Page last updated: 2024-11-05

tranexamic acid and Pain

tranexamic acid has been researched along with Pain in 20 studies

Tranexamic Acid: Antifibrinolytic hemostatic used in severe hemorrhage.

Pain: An unpleasant sensation induced by noxious stimuli which are detected by NERVE ENDINGS of NOCICEPTIVE NEURONS.

Research Excerpts

ExcerptRelevanceReference
"Administration of intravenous tranexamic acid significantly improved swelling, pain and lower ROM restriction in patients undergoing ACL reconstruction."9.69The effect of tranexamic acid injection during anterior cruciate ligament reconstruction surgery on postoperative bleeding, pain and swelling. ( Akbari-Aghdam, H; Entezari, R; Mousavi, H, 2023)
"Multiple doses of dexamethasone and tranexamic acid can inhibit postoperative inflammation and reduce fibrinolysis and perioperative blood loss in total knee arthroplasty."9.69Tourniquets can further reduce perioperative blood loss in patients on dexamethasone and tranexamic acid during cemented total knee arthritis: a single-center, double-blind, randomized controlled trial. ( Huang, Q; Jiang, W; Liu, M; Pei, F; Wang, X; Xie, J; Xu, H; Zhou, R; Zhou, Z, 2023)
" We included controlled trials, either randomized (RCT) or non-randomized studies of intervention (NRSI) comparing the effects of intravenous tranexamic acid (TXA) treatment with placebo/no treatment on postoperative blood loss, pain VAS score, elbow ROM, and complications, in patients who underwent open or closed elbow arthrolysis surgery."9.41Does tranexamic acid diminish hemorrhage and pain in open elbow arthrolysis? a systematic review and meta-analysis. ( Daliri, M; Ebrahimzadeh, MH; Khayami, A; Moradi, A; Nejat, MH; Sadeghi, M, 2023)
"We recently reported that tranexamic acid (TXA) evokes pain in rats by inhibiting γ-aminobutyric acid and glycine receptors on neurons in the spinal dorsal horn."9.24Administration of tranexamic acid to patients undergoing surgery for adolescent idiopathic scoliosis evokes pain and increases the infusion rate of remifentanil during the surgery. ( Endo, N; Kohno, T; Ohashi, M; Ohashi, N, 2017)
"Tranexamic acid reduces blood loss in patients with bleeding diatheses and is used in a number of gynaecologic and non-gynaecologic conditions CASE: We discuss the case of a 27-year-old woman with type 1 von Willebrand disease, who presented with a two-year history of severe mittelschmerz secondary to recurrent hemorrhagic cysts."7.96Use of Tranexamic Acid for the Treatment of Mittelschmerz in a Patient with Type 1 von Willebrand Disease and Recurrent Hemorrhagic Cysts. ( Balayla, J; Gil, Y; Lasry, A, 2020)
"The hemostatic effect of tranexamic acid (TXA) combined with carbazochrome sodium sulfonate (CSS) in total hip arthroplasty (THA) has not been determined."7.11Effects of carbazochrome sodium sulfonate combined with tranexamic acid on hemostasis and inflammation during perioperative period of total hip arthroplasty: A randomized controlled trial. ( Kang, P; Liu, Z; Luo, Y; Releken, Y; Yang, D; Yue, Y, 2022)
"Administration of intravenous tranexamic acid significantly improved swelling, pain and lower ROM restriction in patients undergoing ACL reconstruction."5.69The effect of tranexamic acid injection during anterior cruciate ligament reconstruction surgery on postoperative bleeding, pain and swelling. ( Akbari-Aghdam, H; Entezari, R; Mousavi, H, 2023)
