2-amino-5-phosphonovalerate has been researched along with Pain in 80 studies
2-Amino-5-phosphonovalerate: The D-enantiomer is a potent and specific antagonist of NMDA glutamate receptors (RECEPTORS, N-METHYL-D-ASPARTATE). The L form is inactive at NMDA receptors but may affect the AP4 (2-amino-4-phosphonobutyrate; APB) excitatory amino acid receptors.
Pain: An unpleasant sensation induced by noxious stimuli which are detected by NERVE ENDINGS of NOCICEPTIVE NEURONS.
| Excerpt | Relevance | Reference |
|---|---|---|
| " The current study examined spinal coadministration of low doses of NMDA receptor antagonist, D-(-)-2-Amino-5-phosphonovalerate (D-APV), and mu-opioid receptor agonist, morphine sulfate (MS), in reducing visceral nociception using an acute bradykinin induced pancreatitis model in rats." | 7.72 | Intrathecal coadministration of D-APV and morphine is maximally effective in a rat experimental pancreatitis model. ( Lu, Y; Vera-Portocarrero, LP; Westlund, KN, 2003) |
| " To study the participation of histamine in pain perception, histidine decarboxylase knockout mice were examined for pain threshold by means of three different kinds of noxious stimuli: thermal nociception (hot-plate, tail-flick, and paw-withdrawal), mechanical nociception (tail-pressure), and chemical nociception (formalin test and capsaicin test)." | 3.73 | Intrathecally-administered histamine facilitates nociception through tachykinin NK1 and histamine H1 receptors: a study in histidine decarboxylase gene knockout mice. ( Kato, M; Kuramasu, A; Mobarakeh, JI; Orito, T; Sakurada, S; Sakurai, E; Yanai, K; Yoshida, A, 2005) |
| " The current study examined spinal coadministration of low doses of NMDA receptor antagonist, D-(-)-2-Amino-5-phosphonovalerate (D-APV), and mu-opioid receptor agonist, morphine sulfate (MS), in reducing visceral nociception using an acute bradykinin induced pancreatitis model in rats." | 3.72 | Intrathecal coadministration of D-APV and morphine is maximally effective in a rat experimental pancreatitis model. ( Lu, Y; Vera-Portocarrero, LP; Westlund, KN, 2003) |
| " Recent electrophysiological studies by our group have suggested that increased excitation of spinal GABAergic neurons by activation of N-methyl-D-aspartate (NMDA) and non-NMDA receptors following intradermal injection of capsaicin results in the generation of DRRs that contribute to neurogenic inflammation." | 3.71 | NMDA or non-NMDA receptor antagonists attenuate increased Fos expression in spinal dorsal horn GABAergic neurons after intradermal injection of capsaicin in rats. ( Lin, Q; Willis, WD; Zou, X, 2001) |
| "The NMDA receptor and the NK-1 receptor are important determinants of the MAC of isoflurane, exerting this influence by inhibition of pain transmission in the spinal cord, while mGlu and AMPA receptors have no effect on the MAC of isoflurane." | 3.70 | Intrathecal co-administration of NMDA antagonist and NK-1 antagonist reduces MAC of isoflurane in rats. ( Goto, F; Ishizaki, K; Karasawa, S; Nara, T; Obata, H; Sasaki, M, 1999) |
| "While much evidence implicates substance P (SP), an endogenous neurokinin (NK), as a primary sensory transmitter of acute pain in mammalian spinal cord, its role in continuous (tonic) pain is less clear." | 3.68 | Neurokinin and NMDA antagonists (but not a kainic acid antagonist) are antinociceptive in the mouse formalin model. ( Cowan, A; Larson, AA; Murray, CW, 1991) |
