d-phenylalanyl-cysteinyl-tyrosyl-tryptophyl-lysyl-cysteinyl-threoninamide profile

TT2-32: induces a biphasic activation of phosphotyrosine phosphatase activity in human colon tumor cell line, SW620 [Medical Subject Headings (MeSH), National Library of Medicine, extracted Dec-2023]

ID Source	ID
PubMed CID	6918265
CHEMBL ID	539934
MeSH ID	M0248878

Synonym
tln-232
tt-232
147159-51-1
phenylalanyl-cysteinyl-tyrosyl-tryptophyl-lysyl-cysteinyl-threoninamide (2-6)-disulfide
phe-cys-tyr-trp-lys-cys-thr-nh2 (2-6)-disulfide
l-threoninamide, d-phenylalanyl-l-cysteinyl-l-tyrosyl-d-tryptophyl-l-lysyl-l-cysteinyl-, cyclic (2-6)-disulfide
CHEMBL539934
NCGC00249606-01
(4r,7s,10r,13s,16r)-7-(4-aminobutyl)-n-[(2s,3r)-1-amino-3-hydroxy-1-oxobutan-2-yl]-16-[[(2r)-2-amino-3-phenylpropanoyl]amino]-13-[(4-hydroxyphenyl)methyl]-10-(1h-indol-3-ylmethyl)-6,9,12,15-tetraoxo-1,2-dithia-5,8,11,14-tetrazacycloheptadecane-4-carboxami
unii-49d4q4254z
tln 232
tt2-32
d-phenylalanyl-cysteinyl-tyrosyl-tryptophyl-lysyl-cysteinyl-threoninamide
d-phe-cys-tyr-d-trp-lys-cys-thr(nh2)
cap 232
49d4q4254z ,
d-phe-cys-tyr-d-trp-lys-cys-thr-nh2 (disulphide bridge:2-6)
AKOS024458270
DB12088
(4r,7s,10r,13s,16r)-10-((1h-indol-3-yl)methyl)-n-((2s,3r)-1-amino-3-hydroxy-1-oxobutan-2-yl)-16-((r)-2-amino-3-phenylpropanamido)-7-(4-aminobutyl)-13-(4-hydroxybenzyl)-6,9,12,15-tetraoxo-1,2-dithia-5,8,11,14-tetraazacycloheptadecane-4-carboxamide
l-threoninamide, d-phenylalanyl-l-cysteinyl-l-tyrosyl-d-tryptophyl-l-lysyl-l-cysteinyl-, cyclic (2-->6)-disulfide
Q27259274
HY-105172
CS-0025194

Excerpt	Reference	Relevance
"A novel somatostatin analogue, TT-232 (which inhibits the proliferation of various cell cultures and transplantable mouse tumours), was examined regarding its effect on human melanoma and lymphoma xenografts as a single treatment or in combination with DTIC (dacarbazine) and etoposide."	( Effect of a novel somatostatin analogue combined with cytotoxic drugs on human tumour xenografts and metastasis of B16 melanoma. Bökönyi, G; Horváth, A; Kéri, G; Szende, B, 2003)	0.32

Excerpt	Relevance	Reference
") significantly inhibited phenylquinone-evoked writhing movements in mice, but within this dose range no clear dose-response correlation was found."	( Analgesic effect of TT-232, a heptapeptide somatostatin analogue, in acute pain models of the rat and the mouse and in streptozotocin-induced diabetic mechanical allodynia. Almási, R; Bölcskei, K; Börzsei, R; Elekes, K; Helyes, Z; Kéri, G; Petho, G; Pintér, E; Szabó, A; Szolcsányi, J; Szuts, T, 2004)	0.32

