Page last updated: 2024-10-30

khellin and Pain

khellin has been researched along with Pain in 55 studies

Khellin: A vasodilator that also has bronchodilatory action. It has been employed in the treatment of angina pectoris, in the treatment of asthma, and in conjunction with ultraviolet light A, has been tried in the treatment of vitiligo. (From Martindale, The Extra Pharmacopoeia, 30th ed, p1024)
khellin : A furanochrome in which the basic tricyclic skeleton is substituted at positions 4 and 9 with methoxy groups and at position 7 with a methyl group. A major constituent of the plant Ammi visnaga it is a herbal folk medicine used for various illnesses, its main effect being as a vasodilator.

Pain: An unpleasant sensation induced by noxious stimuli which are detected by NERVE ENDINGS of NOCICEPTIVE NEURONS.

Research Excerpts

ExcerptRelevanceReference
"Keloids are abnormal overgrowth of collagen fibers, and the first-line treatment includes intralesional injection of triamcinolone acetonide (TA), which is associated with pain."9.24A Topical Anesthetic and Lidocaine Mixture for Pain Relief During Keloid Treatment: A Double-Blind, Randomized Controlled Trial. ( Burusapat, C; Usanakornkul, A, 2017)
"This prospective study evaluates an argon gas-based system for the treatment of keloids in a patient population including all Fitzpatrick skin types with a 1-year follow-up."9.19A new argon gas-based device for the treatment of keloid scars with the use of intralesional cryotherapy. ( Bulstra, AE; Niessen, FB; van Leeuwen, MC; van Leeuwen, PA, 2014)
"When comparing with topical lidocaine/prilocaine (EMLA) cream, a 1:1 mixture of 1% lidocaine and epinephrine significantly alleviated pain during and after the corticosteroid injection."8.31Topical Anesthetic versus Lidocaine Mixture for Pain Relief During Keloid Treatment: A Prospective, Split Study. ( Park, TH, 2023)
"The histopathological changes and immunohistochemical studies occurring in keloids in vivo after treatment by intralesional (IL) verapamil are not yet assessed."8.02Intralesional verapamil in the treatment of keloids: A clinical, histopathological, and immunohistochemical study. ( Abou-Taleb, DAE; Badary, DM, 2021)
"Because intralesional injection of triamcinolone acetonide (TA), a widely used for the treatment of keloid, is painful, many patients discontinue treatment."7.75Effect of lidocaine tape on pain during intralesional injection of triamcinolone acetonide for the treatment of keloid. ( Hyakusoku, H; Murakami, M; Tosa, M, 2009)
"We studied the long-term outcome of injection of triamcinolone acetonide into keloid scars in Asian patients."7.73Long-term outcome of intralesional injection of triamcinolone acetonide for the treatment of keloid scars in Asian patients. ( Hata, Y; Igawa, HH; Ito, O; Muneuchi, G; Onodera, M; Suzuki, S, 2006)
"The feasibility of iontophoretic transdermal delivery of tranilast (N-(3,4-dimethoxycinnamoyl) anthranilic acid) for the treatment of keloid and hypertrophic scars was evaluated in hairless rats and humans."7.69Treatment of keloid and hypertrophic scars by iontophoretic transdermal delivery of tranilast. ( Ikuta, Y; Murakami, T; Shigeki, S; Yata, N, 1997)
"Hyperpigmentation was the most irritating side effect of 5-FU that occurred."5.72Comparative efficacy of intralesional 5 flurouracil and intralesional triamcinolone acetonide in localized plaque psoriasis. ( Attwa, E; Essam, R; Khater, MH; Selim, HM, 2022)
"Keloids are abnormal overgrowth of collagen fibers, and the first-line treatment includes intralesional injection of triamcinolone acetonide (TA), which is associated with pain."5.24A Topical Anesthetic and Lidocaine Mixture for Pain Relief During Keloid Treatment: A Double-Blind, Randomized Controlled Trial. ( Burusapat, C; Usanakornkul, A, 2017)
"This prospective study evaluates an argon gas-based system for the treatment of keloids in a patient population including all Fitzpatrick skin types with a 1-year follow-up."5.19A new argon gas-based device for the treatment of keloid scars with the use of intralesional cryotherapy. ( Bulstra, AE; Niessen, FB; van Leeuwen, MC; van Leeuwen, PA, 2014)
