diarrhea; Drug Combinations; Drug Evaluation; D

1975
Treatment of impotence by intrapenile injections. A comparison of papaverine versus papaverine and phentolamine: a double-blind, crossover trial.
    The Journal of urology, 1989, Volume: 142, Issue:3

    Topics: Adult; Aged; Clinical Trials as Topic; Double-Blind Method; Drug Combinations; Erectile Dysfunction;

1989
Intravenous indomethacin and oxycone-papaverine in the treatment of acute renal colic. A double-blind study.
    British journal of urology, 1987, Volume: 59, Issue:5

    Topics: Acute Disease; Adult; Aged; Clinical Trials as Topic; Codeine; Colic; Double-Blind Method; Drug Comb

1987
[Treatment of severe chronic pains with a combination of thymoleptics and neuroleptics (author's transl)].
    Schweizerische Rundschau fur Medizin Praxis = Revue suisse de medecine Praxis, 1974, Dec-31, Volume: 63, Issue:52

    Topics: Adult; Antidepressive Agents; Atropine; Chlorpromazine; Clinical Trials as Topic; Clomipramine; Drug

1974
[Carbochromen in therapy of acute and chronic coronary insufficiency].
    Arzneimittel-Forschung, 1970, Volume: 20

    Topics: Acute Disease; Adult; Aged; Angina Pectoris; Arrhythmias, Cardiac; Blood Pressure; Chronic Disease;

1970

Other Studies

22 other studies available for papaverine and Pain

ArticleYear
Antinociceptive activity of the novel RAGE inhibitor, papaverine, in a mouse model of chronic inflammatory pain.
    Synapse (New York, N.Y.), 2021, Volume: 75, Issue:3

    Topics: Analgesics; Animals; Disease Models, Animal; Mice; Pain; Papaverine; Receptor for Advanced Glycation

2021
Injection anxiety and pain in men using intracavernosal injection therapy after radical pelvic surgery.
    The journal of sexual medicine, 2013, Volume: 10, Issue:10

    Topics: Aged; Alprostadil; Anxiety; Drug Combinations; Erectile Dysfunction; Humans; Injections; Male; Middl

2013
Use of intra-arterial papaverine for severe arterial spasm during radial cardiac catheterization.
    The Journal of invasive cardiology, 2008, Volume: 20, Issue:10

    Topics: Cardiac Catheterization; Coronary Angiography; Female; Humans; Middle Aged; Pain; Papaverine; Radial

2008
[Experimental analgesia with papaverine and certain of its derivatives].
    Comptes rendus des seances de la Societe de biologie et de ses filiales, 1952, Volume: 146, Issue:21-22

    Topics: Analgesia; Humans; Pain; Pain Management; Papaverine

1952
[The treatment of painful conditions in the true pelvis of the female with ichthobellol compositum].
    Medizinische Klinik, 1957, Oct-11, Volume: 52, Issue:41

    Topics: Aminopyrine; Belladonna Alkaloids; Disease; Female; Humans; Lesser Pelvis; Pain; Papaverine; Pelvis;

1957
Drug synergism (potentiation) in pain relief in man: papaverine and morphine.
    Science (New York, N.Y.), 1958, Jul-11, Volume: 128, Issue:3315

    Topics: Drug Synergism; Humans; Male; Morphine; Pain; Papaverine

1958
[Analgetic reducing therapy for pain associated with circulatory insufficiency].
    Svenska lakartidningen, 1962, Oct-25, Volume: 59

    Topics: Baths; Geriatrics; Heparin; Humans; Lidocaine; Pain; Papaverine; Vascular Diseases

1962
Treatment of painful sickle cell crises with papaverine: preliminary report.
    Southern medical journal, 1963, Volume: 56

    Topics: Anemia; Anemia, Sickle Cell; Erythrocytes, Abnormal; Humans; Pain; Papaverine

1963
Responses of the abnormal arterial circulation to various stimuli, as studied by the use of radioactive sodium. II. Intraarterial histamine, papaverine, aminophylline and adrenaline; sympathectomy and etamon; pain.
    Annals of internal medicine, 1951, Volume: 34, Issue:2

    Topics: Aminophylline; Arteries; Blood Vessels; Epinephrine; Histamine; Humans; Pain; Papaverine; Sodium; So