Assay ID	Title	Year	Journal	Article
AID344867	Antiproliferative activity against human A431 cells at 50 uM by MTT assay	2008	Bioorganic & medicinal chemistry letters, Dec-01, Volume: 18, Issue:23	New cyclic somatostatin analogues containing a pyrazinone ring: importance of Tyr for antiproliferative activity.
AID344869	Antiproliferative activity against human SW480 cells at 25 uM by MTT assay	2008	Bioorganic & medicinal chemistry letters, Dec-01, Volume: 18, Issue:23	New cyclic somatostatin analogues containing a pyrazinone ring: importance of Tyr for antiproliferative activity.
AID362515	Antiproliferative activity against human SW480 cells at 50 uM after 48 hrs by MTT assay	2008	Journal of medicinal chemistry, Aug-28, Volume: 51, Issue:16	Synthesis of somatostatin analogues containing C-terminal adamantane and their antiproliferative properties.
AID344865	Antiproliferative activity against human A431 cells at 10 uM by MTT assay	2008	Bioorganic & medicinal chemistry letters, Dec-01, Volume: 18, Issue:23	New cyclic somatostatin analogues containing a pyrazinone ring: importance of Tyr for antiproliferative activity.
AID362513	Antiproliferative activity against human SW480 cells at 10 uM after 48 hrs by MTT assay	2008	Journal of medicinal chemistry, Aug-28, Volume: 51, Issue:16	Synthesis of somatostatin analogues containing C-terminal adamantane and their antiproliferative properties.
AID344866	Antiproliferative activity against human A431 cells at 25 uM by MTT assay	2008	Bioorganic & medicinal chemistry letters, Dec-01, Volume: 18, Issue:23	New cyclic somatostatin analogues containing a pyrazinone ring: importance of Tyr for antiproliferative activity.
AID344868	Antiproliferative activity against human SW480 cells at 10 uM by MTT assay	2008	Bioorganic & medicinal chemistry letters, Dec-01, Volume: 18, Issue:23	New cyclic somatostatin analogues containing a pyrazinone ring: importance of Tyr for antiproliferative activity.
AID344870	Antiproliferative activity against human SW480 cells at 50 uM by MTT assay	2008	Bioorganic & medicinal chemistry letters, Dec-01, Volume: 18, Issue:23	New cyclic somatostatin analogues containing a pyrazinone ring: importance of Tyr for antiproliferative activity.
AID362512	Antiproliferative activity against human A431 cells at 50 uM after 48 hrs by MTT assay	2008	Journal of medicinal chemistry, Aug-28, Volume: 51, Issue:16	Synthesis of somatostatin analogues containing C-terminal adamantane and their antiproliferative properties.
AID362511	Antiproliferative activity against human A431 cells at 25 uM after 48 hrs by MTT assay	2008	Journal of medicinal chemistry, Aug-28, Volume: 51, Issue:16	Synthesis of somatostatin analogues containing C-terminal adamantane and their antiproliferative properties.
AID362514	Antiproliferative activity against human SW480 cells at 25 uM after 48 hrs by MTT assay	2008	Journal of medicinal chemistry, Aug-28, Volume: 51, Issue:16	Synthesis of somatostatin analogues containing C-terminal adamantane and their antiproliferative properties.
AID362510	Antiproliferative activity against human A431 cells at 10 uM after 48 hrs by MTT assay	2008	Journal of medicinal chemistry, Aug-28, Volume: 51, Issue:16	Synthesis of somatostatin analogues containing C-terminal adamantane and their antiproliferative properties.
[information is prepared from bioassay data collected from National Library of Medicine (NLM), extracted Dec-2023]

Timeframe	Studies, This Drug (%)	All Drugs %
pre-1990	0 (0.00)	18.7374
1990's	7 (23.33)	18.2507
2000's	22 (73.33)	29.6817
2010's	1 (3.33)	24.3611
2020's	0 (0.00)	2.80
[information is prepared from research data collected from National Library of Medicine (NLM), extracted Dec-2023]

Publication Type	This drug (%)	All Drugs (%)
Trials	0 (0.00%)	5.53%
Reviews	2 (5.13%)	6.00%
Case Studies	0 (0.00%)	4.05%
Observational	0 (0.00%)	0.25%
Other	37 (94.87%)	84.16%
[information is prepared from research data collected from National Library of Medicine (NLM), extracted Dec-2023]