| "Secondary mechanical allodynia resulting from a thermal stimulus (52." | 1.33 | Activated PKA and PKC, but not CaMKIIalpha, are required for AMPA/Kainate-mediated pain behavior in the thermal stimulus model. ( Jones, TL; Sorkin, LS, 2005) |
| "Since hyperalgesia is a behavioral consequence of central sensitization, it should be attenuated at the level of the dorsal horn with NMDA receptor antagonists." | 1.32 | Differential efficacy of intrathecal NMDA receptor antagonists on inflammatory mechanical and thermal hyperalgesia in rats. ( Hama, A; Sagen, J; Woon Lee, J, 2003) |
| " After obtaining dose-response curves for each agent, combinations of morphine and AP-5, ACEA 1021 or ACEA 2752 were tested for their effect on the number of flinches in the formalin test and for associated side-effects, such as motor disturbances, flaccidity, and agitation/allodynia." | 1.31 | Interaction between intrathecal morphine and glutamate receptor antagonists in formalin test. ( Nishiyama, T, 2000) |
| "Muscle inflammation was induced by injection of turpentine oil into the gastrocnemius muscle, whereas superficial tissue inflammation was induced by an intraplantar injection of turpentine oil into the hindpaw." | 1.31 | Differential contributions of NMDA and non-NMDA receptors to spinal Fos expression evoked by superficial tissue and muscle inflammation in the rat. ( Hu, JY; Zhao, ZQ, 2001) |
| "Pretreatment with mexiletine (5-30 mg/kg i." | 1.30 | Comparable dose-dependent inhibition of AP-7 sensitive strychnine-induced allodynia and paw pinch-induced nociception by mexiletine in the rat. ( Hodge, E; Khandwala, H; Loomis, CW, 1997) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 5 (6.25) | 18.7374 |
| 1990's | 38 (47.50) | 18.2507 |
| 2000's | 32 (40.00) | 29.6817 |
| 2010's | 5 (6.25) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Xu, Y | 1 |
| Zhang, K | 1 |
| Miao, J | 1 |
| Zhao, P | 1 |
| Lv, M | 1 |
| Li, J | 1 |
| Fu, X | 1 |
| Luo, X | 1 |
| Zhu, P | 1 |
| Watanabe, C | 1 |
| Mizoguchi, H | 1 |
| Bagetta, G | 1 |
| Sakurada, S | 3 |
| Zhang, GH | 1 |
| Min, SS | 1 |
| Seol, GH | 1 |
| Lee, KS | 1 |
| Han, H | 1 |
| In Kim, Y | 1 |
| Han, HC | 1 |
| Dong, XD | 1 |
| Svensson, P | 1 |
| Cairns, BE | 1 |
| Traub, RJ | 1 |
| Zhai, Q | 1 |
| Ji, Y | 1 |
| Kovalenko, M | 1 |
| Rahman, OI | 1 |
| Terayama, R | 1 |
| Ikeda, T | 1 |
| Koganemaru, M | 1 |
| Nakamura, T | 1 |
| Shiba, R | 1 |
| Nishimori, T | 1 |
| Lu, Y | 1 |
| Vera-Portocarrero, LP | 1 |
| Westlund, KN | 2 |
| Sumikura, H | 1 |
| Arendt-Nielsen, L | 2 |
| Hua, XY | 1 |
| Hayes, CS | 1 |
| Hofer, A | 1 |
| Fitzsimmons, B | 1 |
| Kilk, K | 1 |
| Langel, U | 1 |
| Bartfai, T | 1 |
| Yaksh, TL | 4 |
| Li, W | 1 |
| Neugebauer, V | 3 |
| Liang, YC | 1 |
| Huang, CC | 1 |
| Hsu, KS | 1 |
| Bie, B | 1 |
| Peng, Y | 1 |
| Zhang, Y | 1 |
| Pan, ZZ | 1 |
| Jones, TL | 1 |
| Sorkin, LS | 1 |
| Yoshida, A | 1 |
| Mobarakeh, JI | 1 |
| Sakurai, E | 1 |
| Orito, T | 1 |
| Kuramasu, A | 1 |
| Kato, M | 1 |
| Yanai, K | 1 |
| Haghparast, A | 1 |
| Gheitasi, IP | 1 |
| Lashgari, R | 1 |
| Soleimannejad, E | 1 |
| Naghdi, N | 1 |
| Semnanian, S | 2 |
| Fathollahi, Y | 1 |
| Kazemnejad, A | 1 |
| Tan-No, K | 1 |
| Esashi, A | 1 |
| Nakagawasai, O | 1 |
| Niijima, F | 1 |
| Furuta, S | 1 |
| Sato, T | 1 |
| Satoh, S | 1 |
| Yasuhara, H | 1 |
| Tadano, T | 1 |
| Nishiyama, T | 4 |
| Jedema, HP | 1 |
| Moghaddam, B | 1 |
| Nagaoka, H | 1 |
| Sakurada, T | 1 |
| Takeda, S | 1 |
| Nakagawa, Y | 1 |
| Kisara, K | 1 |
