reserpine has been researched along with Pain in 63 studies
Reserpine: An alkaloid found in the roots of Rauwolfia serpentina and R. vomitoria. Reserpine inhibits the uptake of norepinephrine into storage vesicles resulting in depletion of catecholamines and serotonin from central and peripheral axon terminals. It has been used as an antihypertensive and an antipsychotic as well as a research tool, but its adverse effects limit its clinical use.
reserpine : An alkaloid found in the roots of Rauwolfia serpentina and R. vomitoria.
Pain: An unpleasant sensation induced by noxious stimuli which are detected by NERVE ENDINGS of NOCICEPTIVE NEURONS.
| Excerpt | Relevance | Reference |
|---|---|---|
| "Both regional intravenous guanethidine and reserpine have been reported as effective in the treatment of reflex sympathetic dystrophy." | 9.06 | A comparison of regional intravenous guanethidine and reserpine in reflex sympathetic dystrophy. A controlled, randomized, double-blind crossover study. ( Gallo, JP; Kaul, AF; Lief, PA; Reisman, RM; Rocco, AG, 1989) |
| " Recently, a rat reserpine-induced pain model showing exaggerated pain-related behaviors to mechanical and thermal stimuli has been used in FM research." | 8.12 | Nociceptive chemical hypersensitivity in the spinal cord of a rat reserpine-induced fibromyalgia model. ( Ejiri, Y; Mizumura, K; Ota, H; Taguchi, T; Uta, D, 2022) |
| "This study is to offer a clinical pain-depression dyad therapy of ferulic acid, the pain-depression dyad induced by reserpine was established and the dose-effect relationship of ferulic acid on ameliorating pain-depression dyad was explored." | 7.79 | [Influence of ferulic acid on the pain-depression dyad induced by reserpine]. ( Pan, JC; Shi, HM; Wang, QD; Zhang, L, 2013) |
| "Pain and depression are often co-existing pathological states that promote mutual severity resulting in limited efficacy of current treatment strategies." | 5.62 | Skimmetin/osthole mitigates pain-depression dyad via inhibiting inflammatory and oxidative stress-mediated neurotransmitter dysregulation. ( Bhatti, R; Garg, S; Kaur, A; Singh, L, 2021) |
| "Chronic pain has consistently been correlated with depression." | 5.43 | Echinocystic acid reduces reserpine-induced pain/depression dyad in mice. ( Deng, YT; Feng, B; Han, J; Li, S; Wang, DS; Wang, XS; Yang, Q; Zhao, MG, 2016) |
| "The activated microglia and behavioral hyperalgesia were significantly tranquilized by intraperitoneal injection of minocycline." | 5.42 | Peripheral and spinal mechanisms of nociception in a rat reserpine-induced pain model. ( Hayashi, K; Katanosaka, K; Kiyama, H; Mizumura, K; Taguchi, T; Wakatsuki, K; Yamanaka, A; Yamashita, M; Yasui, M, 2015) |
| "Gentiopicroside (Gent) is a secoiridoid compound isolated from Gentiana lutea that exhibits analgesic properties and inhibits the expression of GluN2B-containing N-methyl-D-aspartate (NMDA) receptors in the anterior cingulate cortex of mice." | 5.40 | Attenuation of reserpine-induced pain/depression dyad by gentiopicroside through downregulation of GluN2B receptors in the amygdala of mice. ( Gao, GD; Guo, HJ; Li, XS; Liu, SB; Tian, Z; Zhang, N; Zhao, MG; Zhao, R, 2014) |