Substance	Relationship Strength	Studies	Classes	Roles
formaldehyde paraform: polymerized formaldehyde; RN given refers to parent cpd; used in root canal therapy	2.02	1	aldehyde; one-carbon compound	allergen; carcinogenic agent; disinfectant; EC 3.5.1.4 (amidase) inhibitor; environmental contaminant; Escherichia coli metabolite; mouse metabolite; Saccharomyces cerevisiae metabolite
bisindolylmaleimide i bisindolylmaleimide I: a bis(indolyl)maleimide	2	1
diclofenac Diclofenac: A non-steroidal anti-inflammatory agent (NSAID) with antipyretic and analgesic actions. It is primarily available as the sodium salt.. diclofenac : A monocarboxylic acid consisting of phenylacetic acid having a (2,6-dichlorophenyl)amino group at the 2-position.	2	1	amino acid; aromatic amine; dichlorobenzene; monocarboxylic acid; secondary amino compound	antipyretic; drug allergen; EC 1.14.99.1 (prostaglandin-endoperoxide synthase) inhibitor; environmental contaminant; non-narcotic analgesic; non-steroidal anti-inflammatory drug; xenobiotic
indomethacin Indomethacin: A non-steroidal anti-inflammatory agent (NSAID) that inhibits CYCLOOXYGENASE, which is necessary for the formation of PROSTAGLANDINS and other AUTACOIDS. It also inhibits the motility of POLYMORPHONUCLEAR LEUKOCYTES.. indometacin : A member of the class of indole-3-acetic acids that is indole-3-acetic acid in which the indole ring is substituted at positions 1, 2 and 5 by p-chlorobenzoyl, methyl, and methoxy groups, respectively. A non-steroidal anti-inflammatory drug, it is used in the treatment of musculoskeletal and joint disorders including osteoarthritis, rheumatoid arthritis, gout, bursitis and tendinitis.	2.01	1	aromatic ether; indole-3-acetic acids; monochlorobenzenes; N-acylindole	analgesic; drug metabolite; EC 1.14.99.1 (prostaglandin-endoperoxide synthase) inhibitor; environmental contaminant; gout suppressant; non-steroidal anti-inflammatory drug; xenobiotic metabolite; xenobiotic
pd 98059 2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one: inhibits MAP kinase kinase (MEK) activity, p42 MAPK and p44 MAPK; structure in first source. 2-(2-amino-3-methoxyphenyl)chromen-4-one : A member of the class of monomethoxyflavones that is 3'-methoxyflavone bearing an additional amino substituent at position 2'.	2	1	aromatic amine; monomethoxyflavone	EC 2.7.11.24 (mitogen-activated protein kinase) inhibitor; geroprotector
carbachol Carbachol: A slowly hydrolyzed CHOLINERGIC AGONIST that acts at both MUSCARINIC RECEPTORS and NICOTINIC RECEPTORS.	2.04	1	ammonium salt; carbamate ester	cardiotonic drug; miotic; muscarinic agonist; nicotinic acetylcholine receptor agonist; non-narcotic analgesic
serine Serine: A non-essential amino acid occurring in natural form as the L-isomer. It is synthesized from GLYCINE or THREONINE. It is involved in the biosynthesis of PURINES; PYRIMIDINES; and other amino acids.. serine : An alpha-amino acid that is alanine substituted at position 3 by a hydroxy group.	2	1	L-alpha-amino acid; proteinogenic amino acid; serine family amino acid; serine zwitterion; serine	algal metabolite; Escherichia coli metabolite; human metabolite; mouse metabolite; Saccharomyces cerevisiae metabolite
cycloheximide Cycloheximide: Antibiotic substance isolated from streptomycin-producing strains of Streptomyces griseus. It acts by inhibiting elongation during protein synthesis.. cycloheximide : A dicarboximide that is 4-(2-hydroxyethyl)piperidine-2,6-dione in which one of the hydrogens attached to the carbon bearing the hydroxy group is replaced by a 3,5-dimethyl-2-oxocyclohexyl group. It is an antibiotic produced by the bacterium Streptomyces griseus.	2.44	2	antibiotic fungicide; cyclic ketone; dicarboximide; piperidine antibiotic; piperidones; secondary alcohol	anticoronaviral agent; bacterial metabolite; ferroptosis inhibitor; neuroprotective agent; protein synthesis inhibitor
