theophylline has been researched along with Pain in 45 studies
Pain: An unpleasant sensation induced by noxious stimuli which are detected by NERVE ENDINGS of NOCICEPTIVE NEURONS.
| Excerpt | Relevance | Reference |
|---|---|---|
| "The sum of pain scores (accumulation of VAS scores) was attenuated by theophylline, 691 [200-1550 (median and 25-75% percentiles)], compared with placebo, 1231 (545-1675), P < 0." | 9.11 | Experimentally induced ischaemic pain in healthy humans is attenuated by the adenosine receptor antagonist theophylline. ( Karelov, A; Segerdahl, M, 2004) |
| "Bamiphylline prolonged the time to pain onset caused by the intrailiac adenosine infusion from 444 +/- 96 to 749 +/- 120 s (p < 0." | 9.08 | Muscular and cardiac adenosine-induced pain is mediated by A1 receptors. ( Chiariello, L; Crea, F; Gaspardone, A; Gioffrè, G; Gioffrè, PA; Iamele, M; Tomai, F; Versaci, F, 1995) |
| "Adenosine is known to cause pain when injected intravenously or intra-arterially." | 9.07 | Analgesic effect of bamiphylline on pain induced by intradermal injection of adenosine. ( Crea, F; Gaspardone, A; Gioffré, PA; Iamele, M; Pappagallo, M; Tomai, F, 1993) |
| "To study the hypothesis that endogenous adenosine is a mediator of the ischaemic pain sensation, the effect of the adenosine receptor blocker theophylline (5." | 9.06 | Theophylline decreases pain in the ischaemic forearm test. ( Jonzon, B; Kaijser, L; Sylvén, C, 1989) |
| " The aim of this study was to highlight the brief initial time for a remarkable decrease of PLPH pain levels after the administration of IV theophylline infusion." | 7.83 | Intravenous theophylline rapidly decreases post-lumbar puncture headaches. ( Ergün, U; İnan, LE; Ünal-Artık, HA; Yoldaş, T, 2016) |
| "The purpose of this investigation was to determine the effects of adrenalectomy and adrenalectomy with corticosterone replacement on pain sensitivity and on the pharmacodynamics of a central nervous system depressant, phenobarbital, and a central nervous system stimulant, theophylline." | 7.68 | Kinetics of drug action in disease states. XLI. Effect of adrenalectomy on the hypnotic activity of phenobarbital, the neurotoxicity of theophylline and pain sensitivity in rats. ( Hoffman, A; Levy, G, 1993) |
| "In the rat, theophylline increases, in proporation to dose, the sensitivity to painful stimulation." | 7.65 | Pharmacokinetics of theophylline in relation to increased pain sensitivity in the rat. ( Paalzow, LK, 1975) |
| "Drug poisoning was suspected on the basis of persistent tachycardia in the absence of other signs of dehydration." | 5.30 | Theophylline intoxication mimicking diabetic ketoacidosis in a child. ( Chouchana, A; Czernichow, P; Polak, M; Rolon, MA, 1999) |
| "The sum of pain scores (accumulation of VAS scores) was attenuated by theophylline, 691 [200-1550 (median and 25-75% percentiles)], compared with placebo, 1231 (545-1675), P < 0." | 5.11 | Experimentally induced ischaemic pain in healthy humans is attenuated by the adenosine receptor antagonist theophylline. ( Karelov, A; Segerdahl, M, 2004) |
| "Bamiphylline prolonged the time to pain onset caused by the intrailiac adenosine infusion from 444 +/- 96 to 749 +/- 120 s (p < 0." | 5.08 | Muscular and cardiac adenosine-induced pain is mediated by A1 receptors. ( Chiariello, L; Crea, F; Gaspardone, A; Gioffrè, G; Gioffrè, PA; Iamele, M; Tomai, F; Versaci, F, 1995) |
| "Adenosine is known to cause pain when injected intravenously or intra-arterially." | 5.07 | Analgesic effect of bamiphylline on pain induced by intradermal injection of adenosine. ( Crea, F; Gaspardone, A; Gioffré, PA; Iamele, M; Pappagallo, M; Tomai, F, 1993) |
