Page last updated: 2024-11-08

aspartic acid and Pain

aspartic acid has been researched along with Pain in 38 studies

Aspartic Acid: One of the non-essential amino acids commonly occurring in the L-form. It is found in animals and plants, especially in sugar cane and sugar beets. It may be a neurotransmitter.
aspartic acid : An alpha-amino acid that consists of succinic acid bearing a single alpha-amino substituent
L-aspartic acid : The L-enantiomer of aspartic acid.

Pain: An unpleasant sensation induced by noxious stimuli which are detected by NERVE ENDINGS of NOCICEPTIVE NEURONS.

Research Excerpts

ExcerptRelevanceReference
"Morphine pretreatment produced an increase in GABA levels and a decrease in glutamate levels in the first few minutes."5.35[Effect of a simple morphine system injection in some aminoacids in the anterior cingulate cortex during acute pain]. ( Hernández, L; Páez, X; Quiñones, B; Silva, E, 2008)
" Effects of intrathecal glutamate transporter activator (R)-(-)-5-methyl-1-nicotinoyl-2-pyrazoline and inhibitors (DL-threo-β-benzyloxyaspartate [TBOA], dihydrokainate, and DL-threo-β-hydroxyaspartate), or TBOA plus group III metabotropic glutamate receptor antagonist (RS)-α-methylserine-O-phosphate, on formalin- and CFA-induced inflammatory pain were examined."3.77Effect of inhibition of spinal cord glutamate transporters on inflammatory pain induced by formalin and complete Freund's adjuvant. ( Guan, X; Lu, W; Petralia, RS; Rothstein, JD; Tao, YX; Yaster, M, 2011)
"The single nucleotide polymorphism 118A>G of the human micro-opioid receptor gene OPRM1, which leads to an exchange of the amino acid asparagine (N) to aspartic acid (D) at position 40 of the extracellular receptor region, alters the in vivo effects of opioids to different degrees in pain-processing brain regions."3.75A common human micro-opioid receptor genetic variant diminishes the receptor signaling efficacy in brain regions processing the sensory information of pain. ( Geisslinger, G; Kettner, M; Lötsch, J; Oertel, BG; Renné, C; Roskam, B; Schmidt, PH; Scholich, K, 2009)
"Chronic visceral pain is frequent, extremely debilitating, and generally resistant to pharmacological treatment."2.76Clinical effects and brain metabolic correlates in non-invasive cortical neuromodulation for visceral pain. ( Dasilva, D; Freedman, SD; Fregni, F; Lenkinski, RE; Pascual-Leone, A; Potvin, K; Wang, X, 2011)
"More pain was associated with reduced GMVs and NAA/Cr, over and above the effects of fatigue, depressive symptoms, physical activity, and psychomotor speed."1.46Prefrontal Structure Varies as a Function of Pain Symptoms in Chronic Fatigue Syndrome. ( De Lange, FP; Geurts, DEM; Knoop, H; Roelofs, K; Schmits, IC; Toni, I; van der Meer, JWM; van der Schaaf, ME, 2017)
"Morphine pretreatment produced an increase in GABA levels and a decrease in glutamate levels in the first few minutes."1.35[Effect of a simple morphine system injection in some aminoacids in the anterior cingulate cortex during acute pain]. ( Hernández, L; Páez, X; Quiñones, B; Silva, E, 2008)
"Pretreatment with taurine inhibited the nociceptive-related writhing behavior produced by an intraperitoneal injection of acetic acid in mice but failed to alter the latency of response in the hot plate or tail flick assay."1.28Interactions between substance P, calcitonin gene-related peptide, taurine and excitatory amino acids in the spinal cord. ( Larson, AA; Skilling, SR; Smullin, DH, 1990)

Research

Studies (38)

TimeframeStudies, this research(%)All Research%
pre-199010 (26.32)18.7374
1990's3 (7.89)18.2507
2000's17 (44.74)29.6817
2010's8 (21.05)24.3611
2020's0 (0.00)2.80