| "Depression and pain are often diagnosed in the same patients." | 5.37 | Curcumin ameliorates reserpine-induced pain-depression dyad: behavioural, biochemical, neurochemical and molecular evidences. ( Arora, V; Chopra, K; Kuhad, A; Tiwari, V, 2011) |
| "Both regional intravenous guanethidine and reserpine have been reported as effective in the treatment of reflex sympathetic dystrophy." | 5.06 | A comparison of regional intravenous guanethidine and reserpine in reflex sympathetic dystrophy. A controlled, randomized, double-blind crossover study. ( Gallo, JP; Kaul, AF; Lief, PA; Reisman, RM; Rocco, AG, 1989) |
| " Recently, a rat reserpine-induced pain model showing exaggerated pain-related behaviors to mechanical and thermal stimuli has been used in FM research." | 4.12 | Nociceptive chemical hypersensitivity in the spinal cord of a rat reserpine-induced fibromyalgia model. ( Ejiri, Y; Mizumura, K; Ota, H; Taguchi, T; Uta, D, 2022) |
| " Fibromyalgia was induced by three injections once a day of reserpine at the dose of 1 mg/kg." | 4.12 | Role of Etanercept and Infliximab on Nociceptive Changes Induced by the Experimental Model of Fibromyalgia. ( Cordaro, M; Cuzzocrea, S; D'Amico, R; Di Paola, D; Di Paola, R; Franco, G; Fusco, R; Genovese, T; Impellizzeri, D; Marino, Y; Siracusa, R, 2022) |
| "The present study investigated the efficacy of cationic liposome-encapsulated carotenoids (lutein or beta-carotene) as a treatment in an animal model of fibromyalgia (FM)." | 4.02 | Cationic liposome-encapsulated carotenoids as a potential treatment for fibromyalgia in an animal model. ( Elkholy, NS; Mohammed, HS; Shafaa, MW, 2021) |
| "This study investigated the effects of Phα1β, pregabalin and diclofenac using an animal model of fibromyalgia (FM)." | 3.80 | The effects of Phα1β, a spider toxin, calcium channel blocker, in a mouse fibromyalgia model. ( Castro, CJ; da Costa Lopes, AM; da Silva, CA; da Silva, JF; de Souza, AH; Ferreira, J; Gomez, MV; Klein, CP; Pereira, EM, 2014) |
| "This study is to offer a clinical pain-depression dyad therapy of ferulic acid, the pain-depression dyad induced by reserpine was established and the dose-effect relationship of ferulic acid on ameliorating pain-depression dyad was explored." | 3.79 | [Influence of ferulic acid on the pain-depression dyad induced by reserpine]. ( Pan, JC; Shi, HM; Wang, QD; Zhang, L, 2013) |
| "More studies are still warranted in similar rodent models of pain and depression, so, that the present findings can be further substantiated to establish the clinical effectiveness of berberine in a subset of patients suffering from pain as well as depression." | 3.79 | Possible involvement of oxido-nitrosative stress induced neuro-inflammatory cascade and monoaminergic pathway: underpinning the correlation between nociceptive and depressive behaviour in a rodent model. ( Arora, V; Chopra, K, 2013) |
| " The SD50 (estimated dose required to induce seizures in 50% of test group) of tramadol to antinociceptive ED50 ratio was almost identical to that of codeine." | 3.74 | Unexceptional seizure potential of tramadol or its enantiomers or metabolites in mice. ( Raffa, RB; Stone, DJ, 2008) |