"We investigated treatment outcomes of intralesional triamcinolone acetonide (IL TAC) compared with combination IL TAC and cryotherapy, including changes in pruritus, pain, and keloid size."4.31Combination cryotherapy and intralesional corticosteroid versus steroid monotherapy in the treatment of keloids. ( Banner, L; Cohen, AJ; Gleason, L; Lazarevic, B; Malkani, K; Nikbakht, N; Talasila, S; Uitto, J, 2023)
"When comparing with topical lidocaine/prilocaine (EMLA) cream, a 1:1 mixture of 1% lidocaine and epinephrine significantly alleviated pain during and after the corticosteroid injection."4.31Topical Anesthetic versus Lidocaine Mixture for Pain Relief During Keloid Treatment: A Prospective, Split Study. ( Park, TH, 2023)
"The histopathological changes and immunohistochemical studies occurring in keloids in vivo after treatment by intralesional (IL) verapamil are not yet assessed."4.02Intralesional verapamil in the treatment of keloids: A clinical, histopathological, and immunohistochemical study. ( Abou-Taleb, DAE; Badary, DM, 2021)
"After intralesional injection of triamcinolone acetonide, most of the hypertrophic scars and keloids improved in color, thickness, softness, and vascular distribution."3.91Comparative efficacy of intralesional triamcinolone acetonide injection during early and static stage of pathological scarring. ( Ao, M; Fu, Q; Huang, L; Song, H; Tan, J, 2019)
"The authors recruited 40 patients with 58 keloids who were scheduled to undergo intralesional triamcinolone acetonide (TA) injections."3.85Vibration Anesthesia for Pain Reduction During Intralesional Steroid Injection for Keloid Treatment. ( Chung, WS; Hong, JY; Kim, BJ; Kim, MN; Lee, Y; Park, KY, 2017)
"Because intralesional injection of triamcinolone acetonide (TA), a widely used for the treatment of keloid, is painful, many patients discontinue treatment."3.75Effect of lidocaine tape on pain during intralesional injection of triamcinolone acetonide for the treatment of keloid. ( Hyakusoku, H; Murakami, M; Tosa, M, 2009)
"We studied the long-term outcome of injection of triamcinolone acetonide into keloid scars in Asian patients."3.73Long-term outcome of intralesional injection of triamcinolone acetonide for the treatment of keloid scars in Asian patients. ( Hata, Y; Igawa, HH; Ito, O; Muneuchi, G; Onodera, M; Suzuki, S, 2006)
"Intralesional injection of triamcinolone acetonide (TA) for the treatment of keloid is painful, and lidocaine-mixed preparations are much the same."3.70Pain-free intralesional injection of triamcinolone for the treatment of keloid. ( Ono, N, 1999)
"The feasibility of iontophoretic transdermal delivery of tranilast (N-(3,4-dimethoxycinnamoyl) anthranilic acid) for the treatment of keloid and hypertrophic scars was evaluated in hairless rats and humans."3.69Treatment of keloid and hypertrophic scars by iontophoretic transdermal delivery of tranilast. ( Ikuta, Y; Murakami, T; Shigeki, S; Yata, N, 1997)
"Cryoanesthesia is ideally intended to cool only the epidermis during treatment and has advantage which did not require application time."3.30Cold anesthesia for pain reduction during intralesional steroid injection for nodulocystic acne. ( Kim, GH; Koh, YG; Park, KY; Park, SJ; Rho, NK; Shin, SH, 2023)
"Keloids are chronic progressive dermal pseudo-tumors that can grow considerably in volume and surface area but do not invade other tissues."3.01Keloid disease: Review with clinical atlas. Part I: Definitions, history, epidemiology, clinics and diagnosis. ( Charvet, E; Delaleu, J; Petit, A, 2023)
"First-line treatment of formed keloids involves topical or intralesional steroids."2.90Intralesional triamcinolone alone or in combination with botulinium toxin A is ineffective for the treatment of formed keloid scar: A double blind controlled pilot study. ( Bakhshaeekia, A; Feily, A; Gianfaldoni, S; Hadibarhaghtalab, M; Lange, CS; Lotti, T; Matta, J; Pazyar, N; Ramirez-Fort, MK; Ramirez-Pacheco, LA; Rasaii, S; Seifi, V; Sohrabian, N, 2019)
"Keloids are a burden for patients due to physical, aesthetic and social consequences."2.87Intralesional cryotherapy versus excision with corticosteroid injections or brachytherapy for keloid treatment: Randomised controlled trials. ( Bijlard, E; Hovius, SER; Mureau, MAM; Niessen, FB; Timman, R; Verduijn, GM, 2018)