| Arai, Y | 1 |
| Lücke, T | 2 |
| Schaible, HG | 2 |
| Millan, MJ | 1 |
| Seguin, L | 1 |
| Kolhekar, R | 2 |
| Meller, ST | 2 |
| Gebhart, GF | 3 |
| Grubb, B | 1 |
| Rice, ASC | 1 |
| McMahon, SB | 1 |
| Chaplan, SR | 2 |
| Malmberg, AB | 1 |
| Shors, TJ | 1 |
| Elkabes, S | 1 |
| Selcher, JC | 1 |
| Black, IB | 1 |
| Liu, H | 1 |
| Mantyh, PW | 1 |
| Basbaum, AI | 1 |
| Lawand, NB | 1 |
| Willis, WD | 2 |
| Sandkühler, J | 1 |
| Chen, JG | 1 |
| Cheng, G | 1 |
| Randić, M | 1 |
| Khandwala, H | 1 |
| Hodge, E | 1 |
| Loomis, CW | 1 |
| Vaccarino, AL | 1 |
| Clemmons, HR | 1 |
| Mader, GJ | 1 |
| Magnusson, JE | 1 |
| Calcutt, NA | 1 |
| Svendsen, F | 1 |
| Tjølsen, A | 1 |
| Hole, K | 1 |
| Murase, K | 2 |
| Saka, T | 1 |
| Terao, S | 1 |
| Ikeda, H | 2 |
| Asai, T | 2 |
| Maione, S | 2 |
| Marabese, I | 2 |
| Leyva, J | 1 |
| Palazzo, E | 2 |
| de Novellis, V | 2 |
| Rossi, F | 3 |
| Tao, YX | 1 |
| Zhao, ZQ | 4 |
| Gyermek, L | 2 |
| Lee, C | 2 |
| Kawasaki-Yatsugi, S | 2 |
| Yamaguchi, T | 2 |
| Song, XJ | 1 |
| Chen, J | 1 |
| Li, H | 1 |
| Luo, C | 1 |
| Li, Z | 1 |
| Zheng, J | 1 |
| Kawamata, T | 1 |
| Omote, K | 1 |
| Inoue, M | 1 |
| Mishina, M | 1 |
| Ueda, H | 1 |
| Martin, HA | 1 |
| Shu, YS | 1 |
| Li, P | 1 |
| Zhuo, M | 1 |
| Zou, X | 1 |
| Lin, Q | 1 |
| McKenna, JE | 1 |
| Melzack, R | 2 |
| Afrah, AW | 1 |
| Stiller, CO | 1 |
| Olgart, L | 1 |
| Brodin, E | 1 |
| Gustafsson, H | 1 |
| Cuomo, D | 1 |
| Berrino, L | 1 |
| Jensen, TS | 1 |
| Dykstra, C | 1 |
| Seltzer, Z | 1 |
| Cohn, S | 1 |
| Ginzburg, R | 1 |
| Beilin, B | 1 |
| Coderre, TJ | 1 |
| Murray, CW | 1 |
| Cowan, A | 1 |
| Larson, AA | 1 |
| Kao, MC | 1 |
| Lee, HK | 1 |
| Chai, CY | 1 |
| Wang, Y | 1 |
| Haley, JE | 1 |
| Sullivan, AF | 1 |
| Dickenson, AH | 1 |
| van Praag, H | 1 |
| Frenk, H | 2 |
| Sher, GD | 2 |
| Mitchell, D | 2 |
| Urca, G | 2 |
| Urca, R | 1 |
| Bossut, D | 1 |
| Mayer, DJ | 1 |
| Holohean, AM | 1 |
| Vega, JL | 1 |
| Hackman, JC | 1 |
| Davidoff, RA | 1 |
| Jacquet, YF | 1 |
| Raigorodsky, G | 1 |
| Caudle, RM | 1 |
| Isaac, L | 1 |
| Daou, I | 1 |
| Tuttle, AH | 1 |
| Longo, G | 1 |
| Wieskopf, JS | 1 |
| Bonin, RP | 1 |
| Ase, AR | 1 |
| Wood, JN | 1 |
| De Koninck, Y | 1 |
| Ribeiro-da-Silva, A | 1 |
| Mogil, JS | 1 |
| Séguéla, P | 1 |
| Spuz, CA | 1 |
| Tomaszycki, ML | 1 |
| Borszcz, GS | 1 |
| Khakpay, R | 1 |
| Javan, M | 1 |
| Janahmadi, M | 1 |
| Hama, A | 1 |
| Woon Lee, J | 1 |
| Sagen, J | 1 |
| Yoshimura, M | 1 |
| Yonehara, N | 1 |
| Khan, IM | 1 |
| Buerkle, H | 1 |
| Taylor, P | 1 |
| Ishizaki, K | 1 |
| Sasaki, M | 1 |
| Karasawa, S | 1 |
| Obata, H | 1 |
| Nara, T | 1 |
| Goto, F | 1 |
| Bennett, AD | 1 |
| Everhart, AW | 1 |
| Hulsebosch, CE | 1 |
| Tershner, SA | 1 |
| Helmstetter, FJ | 1 |
| Hanaoka, K | 1 |
| Bhave, G | 1 |
| Karim, F | 1 |
| Carlton, SM | 1 |
| Gereau , RW | 1 |
| Hu, JY | 1 |
| Trial | Phase | Enrollment | Study Type | Start Date | Status | ||
|---|---|---|---|---|---|---|---|
| Phenomics and Genomics of Clinically Relevant Chronic Postsurgical Pain: A Multicenter Prospective Study[NCT04798573] | 10,000 participants (Anticipated) | Observational | 2012-08-03 | Active, not recruiting | |||
| [information is prepared from clinicaltrials.gov, extracted Sep-2024] | |||||||
80 other studies available for 2-amino-5-phosphonovalerate and Pain
| Article | Year |
|---|---|
The spinal NR2BR/ERK2 pathway as a target for the central sensitization of collagen-induced arthritis pain.