thiazoles [no description available]	2	1	1,3-thiazoles; mancude organic heteromonocyclic parent; monocyclic heteroarene
evans blue Evans Blue: An azo dye used in blood volume and cardiac output measurement by the dye dilution method. It is very soluble, strongly bound to plasma albumin, and disappears very slowly.. Evans blue : An organic sodium salt that is the tetrasodium salt of 6,6'-{(3,3'-dimethyl[1,1'-biphenyl]-4,4'-diyl)bis[diazene-2,1-diyl]}bis(4-amino-5-hydroxynaphthalene-1,3-disulfonate). It is sometimes used as a counterstain, especially in fluorescent methods to suppress background autofluorescence.	2	1	organic sodium salt	fluorochrome; histological dye; sodium channel blocker; teratogenic agent
phenylbenzoquinone phenylbenzoquinone: RN given refers to parent cpd	2.02	1
selegiline Selegiline: A selective, irreversible inhibitor of Type B monoamine oxidase that is used for the treatment of newly diagnosed patients with PARKINSON DISEASE, and for the treatment of depressive disorders. The compound without isomeric designation is Deprenyl.	2.01	1	selegiline; terminal acetylenic compound	geroprotector
tetradecanoylphorbol acetate Tetradecanoylphorbol Acetate: A phorbol ester found in CROTON OIL with very effective tumor promoting activity. It stimulates the synthesis of both DNA and RNA.. phorbol ester : Esters of phorbol, originally found in croton oil (from Croton tiglium, of the family Euphorbiaceae). A number of phorbol esters possess activity as tumour promoters and activate the mechanisms associated with cell growth. Some of these are used in experiments as activators of protein kinase C.. phorbol 13-acetate 12-myristate : A phorbol ester that is phorbol in which the hydroxy groups at the cyclopropane ring juction (position 13) and the adjacent carbon (position 12) have been converted into the corresponding acetate and myristate esters. It is a major active constituent of the seed oil of Croton tiglium. It has been used as a tumour promoting agent for skin carcinogenesis in rodents and is associated with increased cell proliferation of malignant cells. However its function is controversial since a decrease in cell proliferation has also been observed in several cancer cell types.	2.04	1	acetate ester; diester; phorbol ester; tertiary alpha-hydroxy ketone; tetradecanoate ester	antineoplastic agent; apoptosis inducer; carcinogenic agent; mitogen; plant metabolite; protein kinase C agonist; reactive oxygen species generator
etoposide [no description available]	3.52	2	beta-D-glucoside; furonaphthodioxole; organic heterotetracyclic compound	antineoplastic agent; DNA synthesis inhibitor
vanadates Vanadates: Oxyvanadium ions in various states of oxidation. They act primarily as ion transport inhibitors due to their inhibition of Na(+)-, K(+)-, and Ca(+)-ATPase transport systems. They also have insulin-like action, positive inotropic action on cardiac ventricular muscle, and other metabolic effects.. vanadate(3-) : A vanadium oxoanion that is a trianion with formula VO4 in which the vanadium is in the +5 oxidation state and is attached to four oxygen atoms.	2.01	1	trivalent inorganic anion; vanadium oxoanion	EC 3.1.3.1 (alkaline phosphatase) inhibitor; EC 3.1.3.16 (phosphoprotein phosphatase) inhibitor; EC 3.1.3.41 (4-nitrophenylphosphatase) inhibitor; EC 3.1.3.48 (protein-tyrosine-phosphatase) inhibitor
beta-aminoglutaric acid 3-aminoglutaric acid: RN given refers to parent cpd; structure given in first source. isoglutamic acid : A 1,5-dicarboxylic acid compound having a 3-amino substituent. It has been isolated from the extracts of the algae, Chondria armata.	2	1	dicarboxylic acid	algal metabolite; marine metabolite
