Neuromedin-B receptor

A neuromedin-B receptor that is encoded in the genome of human. [PRO:WCB, UniProtKB:P28336]

Synonyms

NMB-R;
Epididymis tissue protein Li 185a;
Neuromedin-B-preferring bombesin receptor

Research

Bioassay Publications (2)

Timeframe	Studies on this Protein(%)	All Drugs %
pre-1990	0 (0.00)	18.7374
1990's	1 (50.00)	18.2507
2000's	1 (50.00)	29.6817
2010's	0 (0.00)	24.3611
2020's	0 (0.00)	2.80

Compounds (6)

Drugs with Inhibition Measurements

Drug	Taxonomy	Measurement	Average (mM)	Bioassay(s)	Publication(s)
harmalan	Homo sapiens (human)	Ki	10.0000	1	1
1-methyl-6-methoxy-dihydro-beta-carboline	Homo sapiens (human)	Ki	10.0000	1	1
harmine	Homo sapiens (human)	Ki	10.0000	1	1
pd 176252	Homo sapiens (human)	Ki	0.0002	1	1
pd 168368	Homo sapiens (human)	Ki	0.0001	1	1
bombesin	Homo sapiens (human)	Ki	0.0020	1	1

Drugs with Other Measurements

Drug	Taxonomy	Measurement	Average (mM)	Bioassay(s)	Publication(s)
pd 176252	Homo sapiens (human)	KB app	0.0032	2	2

Enables

This protein enables 2 target(s):

Target	Category	Definition
bombesin receptor activity	molecular function	Combining with bombesin to initiate a change in cell activity. [GOC:ai]
neuropeptide receptor activity	molecular function	Combining with a neuropeptide to initiate a change in cell activity. [GOC:ai]

Located In

This protein is located in 2 target(s):

Target	Category	Definition
cytosol	cellular component	The part of the cytoplasm that does not contain organelles but which does contain other particulate matter, such as protein complexes. [GOC:hjd, GOC:jl]
plasma membrane	cellular component	The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins. [ISBN:0716731363]

Active In

This protein is active in 1 target(s):

Target	Category	Definition
plasma membrane	cellular component	The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins. [ISBN:0716731363]

Involved In

This protein is involved in 10 target(s):

Target	Category	Definition
phospholipase C-activating G protein-coupled receptor signaling pathway	biological process	A G protein-coupled receptor signaling pathway in which the signal is transmitted via the activation of phospholipase C (PLC) and a subsequent increase in the intracellular concentration of inositol trisphosphate (IP3) and diacylglycerol (DAG). [GOC:dph, GOC:mah, GOC:signaling, GOC:tb, ISBN:0815316194]
neuropeptide signaling pathway	biological process	A G protein-coupled receptor signaling pathway initiated by a neuropeptide binding to its receptor on the surface of a target cell, and ending with the regulation of a downstream cellular process. [GOC:mah, ISBN:0815316194]
bombesin receptor signaling pathway	biological process	A G protein-coupled receptor signaling pathway initiated by a bombesin binding to its receptor, and ending with the regulation of a downstream cellular process, e.g. transcription. [GOC:mah]
negative regulation of interleukin-6 production	biological process	Any process that stops, prevents, or reduces the frequency, rate, or extent of interleukin-6 production. [GOC:mah]
positive regulation of interferon-alpha production	biological process	Any process that activates or increases the frequency, rate, or extent of interferon-alpha production. [GOC:mah, PMID:15546383]
positive regulation of osteoclast proliferation	biological process	Any process that increases the rate, frequency, or extent of the multiplication or reproduction of osteoclasts, resulting in the expansion of an osteoclast cell population. [GOC:tb]
antiviral innate immune response	biological process	A defense response against viruses mediated through an innate immune response. An innate immune response is mediated by germline encoded components that directly recognize components of potential pathogens. [PMID:31006531]
sneeze reflex	biological process	A reflex process that expels air forcibly from the mouth and nose in an explosive, spasmodic involuntary action resulting chiefly from irritation of the nasal mucous membrane. [https://www.thefreedictionary.com/sneeze, PMID:34133943]
positive regulation of respiratory gaseous exchange	biological process	Any process that activates or increases the frequency, rate or extent of respiratory gaseous exchange. [GO_REF:0000058, GOC:TermGenie, PMID:22819705]
G protein-coupled receptor signaling pathway	biological process	The series of molecular signals initiated by a ligand binding to its receptor, in which the activated receptor promotes the exchange of GDP for GTP on the alpha-subunit of an associated heterotrimeric G-protein complex. The GTP-bound activated alpha-G-protein then dissociates from the beta- and gamma-subunits to further transmit the signal within the cell. The pathway begins with receptor-ligand interaction, and ends with regulation of a downstream cellular process. The pathway can start from the plasma membrane, Golgi or nuclear membrane. [GOC:bf, GOC:mah, PMID:16902576, PMID:24568158, Wikipedia:G_protein-coupled_receptor]

chemdatabank.com