guanethidine has been researched along with Pain in 41 studies
Guanethidine: An antihypertensive agent that acts by inhibiting selectively transmission in post-ganglionic adrenergic nerves. It is believed to act mainly by preventing the release of norepinephrine at nerve endings and causes depletion of norepinephrine in peripheral sympathetic nerve terminals as well as in tissues.
guanethidine : A member of the class of guanidines in which one of the hydrogens of the amino group has been replaced by a 2-azocan-1-ylethyl group.
guanethidine sulfate : A organic sulfate salt composed of two molecules of guanethidine and one of sulfuric acid.
Pain: An unpleasant sensation induced by noxious stimuli which are detected by NERVE ENDINGS of NOCICEPTIVE NEURONS.
| Excerpt | Relevance | Reference |
|---|---|---|
| "Both regional intravenous guanethidine and reserpine have been reported as effective in the treatment of reflex sympathetic dystrophy." | 9.06 | A comparison of regional intravenous guanethidine and reserpine in reflex sympathetic dystrophy. A controlled, randomized, double-blind crossover study. ( Gallo, JP; Kaul, AF; Lief, PA; Reisman, RM; Rocco, AG, 1989) |
| "Thirty-one patients with pain in one or both hands associated with sympathetic dystrophy or Raynaud's disease were studied before and after the administration of a placebo and guanethidine 10mg i." | 9.05 | Pain relief following post-ganglionic sympathetic blockade with I.V. guanethidine. ( Basedow, RW; Glynn, CJ; Walsh, JA, 1981) |
| "The topical application of guanethidine solution to the affected teeth has been successful in relieving natural and clinically induced dentinal pain and hypersensitivity in 13 of 14 dental patients in a pilot study." | 7.68 | Topical guanethidine relieves dentinal hypersensitivity and pain. ( Dunne, SM; Hannington-Kiff, JG, 1993) |
| "Twenty patients with documented reflex sympathetic dystrophy were treated with a series of regional intravenous guanethidine blocks." | 7.66 | Clinical effects of regional intravenous guanethidine (Ismelin) in reflex sympathetic dystrophy. ( Crul, JF; Driessen, JJ; Nicolai, JP; van der Werken, C, 1983) |
| "Guanethidine was infused by the regional intravenous technique into upper and lower limbs of patients with painful hyperpathic states, due to peripheral or central lesions." | 7.66 | Effects of regional guanethidine infusion in certain painful states. ( Loh, L; Nathan, PW; Schott, GD; Wilson, PG, 1980) |
| "Both regional intravenous guanethidine and reserpine have been reported as effective in the treatment of reflex sympathetic dystrophy." | 5.06 | A comparison of regional intravenous guanethidine and reserpine in reflex sympathetic dystrophy. A controlled, randomized, double-blind crossover study. ( Gallo, JP; Kaul, AF; Lief, PA; Reisman, RM; Rocco, AG, 1989) |
| "Thirty-one patients with pain in one or both hands associated with sympathetic dystrophy or Raynaud's disease were studied before and after the administration of a placebo and guanethidine 10mg i." | 5.05 | Pain relief following post-ganglionic sympathetic blockade with I.V. guanethidine. ( Basedow, RW; Glynn, CJ; Walsh, JA, 1981) |
| "The putative antinociceptive action of guanethidine and calcitonin systemically injected has been compared in 2 rat models of persistent experimental pain: Freund's adjuvant-induced arthritis (n = 29) and mononeuropathy induced by 4 loose ligatures around the sciatic nerve (n = 24)." | 3.68 | Are mechanical and cold allodynia in mononeuropathic and arthritic rats relieved by systemic treatment with calcitonin or guanethidine? ( Ardid, D; Attal, N; Guilbaud, G; Perrot, S, 1993) |