| "To study the hypothesis that endogenous adenosine is a mediator of the ischaemic pain sensation, the effect of the adenosine receptor blocker theophylline (5." | 5.06 | Theophylline decreases pain in the ischaemic forearm test. ( Jonzon, B; Kaijser, L; Sylvén, C, 1989) |
| "The frequency and intensity of discomfort and pain at the site of injection during intravenous infusion of theophylline sodium glycinate and theophylline ethylenediamine were compared in a single blind crossover study on 6 healthy adult volunteers." | 5.05 | [Intravenous theophylline therapy. Effect of solubilizers on the incidence of adverse local effects in the area of infusion?]. ( Kyrein, HJ; Staib, AH, 1984) |
| " The aim of this study was to highlight the brief initial time for a remarkable decrease of PLPH pain levels after the administration of IV theophylline infusion." | 3.83 | Intravenous theophylline rapidly decreases post-lumbar puncture headaches. ( Ergün, U; İnan, LE; Ünal-Artık, HA; Yoldaş, T, 2016) |
| " Rolipram, a selective PDE IV inhibitor and theophylline a nonspecific PDE inhibitor exerted dose dependent analgesic and anti-inflammatory effect against acetic acid-induced writhing in mice and carrageenan-induced paw edema in rats, respectively." | 3.70 | Analgesic and anti-inflammatory effects of phosphodiesterase inhibitors. ( Jain, NK; Kulkarni, SK; Kumar, A, 2000) |
| "The purpose of this investigation was to determine the effects of adrenalectomy and adrenalectomy with corticosterone replacement on pain sensitivity and on the pharmacodynamics of a central nervous system depressant, phenobarbital, and a central nervous system stimulant, theophylline." | 3.68 | Kinetics of drug action in disease states. XLI. Effect of adrenalectomy on the hypnotic activity of phenobarbital, the neurotoxicity of theophylline and pain sensitivity in rats. ( Hoffman, A; Levy, G, 1993) |
| "In the rat, theophylline increases, in proporation to dose, the sensitivity to painful stimulation." | 3.65 | Pharmacokinetics of theophylline in relation to increased pain sensitivity in the rat. ( Paalzow, LK, 1975) |
| "Ventricular fibrillation is a major mechanism of sudden death." | 2.36 | Catecholamine-mediated arrhythmias in acute myocardial infarction. Experimental evidence and role of beta-adrenoceptor blockade. ( Lubbe, WF; Opie, LH, 1979) |
| "Dysmenorrhea was more prevalent among nutrition and psychology students than among medicine, pharmacy and dentistry students (p<0." | 1.36 | Primary dysmenorrhea among Mexican university students: prevalence, impact and treatment. ( Ortiz, MI, 2010) |
| ", its pharmacokinetic (PK) properties] and how these PK properties differ between individuals in a population (i." | 1.32 | An evaluation of population D-optimal designs via pharmacokinetic simulations. ( Dodds, MG; Foracchia, M; Hooker, AC; Vicini, P, 2003) |
| "Systemic capillary leak syndrome is a rare idiopathic disorder characterized by recurrent episodes of hypotension and hemoconcentration due to sudden transient extravasation of up to 70% of plasma." | 1.31 | [A rare cause of muscle pain and elevated creatine kinase level--the paroxysmal non-hereditary angioedema]. ( Fischer, R; Klein, M; Leschke, M; Peters, A; Schneider, M, 2000) |
| "Adenosine analogs have been shown to produce antinociception after intrathecal administration." | 1.30 | Characterization of adenosine receptors mediating spinal sensory transmission related to nociceptive information in the rat. ( Kemmotsu, O; Nakamura, I; Ohta, Y, 1997) |