1951
Use of a visual analog scale to assess pain of injection with intracavernous injection therapy.
    The journal of sexual medicine, 2005, Volume: 2, Issue:3

    Topics: Adult; Aged; Alprostadil; Diabetes Mellitus; Drug Administration Routes; Humans; Injections; Male; M

2005
Selective reduction by some vasodilators and the prostaglandin antagonist SC-19220 of a response to the algesic effect of bradykinin.
    European journal of pharmacology, 1980, Jul-25, Volume: 65, Issue:2-3

    Topics: Acetylcholine; Aminophylline; Animals; Bradykinin; Depression, Chemical; Dibenz(b,f)(1,4)oxazepine-1

1980
Examination of the pain relieving-effect of intra-arterial No-Spa treatment of coxarthrosis.
    Therapia Hungarica (English edition), 1982, Volume: 30, Issue:2

    Topics: Adult; Aged; Female; Hip Joint; Humans; Injections, Intra-Arterial; Male; Middle Aged; Osteoarthriti

1982
[Analgesic effect of clopheline].
    Biulleten' eksperimental'noi biologii i meditsiny, 1981, Volume: 92, Issue:12

    Topics: Analgesics; Animals; Behavior, Animal; Cats; Clonidine; Drug Interactions; Hemodynamics; Naloxone; P

1981
Effect of zaldaride maleate, an antidiarrheal compound, on visceral pain reflex induced by small intestinal distention in anesthetized rats.
    Japanese journal of pharmacology, 1999, Volume: 81, Issue:4

    Topics: Adrenergic alpha-Antagonists; Anesthesia; Animals; Animals, Newborn; Antidiarrheals; Atropine; Benzi

1999
The effect of Quarelin on pain in old age.
    Therapia Hungarica (English edition), 1977, Volume: 25, Issue:1

    Topics: Age Factors; Aged; Aminopyrine; Analgesics; Dipyrone; Drug Combinations; Female; Humans; Male; Pain;

1977
[Control of pain in the pre-clinical phase].
    Zentralblatt fur Chirurgie, 1975, Volume: 100, Issue:15

    Topics: Acute Disease; Analgesics; Autonomic Nerve Block; Colchicine; Hospitalization; Humans; Hypnotics and

1975
Radiologic contrast material and a vasodilator can produce arterial thrombosis.
    Proceedings of the Western Pharmacology Society, 1991, Volume: 34

    Topics: Arm; Brachial Artery; Contrast Media; Drug Incompatibility; Female; Humans; Iopamidol; Middle Aged;

1991
Intracavernous self-injection for impotence: a long-term therapeutic option? Experience in 78 patients.
    The Journal of urology, 1988, Volume: 140, Issue:5

    Topics: Consumer Behavior; Drug Combinations; Erectile Dysfunction; Humans; Male; Middle Aged; Pain; Papaver

1988
[Therapeutic possibilities in coronary disease].
    Minerva medica, 1973, Nov-24, Volume: 64, Issue:84

    Topics: Adult; Aged; Angina Pectoris; Arrhythmias, Cardiac; Arteriosclerosis; Cardiomegaly; Coronary Disease

1973
[Dolo-Eupaco as an analgesic in gynecology].
    Die Medizinische Welt, 1970, Jan-31, Volume: 5

    Topics: Adult; Aminopyrine; Analgesics; Benzilates; Codeine; Esters; Female; Genital Diseases, Female; Genit

1970
[Studies on anti-inflammatory agents. II. Analgesic and anti-edematous activities of 2-amino-3-ethoxycarbonyl-6-benzyl-4,5,6, 7-tetrahydrothieno (2,3-c)pyridine (Y-3642)].
    Yakugaku zasshi : Journal of the Pharmaceutical Society of Japan, 1970, Volume: 90, Issue:3

    Topics: Aminopyrine; Amphetamine; Analgesics; Animals; Anti-Inflammatory Agents; Edema; Imipramine; Male; Mi

1970
Vocalization response of puppies to intra-arterial administration of bradykinin and other algesic agents, and mode of actions of blocking agents.
    The Tohoku journal of experimental medicine, 1968, Volume: 96, Issue:4

    Topics: Acetylcholine; Age Factors; Analgesics; Animals; Atropine; Barium; Bradykinin; Catheterization; Chlo

1968