| "Pain and depression are often co-existing pathological states that promote mutual severity resulting in limited efficacy of current treatment strategies." | 1.62 | Skimmetin/osthole mitigates pain-depression dyad via inhibiting inflammatory and oxidative stress-mediated neurotransmitter dysregulation. ( Bhatti, R; Garg, S; Kaur, A; Singh, L, 2021) |
| "Fibromyalgia is a disease characterised as generalised chronic primary pain that causes functional disability and a reduction in patients' quality of life, without specific pathophysiology or appropriate treatment." | 1.51 | Kinins and their B ( Brusco, I; Cunha, TM; Ferreira, J; Fischer, S; Justino, AB; Machado-de-Ávila, RA; Oliveira, SM; Scussel, R; Silva, CR, 2019) |
| "Chronic pain has consistently been correlated with depression." | 1.43 | Echinocystic acid reduces reserpine-induced pain/depression dyad in mice. ( Deng, YT; Feng, B; Han, J; Li, S; Wang, DS; Wang, XS; Yang, Q; Zhao, MG, 2016) |
| "The activated microglia and behavioral hyperalgesia were significantly tranquilized by intraperitoneal injection of minocycline." | 1.42 | Peripheral and spinal mechanisms of nociception in a rat reserpine-induced pain model. ( Hayashi, K; Katanosaka, K; Kiyama, H; Mizumura, K; Taguchi, T; Wakatsuki, K; Yamanaka, A; Yamashita, M; Yasui, M, 2015) |
| "Gentiopicroside (Gent) is a secoiridoid compound isolated from Gentiana lutea that exhibits analgesic properties and inhibits the expression of GluN2B-containing N-methyl-D-aspartate (NMDA) receptors in the anterior cingulate cortex of mice." | 1.40 | Attenuation of reserpine-induced pain/depression dyad by gentiopicroside through downregulation of GluN2B receptors in the amygdala of mice. ( Gao, GD; Guo, HJ; Li, XS; Liu, SB; Tian, Z; Zhang, N; Zhao, MG; Zhao, R, 2014) |
| "Depression and pain are often diagnosed in the same patients." | 1.37 | Curcumin ameliorates reserpine-induced pain-depression dyad: behavioural, biochemical, neurochemical and molecular evidences. ( Arora, V; Chopra, K; Kuhad, A; Tiwari, V, 2011) |
| "Berberine at lower dose did not affect the locomotor activity and barbiturate-induced sleep time." | 1.35 | On the mechanism of antidepressant-like action of berberine chloride. ( Dhir, A; Kulkarni, SK, 2008) |
| "To develop better treatments for pain-centered fibromyalgia symptoms, there is still a need for animal models which mimic the features of fibromyalgia patients." | 1.35 | Biogenic amine depletion causes chronic muscular pain and tactile allodynia accompanied by depression: A putative animal model of fibromyalgia. ( Aoki, T; Matsuoka, N; Nagakura, Y; Oe, T, 2009) |
| "Pretreatment with reserpine (2 mg/kg) significantly reduced the antinociceptive activity of FR64822, when tested against acetic acid writhing." | 1.28 | Involvement of dopamine in the mechanism of action of FR64822, a novel non-opioid antinociceptive compound. ( Nomura, K; Ohkubo, Y; Yamaguchi, I, 1991) |
| "When baclofen was administered intraperitoneally, pretreatment with depletors of monoamines and catecholamines (reserpine, alpha-MPT) produced a marked increase in antinociceptive activity in both tests." | 1.27 | Monoamines as mediators of the antinociceptive effect of baclofen. ( Sawynok, J, 1983) |