| "Drug poisoning was suspected on the basis of persistent tachycardia in the absence of other signs of dehydration." | 1.30 | Theophylline intoxication mimicking diabetic ketoacidosis in a child. ( Chouchana, A; Czernichow, P; Polak, M; Rolon, MA, 1999) |
| "Clonidine pretreatment did not significantly alter the effect of baclofen alone, but reversed the potentiation of the action of baclofen produced by both theophylline and isobutylmethylxanthine." | 1.27 | Clonidine reverses methylxanthine-induced potentiation of baclofen antinociception. ( Sawynok, J; Steardo, L, 1985) |
| " Dosing errors accounted for the majority of cases." | 1.27 | Theophylline toxicity in children. ( Baker, MD, 1986) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 20 (44.44) | 18.7374 |
| 1990's | 13 (28.89) | 18.2507 |
| 2000's | 7 (15.56) | 29.6817 |
| 2010's | 4 (8.89) | 24.3611 |
| 2020's | 1 (2.22) | 2.80 |
| Authors | Studies |
|---|---|
| Stefanucci, A | 1 |
| Dimmito, MP | 1 |
| Macedonio, G | 1 |
| Ciarlo, L | 1 |
| Pieretti, S | 1 |
| Novellino, E | 1 |
| Lei, W | 1 |
| Barlow, D | 1 |
| Houseknecht, KL | 1 |
| Streicher, JM | 1 |
| Mollica, A | 1 |
| Kaleem, WA | 1 |
| Muhammad, N | 1 |
| Qayum, M | 1 |
| Khan, H | 1 |
| Khan, A | 1 |
| Aliberti, L | 1 |
| De Feo, V | 1 |
| Ergün, U | 1 |
| Ünal-Artık, HA | 1 |
| İnan, LE | 1 |
| Yoldaş, T | 1 |
| Ortiz, MI | 1 |
| Katyal, J | 1 |
| Gupta, YK | 1 |
| Hooker, AC | 1 |
| Foracchia, M | 1 |
| Dodds, MG | 1 |
| Vicini, P | 1 |
| MCNICOL, GP | 1 |
| DOUGLAS, AS | 1 |
| Furuta, S | 1 |
| Onodera, K | 1 |
| Kumagai, M | 1 |
| Honma, I | 1 |
| Miyazaki, S | 1 |
| Sato, T | 1 |
| Sakurada, S | 2 |
| Segerdahl, M | 1 |
| Karelov, A | 1 |
| Aumeerally, N | 1 |
| Allen, G | 1 |
| Sawynok, J | 6 |
| Staib, AH | 1 |
| Kyrein, HJ | 1 |
| Brown, BG | 1 |
| Josephson, MA | 1 |
| Petersen, RB | 1 |
| Pierce, CD | 1 |
| Wong, M | 1 |
| Hecht, HS | 1 |
| Bolson, E | 1 |
| Dodge, HT | 1 |
| Levy, RA | 1 |
| Goldstein, BD | 1 |
| Katevuo, K | 1 |
| Kanto, J | 1 |
| Kleimola, T | 1 |
| Nagaoka, H | 1 |
| Sakurada, T | 1 |
| Takeda, S | 1 |
| Nakagawa, Y | 1 |
| Kisara, K | 1 |
| Arai, Y | 1 |
| Gaspardone, A | 2 |
| Crea, F | 2 |
| Tomai, F | 2 |
| Versaci, F | 1 |
| Iamele, M | 2 |
| Gioffrè, G | 1 |
| Chiariello, L | 1 |
| Gioffrè, PA | 2 |
| Pappagallo, M | 1 |
| Hoffman, A | 1 |
| Levy, G | 1 |
| Keil, GJ | 1 |
| DeLander, GE | 1 |
| Barrett, RJ | 1 |
| Zarrindast, MR | 1 |
| Reid, AR | 1 |
| Doak, GJ | 1 |
| Nakamura, I | 1 |
| Ohta, Y | 1 |
| Kemmotsu, O | 1 |
| Lynch, JJ | 1 |
| Jarvis, MF | 2 |
| Kowaluk, EA | 2 |
| Polak, M | 1 |
| Rolon, MA | 1 |
| Chouchana, A | 1 |
| Czernichow, P | 1 |
| Fischer, R | 1 |
| Peters, A | 1 |
| Klein, M | 1 |
| Leschke, M | 1 |
| Schneider, M | 1 |
| Kumar, A | 1 |
| Jain, NK | 1 |
| Kulkarni, SK | 1 |
| Zhu, CZ | 1 |
| Mikusa, J | 1 |
| Chu, KL | 1 |
| Cowart, M | 1 |
| McGaraughty, S | 1 |
| Opie, LH | 1 |
| Lubbe, WF | 1 |
| Duggan, AW | 1 |
| Griersmith, BT | 1 |
| Paalzow, LK | 1 |
| Paalzow, G | 2 |
| Paalzow, L | 2 |
| De Koninck, Y | 1 |
| Henry, JL | 2 |
| Reid, A | 2 |
| Isbrucker, R | 1 |
| Steardo, L | 1 |
| Jonzon, B | 1 |
| Sylvén, C | 1 |
| Kaijser, L | 1 |
| Salter, MW | 1 |
| Sweeney, MI | 1 |
| White, TD | 1 |
| Baker, MD | 1 |
| Mertz, DP | 1 |
| Mann, K | 1 |
| Jahr, R | 1 |
| Neuhaus, GA | 1 |
| Monteiro, JA | 1 |
| Dobrowolski, L | 1 |
| Qaqundah, BY | 1 |
| Taylor, WF | 1 |
2 reviews available for theophylline and Pain
| Article | Year |
|---|---|
Realizing the potential of adenosine-receptor-based therapeutics.
