aspartic acid has been researched along with Pain in 38 studies
Aspartic Acid: One of the non-essential amino acids commonly occurring in the L-form. It is found in animals and plants, especially in sugar cane and sugar beets. It may be a neurotransmitter.
aspartic acid : An alpha-amino acid that consists of succinic acid bearing a single alpha-amino substituent
L-aspartic acid : The L-enantiomer of aspartic acid.
Pain: An unpleasant sensation induced by noxious stimuli which are detected by NERVE ENDINGS of NOCICEPTIVE NEURONS.
| Excerpt | Relevance | Reference |
|---|---|---|
| "Morphine pretreatment produced an increase in GABA levels and a decrease in glutamate levels in the first few minutes." | 5.35 | [Effect of a simple morphine system injection in some aminoacids in the anterior cingulate cortex during acute pain]. ( Hernández, L; Páez, X; Quiñones, B; Silva, E, 2008) |
| " Effects of intrathecal glutamate transporter activator (R)-(-)-5-methyl-1-nicotinoyl-2-pyrazoline and inhibitors (DL-threo-β-benzyloxyaspartate [TBOA], dihydrokainate, and DL-threo-β-hydroxyaspartate), or TBOA plus group III metabotropic glutamate receptor antagonist (RS)-α-methylserine-O-phosphate, on formalin- and CFA-induced inflammatory pain were examined." | 3.77 | Effect of inhibition of spinal cord glutamate transporters on inflammatory pain induced by formalin and complete Freund's adjuvant. ( Guan, X; Lu, W; Petralia, RS; Rothstein, JD; Tao, YX; Yaster, M, 2011) |
| "The single nucleotide polymorphism 118A>G of the human micro-opioid receptor gene OPRM1, which leads to an exchange of the amino acid asparagine (N) to aspartic acid (D) at position 40 of the extracellular receptor region, alters the in vivo effects of opioids to different degrees in pain-processing brain regions." | 3.75 | A common human micro-opioid receptor genetic variant diminishes the receptor signaling efficacy in brain regions processing the sensory information of pain. ( Geisslinger, G; Kettner, M; Lötsch, J; Oertel, BG; Renné, C; Roskam, B; Schmidt, PH; Scholich, K, 2009) |
| "Chronic visceral pain is frequent, extremely debilitating, and generally resistant to pharmacological treatment." | 2.76 | Clinical effects and brain metabolic correlates in non-invasive cortical neuromodulation for visceral pain. ( Dasilva, D; Freedman, SD; Fregni, F; Lenkinski, RE; Pascual-Leone, A; Potvin, K; Wang, X, 2011) |
| "More pain was associated with reduced GMVs and NAA/Cr, over and above the effects of fatigue, depressive symptoms, physical activity, and psychomotor speed." | 1.46 | Prefrontal Structure Varies as a Function of Pain Symptoms in Chronic Fatigue Syndrome. ( De Lange, FP; Geurts, DEM; Knoop, H; Roelofs, K; Schmits, IC; Toni, I; van der Meer, JWM; van der Schaaf, ME, 2017) |
| "Morphine pretreatment produced an increase in GABA levels and a decrease in glutamate levels in the first few minutes." | 1.35 | [Effect of a simple morphine system injection in some aminoacids in the anterior cingulate cortex during acute pain]. ( Hernández, L; Páez, X; Quiñones, B; Silva, E, 2008) |