Topics: 2-Amino-5-phosphonovalerate; Animals; Arthritis, Experimental; Central Nervous System Sensitization; | 2018 |
Involvement of spinal glutamate in nociceptive behavior induced by intrathecal administration of hemokinin-1 in mice.
Topics: 2-Amino-5-phosphonovalerate; Animals; Behavior, Animal; Dizocilpine Maleate; Glutamic Acid; Injectio | 2016 |
Inhibition of the N-methyl-d-aspartate receptor unmasks the antinociception of endogenous opioids in the periphery.
Topics: 2-Amino-5-phosphonovalerate; Analgesics, Opioid; Animals; Arthralgia; Arthritis; beta-Endorphin; Car | 2009 |
The analgesic action of topical diclofenac may be mediated through peripheral NMDA receptor antagonism.
Topics: 2-Amino-5-phosphonovalerate; alpha-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic Acid; Anesthetics, | 2009 |
NMDA receptor antagonists attenuate noxious and nonnoxious colorectal distention-induced Fos expression in the spinal cord and the visceromotor reflex.
Topics: 2-Amino-5-phosphonovalerate; Animals; Behavior, Animal; Colon; Dizocilpine Maleate; Excitatory Amino | 2002 |
Differential effects of NMDA and AMPA/KA receptor antagonists on c-Fos or Zif/268 expression in the rat spinal dorsal horn induced by noxious thermal or mechanical stimulation, or formalin injection.
Topics: 2-Amino-5-phosphonovalerate; 6-Cyano-7-nitroquinoxaline-2,3-dione; Animals; DNA-Binding Proteins; Dr | 2002 |
Intrathecal coadministration of D-APV and morphine is maximally effective in a rat experimental pancreatitis model.
Topics: 2-Amino-5-phosphonovalerate; Animals; Bradykinin; Disease Models, Animal; Drug Therapy, Combination; | 2003 |
MAC reduction after intrathecal coadministration of GABA(A) agonist and glutamate antagonist in rats.
Topics: 2-Amino-5-phosphonovalerate; Anesthetics, Inhalation; Animals; Drug Synergism; Excitatory Amino Acid | 2003 |
Galanin acts at GalR1 receptors in spinal antinociception: synergy with morphine and AP-5.
Topics: 2-Amino-5-phosphonovalerate; Analgesics; Animals; Disease Models, Animal; Drug Synergism; Galanin; I | 2004 |
Block of NMDA and non-NMDA receptor activation results in reduced background and evoked activity of central amygdala neurons in a model of arthritic pain.
Topics: 2-Amino-5-phosphonovalerate; Action Potentials; Amygdala; Analysis of Variance; Animals; Arthritis; | 2004 |
Characterization of long-term potentiation of primary afferent transmission at trigeminal synapses of juvenile rats: essential role of subtype 5 metabotropic glutamate receptors.
Topics: 2-Amino-5-phosphonovalerate; 6-Cyano-7-nitroquinoxaline-2,3-dione; Afferent Pathways; Animals; Calci | 2005 |
cAMP-mediated mechanisms for pain sensitization during opioid withdrawal.
Topics: 2-Amino-5-phosphonovalerate; 6-Cyano-7-nitroquinoxaline-2,3-dione; 8-Bromo Cyclic Adenosine Monophos | 2005 |
Activated PKA and PKC, but not CaMKIIalpha, are required for AMPA/Kainate-mediated pain behavior in the thermal stimulus model.
Topics: 2-Amino-5-phosphonovalerate; alpha-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic Acid; Animals; Area | 2005 |
Intrathecally-administered histamine facilitates nociception through tachykinin NK1 and histamine H1 receptors: a study in histidine decarboxylase gene knockout mice.
Topics: 2-Amino-5-phosphonovalerate; Analgesics; Animals; Behavior, Animal; Capsaicin; Excitatory Amino Acid | 2005 |
Involvement of glutamatergic receptors in the nucleus cuneiformis in modulating morphine-induced antinociception in rats.