| "Reserpine pretreatment antagonized the antinociceptive effect of morphine; this effect was reversed by intraventricular injection of 5-HT." | 1.25 | Antinociceptive activity of morphine after injection of biogenic amines in the cerebral ventricles of the conscious rat. ( Sparkes, CG; Spencer, PS, 1971) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 33 (52.38) | 18.7374 |
| 1990's | 5 (7.94) | 18.2507 |
| 2000's | 7 (11.11) | 29.6817 |
| 2010's | 13 (20.63) | 24.3611 |
| 2020's | 5 (7.94) | 2.80 |
| Authors | Studies |
|---|---|
| Ejiri, Y | 1 |
| Uta, D | 1 |
| Ota, H | 1 |
| Mizumura, K | 2 |
| Taguchi, T | 2 |
| Cordaro, M | 1 |
| Siracusa, R | 1 |
| D'Amico, R | 1 |
| Genovese, T | 1 |
| Franco, G | 1 |
| Marino, Y | 1 |
| Di Paola, D | 1 |
| Cuzzocrea, S | 1 |
| Impellizzeri, D | 1 |
| Di Paola, R | 1 |
| Fusco, R | 1 |
| Ikeda, N | 1 |
| Kawasaki, M | 1 |
| Baba, K | 1 |
| Nishimura, H | 1 |
| Fujitani, T | 1 |
| Suzuki, H | 1 |
| Matsuura, T | 1 |
| Ohnishi, H | 1 |
| Shimizu, M | 1 |
| Sanada, K | 1 |
| Nishimura, K | 1 |
| Yoshimura, M | 1 |
| Maruyama, T | 1 |
| Conway-Campbell, BL | 1 |
| Onaka, T | 1 |
| Teranishi, H | 1 |
| Hanada, R | 1 |
| Ueta, Y | 1 |
| Sakai, A | 1 |
| Nagakura, Y | 2 |
| Miwa, M | 1 |
| Yoshida, M | 1 |
| Miura, R | 1 |
| Tanei, S | 1 |
| Tsuji, M | 1 |
| Takeda, H | 1 |
| Singh, L | 1 |
| Kaur, A | 1 |
| Garg, S | 1 |
| Bhatti, R | 1 |
| Elkholy, NS | 1 |
| Shafaa, MW | 1 |
| Mohammed, HS | 1 |
| Hernandez-Leon, A | 1 |
| Fernández-Guasti, A | 1 |
| Martínez, A | 1 |
| Pellicer, F | 1 |
| González-Trujano, ME | 1 |
| Siemian, JN | 1 |
| Shang, L | 1 |
| Seaman, RW | 1 |
| Zhu, Q | 1 |
| Zhang, Y | 1 |
| Li, JX | 1 |
| De la Luz-Cuellar, YE | 1 |
| Rodríguez-Palma, EJ | 1 |
| Franco-Enzástiga, Ú | 1 |
| Salinas-Abarca, AB | 1 |
| Delgado-Lezama, R | 1 |
| Granados-Soto, V | 1 |
| Brusco, I | 1 |
| Justino, AB | 1 |
| Silva, CR | 1 |
| Fischer, S | 1 |
| Cunha, TM | 1 |
| Scussel, R | 1 |
| Machado-de-Ávila, RA | 1 |
| Ferreira, J | 2 |
| Oliveira, SM | 1 |
| Xu, Y | 1 |
| Zhang, L | 2 |
| Shao, T | 1 |
| Ruan, L | 1 |
| Wang, L | 1 |
| Sun, J | 1 |
| Li, J | 1 |
| Zhu, X | 1 |
| O'Donnell, JM | 1 |
| Pan, J | 1 |
| Wang, QD | 1 |
| Shi, HM | 1 |
| Pan, JC | 1 |
| Arora, V | 2 |
| Chopra, K | 2 |
| de Souza, AH | 1 |
| da Costa Lopes, AM | 1 |
| Castro, CJ | 1 |
| Pereira, EM | 1 |
| Klein, CP | 1 |
| da Silva, CA | 1 |
| da Silva, JF | 1 |
| Gomez, MV | 1 |
| Liu, SB | 1 |
| Zhao, R | 1 |
| Li, XS | 1 |
| Guo, HJ | 1 |
| Tian, Z | 1 |
| Zhang, N | 1 |
| Gao, GD | 1 |
| Zhao, MG | 2 |
| Katanosaka, K | 1 |
| Yasui, M | 1 |
| Hayashi, K | 1 |
| Yamashita, M | 1 |
| Wakatsuki, K | 1 |
| Kiyama, H | 1 |
| Yamanaka, A | 1 |
| Li, S | 1 |
| Han, J | 1 |
| Wang, DS | 1 |
| Feng, B | 1 |
| Deng, YT | 1 |
| Wang, XS | 1 |
| Yang, Q | 1 |
| Kulkarni, SK | 1 |
| Dhir, A | 1 |
| Oe, T | 1 |
| Aoki, T | 1 |
| Matsuoka, N | 1 |
| Kuhad, A | 1 |
| Tiwari, V | 1 |
| SCHNEIDER, JA | 2 |
| SIGG, EB | 1 |
| CAPRIO, G | 1 |
| KOISS, G | 1 |