| "Pretreatment with taurine inhibited the nociceptive-related writhing behavior produced by an intraperitoneal injection of acetic acid in mice but failed to alter the latency of response in the hot plate or tail flick assay." | 1.28 | Interactions between substance P, calcitonin gene-related peptide, taurine and excitatory amino acids in the spinal cord. ( Larson, AA; Skilling, SR; Smullin, DH, 1990) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 10 (26.32) | 18.7374 |
| 1990's | 3 (7.89) | 18.2507 |
| 2000's | 17 (44.74) | 29.6817 |
| 2010's | 8 (21.05) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Fayed, N | 2 |
| Andrés, E | 2 |
| Viguera, L | 1 |
| Modrego, PJ | 1 |
| Garcia-Campayo, J | 2 |
| van der Schaaf, ME | 1 |
| De Lange, FP | 1 |
| Schmits, IC | 1 |
| Geurts, DEM | 1 |
| Roelofs, K | 1 |
| van der Meer, JWM | 1 |
| Toni, I | 1 |
| Knoop, H | 1 |
| Somers, DL | 1 |
| Clemente, FR | 1 |
| Oertel, BG | 1 |
| Kettner, M | 1 |
| Scholich, K | 1 |
| Renné, C | 1 |
| Roskam, B | 1 |
| Geisslinger, G | 1 |
| Schmidt, PH | 1 |
| Lötsch, J | 1 |
| Silva, E | 3 |
| Quiñones, B | 2 |
| Páez, X | 1 |
| Hernández, L | 4 |
| Radhakrishnan, R | 1 |
| Sluka, KA | 1 |
| Gussew, A | 1 |
| Rzanny, R | 1 |
| Erdtel, M | 1 |
| Scholle, HC | 1 |
| Kaiser, WA | 1 |
| Mentzel, HJ | 1 |
| Reichenbach, JR | 1 |
| Magallón, R | 1 |
| Andrés-Bergareche, H | 1 |
| Luciano, JV | 1 |
| Beltrán, J | 1 |
| Fregni, F | 1 |
| Potvin, K | 1 |
| Dasilva, D | 1 |
| Wang, X | 1 |
| Lenkinski, RE | 1 |
| Freedman, SD | 1 |
| Pascual-Leone, A | 1 |
| Gutzeit, A | 1 |
| Meier, D | 1 |
| Meier, ML | 1 |
| von Weymarn, C | 1 |
| Ettlin, DA | 1 |
| Graf, N | 1 |
| Froehlich, JM | 1 |
| Binkert, CA | 1 |
| Brügger, M | 1 |
| Yaster, M | 1 |
| Guan, X | 1 |
| Petralia, RS | 1 |
| Rothstein, JD | 2 |
| Lu, W | 1 |
| Tao, YX | 2 |
| Laurido, C | 1 |
| Hernández, A | 1 |
| Pelissier, T | 1 |
| Constandil, L | 1 |
| Zhang, XY | 1 |
| Zhang, JW | 1 |
| Chen, B | 1 |
| Bai, ZT | 1 |
| Shen, J | 1 |
| Ji, YH | 1 |
| Grachev, ID | 3 |
| Fredrickson, BE | 1 |
| Apkarian, AV | 2 |
| Wen, ZH | 1 |
| Chang, YC | 1 |
| Cherng, CH | 1 |
| Wang, JJ | 1 |
| Tao, PL | 1 |
| Wong, CS | 1 |
| Dmitrieva, N | 1 |
| Rodríguez-Malaver, AJ | 1 |
| Pérez, J | 1 |
| Liaw, WJ | 1 |
| Stephens, RL | 1 |
| Binns, BC | 1 |
| Chu, Y | 1 |
| Sepkuty, JP | 1 |
| Johns, RA | 1 |
| Jin, YH | 1 |
| Nishioka, H | 1 |
| Wakabayashi, K | 1 |
| Fujita, T | 1 |
| Yonehara, N | 1 |
| Sorensen, L | 1 |
| Siddall, PJ | 1 |
| Trenell, MI | 1 |
| Yue, DK | 1 |
| Malmberg, AB | 1 |
| Yaksh, TL | 1 |
| Olofsson, C | 1 |
| Ekblom, A | 1 |
| Ekman-Ordeberg, G | 1 |
| Irestedt, L | 1 |
| Nyberg, F | 1 |
| Ungerstedt, U | 1 |
| Wiklund, P | 1 |
| Tsai, PS | 1 |
| Cheng, JK | 1 |
| Marsala, M | 1 |
| Lin, CR | 1 |
| Wen, GH | 1 |
| Yang, LC | 1 |
| Minami, T | 1 |
| Matsumura, S | 1 |
| Okuda-Ashitaka, E | 1 |
| Shimamoto, K | 1 |
| Sakimura, K | 1 |
| Mishina, M | 1 |
| Mori, H | 1 |
| Ito, S | 1 |
| Fredickson, BE | 1 |
| Freund, N | 1 |
| Gonzalez, LE | 1 |
| Thomas, PS | 1 |
| Ramachandran, TS | 1 |
| Saurugg, D | 1 |
| Hodkewitsch, E | 1 |
| Argyropoulos, G | 1 |
| Clarici, G | 1 |
| Heppner, F | 1 |