Authors

AuthorsStudies
Fayed, N2
Andrés, E2
Viguera, L1
Modrego, PJ1
Garcia-Campayo, J2
van der Schaaf, ME1
De Lange, FP1
Schmits, IC1
Geurts, DEM1
Roelofs, K1
van der Meer, JWM1
Toni, I1
Knoop, H1
Somers, DL1
Clemente, FR1
Oertel, BG1
Kettner, M1
Scholich, K1
Renné, C1
Roskam, B1
Geisslinger, G1
Schmidt, PH1
Lötsch, J1
Silva, E3
Quiñones, B2
Páez, X1
Hernández, L4
Radhakrishnan, R1
Sluka, KA1
Gussew, A1
Rzanny, R1
Erdtel, M1
Scholle, HC1
Kaiser, WA1
Mentzel, HJ1
Reichenbach, JR1
Magallón, R1
Andrés-Bergareche, H1
Luciano, JV1
Beltrán, J1
Fregni, F1
Potvin, K1
Dasilva, D1
Wang, X1
Lenkinski, RE1
Freedman, SD1
Pascual-Leone, A1
Gutzeit, A1
Meier, D1
Meier, ML1
von Weymarn, C1
Ettlin, DA1
Graf, N1
Froehlich, JM1
Binkert, CA1
Brügger, M1
Yaster, M1
Guan, X1
Petralia, RS1
Rothstein, JD2
Lu, W1
Tao, YX2
Laurido, C1
Hernández, A1
Pelissier, T1
Constandil, L1
Zhang, XY1
Zhang, JW1
Chen, B1
Bai, ZT1
Shen, J1
Ji, YH1
Grachev, ID3
Fredrickson, BE1
Apkarian, AV2
Wen, ZH1
Chang, YC1
Cherng, CH1
Wang, JJ1
Tao, PL1
Wong, CS1
Dmitrieva, N1
Rodríguez-Malaver, AJ1
Pérez, J1
Liaw, WJ1
Stephens, RL1
Binns, BC1
Chu, Y1
Sepkuty, JP1
Johns, RA1
Jin, YH1
Nishioka, H1
Wakabayashi, K1
Fujita, T1
Yonehara, N1
Sorensen, L1
Siddall, PJ1
Trenell, MI1
Yue, DK1
Malmberg, AB1
Yaksh, TL1
Olofsson, C1
Ekblom, A1
Ekman-Ordeberg, G1
Irestedt, L1
Nyberg, F1
Ungerstedt, U1
Wiklund, P1
Tsai, PS1
Cheng, JK1
Marsala, M1
Lin, CR1
Wen, GH1
Yang, LC1
Minami, T1
Matsumura, S1
Okuda-Ashitaka, E1
Shimamoto, K1
Sakimura, K1
Mishina, M1
Mori, H1
Ito, S1
Fredickson, BE1
Freund, N1
Gonzalez, LE1
Thomas, PS1
Ramachandran, TS1
Saurugg, D1
Hodkewitsch, E1
Argyropoulos, G1
Clarici, G1
Heppner, F1
Sherman, AD1
Gebhart, GF1
Smullin, DH1
Skilling, SR1
Larson, AA1
DeLander, GE1
Wahl, JJ1
Aanonsen, LM1
Wilcox, GL1
Jacquet, YF1
Palkovits, M1
Láng, T1
Patthy, A1
Elekes, I1
Raigorodsky, G1
Urca, G1
Caudle, RM1
Isaac, L1
Krüger, K1

Clinical Trials (3)

Trial Overview

TrialPhaseEnrollmentStudy TypeStart DateStatus
Effects of Percutaneous Neuromodulation on Plasticity in the Somatosensory System[NCT04475133]29 participants (Actual)Interventional2020-08-13Completed
The Chronic Pain Brain: Structural White and Gray Matter Correlates of Impaired Muscle Control and Deficient Pain Processing[NCT06143319]80 participants (Actual)Observational2015-10-01Completed
tDCS for the Management of Chronic Visceral Pain in Patients With Chronic Pancreatitis[NCT01857492]0 participants (Actual)Interventional2013-03-31Withdrawn (stopped due to Inactive)
[information is prepared from clinicaltrials.gov, extracted Sep-2024]

Trials

3 trials available for aspartic acid and Pain

ArticleYear
Clinical effects and brain metabolic correlates in non-invasive cortical neuromodulation for visceral pain.
    European journal of pain (London, England), 2011, Volume: 15, Issue:1

    Topics: Adult; Analgesia; Aspartic Acid; Brain; Chronic Disease; Female; Glutamic Acid; Humans; Magnetic Res