"Different approaches are used aiming to improve these scars, including intralesional corticosteroids, surgery and more recently, laser therapy."2.82Laser therapy for treating hypertrophic and keloid scars. ( da Silva, CA; da Silva, EM; Kuczynski, U; Leszczynski, R; Pinto, ACPN, 2022)
"Recurrence was seen in seven keloids (24 percent) and hypopigmentation recovered in 69 percent of all keloid scars within 12 months."2.80Intralesional cryotherapy for treatment of keloid scars: a prospective study. ( Bulstra, AJ; Galindo-Garre, F; Molier, J; Niessen, FB; van der Wal, MBA; van Leeuwen, MCE; van Leeuwen, PAM; van Zuijlen, PPM, 2015)
"The symptom of pruritus is frequently overlooked by dermatologists, and treatments are often primarily focused on the gross appearance of the scar."2.72Pruritus in Keloid Scars: Mechanisms and Treatments. ( Hawash, AA; Ingrasci, G; Nouri, K; Yosipovitch, G, 2021)
"Keloid is characterized by tumor-like invasive growth, high incidence, and low remission rate."2.58[Advances in the research of drug intralesional injection therapy in keloid]. ( Guo, QG; Yao, M, 2018)
"The minimal treatment-related pain and high patient satisfaction makes it a promising treatment for patients with needle-phobia and/or severe pain during needle injections."1.91Needle-free electronically controlled jet injection with corticosteroids in recalcitrant keloid scars: a retrospective study and patient survey. ( Bik, L; Elmzoon, I; Prens, EP; van Doorn, MBA; Wolkerstorfer, A, 2023)
"Keloid-associated pruritus is a common manifestation and has negative impacts on quality of life."1.91Pruritus in keloid scars: mechanisms and treatments. ( Biazus Soares, G; Mahmoud, O; Yosipovitch, G, 2023)
"Improvement of skin parameters (scar elasticity, thickness, regularity, color) was also noticed."1.91Effectiveness of various methods of manual scar therapy. ( Garncarczyk, A; Lubczyńska, A; Wcisło-Dziadecka, D, 2023)
"Keloids are the result of abnormal wound healing, and they differ from the normal skin of the patient in the level of blood perfusion and the degrees of inflammation, hypoxia, regeneration of vessels, and expression of sensory receptors."1.72Relative perfusion index: An objective, quantitative and noninvasive method for evaluating the severity of keloids. ( Li, S; Long, X; Wang, X; Zhang, M, 2022)
"Hyperpigmentation was the most irritating side effect of 5-FU that occurred."1.72Comparative efficacy of intralesional 5 flurouracil and intralesional triamcinolone acetonide in localized plaque psoriasis. ( Attwa, E; Essam, R; Khater, MH; Selim, HM, 2022)
"Keloids are disfiguring pathological scars that could cause pain and pruritus."1.62Enhanced Drug Permeation into Human Keloid Tissues by Sonophoresis-Assisted Microneedling. ( Hu, T; Liu, W; Ning, X; Xia, L; Xu, C; Yang, Y, 2021)
"The keloids were most commonly located on the trunk, and seven patients had intralesional steroid injections prior to presentation with persistence of symptoms."1.62Treatment of Pain in Keloids Using Only a Long-Pulsed 1064 nm Nd:YAG Laser. ( Bakus, AD; Garden, BC; Garden, JM; Jones, VA; Lai, O; Patel, PM, 2021)
"The keloids were examined and the sizes were grouped into small, medium, and large keloids; the severities of symptoms were determined using the visual analog scale."1.51Demographic and clinical characteristics of keloids in an urban center in Sub-Sahara Africa. ( Belie, O; Mofikoya, BO; Ugburo, AO, 2019)
"Keloids are associated with small-fiber neuropathy and typically present with itching, pain, and allodynia."1.36Treatment of a painful keloid with botulinum toxin type A. ( Dave, S; Lippincott, B; Uyesugi, B, 2010)
"Acute pain was evaluated in all 21 patients."1.35Reduction of pain in the treatment of vascular lesions with a pulsed dye laser and pneumatic skin flattening. ( Lanigan, S, 2009)
"This pilot study suggests that treatment of keloid and hypertrophic scars with intra-lesional injections of collagenase is ineffective."1.33Intra-lesional injections of collagenase are ineffective in the treatment of keloid and hypertrophic scars. ( Gault, D; Kang, N; Nduka, C; Sanders, R; Sivakumar, B, 2006)
"Itch and pain are common presentations in keloids and are associated with abnormalities in small nerve fiber function, suggesting a small nerve fiber neuropathy."1.32Pruritus, pain, and small nerve fiber function in keloids: a controlled study. ( Chan, YH; Goh, CL; Lee, SS; Yosipovitch, G, 2004)