bradykinin [no description available]	2	1	oligopeptide	human blood serum metabolite; vasodilator agent
ag-213 tyrphostin 47: inhibits protein-tyrosine kinase activity of EGF-R both in vitro and in living cells;	2.01	1
capsaicin ALGRX-4975: an injectable capsaicin (TRPV1 receptor agonist) formulation for longlasting pain relief. capsaicinoid : A family of aromatic fatty amides produced as secondary metabolites by chilli peppers.	2	1	capsaicinoid	non-narcotic analgesic; TRPV1 agonist; voltage-gated sodium channel blocker
cystine [no description available]	2	1
ovalbumin Ovalbumin: An albumin obtained from the white of eggs. It is a member of the serpin superfamily.	2.04	1
11-cis-retinal Rhodopsin: A purplish-red, light-sensitive pigment found in RETINAL ROD CELLS of most vertebrates. It is a complex consisting of a molecule of ROD OPSIN and a molecule of 11-cis retinal (RETINALDEHYDE). Rhodopsin exhibits peak absorption wavelength at about 500 nm.. 11-cis-retinal : A retinal having 2E,4Z,6E,8E-double bond geometry.	2.02	1	retinal	chromophore; human metabolite; mouse metabolite
genistein [no description available]	2.01	1	7-hydroxyisoflavones	antineoplastic agent; EC 5.99.1.3 [DNA topoisomerase (ATP-hydrolysing)] inhibitor; geroprotector; human urinary metabolite; phytoestrogen; plant metabolite; tyrosine kinase inhibitor
resiniferatoxin resiniferatoxin: phorbol related diterpene ester; potent agonist of vanilloid TRPV1 receptors. resiniferatoxin : A heteropentacyclic compound found in Euphorbia poissonii with molecular formula C37H40O9. It is an agonist of the transient receptor potential cation channel subfamily V member 1 (TrpV1).	2.42	2	carboxylic ester; diterpenoid; enone; monomethoxybenzene; organic heteropentacyclic compound; ortho ester; phenols; tertiary alpha-hydroxy ketone	analgesic; neurotoxin; plant metabolite; TRPV1 agonist
(1's, 2s)-4-amino-n-(1'-carbamoyl-2'-phenylethyl)-2-(4''-methyl-1''-naphthalenesulfonylamino)butanamide (1'S, 2S)-4-amino-N-(1'-carbamoyl-2'-phenylethyl)-2-(4''-methyl-1''-naphthalenesulfonylamino)butanamide: a somatostatin receptor 4 agonist; structure in first source	2.04	1
mobic Meloxicam: A benzothiazine and thiazole derivative that acts as a NSAID and cyclooxygenase-2 (COX-2) inhibitor. It is used in the treatment of RHEUMATOID ARTHRITIS; OSTEOARTHRITIS; and ANKYLOSING SPONDYLITIS.. meloxicam : A benzothiazine that is piroxicam in which the pyridin-2-yl group is replaced by a 5-methyl-1,3-thiazol-2-yl group. A non-steroidal anti-inflammatory drug and selective inhibitor of COX-2, it is used particularly for the management of rheumatoid arthritis.	2	1	1,3-thiazoles; benzothiazine; monocarboxylic acid amide	analgesic; antirheumatic drug; cyclooxygenase 2 inhibitor; non-steroidal anti-inflammatory drug
epidermal growth factor Epidermal Growth Factor: A 6-kDa polypeptide growth factor initially discovered in mouse submaxillary glands. Human epidermal growth factor was originally isolated from urine based on its ability to inhibit gastric secretion and called urogastrone. Epidermal growth factor exerts a wide variety of biological effects including the promotion of proliferation and differentiation of mesenchymal and EPITHELIAL CELLS. It is synthesized as a transmembrane protein which can be cleaved to release a soluble active form.	2	1
dacarbazine (E)-dacarbazine : A dacarbazine in which the N=N double bond adopts a trans-configuration.	3.52	2	dacarbazine
cyclo(7-aminoheptanoylphenylalanyl-tryptophyl-lysyl-benzylthreonyl) cyclosomatostatin: involved in hepatocellular transport	2.02	1

