Tumor necrosis factor receptor superfamily member 16

A tumor necrosis factor receptor superfamily member 16 that is encoded in the genome of human. [PRO:JAN, UniProtKB:P08138]

Synonyms

Gp80-LNGFR;
Low affinity neurotrophin receptor p75NTR;
Low-affinity nerve growth factor receptor;
NGF receptor;
p75 ICD

Research

Bioassay Publications (3)

Timeframe	Studies on this Protein(%)	All Drugs %
pre-1990	0 (0.00)	18.7374
1990's	1 (33.33)	18.2507
2000's	1 (33.33)	29.6817
2010's	1 (33.33)	24.3611
2020's	0 (0.00)	2.80

Compounds (3)

Drugs with Inhibition Measurements

Drug	Taxonomy	Measurement	Average (mM)	Bioassay(s)	Publication(s)
ale 0540	Homo sapiens (human)	IC50	151.8600	2	2
pd 90780	Homo sapiens (human)	IC50	55.1000	2	2
2,3,4,10-tetrahydro-7,10-dimethyl-2,4-dioxobenzo(g)pteridine	Homo sapiens (human)	IC50	244.0000	1	1

Enables

This protein enables 11 target(s):

Target	Category	Definition
amyloid-beta binding	molecular function	Binding to an amyloid-beta peptide/protein. [GOC:hjd]
transmembrane signaling receptor activity	molecular function	Combining with an extracellular or intracellular signal and transmitting the signal from one side of the membrane to the other to initiate a change in cell activity or state as part of signal transduction. [GOC:go_curators, Wikipedia:Transmembrane_receptor]
death receptor activity	molecular function	Combining with an extracellular messenger (called a death ligand), and transmitting the signal from one side of the plasma membrane to the other to initiate apoptotic or necrotic cell death. [GOC:bf, GOC:BHF, GOC:ecd, GOC:mtg_apoptosis, GOC:rl, PMID:10209153]
protein binding	molecular function	Binding to a protein. [GOC:go_curators]
calmodulin binding	molecular function	Binding to calmodulin, a calcium-binding protein with many roles, both in the calcium-bound and calcium-free states. [GOC:krc]
coreceptor activity	molecular function	Combining with an extracellular or intracellular messenger, and in cooperation with a nearby primary receptor, initiating a change in cell activity. [GOC:go_curators]
small GTPase binding	molecular function	Binding to a small monomeric GTPase. [GOC:mah, PMID:27218782]
ubiquitin protein ligase binding	molecular function	Binding to a ubiquitin protein ligase enzyme, any of the E3 proteins. [GOC:vp]
signaling receptor activity	molecular function	Receiving a signal and transmitting it in the cell to initiate a change in cell activity. A signal is a physical entity or change in state that is used to transfer information in order to trigger a response. [GOC:bf, GOC:signaling]
neurotrophin binding	molecular function	Binding to a neurotrophin, any of a family of growth factors that prevent apoptosis in neurons and promote nerve growth. [GOC:jl]
nerve growth factor binding	molecular function	Binding to nerve growth factor (NGF). [GOC:dgh]

Located In

This protein is located in 14 target(s):