Topics: 2-Amino-5-phosphonovalerate; Analgesics, Opioid; Animals; Dizocilpine Maleate; Excitatory Amino Acid | 2007 |
Antinociceptive effect of intra-hippocampal CA1 and dentate gyrus injection of MK801 and AP5 in the formalin test in adult male rats.
Topics: 2-Amino-5-phosphonovalerate; Analgesics; Animals; Dentate Gyrus; Dizocilpine Maleate; Excitatory Ami | 2007 |
Intrathecally administered D-cycloserine produces nociceptive behavior through the activation of N-methyl-D-aspartate receptor ion-channel complex acting on the glycine recognition site.
Topics: 2-Amino-5-phosphonovalerate; Agmatine; Animals; Cycloserine; Dizocilpine Maleate; Dose-Response Rela | 2007 |
Interaction between a NMDA receptor antagonist, AP-5 and an AMPA receptor antagonist, YM 872 in antinociception in the spinal cord.
Topics: 2-Amino-5-phosphonovalerate; Acute Disease; Analgesics; Animals; Chronic Disease; Dose-Response Rela | 2008 |
Glutamatergic control of dopamine release during stress in the rat prefrontal cortex.
Topics: 2-Amino-5-phosphonovalerate; 6-Cyano-7-nitroquinoxaline-2,3-dione; alpha-Amino-3-hydroxy-5-methyl-4- | 1994 |
Theophylline-induced nociceptive behavioral response in mice: possible indirect interaction with spinal N-methyl-D-aspartate receptors.
Topics: 2-Amino-5-phosphonovalerate; Adenosine; Adenosine-5'-(N-ethylcarboxamide); Animals; Behavior, Animal | 1993 |
Differential effects of N-methyl-D-aspartate (NMDA) and non-NMDA receptor antagonists on the responses of rat spinal neurons with joint input.
Topics: 2-Amino-5-phosphonovalerate; 6-Cyano-7-nitroquinoxaline-2,3-dione; alpha-Amino-3-hydroxy-5-methyl-4- | 1993 |
Chemically-diverse ligands at the glycine B site coupled to N-methyl-D-aspartate (NMDA) receptors selectively block the late phase of formalin-induced pain in mice.
Topics: 2-Amino-5-phosphonovalerate; Acetates; Acetic Acid; Animals; Anticonvulsants; Cycloserine; Dizocilpi | 1994 |
Characterization of the role of spinal N-methyl-D-aspartate receptors in thermal nociception in the rat.
Topics: 2-Amino-5-phosphonovalerate; Animals; Arginine; Behavior, Animal; Cold Temperature; Hot Temperature; | 1993 |
The involvement of N-methyl-D-aspartate (NMDA) and non-NMDA receptors in the responsiveness of rat spinal neurons with input from the chronically inflamed ankle.
Topics: 2-Amino-5-phosphonovalerate; 6-Cyano-7-nitroquinoxaline-2,3-dione; Afferent Pathways; Animals; Ankle | 1994 |
NMDA and quisqualate modulation of visceral nociception in the rat.
Topics: 2-Amino-5-phosphonovalerate; Animals; Blood Pressure; Colon; Dose-Response Relationship, Drug; Male; | 1994 |
Pre-emptive intrathecal administration of an NMDA receptor antagonist (AP-5) prevents hyper-reflexia in a model of persistent visceral pain.
Topics: 2-Amino-5-phosphonovalerate; Animals; Chronic Disease; Cystitis; Differential Threshold; Dose-Respon | 1994 |
Efficacy of spinal NMDA receptor antagonism in formalin hyperalgesia and nerve injury evoked allodynia in the rat.
Topics: 2-Amino-5-phosphonovalerate; Analgesics; Animals; Dextromethorphan; Dextrorphan; Dizocilpine Maleate | 1997 |
Stress persistently increases NMDA receptor-mediated binding of [3H]PDBu (a marker for protein kinase C) in the amygdala, and re-exposure to the stressful context reactivates the increase.
Topics: 2-Amino-5-phosphonovalerate; Amygdala; Animals; Autoradiography; Biomarkers; Brain; Brain Mapping; C | 1997 |
NMDA-receptor regulation of substance P release from primary afferent nociceptors.
Topics: 2-Amino-5-phosphonovalerate; 6-Cyano-7-nitroquinoxaline-2,3-dione; Animals; Injections, Spinal; N-Me | 1997 |
Excitatory amino acid receptor involvement in peripheral nociceptive transmission in rats.
Topics: 2-Amino-5-phosphonovalerate; 6-Cyano-7-nitroquinoxaline-2,3-dione; Animals; Excitatory Amino Acid An | 1997 |
Low-frequency stimulation of afferent Adelta-fibers induces long-term depression at primary afferent synapses with substantia gelatinosa neurons in the rat.