2011
Brain chemistry reflects dual states of pain and anxiety in chronic low back pain.
    Journal of neural transmission (Vienna, Austria : 1996), 2002, Volume: 109, Issue:10

    Topics: Adult; Anxiety; Aspartic Acid; Biomarkers; Brain Chemistry; Female; Gyrus Cinguli; Humans; Image Pro

2002
[Clinical experiences with an analgesic-acting infusion solution in neurological painful conditions].
    Wiener medizinische Wochenschrift (1946), 1977, Aug-15, Volume: 127, Issue:15

    Topics: Arthritis, Rheumatoid; Aspartic Acid; Dipyrone; Facial Neuralgia; Humans; Injections, Intravenous; M

1977

Other Studies

35 other studies available for aspartic acid and Pain

ArticleYear
Higher glutamate+glutamine and reduction of N-acetylaspartate in posterior cingulate according to age range in patients with cognitive impairment and/or pain.
    Academic radiology, 2014, Volume: 21, Issue:9

    Topics: Adult; Age Factors; Aged; Aged, 80 and over; Aspartic Acid; Case-Control Studies; Cognition Disorder

2014
Prefrontal Structure Varies as a Function of Pain Symptoms in Chronic Fatigue Syndrome.
    Biological psychiatry, 2017, 02-15, Volume: 81, Issue:4

    Topics: Adolescent; Adult; Aspartic Acid; Creatine; Fatigue Syndrome, Chronic; Female; Glutamates; Gray Matt

2017
Contralateral high or a combination of high- and low-frequency transcutaneous electrical nerve stimulation reduces mechanical allodynia and alters dorsal horn neurotransmitter content in neuropathic rats.
    The journal of pain, 2009, Volume: 10, Issue:2

    Topics: Acupuncture Points; Amino Acids; Animals; Aspartic Acid; Chromatography, High Pressure Liquid; gamma

2009
A common human micro-opioid receptor genetic variant diminishes the receptor signaling efficacy in brain regions processing the sensory information of pain.
    The Journal of biological chemistry, 2009, Mar-06, Volume: 284, Issue:10

    Topics: Alleles; Amino Acid Substitution; Analgesics, Opioid; Asparagine; Aspartic Acid; Enkephalin, Ala(2)-

2009
[Effect of a simple morphine system injection in some aminoacids in the anterior cingulate cortex during acute pain].
    Investigacion clinica, 2008, Volume: 49, Issue:4

    Topics: Acute Disease; Amino Acids; Analgesics, Opioid; Animals; Arginine; Aspartic Acid; Cerebral Cortex; D

2008
Increased glutamate and decreased glycine release in the rostral ventromedial medulla during induction of a pre-clinical model of chronic widespread muscle pain.
    Neuroscience letters, 2009, Jul-03, Volume: 457, Issue:3

    Topics: Acids; Analysis of Variance; Animals; Aspartic Acid; Chromatography, High Pressure Liquid; Disease M

2009
Time-resolved functional 1H MR spectroscopic detection of glutamate concentration changes in the brain during acute heat pain stimulation.
    NeuroImage, 2010, Jan-15, Volume: 49, Issue:2

    Topics: Acute Disease; Adult; Aspartic Acid; Cerebral Cortex; Choline; Creatine; Glutamic Acid; Hot Temperat

2010
Localized 1H-NMR spectroscopy in patients with fibromyalgia: a controlled study of changes in cerebral glutamate/glutamine, inositol, choline, and N-acetylaspartate.
    Arthritis research & therapy, 2010, Volume: 12, Issue:4

    Topics: Adult; Aspartic Acid; Brain; Cholic Acid; Cross-Sectional Studies; Diffusion Tensor Imaging; Female;

2010
Insula-specific responses induced by dental pain. A proton magnetic resonance spectroscopy study.
    European radiology, 2011, Volume: 21, Issue:4

    Topics: Adult; Aspartic Acid; Cerebral Cortex; Electrodes; Female; Glutamic Acid; Glutamine; Humans; Inosito

2011
Effect of inhibition of spinal cord glutamate transporters on inflammatory pain induced by formalin and complete Freund's adjuvant.
    Anesthesiology, 2011, Volume: 114, Issue:2

    Topics: Amino Acid Transport System X-AG; Animals; Aspartic Acid; Blotting, Western; Disease Models, Animal;