Target	Category	Definition
extracellular region	cellular component	The space external to the outermost structure of a cell. For cells without external protective or external encapsulating structures this refers to space outside of the plasma membrane. This term covers the host cell environment outside an intracellular parasite. [GOC:go_curators]
nucleoplasm	cellular component	That part of the nuclear content other than the chromosomes or the nucleolus. [GOC:ma, ISBN:0124325653]
endosome	cellular component	A vacuole to which materials ingested by endocytosis are delivered. [ISBN:0198506732, PMID:19696797]
cytosol	cellular component	The part of the cytoplasm that does not contain organelles but which does contain other particulate matter, such as protein complexes. [GOC:hjd, GOC:jl]
plasma membrane	cellular component	The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins. [ISBN:0716731363]
cell-cell junction	cellular component	A cell junction that forms a connection between two or more cells of an organism; excludes direct cytoplasmic intercellular bridges, such as ring canals in insects. [GOC:aruk, GOC:bc, GOC:dgh, GOC:hb, GOC:mah, PMID:21422226, PMID:28096264]
cell surface	cellular component	The external part of the cell wall and/or plasma membrane. [GOC:jl, GOC:mtg_sensu, GOC:sm]
postsynaptic density	cellular component	An electron dense network of proteins within and adjacent to the postsynaptic membrane of an asymmetric, neuron-neuron synapse. Its major components include neurotransmitter receptors and the proteins that spatially and functionally organize them such as anchoring and scaffolding molecules, signaling enzymes and cytoskeletal components. [GOC:BHF, GOC:dos, GOC:ef, GOC:jid, GOC:pr, GOC:sjp, http://molneuro.kaist.ac.kr/psd, PMID:14532281, Wikipedia:Postsynaptic_density]
membrane	cellular component	A lipid bilayer along with all the proteins and protein complexes embedded in it and attached to it. [GOC:dos, GOC:mah, ISBN:0815316194]
growth cone	cellular component	The migrating motile tip of a growing neuron projection, where actin accumulates, and the actin cytoskeleton is the most dynamic. [GOC:aruk, GOC:bc, ISBN:0815316194, PMID:10082468]
neuromuscular junction	cellular component	The junction between the axon of a motor neuron and a muscle fiber. In response to the arrival of action potentials, the presynaptic button releases molecules of neurotransmitters into the synaptic cleft. These diffuse across the cleft and transmit the signal to the postsynaptic membrane of the muscle fiber, leading to a change in post-synaptic potential. [GOC:nln]
dendritic spine	cellular component	A small, membranous protrusion from a dendrite that forms a postsynaptic compartment, typically receiving input from a single presynapse. They function as partially isolated biochemical and an electrical compartments. Spine morphology is variable:they can be thin, stubby, mushroom, or branched, with a continuum of intermediate morphologies. They typically terminate in a bulb shape, linked to the dendritic shaft by a restriction. Spine remodeling is though to be involved in synaptic plasticity. [GOC:nln]
perikaryon	cellular component	The portion of the cell soma (neuronal cell body) that excludes the nucleus. [GOC:jl]
presynapse	cellular component	The part of a synapse that is part of the presynaptic cell. [GOC:dos]

Active In

This protein is active in 2 target(s):

Target	Category	Definition
plasma membrane	cellular component	The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins. [ISBN:0716731363]
cell surface	cellular component	The external part of the cell wall and/or plasma membrane. [GOC:jl, GOC:mtg_sensu, GOC:sm]

Involved In

This protein is involved in 26 target(s):

