| Assay ID | Title | Year | Journal | Article |
|---|
| AID550777 | Inhibition of [3H]norepinephrine reuptake at human NET expressed in MDCK cells by scintillation counting | 2011 | Bioorganic & medicinal chemistry, Jan-01, Volume: 19, Issue:1
| Synthesis and pharmacological evaluation of 4-(3,4-dichlorophenyl)-N-methyl-1,2,3,4-tetrahydronaphthalenyl amines as triple reuptake inhibitors. |
| AID550776 | Inhibition of [3H]serotonin reuptake at human SERT expressed in HEK293 cells by scintillation counting | 2011 | Bioorganic & medicinal chemistry, Jan-01, Volume: 19, Issue:1
| Synthesis and pharmacological evaluation of 4-(3,4-dichlorophenyl)-N-methyl-1,2,3,4-tetrahydronaphthalenyl amines as triple reuptake inhibitors. |
| AID504085 | Potentiation of 5-hydroxytryptamine-induced serotonin syndrome like behavior in po dosed mouse | 2010 | Bioorganic & medicinal chemistry letters, Sep-15, Volume: 20, Issue:18
| Synthesis and pharmacological evaluation of 3-aryl-3-azolylpropan-1-amines as selective triple serotonin/norepinephrine/dopamine reuptake inhibitors. |
| AID345386 | Inhibition of SERT | 2008 | Bioorganic & medicinal chemistry letters, Dec-01, Volume: 18, Issue:23
| Novel 3,3-disubstituted pyrrolidines as selective triple serotonin/norepinephrine/dopamine reuptake inhibitors. |
| AID504090 | Antidepressant activity in mouse assessed as change in locomotion at 30 mg/kg, po | 2010 | Bioorganic & medicinal chemistry letters, Sep-15, Volume: 20, Issue:18
| Synthesis and pharmacological evaluation of 3-aryl-3-azolylpropan-1-amines as selective triple serotonin/norepinephrine/dopamine reuptake inhibitors. |
| AID504070 | Antidepressant activity in po dosed mouse assessed as reduction of mobility time by forced swimming test | 2010 | Bioorganic & medicinal chemistry letters, Sep-15, Volume: 20, Issue:18
| Synthesis and pharmacological evaluation of 3-aryl-3-azolylpropan-1-amines as selective triple serotonin/norepinephrine/dopamine reuptake inhibitors. |
| AID1388103 | In vivo receptor occupancy at DAT in ip dosed rat brain measured 60 mins post dose | 2018 | Journal of medicinal chemistry, 03-22, Volume: 61, Issue:6
| Triple Reuptake Inhibitors as Potential Therapeutics for Depression and Other Disorders: Design Paradigm and Developmental Challenges. |
| AID504077 | Inhibition of serotonin reuptake at human SERT expressed in HEK293 cells | 2010 | Bioorganic & medicinal chemistry letters, Sep-15, Volume: 20, Issue:18
| Synthesis and pharmacological evaluation of 3-aryl-3-azolylpropan-1-amines as selective triple serotonin/norepinephrine/dopamine reuptake inhibitors. |
| AID345390 | Inhibition of CYP2D6 by fluorescence based assay | 2008 | Bioorganic & medicinal chemistry letters, Dec-01, Volume: 18, Issue:23
| Novel 3,3-disubstituted pyrrolidines as selective triple serotonin/norepinephrine/dopamine reuptake inhibitors. |
| AID343842 | Inhibition of norepinephrine uptake at human cloned NET | 2008 | Bioorganic & medicinal chemistry letters, Jul-01, Volume: 18, Issue:13
| Studies on the structure-activity relationship of bicifadine analogs as monoamine transporter inhibitors. |
| AID345391 | Ratio of permeability from apical to basolateral over basolateral to apical side in human Caco-2 cells at 10 uM after 21 days | 2008 | Bioorganic & medicinal chemistry letters, Dec-01, Volume: 18, Issue:23
| Novel 3,3-disubstituted pyrrolidines as selective triple serotonin/norepinephrine/dopamine reuptake inhibitors. |
| AID550778 | Inhibition of [3H]dopamine reuptake at human DAT expressed in CHOK1 cells by scintillation counting | 2011 | Bioorganic & medicinal chemistry, Jan-01, Volume: 19, Issue:1
| Synthesis and pharmacological evaluation of 4-(3,4-dichlorophenyl)-N-methyl-1,2,3,4-tetrahydronaphthalenyl amines as triple reuptake inhibitors. |