Research

Studies (55)

TimeframeStudies, this research(%)All Research%
pre-19904 (7.27)18.7374
1990's3 (5.45)18.2507
2000's10 (18.18)29.6817
2010's17 (30.91)24.3611
2020's21 (38.18)2.80

Authors

AuthorsStudies
Hawash, AA1
Ingrasci, G1
Nouri, K1
Yosipovitch, G3
Chobpenthai, T1
Poosiripinyo, T1
Tuntarattanapong, P1
Thanindratarn, P1
Trathitephun, W1
Kim, M1
Mirsky, N1
Spielman, A1
Mathew, P1
Yechieli, R1
Tang, JC1
Thaller, SR1
Vanhooteghem, O1
Erlendsson, AM1
Rosenberg, LK1
Lerche, CM1
Togsverd-Bo, K1
Wiegell, SR1
Karmisholt, K1
Philipsen, PA1
Hansen, ACN1
Janfelt, C1
Holmes, J1
Rossi, A1
Haedersdal, M1
Li, S1
Zhang, M1
Long, X1
Wang, X2
Moravej, H1
Forghanian, A1
Dadkhahfar, S1
Mozafari, N1
Attwa, E1
Khater, MH1
Selim, HM1
Essam, R1
Leszczynski, R1
da Silva, CA1
Pinto, ACPN1
Kuczynski, U1
da Silva, EM1
Cohen, AJ3
Talasila, S3
Lazarevic, B3
Banner, L3
Gleason, L3
Malkani, K3
Uitto, J3
Nikbakht, N3
Delaleu, J2
Charvet, E2
Petit, A2
Lubczyńska, A1
Garncarczyk, A1
Wcisło-Dziadecka, D1
Park, SJ1
Shin, SH1
Koh, YG1
Kim, GH1
Rho, NK1
Park, KY2
Park, TH1
Biazus Soares, G1
Mahmoud, O1
Bik, L1
Elmzoon, I1
Wolkerstorfer, A1
Prens, EP1
van Doorn, MBA1
Belie, O1
Ugburo, AO1
Mofikoya, BO1
Abou-Taleb, DAE1
Badary, DM1
Morales-Sánchez, MA1
De Villafranca-Dugelby, A1
Cruz, FJ1
Peralta-Pedrero, ML1
Patel, PM1
Bakus, AD1
Garden, BC1
Lai, O1
Jones, VA1
Garden, JM1
Falk, H1
Vissing, M1
Wooler, G1
Gehl, J1
Yang, Y1
Xia, L2
Ning, X1
Hu, T1
Xu, C1
Liu, W2
Wu, X1
Liu, K1
Lin, X1
Gao, Z1
Bijlard, E3
Timman, R2
Verduijn, GM1
Niessen, FB3
Hovius, SER2
Mureau, MAM2
Song, H1
Tan, J1
Fu, Q1
Huang, L1
Ao, M1
Guo, QG1
Yao, M1
Saffari, TM1
Van Bodegraven, EAM1
Huygen, FJPM1
Rasaii, S1
Sohrabian, N1
Gianfaldoni, S1
Hadibarhaghtalab, M1
Pazyar, N1
Bakhshaeekia, A1
Lotti, T1
Ramirez-Pacheco, LA1
Lange, CS1
Matta, J1
Seifi, V1
Ramirez-Fort, MK1
Feily, A1
van Leeuwen, MC1
Bulstra, AE1
van Leeuwen, PA1
van Leeuwen, MCE1
van der Wal, MBA1
Bulstra, AJ1
Galindo-Garre, F1
Molier, J1
van Zuijlen, PPM1
van Leeuwen, PAM1
El-Zawahry, BM1
Sobhi, RM1
Bassiouny, DA1
Tabak, SA1
Frioui, S1
Khachnaoui, F1
Kouwenberg, CA1
Hovius, SE1
Busschbach, JJ1
Mureau, MA1
Usanakornkul, A1
Burusapat, C1
Lee, Y1
Hong, JY1
Chung, WS1
Kim, MN1
Kim, BJ1
Chuang, GS1
Rogers, GS1
Zeltser, R1
Lanigan, S1
Tosa, M1
Murakami, M1
Hyakusoku, H1
Mishra, S1
Uyesugi, B1
Lippincott, B1
Dave, S1
Kamerath, JH1
De Luigi, AJ1
Mandal, A1
Imran, D1
NAEGELI, T1
THOREK, P1
PANDIT, JK1
Eishi, K1
Bae, SJ1
Ogawa, F1
Hamasaki, Y1
Shimizu, K1
Katayama, I1
Lim, K1
Lee, SS1
Chan, YH1
Goh, CL1
Saray, Y1
Güleç, AT1
Muneuchi, G1
Suzuki, S1
Onodera, M1
Ito, O1
Hata, Y1
Igawa, HH1
Kang, N1
Sivakumar, B1
Sanders, R1
Nduka, C1
Gault, D1
Leung, CY1
Roccia, L1
Manfredi, C1
Shigeki, S1
Murakami, T1
Yata, N1
Ikuta, Y1
Ono, N1
Wong, TW1
Lee, JY1
Sheu, HM1
Chao, SC1
Nasilowski, W1

Clinical Trials (5)

Trial Overview

TrialPhaseEnrollmentStudy TypeStart DateStatus
The Effectiveness of Dry Needling in Treating Linear Hypertrophic Scar Tissue: a Randomized Sham-controlled Trial[NCT06033430]80 participants (Anticipated)Interventional2023-10-10Recruiting
Intralesional Cryotherapy With a Argon Gas Based Device for the Treatment of Keloid and Hypertrophic Scars[NCT02063243]33 participants (Actual)Interventional2010-01-31Completed
Intralesional Cryotherapy for Treatment of Keloid Scars: a Prospective Evaluation[NCT01994616]30 participants (Actual)Observational2009-01-31Completed
Investigation of the Effectiveness of Vibratory Stimulus in Trigger Finger Injections[NCT05405452]Phase 41,000 participants (Anticipated)Interventional2023-08-14Recruiting
Vibration Anesthesia for Pain Reduction During Trigger Point Injection to the Gastrocnemius[NCT03365674]60 participants (Actual)Interventional2017-09-30Completed
[information is prepared from clinicaltrials.gov, extracted Sep-2024]

Reviews

6 reviews available for khellin and Pain

ArticleYear
Pruritus in Keloid Scars: Mechanisms and Treatments.
    Acta dermato-venereologica, 2021, Oct-28, Volume: 101, Issue:10

    Topics: Cicatrix, Hypertrophic; Combined Modality Therapy; Humans; Keloid; Pain; Pruritus; Quality of Life

2021
Remarkable efficiency of surgical shave excision of keloids followed by intralesional injection of Bleomycin. A retrospective study of 314 cases.
    Dermatologic therapy, 2022, Volume: 35, Issue:5

    Topics: Adult; Bleomycin; Humans; Injections, Intralesional; Keloid; Middle Aged; Pain; Pruritus; Retrospect

2022
Laser therapy for treating hypertrophic and keloid scars.
    The Cochrane database of systematic reviews, 2022, 09-26, Volume: 9

    Topics: Adrenal Cortex Hormones; Adult; Aluminum; Atrophy; Carbon Dioxide; Child; Cicatrix, Hypertrophic; Di

2022
Keloid disease: Review with clinical atlas. Part I: Definitions, history, epidemiology, clinics and diagnosis.
    Annales de dermatologie et de venereologie, 2023, Volume: 150, Issue:1

    Topics: Cicatrix, Hypertrophic; Keloid; Pain; Pruritus; Quality of Life

2023
Keloid disease: Review with clinical atlas. Part I: Definitions, history, epidemiology, clinics and diagnosis.
    Annales de dermatologie et de venereologie, 2023, Volume: 150, Issue:1