Topics: 2-Amino-5-phosphonovalerate; Animals; Calcium; Chelating Agents; Egtazic Acid; Electric Stimulation; | 1997 |
Comparable dose-dependent inhibition of AP-7 sensitive strychnine-induced allodynia and paw pinch-induced nociception by mexiletine in the rat.
Topics: 2-Amino-5-phosphonovalerate; Animals; Dose-Response Relationship, Drug; Foot; Hyperesthesia; Male; M | 1997 |
A role of periaqueductal grey NMDA receptors in mediating formalin-induced pain in the rat.
Topics: 2-Amino-5-phosphonovalerate; Animals; Formaldehyde; Hot Temperature; Injections; Male; Pain; Periaqu | 1997 |
Spinal pharmacology of tactile allodynia in diabetic rats.
Topics: 2-Amino-5-phosphonovalerate; Analgesics, Non-Narcotic; Analgesics, Opioid; Animals; Anti-Bacterial A | 1997 |
AMPA and NMDA receptor-dependent spinal LTP after nociceptive tetanic stimulation.
Topics: 2-Amino-5-phosphonovalerate; Analysis of Variance; Animals; Excitatory Amino Acid Antagonists; Femal | 1998 |
Slow intrinsic optical signals in the rat spinal dorsal horn in slice.
Topics: 2-Amino-5-phosphonovalerate; 6-Cyano-7-nitroquinoxaline-2,3-dione; Action Potentials; Analgesics; An | 1998 |
Characterisation of mGluRs which modulate nociception in the PAG of the mouse.
Topics: 2-Amino-5-phosphonovalerate; Analgesics; Animals; Cycloleucine; Excitatory Amino Acid Agonists; Exci | 1998 |
NMDA receptors mediating Fos expression in rat spinal cord induced by subcutaneous injection of formalin.
Topics: 2-Amino-5-phosphonovalerate; Animals; Dose-Response Relationship, Drug; Formaldehyde; Male; Neurons; | 1998 |
Analgesic interaction between intrathecal midazolam and glutamate receptor antagonists on thermal-induced pain in rats.
Topics: 2-Amino-5-phosphonovalerate; Animals; Dose-Response Relationship, Drug; Drug Synergism; Excitatory A | 1999 |
Involvement of NMDA and non-NMDA receptors in transmission of spinal visceral nociception in cat.
Topics: 2-Amino-5-phosphonovalerate; Animals; Cats; Excitatory Amino Acid Agonists; Female; Kainic Acid; Mal | 1999 |
Involvement of peripheral NMDA and non-NMDA receptors in development of persistent firing of spinal wide-dynamic-range neurons induced by subcutaneous bee venom injection in the cat.
Topics: 2-Amino-5-phosphonovalerate; 6-Cyano-7-nitroquinoxaline-2,3-dione; Action Potentials; Animals; Bee V | 1999 |
Activation of spinal N-methyl-D-aspartate receptors stimulates a nitric oxide/cyclic guanosine 3,5-monophosphate/glutamate release cascade in nociceptive signaling.
Topics: 2-Amino-5-phosphonovalerate; Animals; Behavior, Animal; Cyclic GMP; Enzyme Inhibitors; Excitatory Am | 1999 |
Enhanced nociception by exogenous and endogenous substance P given into the spinal cord in mice lacking NR(2)A/epsilon(1), an NMDA receptor subunit.
Topics: 2-Amino-5-phosphonovalerate; Analgesics; Animals; Bradykinin; Capsaicin; Dizocilpine Maleate; Excita | 2000 |
Robust changes of afferent-induced excitation in the rat spinal dorsal horn after conditioning high-frequency stimulation.
Topics: 2-Amino-5-phosphonovalerate; Animals; Bicuculline; Chlorides; Conditioning, Psychological; Electric | 2000 |
Interaction between intrathecal morphine and glutamate receptor antagonists in formalin test.
Topics: 2-Amino-5-phosphonovalerate; Analgesics, Opioid; Animals; Behavior, Animal; Dose-Response Relationsh | 2000 |
Effect of muscle pain and intrathecal AP-5 on electromyographic patterns during treadmill walking in the rat.
Topics: 2-Amino-5-phosphonovalerate; Animals; Electromyography; Excitatory Amino Acid Antagonists; Female; I | 2000 |
[Comparison of NMDA and non-NMDA receptor antagonists-induced inhibition in hindpaw withdrawal response to noxious thermal stimulation].
Topics: 2-Amino-5-phosphonovalerate; Animals; Excitatory Amino Acid Antagonists; Hindlimb; Hot Temperature; | 1998 |
Substance P and neurokinin A mediate sensory synaptic transmission in young rat dorsal horn neurons.