Condition	Relationship Strength	Studies
Disease Models, Animal Naturally-occurring or experimentally-induced animal diseases with pathological processes analogous to human diseases.	2.94	4
Cancer of Pancreas [description not available]	2.01	1
Pancreatic Neoplasms Tumors or cancer of the PANCREAS. Depending on the types of ISLET CELLS present in the tumors, various hormones can be secreted: GLUCAGON from PANCREATIC ALPHA CELLS; INSULIN from PANCREATIC BETA CELLS; and SOMATOSTATIN from the SOMATOSTATIN-SECRETING CELLS. Most are malignant except the insulin-producing tumors (INSULINOMA).	2.01	1
Adjuvant Arthritis [description not available]	2.7	3
Anasarca [description not available]	2.42	2
Allodynia [description not available]	2.01	1
Innate Inflammatory Response [description not available]	3.62	3
Gastric Ulcer [description not available]	2.01	1
Edema Abnormal fluid accumulation in TISSUES or body cavities. Most cases of edema are present under the SKIN in SUBCUTANEOUS TISSUE.	2.42	2
Inflammation A pathological process characterized by injury or destruction of tissues caused by a variety of cytologic and chemical reactions. It is usually manifested by typical signs of pain, heat, redness, swelling, and loss of function.	3.62	3
Stomach Ulcer Ulceration of the GASTRIC MUCOSA due to contact with GASTRIC JUICE. It is often associated with HELICOBACTER PYLORI infection or consumption of nonsteroidal anti-inflammatory drugs (NSAIDS).	2.01	1
Germinoblastoma [description not available]	2.01	1
B16 Melanoma [description not available]	2.01	1
Metastase [description not available]	2.01	1
Experimental Neoplasms [description not available]	2.42	2
Lymphoma A general term for various neoplastic diseases of the lymphoid tissue.	2.01	1
Neoplasm Metastasis The transfer of a neoplasm from one organ or part of the body to another remote from the primary site.	2.01	1
Cancer of Colon [description not available]	2.4	2
Leukemia P388 An experimental lymphocytic leukemia originally induced in DBA/2 mice by painting with methylcholanthrene.	2.01	1
Sarcoma 180 An experimental sarcoma of mice.	2.01	1
Experimental Mammary Neoplasms [description not available]	2.01	1
Colonic Neoplasms Tumors or cancer of the COLON.	2.4	2
Benign Neoplasms [description not available]	4.09	3
Neoplasms New abnormal growth of tissue. Malignant neoplasms show a greater degree of anaplasia and have the properties of invasion and metastasis, compared to benign neoplasms.	4.09	3
Chronic Illness [description not available]	2.02	1
Chronic Disease Diseases which have one or more of the following characteristics: they are permanent, leave residual disability, are caused by nonreversible pathological alteration, require special training of the patient for rehabilitation, or may be expected to require a long period of supervision, observation, or care (Dictionary of Health Services Management, 2d ed). For epidemiological studies chronic disease often includes HEART DISEASES; STROKE; CANCER; and diabetes (DIABETES MELLITUS, TYPE 2).	2.02	1
Alloxan Diabetes [description not available]	2.02	1
Ache [description not available]	2.02	1
Acute Disease Disease having a short and relatively severe course.	2.02	1
Pain An unpleasant sensation induced by noxious stimuli which are detected by NERVE ENDINGS of NOCICEPTIVE NEURONS.	2.02	1
Bacterial Pneumonia [description not available]	2.04	1
Asthma, Bronchial [description not available]	2.04	1
Asthma A form of bronchial disorder with three distinct components: airway hyper-responsiveness (RESPIRATORY HYPERSENSITIVITY), airway INFLAMMATION, and intermittent AIRWAY OBSTRUCTION. It is characterized by spasmodic contraction of airway smooth muscle, WHEEZING, and dyspnea (DYSPNEA, PAROXYSMAL).	2.04	1