"Multiple doses of dexamethasone and tranexamic acid can inhibit postoperative inflammation and reduce fibrinolysis and perioperative blood loss in total knee arthroplasty."5.69Tourniquets can further reduce perioperative blood loss in patients on dexamethasone and tranexamic acid during cemented total knee arthritis: a single-center, double-blind, randomized controlled trial. ( Huang, Q; Jiang, W; Liu, M; Pei, F; Wang, X; Xie, J; Xu, H; Zhou, R; Zhou, Z, 2023)
"Tranexamic acid (TXA) is an antifibrinolytic agent widely used to reduce blood loss during surgery."5.42Tranexamic acid evokes pain by modulating neuronal excitability in the spinal dorsal horn. ( Baba, H; Kamiya, Y; Kohno, T; Ohashi, M; Ohashi, N; Sasaki, M, 2015)
" We included controlled trials, either randomized (RCT) or non-randomized studies of intervention (NRSI) comparing the effects of intravenous tranexamic acid (TXA) treatment with placebo/no treatment on postoperative blood loss, pain VAS score, elbow ROM, and complications, in patients who underwent open or closed elbow arthrolysis surgery."5.41Does tranexamic acid diminish hemorrhage and pain in open elbow arthrolysis? a systematic review and meta-analysis. ( Daliri, M; Ebrahimzadeh, MH; Khayami, A; Moradi, A; Nejat, MH; Sadeghi, M, 2023)
"We recently reported that tranexamic acid (TXA) evokes pain in rats by inhibiting γ-aminobutyric acid and glycine receptors on neurons in the spinal dorsal horn."5.24Administration of tranexamic acid to patients undergoing surgery for adolescent idiopathic scoliosis evokes pain and increases the infusion rate of remifentanil during the surgery. ( Endo, N; Kohno, T; Ohashi, M; Ohashi, N, 2017)
"Tranexamic acid reduces blood loss in patients with bleeding diatheses and is used in a number of gynaecologic and non-gynaecologic conditions CASE: We discuss the case of a 27-year-old woman with type 1 von Willebrand disease, who presented with a two-year history of severe mittelschmerz secondary to recurrent hemorrhagic cysts."3.96Use of Tranexamic Acid for the Treatment of Mittelschmerz in a Patient with Type 1 von Willebrand Disease and Recurrent Hemorrhagic Cysts. ( Balayla, J; Gil, Y; Lasry, A, 2020)
"The hemostatic effect of tranexamic acid (TXA) combined with carbazochrome sodium sulfonate (CSS) in total hip arthroplasty (THA) has not been determined."3.11Effects of carbazochrome sodium sulfonate combined with tranexamic acid on hemostasis and inflammation during perioperative period of total hip arthroplasty: A randomized controlled trial. ( Kang, P; Liu, Z; Luo, Y; Releken, Y; Yang, D; Yue, Y, 2022)
"To evaluate the efficacy and safety of dexamethasone (DEXA) combined with tranexamic acid (TXA) in the perioperative period of total hip arthroplasty."3.11Application of dexamethasone combined with tranexamic acid in perioperative period of total hip arthroplasty. ( Huang, W; Huang, X; Li, F; Liu, W; Wang, C; Yin, D, 2022)
"Tranexamic acid (TXA) has been administrated in many orthopaedic surgical procedures to decrease perioperative and postsurgical bleeding."1.62Editorial Commentary: Tranexamic Acid Is Beneficial in the Very Early Postoperative Period in Anterior Cruciate Ligament Reconstruction Patients. ( Chen, KH; Chiang, ER; Ma, HL, 2021)
"Tranexamic acid (TXA) is an antifibrinolytic agent widely used to reduce blood loss during surgery."1.42Tranexamic acid evokes pain by modulating neuronal excitability in the spinal dorsal horn. ( Baba, H; Kamiya, Y; Kohno, T; Ohashi, M; Ohashi, N; Sasaki, M, 2015)
"Cervical cancer is the commonest cancer affecting women in Malawi, which has the highest rate of this disease in the world."1.42A review of patients with advanced cervical cancer presenting to palliative care services at Queen Elizabeth Central Hospital in Blantyre, Malawi. ( Bates, MJ; Mijoya, A, 2015)