| AID504084 | Potentiation of 5-hydroxytryptamine-induced serotonin syndrome like behavior in mouse at 30 mg/kg, po | 2010 | Bioorganic & medicinal chemistry letters, Sep-15, Volume: 20, Issue:18
| Synthesis and pharmacological evaluation of 3-aryl-3-azolylpropan-1-amines as selective triple serotonin/norepinephrine/dopamine reuptake inhibitors. |
| AID504094 | Antidepressant activity in mouse assessed as reduction of mobility time by forced swimming test at 10 mg/kg, po | 2010 | Bioorganic & medicinal chemistry letters, Sep-15, Volume: 20, Issue:18
| Synthesis and pharmacological evaluation of 3-aryl-3-azolylpropan-1-amines as selective triple serotonin/norepinephrine/dopamine reuptake inhibitors. |
| AID345396 | Permeability from apical to basolateral in human Caco-2 cells at 10 uM after 21 days | 2008 | Bioorganic & medicinal chemistry letters, Dec-01, Volume: 18, Issue:23
| Novel 3,3-disubstituted pyrrolidines as selective triple serotonin/norepinephrine/dopamine reuptake inhibitors. |
| AID504092 | Antidepressant activity in mouse assessed as change in locomotion at 90 mg/kg, po | 2010 | Bioorganic & medicinal chemistry letters, Sep-15, Volume: 20, Issue:18
| Synthesis and pharmacological evaluation of 3-aryl-3-azolylpropan-1-amines as selective triple serotonin/norepinephrine/dopamine reuptake inhibitors. |
| AID1181449 | Stability in human liver microsomes assessed as compound remaining at 1 uM after 30 mins by LC/MS analysis | 2014 | Bioorganic & medicinal chemistry letters, Aug-01, Volume: 24, Issue:15
| Synthesis and biological evaluation of 3-phenethylazetidine derivatives as triple reuptake inhibitors. |
| AID343843 | Inhibition of serotonin uptake at human cloned SERT | 2008 | Bioorganic & medicinal chemistry letters, Jul-01, Volume: 18, Issue:13
| Studies on the structure-activity relationship of bicifadine analogs as monoamine transporter inhibitors. |
| AID504088 | Anxiolytic activity in mouse assessed as inhibition of marble buried at 30 mg/kg, ip by marble burying test | 2010 | Bioorganic & medicinal chemistry letters, Sep-15, Volume: 20, Issue:18
| Synthesis and pharmacological evaluation of 3-aryl-3-azolylpropan-1-amines as selective triple serotonin/norepinephrine/dopamine reuptake inhibitors. |
| AID1181452 | Inhibition of recombinant human CYP2C9 preincubated for 5 mins before fluorescent substrate addition by fluorescence assay | 2014 | Bioorganic & medicinal chemistry letters, Aug-01, Volume: 24, Issue:15
| Synthesis and biological evaluation of 3-phenethylazetidine derivatives as triple reuptake inhibitors. |
| AID343841 | Inhibition of dopamine uptake at cloned DAT in rat brain synaptosome | 2008 | Bioorganic & medicinal chemistry letters, Jul-01, Volume: 18, Issue:13
| Studies on the structure-activity relationship of bicifadine analogs as monoamine transporter inhibitors. |
| AID345389 | Stability in human liver microsomes assessed as intrinsic clearance | 2008 | Bioorganic & medicinal chemistry letters, Dec-01, Volume: 18, Issue:23
| Novel 3,3-disubstituted pyrrolidines as selective triple serotonin/norepinephrine/dopamine reuptake inhibitors. |
| AID1388102 | In vivo receptor occupancy at NET in ip dosed rat brain measured 60 mins post dose | 2018 | Journal of medicinal chemistry, 03-22, Volume: 61, Issue:6
| Triple Reuptake Inhibitors as Potential Therapeutics for Depression and Other Disorders: Design Paradigm and Developmental Challenges. |
| AID504076 | Inhibition of dopamine reuptake at human dopamine transporter expressed in CHO cells | 2010 | Bioorganic & medicinal chemistry letters, Sep-15, Volume: 20, Issue:18
| Synthesis and pharmacological evaluation of 3-aryl-3-azolylpropan-1-amines as selective triple serotonin/norepinephrine/dopamine reuptake inhibitors. |
| AID504091 | Antidepressant activity in mouse assessed as change in locomotion at 60 mg/kg, po | 2010 | Bioorganic & medicinal chemistry letters, Sep-15, Volume: 20, Issue:18
