Aldehyde dehydrogenase family 1 member A3

A retinaldehyde dehydrogenase 3 that is encoded in the genome of human. [PRO:DNx, UniProtKB:P47895]

Synonyms

EC 1.2.1.36;
Aldehyde dehydrogenase 6;
Retinaldehyde dehydrogenase 3;
RALDH-3;
RalDH3

Research

Bioassay Publications (4)

Timeframe	Studies on this Protein(%)	All Drugs %
pre-1990	0 (0.00)	18.7374
1990's	0 (0.00)	18.2507
2000's	0 (0.00)	29.6817
2010's	3 (75.00)	24.3611
2020's	1 (25.00)	2.80

Compounds (4)

Drugs with Inhibition Measurements

Drug	Taxonomy	Measurement	Average (mM)	Bioassay(s)	Publication(s)
win 18446	Homo sapiens (human)	Ki	0.2610	1	1
4-(diethylamino)benzaldehyde	Homo sapiens (human)	IC50	10.4000	1	1
daidzin	Homo sapiens (human)	IC50	200.0000	1	1
7-butyl-8-[[4-(3-chlorophenyl)-1-piperazinyl]methyl]-1,3-dimethylpurine-2,6-dione	Homo sapiens (human)	IC50	20.0000	1	1

Enables

This protein enables 6 target(s):

Target	Category	Definition
retinal dehydrogenase activity	molecular function	Catalysis of the reaction: retinal + NAD+ + H2O = retinoate + NADH. Acts on both 11-trans and 13-cis forms of retinal. [EC:1.2.1.36]
aldehyde dehydrogenase [NAD(P)+] activity	molecular function	Catalysis of the reaction: an aldehyde + NAD(P)+ + H2O = an acid + NAD(P)H + H+. [EC:1.2.1.5]
protein homodimerization activity	molecular function	Binding to an identical protein to form a homodimer. [GOC:jl]
thyroid hormone binding	molecular function	Binding to thyroxine (T4) or triiodothyronine (T3), tyrosine-based hormones produced by the thyroid gland. [GOC:rph]
NAD+ binding	molecular function	Binding to the oxidized form, NAD, of nicotinamide adenine dinucleotide, a coenzyme involved in many redox and biosynthetic reactions. [GOC:mah]
aldehyde dehydrogenase (NAD+) activity	molecular function	Catalysis of the reaction: an aldehyde + NAD+ + H2O = an acid + NADH + H+. [EC:1.2.1.3]

Located In

This protein is located in 3 target(s):

Target	Category	Definition
cytoplasm	cellular component	The contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures. [ISBN:0198547684]
cytosol	cellular component	The part of the cytoplasm that does not contain organelles but which does contain other particulate matter, such as protein complexes. [GOC:hjd, GOC:jl]
extracellular exosome	cellular component	A vesicle that is released into the extracellular region by fusion of the limiting endosomal membrane of a multivesicular body with the plasma membrane. Extracellular exosomes, also simply called exosomes, have a diameter of about 40-100 nm. [GOC:BHF, GOC:mah, GOC:vesicles, PMID:15908444, PMID:17641064, PMID:19442504, PMID:19498381, PMID:22418571, PMID:24009894]

Involved In

This protein is involved in 18 target(s):