    Topics: Cicatrix, Hypertrophic; Keloid; Pain; Pruritus; Quality of Life

2023
Keloid disease: Review with clinical atlas. Part I: Definitions, history, epidemiology, clinics and diagnosis.
    Annales de dermatologie et de venereologie, 2023, Volume: 150, Issue:1

    Topics: Cicatrix, Hypertrophic; Keloid; Pain; Pruritus; Quality of Life

2023
Keloid disease: Review with clinical atlas. Part I: Definitions, history, epidemiology, clinics and diagnosis.
    Annales de dermatologie et de venereologie, 2023, Volume: 150, Issue:1

    Topics: Cicatrix, Hypertrophic; Keloid; Pain; Pruritus; Quality of Life

2023
[Advances in the research of drug intralesional injection therapy in keloid].
    Zhonghua shao shang za zhi = Zhonghua shaoshang zazhi = Chinese journal of burns, 2018, Jun-20, Volume: 34, Issue:6

    Topics: Female; Humans; Injections, Intralesional; Keloid; Pain

2018
[Paramount problems in the rehabilitation of severely burned patients].
    Polski tygodnik lekarski (Warsaw, Poland : 1960), 1975, May-19, Volume: 30, Issue:20

    Topics: Adaptation, Psychological; Adrenergic alpha-Antagonists; Burns; Contracture; Expectorants; Hemodynam

1975

Trials

11 trials available for khellin and Pain

ArticleYear
A one-time pneumatic jet-injection of 5-fluorouracil and triamcinolone acetonide for treatment of hypertrophic scars-A blinded randomized controlled trial.
    Lasers in surgery and medicine, 2022, Volume: 54, Issue:5

    Topics: Cicatrix, Hypertrophic; Drug Therapy, Combination; Fluorouracil; Humans; Injections, Intralesional;

2022
Cold anesthesia for pain reduction during intralesional steroid injection for nodulocystic acne.
    Journal of cosmetic dermatology, 2023, Volume: 22, Issue:12

    Topics: Acne Vulgaris; Anesthesia; Humans; Injections, Intralesional; Keloid; Pain; Steroids; Treatment Outc

2023
Calcium Electroporation for Keloids: A First-in-Man Phase I Study.
    Dermatology (Basel, Switzerland), 2021, Volume: 237, Issue:6

    Topics: Adult; Calcium Chloride; Electrochemotherapy; Erythema; Female; Follow-Up Studies; Humans; Keloid; M

2021
Topical cryoanesthesia for the relief of pain caused by steroid injections used to treat hypertrophic scars and keloids.
    Medicine, 2017, Volume: 96, Issue:43

    Topics: Adolescent; Adult; Anesthetics, Local; Cicatrix, Hypertrophic; Cryoanesthesia; Female; Glucocorticoi

2017
Intralesional cryotherapy versus excision with corticosteroid injections or brachytherapy for keloid treatment: Randomised controlled trials.
    Journal of plastic, reconstructive & aesthetic surgery : JPRAS, 2018, Volume: 71, Issue:6

    Topics: Adolescent; Adult; Anti-Inflammatory Agents; Brachytherapy; Combined Modality Therapy; Cryotherapy;

2018
Intralesional triamcinolone alone or in combination with botulinium toxin A is ineffective for the treatment of formed keloid scar: A double blind controlled pilot study.
    Dermatologic therapy, 2019, Volume: 32, Issue:2

    Topics: Botulinum Toxins, Type A; Double-Blind Method; Drug Therapy, Combination; Female; Glucocorticoids; H

2019
A new argon gas-based device for the treatment of keloid scars with the use of intralesional cryotherapy.
    Journal of plastic, reconstructive & aesthetic surgery : JPRAS, 2014, Volume: 67, Issue:12

    Topics: Adolescent; Adult; Aged; Aged, 80 and over; Argon; Cryosurgery; Elasticity; Female; Gases; Humans; H

2014
Intralesional cryotherapy for treatment of keloid scars: a prospective study.
    Plastic and reconstructive surgery, 2015, Volume: 135, Issue:2

    Topics: Adolescent; Adult; Aged; Asian People; Black People; Child; Cryosurgery; Female; Humans; Hypopigment

2015
Ablative CO2 fractional resurfacing in treatment of thermal burn scars: an open-label controlled clinical and histopathological study.
    Journal of cosmetic dermatology, 2015, Volume: 14, Issue:4

    Topics: Adolescent; Adult; Burns; Cicatrix, Hypertrophic; Female; Humans; Keloid; Lasers, Gas; Male; Middle

2015
A Topical Anesthetic and Lidocaine Mixture for Pain Relief During Keloid Treatment: A Double-Blind, Randomized Controlled Trial.
    Dermatologic surgery : official publication for American Society for Dermatologic Surgery [et al.], 2017, Volume: 43, Issue:1

    Topics: Administration, Cutaneous; Adolescent; Adult; Aged; Anesthetics, Local; Anti-Inflammatory Agents; Do

2017
Treatment of keloids and hypertrophic scars with dermojet injections of bleomycin: a preliminary study.
    International journal of dermatology, 2005, Volume: 44, Issue:9

    Topics: Adolescent; Adult; Aged; Antibiotics, Antineoplastic; Bleomycin; Cicatrix, Hypertrophic; Female; Fol

2005

Other Studies

38 other studies available for khellin and Pain

ArticleYear
Outcomes of 2-octyl cyanoacrylate skin adhesives following musculoskeletal oncology surgery: A STROBE-compliant observational study.
    Medicine, 2021, Dec-17, Volume: 100, Issue:50