| "The topical application of guanethidine solution to the affected teeth has been successful in relieving natural and clinically induced dentinal pain and hypersensitivity in 13 of 14 dental patients in a pilot study." | 3.68 | Topical guanethidine relieves dentinal hypersensitivity and pain. ( Dunne, SM; Hannington-Kiff, JG, 1993) |
| "We studied usefulness of iontophoresis on pain relief using several Ca channel blockers, propranolol and guanethidine." | 3.68 | [Influence of calcium channel blockers and beta-blockers on pain relief with iontophoresis]. ( Honda, N; Ikebe, H; Miyagawa, A; Mizutani, A; Sendaya, K; Taniguchi, K; Yoshitake, S, 1992) |
| "Guanethidine treatment decreased morphine analgesia exhibited by restrained rats but had no effect on morphine analgesia exhibited by unrestrained rats or on baseline pain sensitivity." | 3.67 | Sympathetic control of tryptophan uptake and morphine analgesia in stressed rats. ( Franklin, KB; Kelly, SJ, 1986) |
| "Twenty patients with documented reflex sympathetic dystrophy were treated with a series of regional intravenous guanethidine blocks." | 3.66 | Clinical effects of regional intravenous guanethidine (Ismelin) in reflex sympathetic dystrophy. ( Crul, JF; Driessen, JJ; Nicolai, JP; van der Werken, C, 1983) |
| "Guanethidine was infused by the regional intravenous technique into upper and lower limbs of patients with painful hyperpathic states, due to peripheral or central lesions." | 3.66 | Effects of regional guanethidine infusion in certain painful states. ( Loh, L; Nathan, PW; Schott, GD; Wilson, PG, 1980) |
| "In various chronic painful states, the sympathetic nerve supply was blocked either by injecting the sympathetic chain and ganglia with local anaesthesia or by the injection of guanethidine during occlusion of the circulation." | 3.66 | Painful peripheral states and sympathetic blocks. ( Loh, L; Nathan, PW, 1978) |
| "Although chronic pain is the most common symptom of arthritis, relatively little is known about the mechanisms driving it." | 1.39 | Sympathetic fiber sprouting in inflamed joints and adjacent skin contributes to pain-related behavior in arthritis. ( Longo, G; Osikowicz, M; Ribeiro-da-Silva, A, 2013) |
| "The guanethidine pretreatment did not influence thermal hyperalgesia induced by a mild burn, but inhibited pain evoked by electrical stimulation of the skin (0." | 1.35 | Depletion of noradrenaline inhibits electrically-evoked pain in the skin of the human forearm. ( Drummond, PD, 2008) |
| "Both guanethidine treatment and phentolamine coadministration attenuated the constrictor response to nociceptin." | 1.32 | Involvement of sympathetic efferents but not capsaicin-sensitive afferents in nociceptin-mediated dual control of rat synovial blood flow. ( McDougall, JJ, 2003) |
| "Loratadine pretreatment, but neither guanethidine nor indomethacin, reduced edema." | 1.32 | Nociceptive and edematogenic responses elicited by a crude bristle extract of Lonomia obliqua caterpillars. ( de Castro Bastos, L; Guimarães, JA; Tonussi, CR; Veiga, AB, 2004) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 19 (46.34) | 18.7374 |
| 1990's | 13 (31.71) | 18.2507 |
| 2000's | 8 (19.51) | 29.6817 |
