ly2183240 and Pain

ly2183240 has been researched along with Pain* in 1 studies

Other Studies

1 other study(ies) available for ly2183240 and Pain

Article	Year
Synthesis, SAR study, and biological evaluation of a series of piperazine ureas as fatty acid amide hydrolase (FAAH) inhibitors. Bioorganic & medicinal chemistry, 2013, Jan-01, Volume: 21, Issue:1 A series of piperazine ureas was designed, synthesized, and evaluated for their potential as novel orally available fatty acid amide hydrolase (FAAH) inhibitors that are therapeutically effective against pain. We carried out an optimization study of the lead compound 3 to improve its DMPK profile as well as in vitro potency. We identified the thiazole compound 60j with potent inhibitory activity, high brain permeability, and good bioavailability. Compound 60j showed a potent and dose-dependent anti-nociceptive effect in the acetic acid-induced writhing test in mice. Topics: Amidohydrolases; Analgesics; Animals; Humans; Mice; Molecular Docking Simulation; Pain; Piperazine; Piperazines; Rats; Structure-Activity Relationship; Thiazoles; Urea	2013

Article

Year

Synthesis, SAR study, and biological evaluation of a series of piperazine ureas as fatty acid amide hydrolase (FAAH) inhibitors.

Bioorganic & medicinal chemistry, 2013, Jan-01, Volume: 21, Issue:1

A series of piperazine ureas was designed, synthesized, and evaluated for their potential as novel orally available fatty acid amide hydrolase (FAAH) inhibitors that are therapeutically effective against pain. We carried out an optimization study of the lead compound 3 to improve its DMPK profile as well as in vitro potency. We identified the thiazole compound 60j with potent inhibitory activity, high brain permeability, and good bioavailability. Compound 60j showed a potent and dose-dependent anti-nociceptive effect in the acetic acid-induced writhing test in mice.

Topics: Amidohydrolases; Analgesics; Animals; Humans; Mice; Molecular Docking Simulation; Pain; Piperazine; Piperazines; Rats; Structure-Activity Relationship; Thiazoles; Urea

2013