Topics: Adenine; Animals; Clinical Trials as Topic; Humans; Norbornanes; Pain; Purinergic P1 Receptor Agonis | 1996 |
Catecholamine-mediated arrhythmias in acute myocardial infarction. Experimental evidence and role of beta-adrenoceptor blockade.
Topics: Adrenergic beta-Antagonists; Animals; Arrhythmias, Cardiac; Catecholamines; Cats; Coronary Disease; | 1979 |
5 trials available for theophylline and Pain
| Article | Year |
|---|---|
Experimentally induced ischaemic pain in healthy humans is attenuated by the adenosine receptor antagonist theophylline.
Topics: Adult; Blood Pressure; Double-Blind Method; Female; Humans; Infusions, Intravenous; Ischemia; Male; | 2004 |
[Intravenous theophylline therapy. Effect of solubilizers on the incidence of adverse local effects in the area of infusion?].
Topics: Adult; Drug Combinations; Ethylenediamines; Female; Humans; Infusions, Parenteral; Male; Middle Aged | 1984 |
Muscular and cardiac adenosine-induced pain is mediated by A1 receptors.
Topics: Adenosine; Adult; Aged; Analgesics; Angina Pectoris; Dose-Response Relationship, Drug; Female; Human | 1995 |
Analgesic effect of bamiphylline on pain induced by intradermal injection of adenosine.
Topics: Adenosine; Adult; Analgesics; Female; Humans; Injections, Intradermal; Male; Pain; Receptors, Purine | 1993 |
Theophylline decreases pain in the ischaemic forearm test.
Topics: Adult; Blood Flow Velocity; Clinical Trials as Topic; Double-Blind Method; Forearm; Humans; Ischemia | 1989 |
38 other studies available for theophylline and Pain
| Article | Year |
|---|---|
Potent, Efficacious, and Stable Cyclic Opioid Peptides with Long Lasting Antinociceptive Effect after Peripheral Administration.
Topics: Administration, Intravenous; Analgesics, Opioid; Animals; CHO Cells; Cricetulus; Female; Humans; Inf | 2020 |
Antinociceptive activity of cyclopeptide alkaloids isolated from Ziziphus oxyphylla Edgew (Rhamnaceae).
Topics: Abdomen; Acetic Acid; Alkaloids; Analgesics; Animals; Dose-Response Relationship, Drug; Female; Form | 2013 |
Intravenous theophylline rapidly decreases post-lumbar puncture headaches.
Topics: Administration, Intravenous; Adolescent; Adult; Female; Humans; Male; Middle Aged; Pain; Pain Measur | 2016 |
Primary dysmenorrhea among Mexican university students: prevalence, impact and treatment.
Topics: Absenteeism; Acetaminophen; Adolescent; Dipyrone; Drug Combinations; Dysmenorrhea; Female; Humans; M | 2010 |
Dopamine release is involved in antinociceptive effect of theophylline.
Topics: Analgesics; Animals; Disease Models, Animal; Dopamine; Female; Injections, Intraperitoneal; Male; Mi | 2012 |
An evaluation of population D-optimal designs via pharmacokinetic simulations.