Bronchial Hyperreactivity Tendency of the smooth muscle of the tracheobronchial tree to contract more intensely in response to a given stimulus than it does in the response seen in normal individuals. This condition is present in virtually all symptomatic patients with asthma. The most prominent manifestation of this smooth muscle contraction is a decrease in airway caliber that can be readily measured in the pulmonary function laboratory.	2.04	1
Pneumonia, Bacterial Inflammation of the lung parenchyma that is caused by bacterial infections.	2.04	1
Carcinoma, Epidermoid [description not available]	1.99	1
Cancer of Head [description not available]	1.99	1
Cancer of Ovary [description not available]	1.99	1
Colorectal Cancer [description not available]	1.99	1
Cancer of Endometrium [description not available]	1.99	1
Carcinoma, Squamous Cell A carcinoma derived from stratified SQUAMOUS EPITHELIAL CELLS. It may also occur in sites where glandular or columnar epithelium is normally present. (From Stedman, 25th ed)	1.99	1
Head and Neck Neoplasms Soft tissue tumors or cancer arising from the mucosal surfaces of the LIP; oral cavity; PHARYNX; LARYNX; and cervical esophagus. Other sites included are the NOSE and PARANASAL SINUSES; SALIVARY GLANDS; THYROID GLAND and PARATHYROID GLANDS; and MELANOMA and non-melanoma skin cancers of the head and neck. (from Holland et al., Cancer Medicine, 4th ed, p1651)	1.99	1
Ovarian Neoplasms Tumors or cancer of the OVARY. These neoplasms can be benign or malignant. They are classified according to the tissue of origin, such as the surface EPITHELIUM, the stromal endocrine cells, and the totipotent GERM CELLS.	1.99	1
Colorectal Neoplasms Tumors or cancer of the COLON or the RECTUM or both. Risk factors for colorectal cancer include chronic ULCERATIVE COLITIS; FAMILIAL POLYPOSIS COLI; exposure to ASBESTOS; and irradiation of the CERVIX UTERI.	1.99	1
Endometrial Neoplasms Tumors or cancer of ENDOMETRIUM, the mucous lining of the UTERUS. These neoplasms can be benign or malignant. Their classification and grading are based on the various cell types and the percent of undifferentiated cells.	1.99	1
Hepatocellular Carcinoma [description not available]	2	1
Cancer of Liver [description not available]	2	1
Carcinoma, Hepatocellular A primary malignant neoplasm of epithelial liver cells. It ranges from a well-differentiated tumor with EPITHELIAL CELLS indistinguishable from normal HEPATOCYTES to a poorly differentiated neoplasm. The cells may be uniform or markedly pleomorphic, or form GIANT CELLS. Several classification schemes have been suggested.	2	1
Liver Neoplasms Tumors or cancer of the LIVER.	2	1
Chromosomal Breakage [description not available]	2	1
Abnormalities, Autosome [description not available]	2	1
B-Cell Chronic Lymphocytic Leukemia [description not available]	2	1
Leukemia, Lymphocytic, Chronic, B-Cell A chronic leukemia characterized by abnormal B-lymphocytes and often generalized lymphadenopathy. In patients presenting predominately with blood and bone marrow involvement it is called chronic lymphocytic leukemia (CLL); in those predominately with enlarged lymph nodes it is called small lymphocytic lymphoma. These terms represent spectrums of the same disease.	2	1

d-phenylalanyl-cysteinyl-tyrosyl-tryptophyl-lysyl-cysteinyl-threoninamide

Description

Cross-References

Synonyms (24)

Research Excerpts

Compound-Compound Interactions

Dosage Studied

Bioassays (12)

Research

Studies (30)

Market Indicators

Research Demand Index: 10.73

Study Types

d-phenylalanyl-cysteinyl-tyrosyl-tryptophyl-lysyl-cysteinyl-threoninamide

Description

Cross-References

Synonyms (24)

Research Excerpts

Compound-Compound Interactions

Dosage Studied

Bioassays (12)

Research

Studies (30)

Market Indicators

Research Demand Index: 10.73

Study Types

Related Drugs (29)

Related Conditions (53)