| MILETITS, I | 1 |
| Jain, S | 1 |
| Sharma, R | 2 |
| TONKIKH, AV | 1 |
| IL'INA, AI | 1 |
| TEPLOV, SI | 1 |
| TSOU, K | 1 |
| TU, ZH | 1 |
| MEDAKOVIC, M | 1 |
| BANIC, B | 1 |
| TAKAGI, H | 1 |
| TAKASHIMA, T | 1 |
| KIMURA, K | 1 |
| GASCON, A | 1 |
| NOCETI, D | 1 |
| NASTA, AG | 1 |
| Fusa, K | 1 |
| Takahashi, I | 1 |
| Watanabe, S | 1 |
| Aono, Y | 1 |
| Ikeda, H | 1 |
| Saigusa, T | 1 |
| Nagase, H | 1 |
| Suzuki, T | 1 |
| Koshikawa, N | 1 |
| Cools, AR | 1 |
| Jürgensen, S | 1 |
| Dalbó, S | 1 |
| Angers, P | 1 |
| Santos, AR | 1 |
| Ribeiro-do-Valle, RM | 1 |
| Raffa, RB | 1 |
| Stone, DJ | 1 |
| Sawynok, J | 1 |
| de Meglio, P | 1 |
| Carissimi, M | 1 |
| Ravenna, F | 1 |
| Gentili, P | 1 |
| Smith, DW | 1 |
| Day, TA | 1 |
| Takita, M | 1 |
| Kawashima, T | 1 |
| Kaneko, H | 1 |
| Suzuki, SS | 1 |
| Yokoi, H | 1 |
| Beani, L | 1 |
| Siniscalchi, A | 1 |
| Sarto, G | 1 |
| Sicuteri, F | 1 |
| Nieminen, L | 1 |
| Möttönen, M | 1 |
| Manchanda, SK | 1 |
| Nayar, U | 1 |
| Ohkubo, Y | 1 |
| Nomura, K | 1 |
| Yamaguchi, I | 1 |
| Muller, A | 1 |
| Sudbrack, G | 1 |
| Guo, X | 1 |
| Tang, XC | 2 |
| Rocco, AG | 1 |
| Kaul, AF | 1 |
| Reisman, RM | 1 |
| Gallo, JP | 1 |
| Lief, PA | 1 |
| Thompson, ML | 1 |
| Miczek, KA | 1 |
| Noda, K | 1 |
| Shuster, L | 1 |
| Kumar, MS | 1 |
| Bragin, EO | 1 |
| Zheng, P | 1 |
| Yang, YR | 1 |
| Hong, GX | 1 |
| Wei, BW | 1 |
| Yang, JG | 1 |
| Qin, WC | 1 |
| Teng, Z | 1 |
| Liu, XJ | 1 |
| Lu, WH | 1 |
| Wang, MD | 1 |
| Li, AL | 1 |
| Chase, TN | 1 |
| Murphy, DL | 1 |
| Contreras, E | 1 |
| Quijada, L | 1 |
| Tamayo, L | 1 |
| Giardina, WJ | 1 |
| Dedov, II | 1 |
| Verri, RA | 1 |
| Graeff, FG | 1 |
| Corrado, AP | 1 |
| Ross, JW | 1 |
| Ashford, A | 1 |
| Malen, CE | 1 |
| Poignant, JC | 1 |
| Zàbojnìkovà, M | 1 |
| Kovalcìk, V | 1 |
| Jiràskovà, M | 1 |
| Wilkinson, B | 1 |
| Williams, JA | 1 |
| Sparkes, CG | 1 |
| Spencer, PS | 1 |
| Solc, J | 1 |
| Sauerová, Z | 1 |
| Pscheidt, GR | 1 |
| Schweigerdt, A | 1 |
| Himwich, HE | 1 |
| Thuránszky, K | 1 |
| Trial | Phase | Enrollment | Study Type | Start Date | Status | ||
|---|---|---|---|---|---|---|---|
| A Double-blind, Randomized, Placebo-controlled Trial of Berberine as an Adjuvant to Treat Antipsychotic-induced Metabolic Syndrome in Patients With Schizophrenia Spectrum Disorders[NCT02983188] | Phase 2/Phase 3 | 113 participants (Actual) | Interventional | 2018-04-25 | Completed | ||
| [information is prepared from clinicaltrials.gov, extracted Sep-2024] | |||||||
2 reviews available for reserpine and Pain
| Article | Year |
|---|---|
Opioid and catecholaminergic mechanisms of different types of analgesia.
Topics: Acetates; Acetic Acid; Acupuncture Therapy; Analgesia; Animals; Electric Stimulation; Electroshock; | 1986 |
Serotonin and central nervous system function.
Topics: Affective Symptoms; Aggression; Animals; Body Temperature Regulation; Cats; Cattle; Central Nervous | 1973 |
1 trial available for reserpine and Pain
| Article | Year |
|---|---|
A comparison of regional intravenous guanethidine and reserpine in reflex sympathetic dystrophy. A controlled, randomized, double-blind crossover study.