Topics: AIDS Vaccines; Algorithms; Asthma; Clinical Trials as Topic; Computer Simulation; Dose-Response Rela | 2003 |
STUDIES WITH COMPLAMIN, A NICOTINIC-ACID-THEOPHYLLINE ESTER, AS A FIBRINOLYTIC AGENT.
Topics: Drug Therapy; Fibrinolysis; Fibrinolytic Agents; Humans; Hypotension; Injections, Intravenous; Niaci | 1965 |
Involvement of adenosine A1 receptors in forced walking stress-induced analgesia in mice.
Topics: Adenosine A1 Receptor Antagonists; Analgesia; Animals; Behavior, Animal; Formaldehyde; Male; Mice; M | 2003 |
Glutamate-evoked release of adenosine and regulation of peripheral nociception.
Topics: Adenosine; Adenosine A1 Receptor Agonists; Adenosine A1 Receptor Antagonists; alpha-Amino-3-hydroxy- | 2004 |
Intravenous dipyridamole combined with isometric handgrip for near maximal acute increase in coronary flow in patients with coronary artery disease.
Topics: Acute Disease; Constriction, Pathologic; Coronary Angiography; Coronary Circulation; Coronary Diseas | 1981 |
Analgesia following microinjection of phosphodiesterase inhibitors at brainstem sites.
Topics: 4-(3-Butoxy-4-methoxybenzyl)-2-imidazolidinone; Analgesia; Animals; Brain Stem; Female; Male; Microi | 1981 |
Aminophylline in ureterolithiasis: preliminary report.
Topics: Adult; Aged; Aminophylline; Humans; Middle Aged; Pain; Theophylline; Time Factors; Ureteral Calculi | 1981 |
Theophylline-induced nociceptive behavioral response in mice: possible indirect interaction with spinal N-methyl-D-aspartate receptors.
Topics: 2-Amino-5-phosphonovalerate; Adenosine; Adenosine-5'-(N-ethylcarboxamide); Animals; Behavior, Animal | 1993 |
Kinetics of drug action in disease states. XLI. Effect of adrenalectomy on the hypnotic activity of phenobarbital, the neurotoxicity of theophylline and pain sensitivity in rats.
Topics: Adrenalectomy; Animals; Blood Proteins; Corticosterone; Male; Pain; Pain Threshold; Phenobarbital; R | 1993 |
Altered sensory behaviors in mice following manipulation of endogenous spinal adenosine neurotransmission.
Topics: Adenosine; Animals; Deoxyadenosines; Grooming; Male; Mice; Neurotransmitter Agents; Pain; Spinal Cor | 1996 |
Adenosine A3 receptor activation produces nociceptive behaviour and edema by release of histamine and 5-hydroxytryptamine.
Topics: Animals; Behavior, Animal; Body Temperature; Edema; Histamine Release; Injections, Subcutaneous; Mal | 1997 |
Characterization of adenosine receptors mediating spinal sensory transmission related to nociceptive information in the rat.
Topics: Adenosine; Adenosine-5'-(N-ethylcarboxamide); Analgesics; Animals; Dose-Response Relationship, Drug; | 1997 |
An adenosine kinase inhibitor attenuates tactile allodynia in a rat model of diabetic neuropathic pain.
Topics: Adenosine Kinase; Animals; Anti-Bacterial Agents; Blood Glucose; Body Weight; Diabetes Mellitus, Exp | 1999 |
Theophylline intoxication mimicking diabetic ketoacidosis in a child.
Topics: Adult; Blood Glucose; Child, Preschool; Diabetic Ketoacidosis; Diagnosis, Differential; Follow-Up St | 1999 |
[A rare cause of muscle pain and elevated creatine kinase level--the paroxysmal non-hereditary angioedema].
Topics: Adrenergic beta-Agonists; Angioedema; Capillary Leak Syndrome; Creatine Kinase; Drug Therapy, Combin | 2000 |
Analgesic and anti-inflammatory effects of phosphodiesterase inhibitors.
Topics: Abdominal Pain; Acetic Acid; Analgesics; Animals; Anti-Inflammatory Agents, Non-Steroidal; Carrageen | 2000 |
A-134974: a novel adenosine kinase inhibitor, relieves tactile allodynia via spinal sites of action in peripheral nerve injured rats.