| Synthesis and pharmacological evaluation of 3-aryl-3-azolylpropan-1-amines as selective triple serotonin/norepinephrine/dopamine reuptake inhibitors. |
| AID1388142 | Reversal of ptosis in po dosed mouse measured at 3rd, 6th and 23rd hr followed by second administration on 24th hr administered as 4 injections for 4 consecutive days measured from day 3 to 10 days post last dose | 2018 | Journal of medicinal chemistry, 03-22, Volume: 61, Issue:6
| Triple Reuptake Inhibitors as Potential Therapeutics for Depression and Other Disorders: Design Paradigm and Developmental Challenges. |
| AID1388100 | Binding affinity to DAT (unknown origin) | 2018 | Journal of medicinal chemistry, 03-22, Volume: 61, Issue:6
| Triple Reuptake Inhibitors as Potential Therapeutics for Depression and Other Disorders: Design Paradigm and Developmental Challenges. |
| AID343840 | Inhibition of serotonin uptake at SERT in rat brain synaptosome | 2008 | Bioorganic & medicinal chemistry letters, Jul-01, Volume: 18, Issue:13
| Studies on the structure-activity relationship of bicifadine analogs as monoamine transporter inhibitors. |
| AID504078 | Inhibition of norepinephrine reuptake at human NET expressed in MDCK cells | 2010 | Bioorganic & medicinal chemistry letters, Sep-15, Volume: 20, Issue:18
| Synthesis and pharmacological evaluation of 3-aryl-3-azolylpropan-1-amines as selective triple serotonin/norepinephrine/dopamine reuptake inhibitors. |
| AID343839 | Inhibition of norepinephrine uptake at NET in rat brain synaptosome | 2008 | Bioorganic & medicinal chemistry letters, Jul-01, Volume: 18, Issue:13
| Studies on the structure-activity relationship of bicifadine analogs as monoamine transporter inhibitors. |
| AID345387 | Inhibition of NET | 2008 | Bioorganic & medicinal chemistry letters, Dec-01, Volume: 18, Issue:23
| Novel 3,3-disubstituted pyrrolidines as selective triple serotonin/norepinephrine/dopamine reuptake inhibitors. |
| AID1388099 | Binding affinity to NET (unknown origin) | 2018 | Journal of medicinal chemistry, 03-22, Volume: 61, Issue:6
| Triple Reuptake Inhibitors as Potential Therapeutics for Depression and Other Disorders: Design Paradigm and Developmental Challenges. |
| AID1181447 | Inhibition of norepinephrine reuptake at human NET expressed in HEK293 cells after 15 mins by fluorescence neurotransmitter transporter assay | 2014 | Bioorganic & medicinal chemistry letters, Aug-01, Volume: 24, Issue:15
| Synthesis and biological evaluation of 3-phenethylazetidine derivatives as triple reuptake inhibitors. |
| AID1388141 | Reversal of motor depression in po dosed mouse measured at 3rd, 6th and 23rd hr followed by second administration on 24th hr administered as 4 injections for 4 consecutive days measured from day 3 to 10 days post last dose | 2018 | Journal of medicinal chemistry, 03-22, Volume: 61, Issue:6
| Triple Reuptake Inhibitors as Potential Therapeutics for Depression and Other Disorders: Design Paradigm and Developmental Challenges. |
| AID1388101 | In vivo receptor occupancy at SERT in ip dosed rat brain measured 60 mins post dose | 2018 | Journal of medicinal chemistry, 03-22, Volume: 61, Issue:6
| Triple Reuptake Inhibitors as Potential Therapeutics for Depression and Other Disorders: Design Paradigm and Developmental Challenges. |
| AID1181453 | Inhibition of recombinant human CYP3A4 preincubated for 5 mins before fluorescent substrate addition by fluorescence assay | 2014 | Bioorganic & medicinal chemistry letters, Aug-01, Volume: 24, Issue:15
| Synthesis and biological evaluation of 3-phenethylazetidine derivatives as triple reuptake inhibitors. |
| AID345388 | Inhibition of DAT | 2008 | Bioorganic & medicinal chemistry letters, Dec-01, Volume: 18, Issue:23
| Novel 3,3-disubstituted pyrrolidines as selective triple serotonin/norepinephrine/dopamine reuptake inhibitors. |
