diazoxide has been researched along with Pain in 10 studies
Diazoxide: A benzothiadiazine derivative that is a peripheral vasodilator used for hypertensive emergencies. It lacks diuretic effect, apparently because it lacks a sulfonamide group.
diazoxide : A benzothiadiazine that is the S,S-dioxide of 2H-1,2,4-benzothiadiazine which is substituted at position 3 by a methyl group and at position 7 by chlorine. A peripheral vasodilator, it increases the concentration of glucose in the plasma and inhibits the secretion of insulin by the beta- cells of the pancreas. It is used orally in the management of intractable hypoglycaemia and intravenously in the management of hypertensive emergencies.
Pain: An unpleasant sensation induced by noxious stimuli which are detected by NERVE ENDINGS of NOCICEPTIVE NEURONS.
| Excerpt | Relevance | Reference |
|---|---|---|
| "This study investigated the role of K(ATP) channels in morphine-induced antinociception and hepatic oxidative stress in acute and inflammatory pain." | 7.79 | The involvement of K(ATP) channels in morphine-induced antinociception and hepatic oxidative stress in acute and inflammatory pain in rats. ( Afify, EA; Khedr, MM; Nasser, SA; Omar, AG, 2013) |
| "The use of diazoxide in the treatment of pulmonary hypertension has been advocated recently." | 7.66 | Hazards of diazoxide in pulmonary hypertension. ( Buch, J; Wennevold, A, 1981) |
| "This study investigated the role of K(ATP) channels in morphine-induced antinociception and hepatic oxidative stress in acute and inflammatory pain." | 3.79 | The involvement of K(ATP) channels in morphine-induced antinociception and hepatic oxidative stress in acute and inflammatory pain in rats. ( Afify, EA; Khedr, MM; Nasser, SA; Omar, AG, 2013) |
| "The use of diazoxide in the treatment of pulmonary hypertension has been advocated recently." | 3.66 | Hazards of diazoxide in pulmonary hypertension. ( Buch, J; Wennevold, A, 1981) |
| "Pinacidil activity was not blocked by L-NAME, D-NAME, 7-nitroindazole, ODQ, KT-5823 or okadaic acid." | 1.33 | The nitric oxide-cyclic GMP-protein kinase G-K+ channel pathway participates in the antiallodynic effect of spinal gabapentin. ( Flores-Murrieta, FJ; Granados-Soto, V; Mixcoatl-Zecuatl, T, 2006) |
| " Diazoxide (2 microg/mouse) shifted morphine's dose-response curve 47-fold, while levcromakalim (0." | 1.30 | ATP-gated K(+) channel openers enhance opioid antinociception: indirect evidence for the release of endogenous opioid peptides. ( Lohmann, AB; Welch, SP, 1999) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 2 (20.00) | 18.7374 |
| 1990's | 2 (20.00) | 18.2507 |
| 2000's | 2 (20.00) | 29.6817 |
| 2010's | 4 (40.00) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Khanna, N | 2 |
| Malhotra, RS | 2 |
| Mehta, AK | 2 |
| Garg, GR | 2 |
| Halder, S | 2 |
| Sharma, KK | 2 |
| Du, X | 1 |
| Wang, C | 1 |
| Zhang, H | 1 |
| Afify, EA | 1 |
| Khedr, MM | 1 |
| Omar, AG | 1 |
| Nasser, SA | 1 |
| Sarantopoulos, C | 1 |
| McCallum, B | 1 |
| Sapunar, D | 1 |
| Kwok, WM | 1 |
| Hogan, Q | 1 |
| Mixcoatl-Zecuatl, T | 1 |
| Flores-Murrieta, FJ | 1 |
| Granados-Soto, V | 1 |
| Schranz, W | 1 |
| Buch, J | 1 |
| Wennevold, A | 1 |
| Lohmann, AB | 2 |
| Welch, SP | 2 |
10 other studies available for diazoxide and Pain
| Article | Year |
|---|---|
Interaction of morphine and potassium channel openers on experimental models of pain in mice.
Topics: Animals; Calcium Channel Agonists; Cromakalim; Diazoxide; Drug Interactions; Drug Therapy, Combinati | 2011 |
Potassium channel openers exhibit cross-tolerance with morphine in two experimental models of pain.
Topics: Analgesics, Opioid; Animals; Cromakalim; Diazoxide; Drug Tolerance; Ion Channel Gating; Mice; Minoxi | 2010 |
Activation of ATP-sensitive potassium channels antagonize nociceptive behavior and hyperexcitability of DRG neurons from rats.
Topics: Animals; Behavior, Animal; Bradykinin; Diazoxide; Ganglia, Spinal; Glyburide; Ion Channel Gating; KA | 2011 |
The involvement of K(ATP) channels in morphine-induced antinociception and hepatic oxidative stress in acute and inflammatory pain in rats.
Topics: Acute Pain; Analgesics, Opioid; Animals; Chemical and Drug Induced Liver Injury; Diazoxide; Disease | 2013 |
ATP-sensitive potassium channels in rat primary afferent neurons: the effect of neuropathic injury and gabapentin.
Topics: Acetates; Amines; Animals; ATP-Binding Cassette Transporters; Basal Ganglia; Cyclohexanecarboxylic A | 2003 |
The nitric oxide-cyclic GMP-protein kinase G-K+ channel pathway participates in the antiallodynic effect of spinal gabapentin.
Topics: Amines; Analgesics; Animals; Apamin; Carbazoles; Charybdotoxin; Cyclic GMP; Cyclic GMP-Dependent Pro | 2006 |
[Vision disorders--nausea--chest pain].
Topics: Diazoxide; Dihydralazine; Emergencies; Furosemide; Humans; Hypertension; Male; Middle Aged; Nausea; | 1982 |
Hazards of diazoxide in pulmonary hypertension.
Topics: Abdomen; Adolescent; Adult; Diazoxide; Female; Heart Arrest; Heart Block; Humans; Hypertension, Pulm | 1981 |
ATP-gated K(+) channel openers enhance opioid antinociception: indirect evidence for the release of endogenous opioid peptides.
Topics: 3,4-Dichloro-N-methyl-N-(2-(1-pyrrolidinyl)-cyclohexyl)-benzeneacetamide, (trans)-Isomer; Adenosine | 1999 |
Antisenses to opioid receptors attenuate ATP-gated K(+) channel opener-induced antinociception.
Topics: 3,4-Dichloro-N-methyl-N-(2-(1-pyrrolidinyl)-cyclohexyl)-benzeneacetamide, (trans)-Isomer; Adenosine | 1999 |