Topics: Adenosine Kinase; Animals; Disease Models, Animal; Dose-Response Relationship, Drug; Enzyme Inhibito | 2001 |
Methyl xanthines, adenosine 3',5'-cyclic monophosphate and the spinal transmission of nociceptive information.
Topics: 1-Methyl-3-isobutylxanthine; Animals; Cats; Cyclic AMP; Injections, Intravenous; Pain; Spinal Cord; | 1979 |
Pharmacokinetics of theophylline in relation to increased pain sensitivity in the rat.
Topics: Animals; Computers; Electric Stimulation; Kinetics; Male; Motor Activity; Pain; Rats; Theophylline; | 1975 |
Enhancement of apomorphine-induced inhibition of vocalisation afterdischarge response by theophylline.
Topics: Animals; Apomorphine; Depression, Chemical; Dopamine; Dose-Response Relationship, Drug; Drug Synergi | 1975 |
Peripheral vibration causes an adenosine-mediated postsynaptic inhibitory potential in dorsal horn neurons of the cat spinal cord.
Topics: Adenosine; Adenosine Monophosphate; Animals; Bicuculline; Cats; Evoked Potentials; Iontophoresis; Me | 1992 |
Noradrenergic and purinergic involvement in spinal antinociception by 5-hydroxytryptamine and 2-methyl-5-hydroxytryptamine.
Topics: Analgesics; Animals; Dose-Response Relationship, Drug; Injections, Spinal; Male; Oxidopamine; Pain; | 1991 |
Adenosine mediates calcium-induced antinociception and potentiation of noradrenergic antinociception in the spinal cord.
Topics: 5,7-Dihydroxytryptamine; Adenosine; Adenosine-5'-(N-ethylcarboxamide); Animals; Calcium; Drug Synerg | 1990 |
Clonidine reverses methylxanthine-induced potentiation of baclofen antinociception.
Topics: 1-Methyl-3-isobutylxanthine; Animals; Baclofen; Clonidine; Drug Interactions; Male; Neural Pathways; | 1985 |
Effects of adenosine 5'-monophosphate and adenosine 5'-triphosphate on functionally identified units in the cat spinal dorsal horn. Evidence for a differential effect of adenosine 5'-triphosphate on nociceptive vs non-nociceptive units.
Topics: Adenosine Monophosphate; Adenosine Triphosphate; Animals; Cats; Citrates; Citric Acid; Neurons, Affe | 1985 |
Classification of adenosine receptors mediating antinociception in the rat spinal cord.
Topics: 2-Chloroadenosine; Adenosine; Adenosine-5'-(N-ethylcarboxamide); Animals; Dose-Response Relationship | 1986 |
Theophylline toxicity in children.
Topics: Abdomen; Adolescent; Child; Child, Preschool; Female; Humans; Infant; Male; Pain; Seizures; Tachycar | 1986 |
[Effect of adenosine-3,'5'-cyclic monophosphate on basal gastric acid secretion in human].
Topics: Adenine Nucleotides; Adult; Chlorides; Cyclic AMP; Female; Gastric Juice; Gastric Mucosa; Gastritis; | 1971 |
The effects of caffeine and theophylline on nociceptive stimulation in the rat.
Topics: Animals; Caffeine; Central Nervous System; Dose-Response Relationship, Drug; Electric Stimulation; I | 1973 |
[What is reliable in the therapy of coronary disease?].
Topics: Aminophylline; Amyl Nitrite; Angina Pectoris; Blood Pressure; Cardiac Glycosides; Coronary Disease; | 1970 |
[Treatment of various hyperalgic syndromes using a new analgesic-hormone combination. Preliminary note].
Topics: Adult; Bursitis; Dexamethasone; Female; Humans; Male; Middle Aged; Pain; Spinal Diseases; Tendinopat | 1967 |
[Circulatory stimulation in rheumatic patients].
Topics: Aged; Arthritis, Rheumatoid; Blood Circulation; Female; Humans; Male; Middle Aged; Nicotinic Acids; | 1970 |
Recurrent right middle lobe syndrome in an asthmatic child. Case report and serial vectorcardiographic study.
Topics: Asthma; Child; Cough; Ephedrine; Female; Humans; Middle Lobe Syndrome; Pain; Phenobarbital; Predniso | 1970 |