Research

Studies (20)

TimeframeStudies, this research(%)All Research%
pre-19900 (0.00)18.7374
1990's0 (0.00)18.2507
2000's0 (0.00)29.6817
2010's4 (20.00)24.3611
2020's16 (80.00)2.80

Authors

AuthorsStudies
Luo, Y1
Releken, Y1
Yang, D1
Yue, Y1
Liu, Z1
Kang, P1
Jiang, W2
Fu, M1
Dong, W1
Zhou, N1
Shen, J1
Zhang, X1
Hao, J1
Greimel, F1
Maderbacher, G1
Mousavi, H1
Akbari-Aghdam, H1
Entezari, R1
Li, F1
Huang, X1
Liu, W1
Huang, W1
Wang, C1
Yin, D1
Chen, Z3
Bains, SS3
Hameed, D3
Dubin, JA3
Stern, JM3
Mont, MA3
Wang, X1
Xu, H1
Liu, M1
Xie, J1
Huang, Q1
Zhou, R1
Zhou, Z1
Pei, F1
Amodeo, G1
Cerbelli, E1
Pisano, A1
Minieri, L1
Scopelliti, D1
Huang, Z1
Dong, H1
Ye, C1
Zou, Z1
Wan, W1
Nejat, MH1
Khayami, A1
Daliri, M1
Ebrahimzadeh, MH1
Sadeghi, M1
Moradi, A1
Cassiano, D1
Esposito, ACC1
Hassun, K1
Bagatin, E1
Lima, MMDA1
Lima, EVA1
Miot, LDB1
Miot, HA1
Lasry, A1
Gil, Y1
Balayla, J1
Cui, H1
Yu, S1
Ruan, J1
Sun, Z1
Li, J1
Chen, S1
Fan, C1
Chiang, ER1
Chen, KH1
Ma, HL1
Zhang, S1
Dai, Y1
Xiao, C1
Alaia, MJ1
Fried, JW1
Bloom, DA1
Hurley, ET1
Popovic, J1
Baron, SL1
Campbell, KA1
Strauss, EJ1
Jazrawi, LM1
Ohashi, N2
Sasaki, M1
Ohashi, M2
Kamiya, Y1
Baba, H1
Kohno, T2
Bates, MJ1
Mijoya, A1
Endo, N1
Skovgaard, C1
Holm, B1
Troelsen, A1
Lunn, TH1
Gaarn-Larsen, L1
Kehlet, H1
Husted, H1

Reviews

2 reviews available for tranexamic acid and Pain

ArticleYear
[Perioperative management in fast-track arthroplasty].
    Der Orthopade, 2022, Volume: 51, Issue:5

    Topics: Arthroplasty, Replacement, Hip; Arthroplasty, Replacement, Knee; Humans; Length of Stay; Pain; Pain

2022
Does tranexamic acid diminish hemorrhage and pain in open elbow arthrolysis? a systematic review and meta-analysis.
    BMC musculoskeletal disorders, 2023, Oct-06, Volume: 24, Issue:1

    Topics: Antifibrinolytic Agents; Blood Loss, Surgical; Elbow; Humans; Pain; Postoperative Hemorrhage; Tranex

2023

Trials

11 trials available for tranexamic acid and Pain

ArticleYear
Effects of carbazochrome sodium sulfonate combined with tranexamic acid on hemostasis and inflammation during perioperative period of total hip arthroplasty: A randomized controlled trial.
    Orthopaedics & traumatology, surgery & research : OTSR, 2022, Volume: 108, Issue:1

    Topics: Adrenochrome; Antifibrinolytic Agents; Arthroplasty, Replacement, Hip; Blood Loss, Surgical; Hemosta

2022
Use of a Multifunctional Cocktail for Postoperative Bleeding and Pain Control in Spinal Fusion: A Randomized, Double-blind, Controlled Trial.
    Spine, 2022, 09-15, Volume: 47, Issue:18

    Topics: Analgesics, Opioid; Blood Loss, Surgical; Double-Blind Method; Hemoglobins; Humans; Pain; Pain Manag

2022
The effect of tranexamic acid injection during anterior cruciate ligament reconstruction surgery on postoperative bleeding, pain and swelling.
    European journal of orthopaedic surgery & traumatology : orthopedie traumatologie, 2023, Volume: 33, Issue:3

    Topics: Anterior Cruciate Ligament Injuries; Anterior Cruciate Ligament Reconstruction; Humans; Knee Joint;

2023
Application of dexamethasone combined with tranexamic acid in perioperative period of total hip arthroplasty.
    Medicine, 2022, Oct-21, Volume: 101, Issue:42

    Topics: Analgesics; Antiemetics; Arthroplasty, Replacement, Hip; C-Reactive Protein; Dexamethasone; Drug The