| 2010's | 1 (2.44) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Longo, G | 1 |
| Osikowicz, M | 1 |
| Ribeiro-da-Silva, A | 1 |
| McDougall, JJ | 1 |
| RIPKA, O | 1 |
| MALIS, F | 1 |
| GASCON, A | 1 |
| de Castro Bastos, L | 1 |
| Veiga, AB | 1 |
| Guimarães, JA | 1 |
| Tonussi, CR | 1 |
| Nordmann, GR | 1 |
| Lauder, GR | 1 |
| Grier, DJ | 1 |
| Ferreira, J | 1 |
| Trichês, KM | 1 |
| Medeiros, R | 1 |
| Calixto, JB | 1 |
| Drummond, PD | 2 |
| Coderre, TJ | 3 |
| Abbott, FV | 1 |
| Melzack, R | 3 |
| Driessen, JJ | 1 |
| van der Werken, C | 1 |
| Nicolai, JP | 1 |
| Crul, JF | 1 |
| Glynn, CJ | 1 |
| Basedow, RW | 1 |
| Walsh, JA | 1 |
| Loh, L | 2 |
| Nathan, PW | 2 |
| Schott, GD | 2 |
| Wilson, PG | 1 |
| Fawcett, JP | 1 |
| Coville, PF | 1 |
| Cheung, E | 1 |
| Jones, D | 1 |
| Kim, SH | 1 |
| Na, HS | 1 |
| Kwangsup, S | 1 |
| Jin, MC | 1 |
| Vijayan, R | 1 |
| Low, KH | 1 |
| Perrot, S | 1 |
| Attal, N | 1 |
| Ardid, D | 1 |
| Guilbaud, G | 1 |
| Hannington-Kiff, JG | 1 |
| Dunne, SM | 1 |
| Breivik, H | 1 |
| Marchettini, P | 1 |
| Lacerenza, M | 1 |
| Formaglio, F | 1 |
| Malmberg, AB | 1 |
| Hedley, LR | 1 |
| Jasper, JR | 1 |
| Hunter, JC | 1 |
| Basbaum, AI | 1 |
| Wall, PD | 1 |
| Scadding, JW | 1 |
| Tomkiewicz, MM | 1 |
| Benzon, HT | 1 |
| Miyagawa, A | 1 |
| Taniguchi, K | 1 |
| Sendaya, K | 1 |
| Mizutani, A | 1 |
| Yoshitake, S | 1 |
| Ikebe, H | 1 |
| Honda, N | 1 |
| Cunha, FQ | 1 |
| Lorenzetti, BB | 1 |
| Poole, S | 1 |
| Ferreira, SH | 1 |
| Arnér, S | 1 |
| Owen, JEL | 1 |
| Muller, A | 1 |
| Sudbrack, G | 1 |
| Franklin, KB | 1 |
| Kelly, SJ | 1 |
| Leino, E | 1 |
| Lindgren, KA | 1 |
| Rocco, AG | 1 |
| Kaul, AF | 1 |
| Reisman, RM | 1 |
| Gallo, JP | 1 |
| Lief, PA | 1 |
| Grimes, RW | 1 |
| Engkvist, O | 1 |
| Wahren, LK | 1 |
| Wallin, G | 1 |
| Torebjrk, E | 1 |
| Nystrom, B | 1 |
| Saarnivaara, L | 1 |
| Carstens, E | 1 |
| Wahlberg, P | 1 |
| Lindquist, B | 1 |
| Zăgreanu, J | 1 |
| Hărăgus, S | 1 |
| Uza, G | 1 |
| Vlaicu, R | 1 |
| Schneider, E | 1 |
1 review available for guanethidine and Pain
| Article | Year |
|---|---|
Deafferentation and chronic pain in animals: an evaluation of evidence suggesting autotomy is related to pain.
Topics: Afferent Pathways; Animals; Behavior, Animal; Capsaicin; Chronic Disease; Denervation; Disease Model | 1986 |
2 trials available for guanethidine and Pain
| Article | Year |
|---|---|
Pain relief following post-ganglionic sympathetic blockade with I.V. guanethidine.
Topics: Adolescent; Adult; Aged; Autonomic Nerve Block; Cold Temperature; Female; Guanethidine; Hand; Humans | 1981 |
A comparison of regional intravenous guanethidine and reserpine in reflex sympathetic dystrophy. A controlled, randomized, double-blind crossover study.
Topics: Adult; Body Temperature; Double-Blind Method; Female; Guanethidine; Humans; Injections, Intravenous; | 1989 |
38 other studies available for guanethidine and Pain
| Article | Year |
|---|---|
Sympathetic fiber sprouting in inflamed joints and adjacent skin contributes to pain-related behavior in arthritis.
Topics: Adrenergic Fibers; Analysis of Variance; Animals; Ankle Joint; Arthritis; Calcitonin Gene-Related Pe | 2013 |
Involvement of sympathetic efferents but not capsaicin-sensitive afferents in nociceptin-mediated dual control of rat synovial blood flow.
Topics: Adrenergic Fibers; Afferent Pathways; Animals; Capsaicin; Dose-Response Relationship, Drug; Efferent | 2003 |
[GUANETHIDINE. A NEW TYPE HYPOTENSIVE DRUG].