Topics: 2-Amino-5-phosphonovalerate; 6-Cyano-7-nitroquinoxaline-2,3-dione; Age Factors; Analgesics, Opioid; | 2001 |
NMDA or non-NMDA receptor antagonists attenuate increased Fos expression in spinal dorsal horn GABAergic neurons after intradermal injection of capsaicin in rats.
Topics: 2-Amino-5-phosphonovalerate; 6-Cyano-7-nitroquinoxaline-2,3-dione; Animals; Blotting, Western; Capsa | 2001 |
Blocking NMDA receptors in the hippocampal dentate gyrus with AP5 produces analgesia in the formalin pain test.
Topics: 2-Amino-5-phosphonovalerate; Analgesia; Animals; Behavior, Animal; Dentate Gyrus; Disease Models, An | 2001 |
Involvement of spinal N-methyl-D-aspartate receptors in capsaicin-induced in vivo release of substance P in the rat dorsal horn.
Topics: 2-Amino-5-phosphonovalerate; Animals; Capsaicin; Dose-Response Relationship, Drug; Excitatory Amino | 2001 |
Interaction between vanilloid and glutamate receptors in the central modulation of nociception.
Topics: 2-Amino-5-phosphonovalerate; Animals; Capsaicin; Chromones; Excitatory Amino Acid Antagonists; Male; | 2002 |
The antinociceptive activity of excitatory amino acids in the rat brainstem: an anatomical and pharmacological analysis.
Topics: 2-Amino-5-phosphonovalerate; Animals; Brain Mapping; Brain Stem; Diencephalon; Dizocilpine Maleate; | 1992 |
Production of endogenous nitric oxide and activation of soluble guanylate cyclase are required for N-methyl-D-aspartate-produced facilitation of the nociceptive tail-flick reflex.
Topics: 2-Amino-5-phosphonovalerate; Animals; Arginine; Enzyme Activation; Guanylate Cyclase; Male; N-Methyl | 1992 |
Modulation of neuropathic pain behavior in rats by spinal disinhibition and NMDA receptor blockade of injury discharge.
Topics: 2-Amino-5-phosphonovalerate; Animals; Behavior, Animal; Dizocilpine Maleate; Electric Stimulation; G | 1991 |
Central neural mediators of secondary hyperalgesia following heat injury in rats: neuropeptides and excitatory amino acids.
Topics: 2-Amino-5-phosphonovalerate; 6-Cyano-7-nitroquinoxaline-2,3-dione; alpha-Amino-3-hydroxy-5-methyl-4- | 1991 |
Neurokinin and NMDA antagonists (but not a kainic acid antagonist) are antinociceptive in the mouse formalin model.
Topics: 2-Amino-5-phosphonovalerate; Analgesics; Animals; Dose-Response Relationship, Drug; Formaldehyde; In | 1991 |
NMDA antagonists attenuate hypertension induced by carotid clamping in the rostral ventrolateral medulla of rats.
Topics: 2-Amino-5-phosphonovalerate; Action Potentials; Amino Acids; Animals; Anticonvulsants; Arterial Occl | 1991 |
Evidence for spinal N-methyl-D-aspartate receptor involvement in prolonged chemical nociception in the rat.
Topics: 2-Amino-5-phosphonovalerate; Animals; Dibenzocycloheptenes; Dipeptides; Dizocilpine Maleate; Electri | 1990 |
The role of glutamate in opiate descending inhibition of nociceptive spinal reflexes.
Topics: 2-Amino-5-phosphonovalerate; Analgesia; Analysis of Variance; Animals; Anticonvulsants; Male; Microi | 1990 |
Intrathecal N-methyl-D-aspartate induces hyperexcitability in rat dorsal horn convergent neurones.
Topics: 2-Amino-5-phosphonovalerate; Animals; Injections, Spinal; Male; N-Methylaspartate; Neural Inhibition | 1990 |
Neurotoxic effects of excitatory amino acids in the mouse spinal cord: quisqualate and kainate but not N-methyl-D-aspartate induce permanent neural damage.
Topics: 2-Amino-5-phosphonovalerate; Aggression; Animals; Glutamine; Kainic Acid; Male; Mice; Mice, Inbred I | 1990 |
Is substance P a primary afferent neurotransmitter for nociceptive input? IV. 2-Amino-5-phosphonovalerate (APV) and [D-Pro2,D-Trp7,9]-substance P exert different effects on behaviors induced by intrathecal substance P, strychnine and kainic acid.
Topics: 2-Amino-5-phosphonovalerate; Animals; Dose-Response Relationship, Drug; Drug Interactions; Injection | 1988 |
Excitatory transmitters, ventral root potentials and [K+]o in the isolated frog leg-spinal cord preparation.