2022
Tourniquets can further reduce perioperative blood loss in patients on dexamethasone and tranexamic acid during cemented total knee arthritis: a single-center, double-blind, randomized controlled trial.
    Journal of orthopaedics and traumatology : official journal of the Italian Society of Orthopaedics and Traumatology, 2023, Apr-29, Volume: 24, Issue:1

    Topics: Albumins; Antifibrinolytic Agents; Arthritis; Blood Loss, Surgical; Dexamethasone; Humans; Inflammat

2023
The Influence of Bolus of Methylprednisolone on Postorthognathic Surgery Symptoms: A Controlled Clinical Trial.
    The Journal of craniofacial surgery, 2023, Oct-01, Volume: 34, Issue:7

    Topics: Betamethasone; Humans; Methylprednisolone; Osteotomy; Pain; Tranexamic Acid

2023
Clinical utilization of methylprednisolone in conjunction with tranexamic acid for accelerated rehabilitation in total hip arthroplasty.
    Journal of orthopaedic surgery and research, 2023, Oct-04, Volume: 18, Issue:1

    Topics: Antifibrinolytic Agents; Arthroplasty, Replacement, Hip; Blood Loss, Surgical; Humans; Methylprednis

2023
Efficacy and safety of microneedling and oral tranexamic acid in the treatment of facial melasma in women: An open, evaluator-blinded, randomized clinical trial.
    Journal of the American Academy of Dermatology, 2020, Volume: 83, Issue:4

    Topics: Adult; Aged; Alopecia; Combined Modality Therapy; Dry Needling; Female; Herpes Simplex; Humans; Mela

2020
Intravenous tranexamic acid reduce postoperative drainage and pain after open elbow arthrolysis: a randomized controlled trial.
    Journal of shoulder and elbow surgery, 2021, Volume: 30, Issue:8

    Topics: Administration, Intravenous; Antifibrinolytic Agents; Blood Loss, Surgical; Drainage; Elbow; Humans;

2021
Administration of tranexamic acid to patients undergoing surgery for adolescent idiopathic scoliosis evokes pain and increases the infusion rate of remifentanil during the surgery.
    PloS one, 2017, Volume: 12, Issue:3

    Topics: Adolescent; Animals; Blood Loss, Surgical; Female; Humans; Male; Nociception; Pain; Rats; Scoliosis;

2017
No effect of fibrin sealant on drain output or functional recovery following simultaneous bilateral total knee arthroplasty: a randomized, double-blind, placebo-controlled study.
    Acta orthopaedica, 2013, Volume: 84, Issue:2

    Topics: Adult; Aged; Aged, 80 and over; Antifibrinolytic Agents; Arthroplasty, Replacement, Knee; Double-Bli

2013

Other Studies

7 other studies available for tranexamic acid and Pain

ArticleYear
Robust Randomized Controlled Data Is Lacking in Total Joint Arthroplasty.
    The journal of knee surgery, 2022, Volume: 35, Issue:14

    Topics: Arthroplasty, Replacement, Hip; Arthroplasty, Replacement, Knee; Follow-Up Studies; Humans; Pain; Tr

2022
Robust Randomized Controlled Data Is Lacking in Total Joint Arthroplasty.
    The journal of knee surgery, 2022, Volume: 35, Issue:14

    Topics: Arthroplasty, Replacement, Hip; Arthroplasty, Replacement, Knee; Follow-Up Studies; Humans; Pain; Tr

2022
Robust Randomized Controlled Data Is Lacking in Total Joint Arthroplasty.
    The journal of knee surgery, 2022, Volume: 35, Issue:14

    Topics: Arthroplasty, Replacement, Hip; Arthroplasty, Replacement, Knee; Follow-Up Studies; Humans; Pain; Tr

2022
Robust Randomized Controlled Data Is Lacking in Total Joint Arthroplasty.
    The journal of knee surgery, 2022, Volume: 35, Issue:14

    Topics: Arthroplasty, Replacement, Hip; Arthroplasty, Replacement, Knee; Follow-Up Studies; Humans; Pain; Tr

2022
Robust Randomized Controlled Data Is Lacking in Total Joint Arthroplasty.
    The journal of knee surgery, 2022, Volume: 35, Issue:14

    Topics: Arthroplasty, Replacement, Hip; Arthroplasty, Replacement, Knee; Follow-Up Studies; Humans; Pain; Tr