Topics: Abdomen; Antihypertensive Agents; Bradycardia; Fundus Oculi; Guanethidine; Humans; Hypertension; Hyp | 1963 |
[ROLE OF SEVERAL SEROTONIN AND CATECHOLAMINE LIBERATORS IN THE PHENOMENON OF PAIN IN THE RAT].
Topics: Bretylium Compounds; Carboxy-Lyases; Catecholamines; Enzyme Inhibitors; Guanethidine; Morphine; Pain | 1964 |
Nociceptive and edematogenic responses elicited by a crude bristle extract of Lonomia obliqua caterpillars.
Topics: Animals; Anti-Inflammatory Agents, Non-Steroidal; Arthropod Venoms; Dose-Response Relationship, Drug | 2004 |
Computed tomography guided lumbar sympathetic block for complex regional pain syndrome in a child: a case report and review.
Topics: Amines; Amitriptyline; Analgesics; Anesthetics, Local; Antidepressive Agents, Tricyclic; Autonomic N | 2006 |
Mechanisms involved in the nociception produced by peripheral protein kinase c activation in mice.
Topics: Adrenergic beta-Antagonists; Analgesics; Animals; Antibodies; Behavior, Animal; Blotting, Western; B | 2005 |
Immersion of the hand in ice water releases adrenergic vasoconstrictor tone in the ipsilateral temple.
Topics: Adolescent; Adult; Cold Temperature; Female; Guanethidine; Hand; Humans; Laser-Doppler Flowmetry; Ma | 2006 |
Depletion of noradrenaline inhibits electrically-evoked pain in the skin of the human forearm.
Topics: Adult; Drug Administration Schedule; Electric Stimulation; Forearm; Guanethidine; Humans; Hyperalges | 2008 |
Effects of peripheral antisympathetic treatments in the tail-flick, formalin and autotomy tests.
Topics: Animals; Bis(4-Methyl-1-Homopiperazinylthiocarbonyl)disulfide; Formaldehyde; Guanethidine; Hot Tempe | 1984 |
Clinical effects of regional intravenous guanethidine (Ismelin) in reflex sympathetic dystrophy.
Topics: Adult; Aged; Analgesics; Arm; Autonomic Nerve Block; Female; Follow-Up Studies; Guanethidine; Humans | 1983 |
Effects of regional guanethidine infusion in certain painful states.
Topics: Chronic Disease; Extremities; Fingers; Galvanic Skin Response; Guanethidine; Humans; Infusions, Pare | 1980 |
Use of local anaesthetics in guanethidine-induced regional sympathetic blockade.
Topics: Anesthesia, Local; Animals; Autonomic Nerve Block; Drug Therapy, Combination; Guanethidine; Humans; | 1995 |
Effects of sympathectomy on a rat model of peripheral neuropathy.
Topics: Animals; Disease Models, Animal; Guanethidine; Hot Temperature; Male; Pain; Pain Measurement; Periph | 1993 |
Pain relief with intravenous regional guanethedine in post-traumatic reflex sympathetic dystrophy--a case report.
Topics: Female; Guanethidine; Humans; Injections, Intravenous; Middle Aged; Nerve Block; Pain; Pain Manageme | 1993 |
Are mechanical and cold allodynia in mononeuropathic and arthritic rats relieved by systemic treatment with calcitonin or guanethidine?
Topics: Animals; Anti-Inflammatory Agents, Non-Steroidal; Antidepressive Agents; Arthritis, Experimental; Be | 1993 |
Topical guanethidine relieves dentinal hypersensitivity and pain.
Topics: Administration, Topical; Adult; Dentin Sensitivity; Female; Guanethidine; Humans; Male; Middle Aged; | 1993 |
Chronic pain and the sympathetic nervous system.
Topics: Autonomic Nervous System Diseases; Causalgia; Chronic Disease; Clinical Trials as Topic; Double-Blin | 1997 |
Interrupting the sympathetic outflow in causalgia and reflex sympathetic dystrophy.
Topics: Autonomic Nerve Block; Causalgia; Guanethidine; Humans; Meta-Analysis as Topic; Pain; Phentolamine; | 1998 |
Sympathetically maintained pain.
Topics: Adolescent; Adult; Aged; Female; Guanethidine; Humans; Male; Pain; Pain Management; Reflex Sympathet | 2000 |
Contribution of alpha(2) receptor subtypes to nerve injury-induced pain and its regulation by dexmedetomidine.
