Neutral alpha-glucosidase AB

A neutral alpha-glucosidase AB that is encoded in the genome of human. [PRO:DNx, UniProtKB:Q14697]

Synonyms

EC 3.2.1.207;
Alpha-glucosidase 2;
Glucosidase II subunit alpha

Research

Bioassay Publications (3)

Timeframe	Studies on this Protein(%)	All Drugs %
pre-1990	1 (33.33)	18.7374
1990's	2 (66.67)	18.2507
2000's	0 (0.00)	29.6817
2010's	0 (0.00)	24.3611
2020's	0 (0.00)	2.80

Compounds (3)

Drugs with Inhibition Measurements

Drug	Taxonomy	Measurement	Average (mM)	Bioassay(s)	Publication(s)
cisapride	Homo sapiens (human)	Ki	0.0300	1	1
1-deoxynojirimycin	Homo sapiens (human)	IC50	472.8250	3	4
1-deoxynojirimycin	Homo sapiens (human)	Ki	410.0000	1	1

Drugs with Activation Measurements

Drug	Taxonomy	Measurement	Average (mM)	Bioassay(s)	Publication(s)
labetalol hydrochloride	Homo sapiens (human)	Kd	0.0355	1	2

Enables

This protein enables 5 target(s):

Target	Category	Definition
RNA binding	molecular function	Binding to an RNA molecule or a portion thereof. [GOC:jl, GOC:mah]
protein binding	molecular function	Binding to a protein. [GOC:go_curators]
carbohydrate binding	molecular function	Binding to a carbohydrate, which includes monosaccharides, oligosaccharides and polysaccharides as well as substances derived from monosaccharides by reduction of the carbonyl group (alditols), by oxidation of one or more hydroxy groups to afford the corresponding aldehydes, ketones, or carboxylic acids, or by replacement of one or more hydroxy group(s) by a hydrogen atom. Cyclitols are generally not regarded as carbohydrates. [GOC:mah]
glucan 1,3-alpha-glucosidase activity	molecular function	Catalysis of the hydrolysis of terminal (1->3)-alpha-D-glucosidic links in 1,3-alpha-D-glucans. [EC:3.2.1.84]
alpha-glucosidase activity	molecular function	Catalysis of the hydrolysis of terminal, non-reducing alpha-linked alpha-D-glucose residue with release of alpha-D-glucose. [GOC:tb]

Located In

This protein is located in 6 target(s):

Target	Category	Definition
endoplasmic reticulum lumen	cellular component	The volume enclosed by the membranes of the endoplasmic reticulum. [ISBN:0198547684]
Golgi apparatus	cellular component	A membrane-bound cytoplasmic organelle of the endomembrane system that further processes the core oligosaccharides (e.g. N-glycans) added to proteins in the endoplasmic reticulum and packages them into membrane-bound vesicles. The Golgi apparatus operates at the intersection of the secretory, lysosomal, and endocytic pathways. [ISBN:0198506732]
membrane	cellular component	A lipid bilayer along with all the proteins and protein complexes embedded in it and attached to it. [GOC:dos, GOC:mah, ISBN:0815316194]
melanosome	cellular component	A tissue-specific, membrane-bounded cytoplasmic organelle within which melanin pigments are synthesized and stored. Melanosomes are synthesized in melanocyte cells. [GOC:jl, PMID:11584301]
intracellular membrane-bounded organelle	cellular component	Organized structure of distinctive morphology and function, bounded by a single or double lipid bilayer membrane and occurring within the cell. Includes the nucleus, mitochondria, plastids, vacuoles, and vesicles. Excludes the plasma membrane. [GOC:go_curators]
extracellular exosome	cellular component	A vesicle that is released into the extracellular region by fusion of the limiting endosomal membrane of a multivesicular body with the plasma membrane. Extracellular exosomes, also simply called exosomes, have a diameter of about 40-100 nm. [GOC:BHF, GOC:mah, GOC:vesicles, PMID:15908444, PMID:17641064, PMID:19442504, PMID:19498381, PMID:22418571, PMID:24009894]

Part Of

This protein is part of 1 target(s):

Target	Category	Definition
glucosidase II complex	cellular component	A heterodimeric complex that catalyzes the trimming of glucose residues from N-linked core glycans on newly synthesized glycoproteins. [PMID:10464333, PMID:8910335]

Involved In

This protein is involved in 2 target(s):

Target	Category	Definition
carbohydrate metabolic process	biological process	The chemical reactions and pathways involving carbohydrates, any of a group of organic compounds based of the general formula Cx(H2O)y. [GOC:mah, ISBN:0198506732]
N-glycan processing	biological process	The conversion of N-linked glycan (N = nitrogen) structures from the initially transferred oligosaccharide to a mature form, by the actions of glycosidases and glycosyltransferases. The early processing steps are conserved and play roles in glycoprotein folding and trafficking. [ISBN:0879695595, PMID:12736198]