d-ala(2)-mephe(4)-met(0)-ol-enkephalin and Pain

d-ala(2)-mephe(4)-met(0)-ol-enkephalin has been researched along with Pain* in 3 studies

Reviews

1 review(s) available for d-ala(2)-mephe(4)-met(0)-ol-enkephalin and Pain

ArticleYear
Endorphins and enkephalins.
    Advances in internal medicine, 1980, Volume: 26

    Topics: Animals; Blood Circulation; Body Temperature Regulation; Brain Chemistry; Cats; D-Ala(2),MePhe(4),Met(0)-ol-enkephalin; Emotions; Endorphins; Enkephalins; Guinea Pigs; Humans; Male; Mice; Motor Activity; Pain; Pituitary Gland; Rats; Receptors, Opioid; Respiration; Schizophrenia

1980

Other Studies

2 other study(ies) available for d-ala(2)-mephe(4)-met(0)-ol-enkephalin and Pain

ArticleYear
Inhibition of stress-induced hyperglycemia by tail pinching or intraventricular enkephalin administration in the rat.
    Brain research, 1988, Jun-14, Volume: 452, Issue:1-2

    The tail pinch (t-p) method added to a basal restraint stress produced inhibition of the stress-induced hyperglycemia, an effect that was neutralized with intrathecal anesthesia but not with intracerebroventricular (i.c.v.) naloxone (50, 100, 1000 ng/100 g) or with intraperitoneal naloxone injections (0.1-0.3 mg/100 g). A similar negative result was obtained with i.c.v. administration of 500 and 1000 ng/100 g of beta-endorphin. In contrast, a single i.c.v. injection of 1000 ng/100 g of Met-enkephalin reproduced the t-p inhibitory effect. The latter was not elicited by i.c.v. FK 33824, an enkephalin analogue, a result that supports the specific participation of the delta-opioid receptors. The results obtained with central alpha-adrenoceptor antagonists and central noradrenergic chemical destruction, or central alpha-adrenoceptor agonists, support the production of a reinforcement of the alpha-adrenoceptor stress stimulation by the t-p procedure, probably through noradrenaline and enkephalin mediation.

    Topics: Animals; D-Ala(2),MePhe(4),Met(0)-ol-enkephalin; Enkephalin, Methionine; Hyperglycemia; Injections, Intraventricular; Insulin; Male; Naloxone; Pain; Rats; Rats, Inbred Strains; Restraint, Physical; Tail

1988
Endorphins: "opiates for the masses".
    Medicine and science in sports and exercise, 1985, Volume: 17, Issue:1

    Endogenous opioid peptides rose to prominence with the discovery of the enkephalins in 1975. Since then, a vast amount of research has been directed toward understanding their role in normal and pathophysiological situations. Although the place of endogenous opioids in psychiatry remains uncertain, there is good evidence that a variety of tumors may secrete endorphins or enkephalins, and these may contribute to the non-metastatic complications of malignant disease. In addition, changes in cerebrospinal fluid met-enkephalin and beta-endorphin after acupuncture may be involved in the effectiveness of this therapy in the treatment of heroin withdrawal and severe pain. The hormonal effects of opiate agonists and antagonists are now well characterized; exercise-induced changes in circulating catecholamines are markedly enhanced by the opiate antagonist naloxone. It is possible that the opiate inhibition of catecholamine release during exercise is a reflection of endogenous opioid modulation of effort perception.

    Topics: Acupuncture Therapy; Adrenocorticotropic Hormone; beta-Endorphin; Catecholamines; D-Ala(2),MePhe(4),Met(0)-ol-enkephalin; Endorphins; Enkephalin, Methionine; Growth Hormone; Humans; Luteinizing Hormone; Naloxone; Pain; Physical Exertion; Receptors, Opioid; Sensory Thresholds; Stress, Physiological

1985