2011
Antinociceptive effect of rat D-serine racemase inhibitors, L-serine-O-sulfate, and L-erythro-3-hydroxyaspartate in an arthritic pain model.
    TheScientificWorldJournal, 2012, Volume: 2012

    Topics: Animals; Arthritis; Aspartic Acid; Disease Models, Animal; Enzyme Inhibitors; Pain; Racemases and Ep

2012
Dynamic determination and possible mechanism of amino acid transmitter release from rat spinal dorsal horn induced by the venom and a neurotoxin (BmK I) of scorpion Buthus martensi Karsch.
    Brain research bulletin, 2002, Volume: 58, Issue:1

    Topics: Animals; Aspartic Acid; gamma-Aminobutyric Acid; Glutamic Acid; Male; Microdialysis; Neurotransmitte

2002
Increasing of intrathecal CSF excitatory amino acids concentration following morphine challenge in morphine-tolerant rats.
    Brain research, 2004, Jan-09, Volume: 995, Issue:2

    Topics: Analgesics, Opioid; Animals; Aspartic Acid; Chromatography, High Pressure Liquid; Dizocilpine Maleat

2004
Differential release of neurotransmitters from superficial and deep layers of the dorsal horn in response to acute noxious stimulation and inflammation of the rat paw.
    European journal of pain (London, England), 2004, Volume: 8, Issue:3

    Topics: Afferent Pathways; Animals; Arginine; Aspartic Acid; Chondrus; Extracellular Fluid; Foot; gamma-Amin

2004
Spinal glutamate uptake is critical for maintaining normal sensory transmission in rat spinal cord.
    Pain, 2005, Volume: 115, Issue:1-2

    Topics: Animals; Aspartic Acid; Dose-Response Relationship, Drug; Glutamic Acid; Male; Neurons, Afferent; Ne

2005
Effect of morphine on the release of excitatory amino acids in the rat hind instep: Pain is modulated by the interaction between the peripheral opioid and glutamate systems.
    Neuroscience, 2006, Volume: 138, Issue:4

    Topics: Analgesics, Opioid; Animals; Aspartic Acid; Capsaicin; Disease Models, Animal; Drug Interactions; El

2006
[Extracellular aminoacids in the amygdala and nucleus accumbens in the rat during acute pain].
    Investigacion clinica, 2007, Volume: 48, Issue:2

    Topics: Acute Disease; Amygdala; Animals; Arginine; Aspartic Acid; Glutamic Acid; Male; Nucleus Accumbens; P

2007
Differences in metabolites in pain-processing brain regions in patients with diabetes and painful neuropathy.
    Diabetes care, 2008, Volume: 31, Issue:5

    Topics: Adult; Aged; Aspartic Acid; Brain; Brain Mapping; Choline; Creatine; Diabetic Neuropathies; Female;

2008
Cyclooxygenase inhibition and the spinal release of prostaglandin E2 and amino acids evoked by paw formalin injection: a microdialysis study in unanesthetized rats.
    The Journal of neuroscience : the official journal of the Society for Neuroscience, 1995, Volume: 15, Issue:4

    Topics: Amino Acids; Analysis of Variance; Animals; Aspartic Acid; Dinoprostone; Formaldehyde; Glutamic Acid

1995
Increased cerebrospinal fluid concentration of aspartate but decreased concentration of nitric oxide breakdown products in women experiencing visceral pain during active labour.
    Neuroreport, 1997, Mar-03, Volume: 8, Issue:4

    Topics: Adult; Aged; Analgesia; Aspartic Acid; Cesarean Section; Delivery, Obstetric; Enkephalin, Methionine

1997
Intrathecal magnesium sulfate attenuates algogenic behavior and spinal amino acids release after kainic acid receptor activation in rats.
    Neuroscience letters, 2001, Mar-30, Volume: 301, Issue:2

    Topics: Amino Acids; Animals; Aspartic Acid; Behavior, Animal; Calcium Channel Blockers; Excitatory Amino Ac

2001
Characterization of the glutamatergic system for induction and maintenance of allodynia.
    Brain research, 2001, Mar-23, Volume: 895, Issue:1-2

    Topics: alpha-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic Acid; Amino Acid Transport System X-AG; Animals;

2001
Dissociating anxiety from pain: mapping the neuronal marker N-acetyl aspartate to perception distinguishes closely interrelated characteristics of chronic pain.
    Molecular psychiatry, 2001, Volume: 6, Issue:3