Topics: Adult; Body Temperature; Double-Blind Method; Female; Guanethidine; Humans; Injections, Intravenous; | 1989 |
60 other studies available for reserpine and Pain
| Article | Year |
|---|---|
Nociceptive chemical hypersensitivity in the spinal cord of a rat reserpine-induced fibromyalgia model.
Topics: Animals; Fibromyalgia; Formaldehyde; Nociception; Pain; Proto-Oncogene Proteins c-fos; Rats; Rats, S | 2022 |
Role of Etanercept and Infliximab on Nociceptive Changes Induced by the Experimental Model of Fibromyalgia.
Topics: Animals; Etanercept; Fibromyalgia; Hyperalgesia; Infliximab; Models, Theoretical; Nociception; p38 M | 2022 |
Chemogenetic Activation of Oxytocin Neurons Improves Pain in a Reserpine-induced Fibromyalgia Rat Model.
Topics: Animals; Fibromyalgia; Humans; Luminescent Proteins; Neurons; Oxytocin; Pain; Rats; Rats, Transgenic | 2023 |
Spontaneous pain-associated facial expression and efficacy of clinically used drugs in the reserpine-induced rat model of fibromyalgia.
Topics: Analgesics; Animals; Disease Models, Animal; Facial Expression; Fibromyalgia; Male; Pain; Rats; Rats | 2019 |
Skimmetin/osthole mitigates pain-depression dyad via inhibiting inflammatory and oxidative stress-mediated neurotransmitter dysregulation.
Topics: Animals; Behavior, Animal; Brain; Coumarins; Cytokines; Depression; Drug Therapy, Combination; Femal | 2021 |
Cationic liposome-encapsulated carotenoids as a potential treatment for fibromyalgia in an animal model.
Topics: Animals; Antioxidants; Carotenoids; Female; Fibromyalgia; Liposomes; Lutein; Pain; Rats; Reserpine | 2021 |
Sleep architecture is altered in the reserpine-induced fibromyalgia model in ovariectomized rats.
Topics: Animals; Disease Models, Animal; Female; Fibromyalgia; Fluoxetine; Hyperalgesia; Ovariectomy; Pain; | 2019 |
Effects of imidazoline I2 receptor agonists on reserpine-induced hyperalgesia and depressive-like behavior in rats.
Topics: Analgesics; Animals; Benzofurans; Depression; Disease Models, Animal; Fibromyalgia; Hyperalgesia; Id | 2019 |
Blockade of spinal α
Topics: Animals; Astrocytes; Female; Fibromyalgia; Ganglia, Spinal; Gene Expression Regulation; Hyperalgesia | 2019 |
Kinins and their B
Topics: Animals; Behavior, Animal; Bradykinin; Disease Models, Animal; Fibromyalgia; Gene Knockout Technique | 2019 |
Ferulic acid increases pain threshold and ameliorates depression-like behaviors in reserpine-treated mice: behavioral and neurobiological analyses.
Topics: Animals; Behavior, Animal; Brain; Coumaric Acids; Depression; Disease Models, Animal; Dopamine; Mice | 2013 |
[Influence of ferulic acid on the pain-depression dyad induced by reserpine].
Topics: Animals; Antidepressive Agents; Coumaric Acids; Depression; Dopamine; Dose-Response Relationship, Dr | 2013 |
Possible involvement of oxido-nitrosative stress induced neuro-inflammatory cascade and monoaminergic pathway: underpinning the correlation between nociceptive and depressive behaviour in a rodent model.
Topics: Animals; Berberine; Caspase 3; Cerebral Cortex; Depression; Disease Models, Animal; Dopamine; Hippoc | 2013 |
The effects of Phα1β, a spider toxin, calcium channel blocker, in a mouse fibromyalgia model.
Topics: Animals; Brain; Calcium Channel Blockers; Diclofenac; Disease Models, Animal; Dopamine; Fibromyalgia | 2014 |
Attenuation of reserpine-induced pain/depression dyad by gentiopicroside through downregulation of GluN2B receptors in the amygdala of mice.