Target	Category	Definition
optic cup morphogenesis involved in camera-type eye development	biological process	The invagination of the optic vesicle to form two-walled indentations, the optic cups, that will go on to form the retina. This process begins with the optic vesicle becoming a two-walled structure and its subsequent shape changes. It does not include the fate commitment of cells to become the pigmented retina and the neural retina. An example of this process is found in Mus musculus. [GOC:dph, GOC:mtg_sensu, GOC:sdb_2009, GOC:tb, ISBN:0878932437]
retinoic acid biosynthetic process	biological process	The chemical reactions and pathways resulting in the biosynthesis of retinoic acid, one of the three components that makes up vitamin A. [GOC:hjd]
apoptotic process	biological process	A programmed cell death process which begins when a cell receives an internal (e.g. DNA damage) or external signal (e.g. an extracellular death ligand), and proceeds through a series of biochemical events (signaling pathway phase) which trigger an execution phase. The execution phase is the last step of an apoptotic process, and is typically characterized by rounding-up of the cell, retraction of pseudopodes, reduction of cellular volume (pyknosis), chromatin condensation, nuclear fragmentation (karyorrhexis), plasma membrane blebbing and fragmentation of the cell into apoptotic bodies. When the execution phase is completed, the cell has died. [GOC:cjm, GOC:dhl, GOC:ecd, GOC:go_curators, GOC:mtg_apoptosis, GOC:tb, ISBN:0198506732, PMID:18846107, PMID:21494263]
locomotory behavior	biological process	The specific movement from place to place of an organism in response to external or internal stimuli. Locomotion of a whole organism in a manner dependent upon some combination of that organism's internal state and external conditions. [GOC:dph]
nucleus accumbens development	biological process	The progression of the nucleus accumbens over time from its initial formation until its mature state. The nucleus accumbens is a collection of pleomorphic cells in the caudal part of the anterior horn of the lateral ventricle, in the region of the olfactory tubercle, lying between the head of the caudate nucleus and the anterior perforated substance. It is part of the ventral striatum, a composite structure considered part of the basal ganglia. [GO_REF:0000021, GOC:cls, GOC:dgh, GOC:dph, GOC:jid, ISBN:0878937420]
embryonic camera-type eye development	biological process	The process occurring during the embryonic phase whose specific outcome is the progression of the eye over time, from its formation to the mature structure. [GOC:mah, GOC:mtg_sensu]
inner ear morphogenesis	biological process	The process in which the anatomical structures of the inner ear are generated and organized. The inner ear is the structure in vertebrates that contains the organs of balance and hearing. It consists of soft hollow sensory structures (the membranous labyrinth) containing fluid (endolymph) surrounded by fluid (perilymph) and encased in a bony cavity (the bony labyrinth). It consists of two chambers, the sacculus and utriculus, from which arise the cochlea and semicircular canals respectively. [GOC:jl, ISBN:0192801023]
retinol metabolic process	biological process	The chemical reactions and pathways involving retinol, one of the three compounds that makes up vitamin A. [GOC:jl, http://www.indstate.edu/thcme/mwking/vitamins.html, PMID:1924551]
retinoic acid metabolic process	biological process	The chemical reactions and pathways involving retinoic acid, one of the three components that makes up vitamin A. [GOC:jl, http://www.indstate.edu/thcme/mwking/vitamins.html]
retinal metabolic process	biological process	The chemical reactions and pathways involving retinal, a compound that plays an important role in the visual process in most vertebrates. In the retina, retinal combines with opsins to form visual pigments. Retinal is one of the forms of vitamin A. [ISBN:0198506732]
positive regulation of apoptotic process	biological process	Any process that activates or increases the frequency, rate or extent of cell death by apoptotic process. [GOC:jl, GOC:mtg_apoptosis]
embryonic eye morphogenesis	biological process	The process occurring in the embryo by which the anatomical structures of the post-embryonic eye are generated and organized. [GOC:jid]
neuromuscular process controlling balance	biological process	Any process that an organism uses to control its balance, the orientation of the organism (or the head of the organism) in relation to the source of gravity. In humans and animals, balance is perceived through visual cues, the labyrinth system of the inner ears and information from skin pressure receptors and muscle and joint receptors. [GOC:ai, GOC:dph]
protein homotetramerization	biological process	The formation of a protein homotetramer, a macromolecular structure consisting of four noncovalently associated identical subunits. [GOC:go_curators]
righting reflex	biological process	A reflex process in which an animal immediately tries to turn over after being placed in a supine position. [GOC:dph, PMID:8635460]
olfactory pit development	biological process	The biological process whose specific outcome is the progression of the olfactory pit from an initial condition to its mature state. This process begins with the formation of the olfactory pit, which is an indentation of the olfactory placode, and ends when the pits hollows out to form the nasopharynx. [GOC:dph, ISBN:0124020607]
face development	biological process	The biological process whose specific outcome is the progression of a face from an initial condition to its mature state. The face is the ventral division of the head. [GOC:dph]
Harderian gland development	biological process	The process whose specific outcome is the progression of the Harderian gland over time, from its formation to the mature structure. The Harderian gland is an anterior orbital structure usually associated with the nictitating membrane, and produces and secretes a variety of substances to the eye, depending upon the species. [GOC:hjd, PMID:16856596, PMID:7559104]