| Sherman, AD | 1 |
| Gebhart, GF | 1 |
| Smullin, DH | 1 |
| Skilling, SR | 1 |
| Larson, AA | 1 |
| DeLander, GE | 1 |
| Wahl, JJ | 1 |
| Aanonsen, LM | 1 |
| Wilcox, GL | 1 |
| Jacquet, YF | 1 |
| Palkovits, M | 1 |
| Láng, T | 1 |
| Patthy, A | 1 |
| Elekes, I | 1 |
| Raigorodsky, G | 1 |
| Urca, G | 1 |
| Caudle, RM | 1 |
| Isaac, L | 1 |
| Krüger, K | 1 |
| Trial | Phase | Enrollment | Study Type | Start Date | Status | ||
|---|---|---|---|---|---|---|---|
| Effects of Percutaneous Neuromodulation on Plasticity in the Somatosensory System[NCT04475133] | 29 participants (Actual) | Interventional | 2020-08-13 | Completed | |||
| The Chronic Pain Brain: Structural White and Gray Matter Correlates of Impaired Muscle Control and Deficient Pain Processing[NCT06143319] | 80 participants (Actual) | Observational | 2015-10-01 | Completed | |||
| tDCS for the Management of Chronic Visceral Pain in Patients With Chronic Pancreatitis[NCT01857492] | 0 participants (Actual) | Interventional | 2013-03-31 | Withdrawn (stopped due to Inactive) | |||
| [information is prepared from clinicaltrials.gov, extracted Sep-2024] | |||||||
3 trials available for aspartic acid and Pain
| Article | Year |
|---|---|
Clinical effects and brain metabolic correlates in non-invasive cortical neuromodulation for visceral pain.
Topics: Adult; Analgesia; Aspartic Acid; Brain; Chronic Disease; Female; Glutamic Acid; Humans; Magnetic Res | 2011 |
Brain chemistry reflects dual states of pain and anxiety in chronic low back pain.
Topics: Adult; Anxiety; Aspartic Acid; Biomarkers; Brain Chemistry; Female; Gyrus Cinguli; Humans; Image Pro | 2002 |
[Clinical experiences with an analgesic-acting infusion solution in neurological painful conditions].
Topics: Arthritis, Rheumatoid; Aspartic Acid; Dipyrone; Facial Neuralgia; Humans; Injections, Intravenous; M | 1977 |
35 other studies available for aspartic acid and Pain
| Article | Year |
|---|---|
Higher glutamate+glutamine and reduction of N-acetylaspartate in posterior cingulate according to age range in patients with cognitive impairment and/or pain.
Topics: Adult; Age Factors; Aged; Aged, 80 and over; Aspartic Acid; Case-Control Studies; Cognition Disorder | 2014 |
Prefrontal Structure Varies as a Function of Pain Symptoms in Chronic Fatigue Syndrome.
Topics: Adolescent; Adult; Aspartic Acid; Creatine; Fatigue Syndrome, Chronic; Female; Glutamates; Gray Matt | 2017 |
Contralateral high or a combination of high- and low-frequency transcutaneous electrical nerve stimulation reduces mechanical allodynia and alters dorsal horn neurotransmitter content in neuropathic rats.
Topics: Acupuncture Points; Amino Acids; Animals; Aspartic Acid; Chromatography, High Pressure Liquid; gamma | 2009 |
A common human micro-opioid receptor genetic variant diminishes the receptor signaling efficacy in brain regions processing the sensory information of pain.
Topics: Alleles; Amino Acid Substitution; Analgesics, Opioid; Asparagine; Aspartic Acid; Enkephalin, Ala(2)- | 2009 |
[Effect of a simple morphine system injection in some aminoacids in the anterior cingulate cortex during acute pain].