| AID1388098 | Binding affinity to SERT (unknown origin) | 2018 | Journal of medicinal chemistry, 03-22, Volume: 61, Issue:6
| Triple Reuptake Inhibitors as Potential Therapeutics for Depression and Other Disorders: Design Paradigm and Developmental Challenges. |
| AID345392 | Inhibition of human ERG expressed in CHO cells | 2008 | Bioorganic & medicinal chemistry letters, Dec-01, Volume: 18, Issue:23
| Novel 3,3-disubstituted pyrrolidines as selective triple serotonin/norepinephrine/dopamine reuptake inhibitors. |
| AID504087 | Analgesic activity in mouse assessed as reduction of acetic acid-induced writhing at 30 mg/kg, po | 2010 | Bioorganic & medicinal chemistry letters, Sep-15, Volume: 20, Issue:18
| Synthesis and pharmacological evaluation of 3-aryl-3-azolylpropan-1-amines as selective triple serotonin/norepinephrine/dopamine reuptake inhibitors. |
| AID504098 | Antidepressant activity in mouse assessed as reduction of mobility time at 5 mg/kg, po by tail suspension test | 2010 | Bioorganic & medicinal chemistry letters, Sep-15, Volume: 20, Issue:18
| Synthesis and pharmacological evaluation of 3-aryl-3-azolylpropan-1-amines as selective triple serotonin/norepinephrine/dopamine reuptake inhibitors. |
| AID1181448 | Inhibition of DA reuptake at human DAT expressed in HEK293 cells after 15 mins by fluorescence neurotransmitter transporter assay | 2014 | Bioorganic & medicinal chemistry letters, Aug-01, Volume: 24, Issue:15
| Synthesis and biological evaluation of 3-phenethylazetidine derivatives as triple reuptake inhibitors. |
| AID345395 | Permeability from basolateral to apical side in human Caco-2 cells at 10 uM after 21 days | 2008 | Bioorganic & medicinal chemistry letters, Dec-01, Volume: 18, Issue:23
| Novel 3,3-disubstituted pyrrolidines as selective triple serotonin/norepinephrine/dopamine reuptake inhibitors. |
| AID1181454 | Inhibition of recombinant human CYP2C19 preincubated for 5 mins before fluorescent substrate addition by fluorescence assay | 2014 | Bioorganic & medicinal chemistry letters, Aug-01, Volume: 24, Issue:15
| Synthesis and biological evaluation of 3-phenethylazetidine derivatives as triple reuptake inhibitors. |
| AID1181446 | Inhibition of serotonin reuptake at human SERT expressed in HEK293 cells after 15 mins by fluorescence neurotransmitter transporter assay | 2014 | Bioorganic & medicinal chemistry letters, Aug-01, Volume: 24, Issue:15
| Synthesis and biological evaluation of 3-phenethylazetidine derivatives as triple reuptake inhibitors. |
| AID343844 | Inhibition of dopamine uptake at human cloned DAT | 2008 | Bioorganic & medicinal chemistry letters, Jul-01, Volume: 18, Issue:13
| Studies on the structure-activity relationship of bicifadine analogs as monoamine transporter inhibitors. |
| AID1181450 | Inhibition of recombinant human CYP1A2 preincubated for 5 mins before fluorescent substrate addition by fluorescence assay | 2014 | Bioorganic & medicinal chemistry letters, Aug-01, Volume: 24, Issue:15
| Synthesis and biological evaluation of 3-phenethylazetidine derivatives as triple reuptake inhibitors. |
| AID504086 | Antidepressant activity in po dosed mouse assessed as reduction of mobility time by tail suspension test | 2010 | Bioorganic & medicinal chemistry letters, Sep-15, Volume: 20, Issue:18
| Synthesis and pharmacological evaluation of 3-aryl-3-azolylpropan-1-amines as selective triple serotonin/norepinephrine/dopamine reuptake inhibitors. |
| AID1181451 | Inhibition of recombinant human CYP2D6 preincubated for 5 mins before fluorescent substrate addition by fluorescence assay | 2014 | Bioorganic & medicinal chemistry letters, Aug-01, Volume: 24, Issue:15
| Synthesis and biological evaluation of 3-phenethylazetidine derivatives as triple reuptake inhibitors. |
| [information is prepared from bioassay data collected from National Library of Medicine (NLM), extracted Dec-2023] |