Target	Category	Definition
intracellular glucose homeostasis	biological process	A homeostatic process involved in the maintenance of a steady state level of glucose within a cell. [GOC:dph, GOC:go_curators, GOC:tb]
intracellular protein transport	biological process	The directed movement of proteins in a cell, including the movement of proteins between specific compartments or structures within a cell, such as organelles of a eukaryotic cell. [GOC:mah]
activation of cysteine-type endopeptidase activity involved in apoptotic process	biological process	Any process that initiates the activity of the inactive enzyme cysteine-type endopeptidase in the context of an apoptotic process. [GOC:al, GOC:dph, GOC:jl, GOC:mtg_apoptosis, GOC:tb, PMID:14744432, PMID:18328827, Wikipedia:Caspase]
Rho protein signal transduction	biological process	An intracellular signaling cassette in which a small monomeric GTPase of the Rho subfamily relays a signal. [GOC:bf]
axon guidance	biological process	The chemotaxis process that directs the migration of an axon growth cone to a specific target site in response to a combination of attractive and repulsive cues. [ISBN:0878932437]
central nervous system development	biological process	The process whose specific outcome is the progression of the central nervous system over time, from its formation to the mature structure. The central nervous system is the core nervous system that serves an integrating and coordinating function. In vertebrates it consists of the brain and spinal cord. In those invertebrates with a central nervous system it typically consists of a brain, cerebral ganglia and a nerve cord. [GOC:bf, GOC:jid, ISBN:0582227089]
fibroblast growth factor receptor signaling pathway	biological process	The series of molecular signals generated as a consequence of a fibroblast growth factor receptor binding to one of its physiological ligands. [GOC:ceb]
detection of temperature stimulus	biological process	The series of events in which a temperature stimulus (hot or cold) is received and converted into a molecular signal. [GOC:hb]
nerve development	biological process	The process whose specific outcome is the progression of a nerve over time, from its formation to the mature structure. [GO_REF:0000021, GOC:cls, GOC:dgh, GOC:dph, GOC:jid]
negative regulation of cell migration	biological process	Any process that stops, prevents, or reduces the frequency, rate or extent of cell migration. [GOC:go_curators]
hair follicle morphogenesis	biological process	The process in which the anatomical structures of the hair follicle are generated and organized. [GOC:ln]
circadian regulation of gene expression	biological process	Any process that modulates the frequency, rate or extent of gene expression such that an expression pattern recurs with a regularity of approximately 24 hours. [GOC:mah]
dorsal aorta development	biological process	The progression of the dorsal aorta over time, from its initial formation to the mature structure. The dorsal aorta is a blood vessel in a single-pass circulatory system that carries oxygenated blood from the gills to the rest of the body. In a single-pass circulatory system blood passes once through the heart to supply the body once. [GOC:bf, GOC:dgh, UBERON:0005805, Wikipedia:Aorta, ZFA:0000014]
negative regulation of fibroblast growth factor receptor signaling pathway	biological process	Any process that stops, prevents, or reduces the frequency, rate or extent of fibroblast growth factor receptor signaling pathway activity. [GOC:go_curators]
odontogenesis of dentin-containing tooth	biological process	The process whose specific outcome is the progression of a dentin-containing tooth over time, from its formation to the mature structure. A dentin-containing tooth is a hard, bony organ borne on the jaw or other bone of a vertebrate, and is composed mainly of dentin, a dense calcified substance, covered by a layer of enamel. [GOC:cjm, GOC:mah, GOC:mtg_sensu, PMID:10333884, PMID:15355794]
positive regulation of odontogenesis of dentin-containing tooth	biological process	Any process that activates or increases the frequency, rate or extent of the formation and development of teeth, the hard, bony appendages that are borne on the jaws, or on other bones in the walls of the mouth or pharynx of most vertebrates. [GOC:jl, PMID:15355794]
glucose homeostasis	biological process	Any process involved in the maintenance of an internal steady state of glucose within an organism or cell. [GOC:go_curators]
fibroblast proliferation	biological process	The multiplication or reproduction of fibroblast cells, resulting in the expansion of the fibroblast population. [GOC:jid]
positive regulation of fibroblast proliferation	biological process	Any process that activates or increases the frequency, rate or extent of multiplication or reproduction of fibroblast cells. [GOC:jid]
neuron apoptotic process	biological process	Any apoptotic process in a neuron, the basic cellular unit of nervous tissue. Each neuron consists of a body, an axon, and dendrites. Their purpose is to receive, conduct, and transmit impulses in the nervous system. [CL:0000540, GOC:mtg_apoptosis]
negative regulation of hair follicle development	biological process	Any process that stops, prevents, or reduces the frequency, rate or extent of hair follicle development. [GOC:ai]
presynaptic modulation of chemical synaptic transmission	biological process	Any process, acting in the presynapse that results in modulation of chemical synaptic transmission. [GOC:dos]
positive regulation of protein localization to nucleus	biological process	Any process that activates or increases the frequency, rate or extent of protein localization to nucleus. [GOC:TermGenie]
positive regulation of miRNA transcription	biological process	Any process that activates or increases the frequency, rate or extent of microRNA (miRNA) gene transcription. [GO_REF:0000058, GOC:dph, GOC:kmv, GOC:TermGenie, PMID:24699545]
negative regulation of blood vessel endothelial cell proliferation involved in sprouting angiogenesis	biological process	Any process that stops, prevents or reduces the frequency, rate or extent of blood vessel endothelial cell proliferation involved in sprouting angiogenesis. [GO_REF:0000058, GOC:TermGenie, PMID:23388056]
positive regulation of apoptotic signaling pathway	biological process	Any process that activates or increases the frequency, rate or extent of apoptotic signaling pathway. [GOC:mtg_apoptosis]