    Topics: Administration, Topical; Adult; Aged; Cyanoacrylates; Female; Hematoma; Humans; Keloid; Male; Middle

2021
Evaluating Symptomatic and Psychosocial Well-being After Keloid Treatment With SCAR-Q.
    Aesthetic surgery journal, 2022, 05-18, Volume: 42, Issue:6

    Topics: Humans; Injections, Intralesional; Keloid; Pain; Pruritus; Treatment Outcome

2022
Relative perfusion index: An objective, quantitative and noninvasive method for evaluating the severity of keloids.
    Lasers in surgery and medicine, 2022, Volume: 54, Issue:8

    Topics: Cross-Sectional Studies; Humans; Hypoxia; Interleukin-17; Keloid; Pain; Perfusion Index; Pruritus; S

2022
Intralesional bleomycin versus intralesional triamcinolone in the treatment of keloids and hypertrophic scars.
    Dermatologic therapy, 2022, Volume: 35, Issue:9

    Topics: Bleomycin; Cicatrix, Hypertrophic; Humans; Hyperpigmentation; Injections, Intralesional; Keloid; Pai

2022
Comparative efficacy of intralesional 5 flurouracil and intralesional triamcinolone acetonide in localized plaque psoriasis.
    Dermatologic therapy, 2022, Volume: 35, Issue:11

    Topics: Drug Therapy, Combination; Fluorouracil; Humans; Hyperpigmentation; Injections, Intralesional; Keloi

2022
Combination cryotherapy and intralesional corticosteroid versus steroid monotherapy in the treatment of keloids.
    Journal of cosmetic dermatology, 2023, Volume: 22, Issue:3

    Topics: Adrenal Cortex Hormones; Cryotherapy; Humans; Injections, Intralesional; Keloid; Pain; Prospective S

2023
Combination cryotherapy and intralesional corticosteroid versus steroid monotherapy in the treatment of keloids.
    Journal of cosmetic dermatology, 2023, Volume: 22, Issue:3

    Topics: Adrenal Cortex Hormones; Cryotherapy; Humans; Injections, Intralesional; Keloid; Pain; Prospective S

2023
Combination cryotherapy and intralesional corticosteroid versus steroid monotherapy in the treatment of keloids.
    Journal of cosmetic dermatology, 2023, Volume: 22, Issue:3

    Topics: Adrenal Cortex Hormones; Cryotherapy; Humans; Injections, Intralesional; Keloid; Pain; Prospective S

2023
Combination cryotherapy and intralesional corticosteroid versus steroid monotherapy in the treatment of keloids.
    Journal of cosmetic dermatology, 2023, Volume: 22, Issue:3

    Topics: Adrenal Cortex Hormones; Cryotherapy; Humans; Injections, Intralesional; Keloid; Pain; Prospective S

2023
Combination cryotherapy and intralesional corticosteroid versus steroid monotherapy in the treatment of keloids.
    Journal of cosmetic dermatology, 2023, Volume: 22, Issue:3

    Topics: Adrenal Cortex Hormones; Cryotherapy; Humans; Injections, Intralesional; Keloid; Pain; Prospective S

2023
Combination cryotherapy and intralesional corticosteroid versus steroid monotherapy in the treatment of keloids.
    Journal of cosmetic dermatology, 2023, Volume: 22, Issue:3

    Topics: Adrenal Cortex Hormones; Cryotherapy; Humans; Injections, Intralesional; Keloid; Pain; Prospective S

2023
Combination cryotherapy and intralesional corticosteroid versus steroid monotherapy in the treatment of keloids.
    Journal of cosmetic dermatology, 2023, Volume: 22, Issue:3

    Topics: Adrenal Cortex Hormones; Cryotherapy; Humans; Injections, Intralesional; Keloid; Pain; Prospective S

2023
Combination cryotherapy and intralesional corticosteroid versus steroid monotherapy in the treatment of keloids.
    Journal of cosmetic dermatology, 2023, Volume: 22, Issue:3

    Topics: Adrenal Cortex Hormones; Cryotherapy; Humans; Injections, Intralesional; Keloid; Pain; Prospective S

2023
Combination cryotherapy and intralesional corticosteroid versus steroid monotherapy in the treatment of keloids.
    Journal of cosmetic dermatology, 2023, Volume: 22, Issue:3

    Topics: Adrenal Cortex Hormones; Cryotherapy; Humans; Injections, Intralesional; Keloid; Pain; Prospective S

2023
Effectiveness of various methods of manual scar therapy.
    Skin research and technology : official journal of International Society for Bioengineering and the Skin (ISBS) [and] International Society for Digital Imaging of Skin (ISDIS) [and] International Society for Skin Imaging (ISSI), 2023, Volume: 29, Issue:3

    Topics: Cicatrix; Cicatrix, Hypertrophic; Complementary Therapies; Cupping Therapy; Dry Needling; Humans; Ke

2023
Topical Anesthetic versus Lidocaine Mixture for Pain Relief During Keloid Treatment: A Prospective, Split Study.
    The Journal of craniofacial surgery, 2023, Oct-01, Volume: 34, Issue:7

    Topics: Adolescent; Adrenal Cortex Hormones; Adult; Aged; Aged, 80 and over; Anesthetics, Local; Female; Hum

2023
Pruritus in keloid scars: mechanisms and treatments.
    Italian journal of dermatology and venereology, 2023, Volume: 158, Issue:5