2022
Robust Randomized Controlled Data Is Lacking in Total Joint Arthroplasty.
    The journal of knee surgery, 2022, Volume: 35, Issue:14

    Topics: Arthroplasty, Replacement, Hip; Arthroplasty, Replacement, Knee; Follow-Up Studies; Humans; Pain; Tr

2022
Robust Randomized Controlled Data Is Lacking in Total Joint Arthroplasty.
    The journal of knee surgery, 2022, Volume: 35, Issue:14

    Topics: Arthroplasty, Replacement, Hip; Arthroplasty, Replacement, Knee; Follow-Up Studies; Humans; Pain; Tr

2022
Robust Randomized Controlled Data Is Lacking in Total Joint Arthroplasty.
    The journal of knee surgery, 2022, Volume: 35, Issue:14

    Topics: Arthroplasty, Replacement, Hip; Arthroplasty, Replacement, Knee; Follow-Up Studies; Humans; Pain; Tr

2022
Robust Randomized Controlled Data Is Lacking in Total Joint Arthroplasty.
    The journal of knee surgery, 2022, Volume: 35, Issue:14

    Topics: Arthroplasty, Replacement, Hip; Arthroplasty, Replacement, Knee; Follow-Up Studies; Humans; Pain; Tr

2022
Use of Tranexamic Acid for the Treatment of Mittelschmerz in a Patient with Type 1 von Willebrand Disease and Recurrent Hemorrhagic Cysts.
    Journal of obstetrics and gynaecology Canada : JOGC = Journal d'obstetrique et gynecologie du Canada : JOGC, 2020, Volume: 42, Issue:11

    Topics: Adult; Cysts; Female; Hemorrhage; Humans; Ovulation; Pain; Pelvic Pain; Tranexamic Acid; Treatment O

2020
Editorial Commentary: Tranexamic Acid Is Beneficial in the Very Early Postoperative Period in Anterior Cruciate Ligament Reconstruction Patients.
    Arthroscopy : the journal of arthroscopic & related surgery : official publication of the Arthroscopy Association of North America and the International Arthroscopy Association, 2021, Volume: 37, Issue:6

    Topics: Anterior Cruciate Ligament Reconstruction; Humans; Pain; Postoperative Period; Tranexamic Acid

2021
Regarding "Tranexamic Acid Has No Effect on Postoperative Hemarthrosis or Pain Control After Anterior Cruciate Ligament Reconstruction Using Bone-Patellar Tendon-Bone Autograft: A Double-Blind, Randomized, Controlled Trial".
    Arthroscopy : the journal of arthroscopic & related surgery : official publication of the Arthroscopy Association of North America and the International Arthroscopy Association, 2021, Volume: 37, Issue:7

    Topics: Anterior Cruciate Ligament Reconstruction; Autografts; Bone-Patellar Tendon-Bone Grafting; Double-Bl

2021
Author Reply to "Regarding 'Tranexamic Acid Has No Effect on Postoperative Hemarthrosis or Pain Control After Anterior Cruciate Ligament Reconstruction Using Bone-Patellar Tendon-Bone Autograft: A Double-Blind, Randomized, Controlled Trial'".
    Arthroscopy : the journal of arthroscopic & related surgery : official publication of the Arthroscopy Association of North America and the International Arthroscopy Association, 2021, Volume: 37, Issue:7

    Topics: Anterior Cruciate Ligament Reconstruction; Autografts; Bone-Patellar Tendon-Bone Grafting; Double-Bl

2021
Tranexamic acid evokes pain by modulating neuronal excitability in the spinal dorsal horn.
    Scientific reports, 2015, Aug-21, Volume: 5

    Topics: Animals; Behavior, Animal; Biomarkers; Enzyme Activation; Extracellular Signal-Regulated MAP Kinases

2015
A review of patients with advanced cervical cancer presenting to palliative care services at Queen Elizabeth Central Hospital in Blantyre, Malawi.
    Malawi medical journal : the journal of Medical Association of Malawi, 2015, Volume: 27, Issue:3

    Topics: Adult; Age Distribution; Anti-HIV Agents; Antifibrinolytic Agents; Female; HIV Infections; Humans; M

2015