Topics: 2-Amino-5-phosphonovalerate; Action Potentials; Animals; In Vitro Techniques; Kynurenic Acid; Pain; | 1988 |
The NMDA receptor: central role in pain inhibition in rat periaqueductal gray.
Topics: 2-Amino-5-phosphonovalerate; Amino Acids; Analgesia; Animals; Aspartic Acid; Kainic Acid; Male; Morp | 1988 |
Intrathecal N-methyl-D-aspartate (NMDA) activates both nociceptive and antinociceptive systems.
Topics: 2-Amino-5-phosphonovalerate; Analgesia; Animals; Aspartic Acid; Behavior, Animal; Decerebrate State; | 1987 |
A novel interaction between dynorphin(1-13) and an N-methyl-D-aspartate site.
Topics: 2-Amino-5-phosphonovalerate; Analgesics; Animals; Aspartic Acid; Atropine; Binding, Competitive; Dip | 1988 |
Remote optogenetic activation and sensitization of pain pathways in freely moving mice.
Topics: Afferent Pathways; Animals; Avoidance Learning; Cells, Cultured; Channelrhodopsins; Female; Ganglia, | 2013 |
N-methyl-D-aspartate receptor agonism and antagonism within the amygdaloid central nucleus suppresses pain affect: differential contribution of the ventrolateral periaqueductal gray.
Topics: Animals; Central Amygdaloid Nucleus; Dose-Response Relationship, Drug; Electroshock; Male; N-Methyla | 2014 |
The effect of intra-locus coeruleus injection of 17beta-estradiol on inflammatory pain modulation in male rat.
Topics: 6-Cyano-7-nitroquinoxaline-2,3-dione; Animals; Bicuculline; Disease Models, Animal; Estradiol; Estro | 2010 |
Differential efficacy of intrathecal NMDA receptor antagonists on inflammatory mechanical and thermal hyperalgesia in rats.
Topics: Animals; Behavior, Animal; Dizocilpine Maleate; Dose-Response Relationship, Drug; Excitatory Amino A | 2003 |
Alteration in sensitivity of ionotropic glutamate receptors and tachykinin receptors in spinal cord contribute to development and maintenance of nerve injury-evoked neuropathic pain.
Topics: Alanine; Analgesics; Animals; Behavior, Animal; Benzamides; Dizocilpine Maleate; Excitatory Amino Ac | 2006 |
Nociceptive and antinociceptive responses to intrathecally administered nicotinic agonists.
Topics: Alkaloids; Analgesia; Animals; Azocines; Bridged Bicyclo Compounds, Heterocyclic; Escape Reaction; H | 1998 |
Intrathecal co-administration of NMDA antagonist and NK-1 antagonist reduces MAC of isoflurane in rats.
Topics: 6-Cyano-7-nitroquinoxaline-2,3-dione; Alanine; Anesthetics, Inhalation; Animals; Biphenyl Compounds; | 1999 |
Intrathecal administration of an NMDA or a non-NMDA receptor antagonist reduces mechanical but not thermal allodynia in a rodent model of chronic central pain after spinal cord injury.
Topics: Animals; Chronic Disease; Disease Models, Animal; Dose-Response Relationship, Drug; Excitatory Amino | 2000 |
Antinociception produced by mu opioid receptor activation in the amygdala is partly dependent on activation of mu opioid and neurotensin receptors in the ventral periaqueductal gray.
Topics: Amygdala; Analgesics, Opioid; Animals; Enkephalin, Ala(2)-MePhe(4)-Gly(5)-; Male; Naltrexone; Narcot | 2000 |
The analgesic interaction between intrathecal clonidine and glutamate receptor antagonists on thermal and formalin-induced pain in rats.
Topics: Adrenergic alpha-Agonists; Analgesics, Non-Narcotic; Animals; Clonidine; Dose-Response Relationship, | 2001 |
Peripheral group I metabotropic glutamate receptors modulate nociception in mice.
Topics: Animals; Chromones; Excitatory Amino Acid Antagonists; Glycine; Hindlimb; Hot Temperature; Immunohis | 2001 |
Differential contributions of NMDA and non-NMDA receptors to spinal Fos expression evoked by superficial tissue and muscle inflammation in the rat.
Topics: Afferent Pathways; Animals; Cell Count; Dose-Response Relationship, Drug; Excitatory Amino Acid Anta | 2001 |
N-methyl-D-aspartate receptors mediate responses of rat dorsal horn neurones to hindlimb ischemia.
Topics: Animals; Anterior Horn Cells; Hindlimb; Injections, Spinal; Ischemia; Ketamine; Male; Pain; Physical | 1990 |