    Topics: Cryotherapy; Humans; Inflammation; Keloid; Pain; Pruritus; Quality of Life

2023
Needle-free electronically controlled jet injection with corticosteroids in recalcitrant keloid scars: a retrospective study and patient survey.
    Lasers in medical science, 2023, Nov-02, Volume: 38, Issue:1

    Topics: Adrenal Cortex Hormones; Cicatrix, Hypertrophic; Humans; Injections, Intralesional; Injections, Jet;

2023
Demographic and clinical characteristics of keloids in an urban center in Sub-Sahara Africa.
    Nigerian journal of clinical practice, 2019, Volume: 22, Issue:8

    Topics: Adult; Demography; Female; Humans; Keloid; Male; Nigeria; Pain; Visual Analog Scale; Wound Healing

2019
Intralesional verapamil in the treatment of keloids: A clinical, histopathological, and immunohistochemical study.
    Journal of cosmetic dermatology, 2021, Volume: 20, Issue:1

    Topics: Glucocorticoids; Humans; Injections, Intralesional; Keloid; Pain; Treatment Outcome; Verapamil

2021
Methodological quality of clinical trials of keloid scars.
    Cirugia y cirujanos, 2020, Volume: 88, Issue:5

    Topics: Cicatrix, Hypertrophic; Clinical Trials as Topic; Humans; Keloid; Pain; Quality of Life

2020
Treatment of Pain in Keloids Using Only a Long-Pulsed 1064 nm Nd:YAG Laser.
    Lasers in surgery and medicine, 2021, Volume: 53, Issue:1

    Topics: Humans; Keloid; Lasers, Solid-State; Low-Level Light Therapy; Pain; Treatment Outcome

2021
Enhanced Drug Permeation into Human Keloid Tissues by Sonophoresis-Assisted Microneedling.
    SLAS technology, 2021, Volume: 26, Issue:6

    Topics: Humans; Keloid; Pain; Pharmaceutical Preparations; Treatment Outcome

2021
Comparative efficacy of intralesional triamcinolone acetonide injection during early and static stage of pathological scarring.
    Journal of cosmetic dermatology, 2019, Volume: 18, Issue:3

    Topics: Adolescent; Adult; Aged; Child; Child, Preschool; Cicatrix, Hypertrophic; Female; Glucocorticoids; H

2019
Sensory perception and nerve fibre innervation in patients with keloid scars: an investigative study.
    European journal of dermatology : EJD, 2018, Dec-01, Volume: 28, Issue:6

    Topics: Biopsy; Humans; Hyperalgesia; Keloid; Nerve Fibers; Neuralgia; Pain; Pain Measurement; Skin

2018
[External branch spinal nerve paralysis on keloid scar].
    The Pan African medical journal, 2016, Volume: 23

    Topics: Humans; Keloid; Male; Pain; Paralysis; Plastic Surgery Procedures; Spinal Nerves; Young Adult

2016
Burden of Keloid Disease: A Cross-sectional Health-related Quality of Life Assessment.
    Acta dermato-venereologica, 2017, Feb-08, Volume: 97, Issue:2

    Topics: Adolescent; Adult; Cross-Sectional Studies; Elasticity; Emotions; Female; Humans; Keloid; Male; Midd

2017
Vibration Anesthesia for Pain Reduction During Intralesional Steroid Injection for Keloid Treatment.
    Dermatologic surgery : official publication for American Society for Dermatologic Surgery [et al.], 2017, Volume: 43, Issue:5

    Topics: Adolescent; Adult; Anesthesia; Cicatrix, Hypertrophic; Female; Glucocorticoids; Humans; Injections,

2017
Vibration Anesthesia for Pain Reduction During Intralesional Steroid Injection for Keloid Treatment.
    Dermatologic surgery : official publication for American Society for Dermatologic Surgery [et al.], 2017, Volume: 43, Issue:5

    Topics: Adolescent; Adult; Anesthesia; Cicatrix, Hypertrophic; Female; Glucocorticoids; Humans; Injections,

2017
Vibration Anesthesia for Pain Reduction During Intralesional Steroid Injection for Keloid Treatment.
    Dermatologic surgery : official publication for American Society for Dermatologic Surgery [et al.], 2017, Volume: 43, Issue:5

    Topics: Adolescent; Adult; Anesthesia; Cicatrix, Hypertrophic; Female; Glucocorticoids; Humans; Injections,

2017
Vibration Anesthesia for Pain Reduction During Intralesional Steroid Injection for Keloid Treatment.
    Dermatologic surgery : official publication for American Society for Dermatologic Surgery [et al.], 2017, Volume: 43, Issue:5

    Topics: Adolescent; Adult; Anesthesia; Cicatrix, Hypertrophic; Female; Glucocorticoids; Humans; Injections,

2017
Poiseuille's law and large-bore needles: insights into the delivery of corticosteroid injections in the treatment of keloids.
    Journal of the American Academy of Dermatology, 2008, Volume: 59, Issue:1

    Topics: Adrenal Cortex Hormones; Anesthetics, Local; Humans; Injections, Intralesional; Keloid; Needles; Pai

2008
Reduction of pain in the treatment of vascular lesions with a pulsed dye laser and pneumatic skin flattening.
    Lasers in medical science, 2009, Volume: 24, Issue:4

    Topics: Adult; Child; Humans; Intermittent Pneumatic Compression Devices; Keloid; Keratosis; Lasers, Dye; Lo