Topics: Acute Disease; Amino Acids; Analgesics, Opioid; Animals; Arginine; Aspartic Acid; Cerebral Cortex; D | 2008 |
Increased glutamate and decreased glycine release in the rostral ventromedial medulla during induction of a pre-clinical model of chronic widespread muscle pain.
Topics: Acids; Analysis of Variance; Animals; Aspartic Acid; Chromatography, High Pressure Liquid; Disease M | 2009 |
Time-resolved functional 1H MR spectroscopic detection of glutamate concentration changes in the brain during acute heat pain stimulation.
Topics: Acute Disease; Adult; Aspartic Acid; Cerebral Cortex; Choline; Creatine; Glutamic Acid; Hot Temperat | 2010 |
Localized 1H-NMR spectroscopy in patients with fibromyalgia: a controlled study of changes in cerebral glutamate/glutamine, inositol, choline, and N-acetylaspartate.
Topics: Adult; Aspartic Acid; Brain; Cholic Acid; Cross-Sectional Studies; Diffusion Tensor Imaging; Female; | 2010 |
Insula-specific responses induced by dental pain. A proton magnetic resonance spectroscopy study.
Topics: Adult; Aspartic Acid; Cerebral Cortex; Electrodes; Female; Glutamic Acid; Glutamine; Humans; Inosito | 2011 |
Effect of inhibition of spinal cord glutamate transporters on inflammatory pain induced by formalin and complete Freund's adjuvant.
Topics: Amino Acid Transport System X-AG; Animals; Aspartic Acid; Blotting, Western; Disease Models, Animal; | 2011 |
Antinociceptive effect of rat D-serine racemase inhibitors, L-serine-O-sulfate, and L-erythro-3-hydroxyaspartate in an arthritic pain model.
Topics: Animals; Arthritis; Aspartic Acid; Disease Models, Animal; Enzyme Inhibitors; Pain; Racemases and Ep | 2012 |
Dynamic determination and possible mechanism of amino acid transmitter release from rat spinal dorsal horn induced by the venom and a neurotoxin (BmK I) of scorpion Buthus martensi Karsch.
Topics: Animals; Aspartic Acid; gamma-Aminobutyric Acid; Glutamic Acid; Male; Microdialysis; Neurotransmitte | 2002 |
Increasing of intrathecal CSF excitatory amino acids concentration following morphine challenge in morphine-tolerant rats.
Topics: Analgesics, Opioid; Animals; Aspartic Acid; Chromatography, High Pressure Liquid; Dizocilpine Maleat | 2004 |
Differential release of neurotransmitters from superficial and deep layers of the dorsal horn in response to acute noxious stimulation and inflammation of the rat paw.
Topics: Afferent Pathways; Animals; Arginine; Aspartic Acid; Chondrus; Extracellular Fluid; Foot; gamma-Amin | 2004 |
Spinal glutamate uptake is critical for maintaining normal sensory transmission in rat spinal cord.
Topics: Animals; Aspartic Acid; Dose-Response Relationship, Drug; Glutamic Acid; Male; Neurons, Afferent; Ne | 2005 |
Effect of morphine on the release of excitatory amino acids in the rat hind instep: Pain is modulated by the interaction between the peripheral opioid and glutamate systems.
Topics: Analgesics, Opioid; Animals; Aspartic Acid; Capsaicin; Disease Models, Animal; Drug Interactions; El | 2006 |
[Extracellular aminoacids in the amygdala and nucleus accumbens in the rat during acute pain].
Topics: Acute Disease; Amygdala; Animals; Arginine; Aspartic Acid; Glutamic Acid; Male; Nucleus Accumbens; P | 2007 |
Differences in metabolites in pain-processing brain regions in patients with diabetes and painful neuropathy.
Topics: Adult; Aged; Aspartic Acid; Brain; Brain Mapping; Choline; Creatine; Diabetic Neuropathies; Female; | 2008 |
Cyclooxygenase inhibition and the spinal release of prostaglandin E2 and amino acids evoked by paw formalin injection: a microdialysis study in unanesthetized rats.
Topics: Amino Acids; Analysis of Variance; Animals; Aspartic Acid; Dinoprostone; Formaldehyde; Glutamic Acid | 1995 |
Increased cerebrospinal fluid concentration of aspartate but decreased concentration of nitric oxide breakdown products in women experiencing visceral pain during active labour.