    Topics: Anxiety; Aspartic Acid; Brain Chemistry; Brain Mapping; Chronic Disease; Humans; Neurons; Pain

2001
Extracellular glutamate, aspartate and arginine increase in the ventral posterolateral thalamic nucleus during nociceptive stimulation.
    Brain research, 2001, Dec-27, Volume: 923, Issue:1-2

    Topics: Amino Acids; Animals; Arginine; Aspartic Acid; Electrophoresis, Capillary; Extracellular Space; Glut

2001
Decreased levels of N-acetylaspartate in dorsolateral prefrontal cortex in a case of intractable severe sympathetically mediated chronic pain (complex regional pain syndrome, type I).
    Brain and cognition, 2002, Volume: 49, Issue:1

    Topics: Adult; Anxiety Disorders; Aspartic Acid; Chronic Disease; Depressive Disorder, Major; Female; Humans

2002
[Infusion therapy of pain in a series of neurological-neurosurgical patients].
    Wiener medizinische Wochenschrift (1946), 1976, Jun-11, Volume: 126, Issue:24

    Topics: Analgesics; Aspartic Acid; Dipyrone; Drug Combinations; Female; Humans; Magnesium; Male; Orphenadrin

1976
Morphine and pain: effects on aspartate, GABA and glutamate in four discrete areas of mouse brain.
    Brain research, 1976, Jul-09, Volume: 110, Issue:2

    Topics: Aminobutyrates; Animals; Aspartic Acid; Brain; Cerebral Cortex; Dose-Response Relationship, Drug; ga

1976
Interactions between substance P, calcitonin gene-related peptide, taurine and excitatory amino acids in the spinal cord.
    Pain, 1990, Volume: 42, Issue:1

    Topics: Animals; Aspartic Acid; Calcitonin Gene-Related Peptide; Drug Interactions; Glutamates; Glutamic Aci

1990
Behavior induced by putative nociceptive neurotransmitters is inhibited by adenosine or adenosine analogs coadministered intrathecally.
    The Journal of pharmacology and experimental therapeutics, 1988, Volume: 246, Issue:2

    Topics: Adenosine; Animals; Aspartic Acid; Behavior, Animal; Excitatory Amino Acid Antagonists; Glutamic Aci

1988
Nociceptive action of excitatory amino acids in the mouse: effects of spinally administered opioids, phencyclidine and sigma agonists.
    The Journal of pharmacology and experimental therapeutics, 1987, Volume: 243, Issue:1

    Topics: Animals; Aspartic Acid; Enkephalins; Hot Temperature; Kainic Acid; Male; Mice; N-Methylaspartate; Na

1987
The NMDA receptor: central role in pain inhibition in rat periaqueductal gray.
    European journal of pharmacology, 1988, Sep-23, Volume: 154, Issue:3

    Topics: 2-Amino-5-phosphonovalerate; Amino Acids; Analgesia; Animals; Aspartic Acid; Kainic Acid; Male; Morp

1988
Distribution and stress-induced increase of glutamate and aspartate levels in discrete brain nuclei of rats.
    Brain research, 1986, May-14, Volume: 373, Issue:1-2

    Topics: Animals; Aspartic Acid; Brain Chemistry; Dextroamphetamine; Glutamates; Glutamic Acid; Male; Pain; R

1986
Intrathecal N-methyl-D-aspartate (NMDA) activates both nociceptive and antinociceptive systems.
    Brain research, 1987, Sep-29, Volume: 422, Issue:1

    Topics: 2-Amino-5-phosphonovalerate; Analgesia; Animals; Aspartic Acid; Behavior, Animal; Decerebrate State;

1987
A novel interaction between dynorphin(1-13) and an N-methyl-D-aspartate site.
    Brain research, 1988, Mar-08, Volume: 443, Issue:1-2

    Topics: 2-Amino-5-phosphonovalerate; Analgesics; Animals; Aspartic Acid; Atropine; Binding, Competitive; Dip

1988
[Metabolic therapeutic possibilities of ischemic heart disease].
    Medizinische Klinik, 1967, Oct-20, Volume: 62, Issue:42

    Topics: Angina Pectoris; Aspartic Acid; Coronary Disease; Electrocardiography; Female; Humans; Hypertension;

1967