2009
Effect of lidocaine tape on pain during intralesional injection of triamcinolone acetonide for the treatment of keloid.
    Journal of Nippon Medical School = Nippon Ika Daigaku zasshi, 2009, Volume: 76, Issue:1

    Topics: Administration, Cutaneous; Adult; Anesthetics, Local; Female; Humans; Injections, Intralesional; Kel

2009
Safe and less painful injection of triamcenolone acetonide into a keloid--a technique.
    Journal of plastic, reconstructive & aesthetic surgery : JPRAS, 2010, Volume: 63, Issue:2

    Topics: Anesthetics, Local; Bupivacaine; Glucocorticoids; Humans; Injections, Intralesional; Keloid; Lidocai

2010
Treatment of a painful keloid with botulinum toxin type A.
    American journal of physical medicine & rehabilitation, 2010, Volume: 89, Issue:2

    Topics: Aged, 80 and over; Botulinum Toxins, Type A; Female; Humans; Keloid; Neuromuscular Agents; Pain

2010
Analgesic benefit of niacin for shrapnel wound pain in war veteran.
    Military medicine, 2010, Volume: 175, Issue:11

    Topics: Aged, 80 and over; Analgesia; Blast Injuries; Cicatrix, Hypertrophic; Humans; Hyperlipidemias; Hypol

2010
Painless steroid injections for hypertrophic scars and keloids.
    British journal of plastic surgery, 2003, Volume: 56, Issue:1

    Topics: Cicatrix, Hypertrophic; Humans; Injections; Keloid; Pain; Steroids

2003
[SECONDARY EFFECTS, SYMPTOMS AND UNDESIRABLE EARLY SEQUELAE IN SURGERY OF THE ABDOMINAL CAVITY. GENERAL PATHOLOGICAL AND CLINICAL PROBLEMS].
    Langenbecks Archiv fur klinische Chirurgie ... vereinigt mit Deutsche Zeitschrift fur Chirurgie, 1963, Nov-05, Volume: 304

    Topics: Abdomen; Abdominal Cavity; Anuria; Blood Glucose; Enterocolitis; Humans; Keloid; Laparotomy; Pain; P

1963
PROTEOLYTIC ENZYMES IN WOUND REPAIR; IMMEDIATE POSTOPERATIVE EFFECTS.
    Applied therapeutics, 1964, Volume: 6

    Topics: Biomedical Research; Drug Therapy; Edema; Hematoma; Humans; Keloid; Pain; Peptide Hydrolases; Postop

1964
Silicone gel sheets relieve pain and pruritus with clinical improvement of keloid: possible target of mast cells.
    The Journal of dermatological treatment, 2003, Volume: 14, Issue:4

    Topics: Administration, Topical; Adult; Aged; Biopsy, Needle; Female; Humans; Immunohistochemistry; Keloid;

2003
Painless steroid injections for hypertrophic scars and keloids.
    British journal of plastic surgery, 2004, Volume: 57, Issue:5

    Topics: Cicatrix, Hypertrophic; Humans; Injections, Intralesional; Keloid; Pain; Steroids; Therapy, Computer

2004
Pruritus, pain, and small nerve fiber function in keloids: a controlled study.
    Journal of the American Academy of Dermatology, 2004, Volume: 51, Issue:6

    Topics: Adult; Female; Humans; Keloid; Male; Middle Aged; Nerve Fibers; Pain; Pain Threshold; Pruritus; Sens

2004
Long-term outcome of intralesional injection of triamcinolone acetonide for the treatment of keloid scars in Asian patients.
    Scandinavian journal of plastic and reconstructive surgery and hand surgery, 2006, Volume: 40, Issue:2

    Topics: Adolescent; Adult; Aged; Asian People; Child; Child, Preschool; Cicatrix; Female; Glucocorticoids; H

2006
Intra-lesional injections of collagenase are ineffective in the treatment of keloid and hypertrophic scars.
    Journal of plastic, reconstructive & aesthetic surgery : JPRAS, 2006, Volume: 59, Issue:7

    Topics: Adult; Anti-Inflammatory Agents; Blister; Child; Cicatrix, Hypertrophic; Drug Administration Schedul

2006
[1st observations on the side effects of soft-laser therapy].
    Minerva medica, 1983, Jun-30, Volume: 74, Issue:27

    Topics: Female; Humans; Keloid; Laser Therapy; Lasers; Pain; Sensation; Tachycardia; Voice Quality

1983
Treatment of keloid and hypertrophic scars by iontophoretic transdermal delivery of tranilast.
    Scandinavian journal of plastic and reconstructive surgery and hand surgery, 1997, Volume: 31, Issue:2

    Topics: Administration, Cutaneous; Administration, Oral; Adolescent; Adult; Aged; Animals; Child; Cicatrix;

1997
Pain-free intralesional injection of triamcinolone for the treatment of keloid.
    Scandinavian journal of plastic and reconstructive surgery and hand surgery, 1999, Volume: 33, Issue:1

    Topics: Glucocorticoids; Humans; Injections, Intralesional; Keloid; Middle Aged; Needles; Pain; Pain Measure

1999
Relief of pain and itch associated with keloids on treatment with oxpentifylline.
    The British journal of dermatology, 1999, Volume: 140, Issue:4

    Topics: Adult; Aged; Dermatologic Agents; Female; Humans; Keloid; Male; Pain; Pentoxifylline; Pruritus

1999