conolidine: analgesic from the stem bark of Tabernaemontana divaricata; structure in first source [Medical Subject Headings (MeSH), National Library of Medicine, extracted Dec-2023]
| Flora | Rank | Flora Definition | Family | Family Definition |
|---|---|---|---|---|
| Tabernaemontana | genus | A plant genus of the family APOCYNACEAE that contains bisindole alkaloids and IBOGAINE.[MeSH] | Apocynaceae | The dogbane family of the order Gentianales. Members of the family have milky, often poisonous juice, smooth-margined leaves, and flowers in clusters.[MeSH] |
| ID Source | ID |
|---|---|
| PubMed CID | 51051652 |
| SCHEMBL ID | 10073828 |
| MeSH ID | M0558819 |
| Synonym |
|---|
| (+)-conolidine |
| (1r,13s,14e)-14-ethylidene-1,10- diazatetracyclo(11.2.2.0(3,11).0{4,9})heptadeca-3(11),4,6,8-tetraen-12-one |
| unii-wj97dl8ycb |
| conolidine |
| ervaticine |
| wj97dl8ycb , |
| 100414-81-1 |
| SCHEMBL10073828 |
| Q15410923 |
| 2,5-ethano-2h-azocino(4,3-b)indol-6(3h)-one, 4-ethylidene-1,4,5,7-tetrahydro-, (2r,4e,5s)- |
| (2r,4e,5s)-4-ethylidene-1,4,5,7-tetrahydro-2,5-ethano-2h-azocino[4,3-b]indol-6(3h)-one |
| (+)-ervaticine |
| 2,5-ethano-2h-azocino[4,3-b]indol-6(3h)-one, 4-ethylidene-1,4,5,7-tetrahydro-, (2r,4e,5s)- |
| DTXSID401126453 |
Conolidine is a rare C5-nor stemmadenine natural product. isolated from the stem bark of Tabernaemontana divaricata. Used in traditional Chinese, Ayurvedic and Thai medicine.
| Excerpt | Reference | Relevance |
|---|---|---|
| "Conolidine is a rare C5-nor stemmadenine natural product recently isolated from the stem bark of Tabernaemontana divaricata (a tropical flowering plant used in traditional Chinese, Ayurvedic and Thai medicine)." | ( Synthesis of conolidine, a potent non-opioid analgesic for tonic and persistent pain. Bohn, LM; Brasher, AK; Cameron, MD; Groer, CE; Micalizio, GC; Raehal, KM; Streicher, JM; Tarselli, MA, 2011) | 1.46 |
| Timeframe | Studies, This Drug (%) | All Drugs % |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 0 (0.00) | 18.2507 |
| 2000's | 0 (0.00) | 29.6817 |
| 2010's | 6 (85.71) | 24.3611 |
| 2020's | 1 (14.29) | 2.80 |
| [information is prepared from research data collected from National Library of Medicine (NLM), extracted Dec-2023] | ||
According to the monthly volume, diversity, and competition of internet searches for this compound, as well the volume and growth of publications, there is estimated to be strong demand-to-supply ratio for research on this compound.
| This Compound (48.10) All Compounds (24.57) |
| Publication Type | This drug (%) | All Drugs (%) |
|---|---|---|
| Trials | 0 (0.00%) | 5.53% |
| Reviews | 0 (0.00%) | 6.00% |
| Case Studies | 0 (0.00%) | 4.05% |
| Observational | 0 (0.00%) | 0.25% |
| Other | 7 (100.00%) | 84.16% |
| [information is prepared from research data collected from National Library of Medicine (NLM), extracted Dec-2023] | ||