Topics: Adult; Aged; Analgesia; Aspartic Acid; Cesarean Section; Delivery, Obstetric; Enkephalin, Methionine | 1997 |
Intrathecal magnesium sulfate attenuates algogenic behavior and spinal amino acids release after kainic acid receptor activation in rats.
Topics: Amino Acids; Animals; Aspartic Acid; Behavior, Animal; Calcium Channel Blockers; Excitatory Amino Ac | 2001 |
Characterization of the glutamatergic system for induction and maintenance of allodynia.
Topics: alpha-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic Acid; Amino Acid Transport System X-AG; Animals; | 2001 |
Dissociating anxiety from pain: mapping the neuronal marker N-acetyl aspartate to perception distinguishes closely interrelated characteristics of chronic pain.
Topics: Anxiety; Aspartic Acid; Brain Chemistry; Brain Mapping; Chronic Disease; Humans; Neurons; Pain | 2001 |
Extracellular glutamate, aspartate and arginine increase in the ventral posterolateral thalamic nucleus during nociceptive stimulation.
Topics: Amino Acids; Animals; Arginine; Aspartic Acid; Electrophoresis, Capillary; Extracellular Space; Glut | 2001 |
Decreased levels of N-acetylaspartate in dorsolateral prefrontal cortex in a case of intractable severe sympathetically mediated chronic pain (complex regional pain syndrome, type I).
Topics: Adult; Anxiety Disorders; Aspartic Acid; Chronic Disease; Depressive Disorder, Major; Female; Humans | 2002 |
[Infusion therapy of pain in a series of neurological-neurosurgical patients].
Topics: Analgesics; Aspartic Acid; Dipyrone; Drug Combinations; Female; Humans; Magnesium; Male; Orphenadrin | 1976 |
Morphine and pain: effects on aspartate, GABA and glutamate in four discrete areas of mouse brain.
Topics: Aminobutyrates; Animals; Aspartic Acid; Brain; Cerebral Cortex; Dose-Response Relationship, Drug; ga | 1976 |
Interactions between substance P, calcitonin gene-related peptide, taurine and excitatory amino acids in the spinal cord.
Topics: Animals; Aspartic Acid; Calcitonin Gene-Related Peptide; Drug Interactions; Glutamates; Glutamic Aci | 1990 |
Behavior induced by putative nociceptive neurotransmitters is inhibited by adenosine or adenosine analogs coadministered intrathecally.
Topics: Adenosine; Animals; Aspartic Acid; Behavior, Animal; Excitatory Amino Acid Antagonists; Glutamic Aci | 1988 |
Nociceptive action of excitatory amino acids in the mouse: effects of spinally administered opioids, phencyclidine and sigma agonists.
Topics: Animals; Aspartic Acid; Enkephalins; Hot Temperature; Kainic Acid; Male; Mice; N-Methylaspartate; Na | 1987 |
The NMDA receptor: central role in pain inhibition in rat periaqueductal gray.
Topics: 2-Amino-5-phosphonovalerate; Amino Acids; Analgesia; Animals; Aspartic Acid; Kainic Acid; Male; Morp | 1988 |
Distribution and stress-induced increase of glutamate and aspartate levels in discrete brain nuclei of rats.
Topics: Animals; Aspartic Acid; Brain Chemistry; Dextroamphetamine; Glutamates; Glutamic Acid; Male; Pain; R | 1986 |
Intrathecal N-methyl-D-aspartate (NMDA) activates both nociceptive and antinociceptive systems.
Topics: 2-Amino-5-phosphonovalerate; Analgesia; Animals; Aspartic Acid; Behavior, Animal; Decerebrate State; | 1987 |
A novel interaction between dynorphin(1-13) and an N-methyl-D-aspartate site.
Topics: 2-Amino-5-phosphonovalerate; Analgesics; Animals; Aspartic Acid; Atropine; Binding, Competitive; Dip | 1988 |
[Metabolic therapeutic possibilities of ischemic heart disease].
Topics: Angina Pectoris; Aspartic Acid; Coronary Disease; Electrocardiography; Female; Humans; Hypertension; | 1967 |