Topics: Adrenergic alpha-Agonists; Adrenergic alpha-Antagonists; Analgesics; Animals; Dexmedetomidine; Femal | 2001 |
The production and prevention of experimental anesthesia dolorosa.
Topics: Animals; Behavior, Animal; Disease Models, Animal; Female; Guanethidine; Leg; Male; Mice; Mice, Inbr | 1979 |
Painful peripheral states and sympathetic blocks.
Topics: Anesthesia, Local; Bupivacaine; Central Nervous System Diseases; Differential Threshold; Female; Gua | 1978 |
Importance of documenting complete sympathetic denervation after sympathectomy.
Topics: Adult; Autonomic Nerve Block; Female; Foot; Guanethidine; Humans; Lumbosacral Region; Pain; Pain Man | 1992 |
[Influence of calcium channel blockers and beta-blockers on pain relief with iontophoresis].
Topics: Adult; Calcium Channel Blockers; Female; Guanethidine; Humans; Iontophoresis; Lidocaine; Male; Pain; | 1992 |
Interleukin-8 as a mediator of sympathetic pain.
Topics: Animals; Atenolol; Benzazepines; Carrageenan; Dinoprostone; Edema; Foot; Guanethidine; Interleukin-1 | 1991 |
Intravenous phentolamine test: diagnostic and prognostic use in reflex sympathetic dystrophy.
Topics: Adolescent; Adult; Aged; Aged, 80 and over; Child; Female; Guanethidine; Humans; Injections, Intrave | 1991 |
Sympathetically maintained pain of the digits in porphyria cutanea tarda relieved by i.v. regional guanethidine.
Topics: Adult; Fingers; Guanethidine; Humans; Injections, Intravenous; Male; Occupational Diseases; Pain; Po | 1991 |
[Intravenous sympatholysis in arterial occlusive diseases and acrosyndromes].
Topics: Arterial Occlusive Diseases; Bretylium Compounds; Guanethidine; Humans; Injections, Intravenous; Isc | 1990 |
Sympathetic control of tryptophan uptake and morphine analgesia in stressed rats.
Topics: Analgesia; Animals; Guanethidine; Hydroxyindoleacetic Acid; Male; Morphine; Pain; Rats; Restraint, P | 1986 |
[Sudeck's syndrome--pain and atrophy of the upper extremities].
Topics: Adult; Diagnosis, Differential; Guanethidine; Humans; Male; Middle Aged; Pain; Physical Therapy Moda | 1987 |
Cutaneous hyperalgesia: contributions of the peripheral and central nervous systems to the increase in pain sensitivity after injury.
Topics: Animals; Burns; Capsaicin; Central Nervous System; Guanethidine; Hyperalgesia; Hyperesthesia; Male; | 1987 |
Effects of regional intravenous guanethidine block in posttraumatic cold intolerance in hand amputees.
Topics: Adult; Amputation Stumps; Amputation, Traumatic; Autonomic Nerve Block; Cold Temperature; Female; Fi | 1985 |
Analgesic activity of some sympathetic drugs and their effect on morphine analgesia in rabbits.
Topics: Adrenergic alpha-Agonists; Adrenergic alpha-Antagonists; Adrenergic beta-Agonists; Adrenergic beta-A | 1969 |
[Antihypertensive agents].
Topics: Acetazolamide; Antihypertensive Agents; Bis-Trimethylammonium Compounds; Bretylium Compounds; Chlori | 1972 |
Treatment of acute intermittant porphyria.
Topics: Acute Disease; Guanethidine; Humans; Male; Oxprenolol; Pain; Porphyrias | 1973 |
Propulsive gastrointestinal motility related to retroperitoneal irritation. An experimental study in the rat.
Topics: Anesthesia, Local; Animals; Autonomic Nerve Block; Blood; Chromium Isotopes; Digestive System; Gastr | 1968 |
[Therapeutic trials with Ismelin in angio-organopathies].
Topics: Adult; Aged; Arteriosclerosis Obliterans; Arteritis; Blood Pressure; Body Temperature; Female; Guane | 1969 |