Topics: Amygdala; Analgesics; Animals; Biogenic Amines; Brain Chemistry; Caspase 3; Chronic Pain; Depression | 2014 |
Peripheral and spinal mechanisms of nociception in a rat reserpine-induced pain model.
Topics: Acid Sensing Ion Channels; Action Potentials; Analysis of Variance; Animals; Antihypertensive Agents | 2015 |
Echinocystic acid reduces reserpine-induced pain/depression dyad in mice.
Topics: Analgesics; Animals; Behavior, Animal; Brain; Depression; Depressive Disorder; Disease Models, Anima | 2016 |
On the mechanism of antidepressant-like action of berberine chloride.
Topics: Analgesics; Animals; Antidepressive Agents; Behavior, Animal; Berberine; Body Temperature; Brain; De | 2008 |
Biogenic amine depletion causes chronic muscular pain and tactile allodynia accompanied by depression: A putative animal model of fibromyalgia.
Topics: Adrenergic Uptake Inhibitors; Animals; Biogenic Amines; Central Nervous System; Depressive Disorder; | 2009 |
Curcumin ameliorates reserpine-induced pain-depression dyad: behavioural, biochemical, neurochemical and molecular evidences.
Topics: Adrenergic Uptake Inhibitors; Animals; Antidepressive Agents; Behavior, Animal; Biomarkers; Curcumin | 2011 |
Reserpine antagonism of morphine analgesia in mice.
Topics: Analgesia; Anesthesia; Anesthesia and Analgesia; Animals; Mice; Morphine; Pain; Pain Management; Rau | 1954 |
Synergism of amines and antagonism of reserpine to morphine analgesia.
Topics: Amines; Analgesia; Drug Interactions; Morphine; Mycobacterium; Pain; Pain Management; Reserpine | 1958 |
[Surgical anesthesia in jaundice patients].
Topics: Analgesia; Anesthesia; Anesthesia and Analgesia; Jaundice; Pain; Procaine; Reserpine | 1959 |
Analgesia in phasic and tonic pain tests in a pharmacological model of autotomy.
Topics: Adrenergic alpha-Antagonists; Adrenergic Uptake Inhibitors; Amphetamine; Analgesia; Animals; Behavio | 2002 |
[Pharmacological analysis of the mechanism of change in the blood pressure and coronary circulation after pain stimulation].
Topics: Blood Pressure; Blood Pressure Determination; Chlorpromazine; Coronary Circulation; Coronary Vessels | 1960 |
[EFFECTS OF RESERPINE, ALPHA-METHYL-DOPA AND THEIR INTERACTIONS ON MORPHINE ANALGESIA].
Topics: Analgesia; Animals; Antihypertensive Agents; Catecholamines; Dihydroxyphenylalanine; Electricity; Ho | 1963 |
THE ACTION OF RESERPINE AND ALPHA-METHYL-M-TYROSINE ON THE ANALGESIC EFFECT OF MORPHINE IN RATS AND MICE.
Topics: Analgesia; Analgesics; Animals; Iproniazid; Methyltyrosines; Mice; Morphine; Pain; Pain Management; | 1964 |
ANTAGONISM OF THE ANALGETIC EFFECT OF MORPHINE IN MICE BY TETRABENAZINE AND RESERPINE.
Topics: Analgesia; Animals; Mice; Morphine; Pain; Pain Management; Pharmacology; Research; Reserpine; Tetrab | 1964 |
[ROLE OF SEVERAL SEROTONIN AND CATECHOLAMINE LIBERATORS IN THE PHENOMENON OF PAIN IN THE RAT].
Topics: Bretylium Compounds; Carboxy-Lyases; Catecholamines; Enzyme Inhibitors; Guanethidine; Morphine; Pain | 1964 |
[Combined serpasil and doriden in the treatment of pain in chronic peripheral arterial diseases and in preoperative and postoperative sedation].
Topics: Anticonvulsants; Antihypertensive Agents; Glutethimide; Humans; Pain; Peripheral Arterial Disease; P | 1955 |
The non-peptidic delta opioid receptor agonist TAN-67 enhances dopamine efflux in the nucleus accumbens of freely moving rats via a mechanism that involves both glutamate and free radicals.
Topics: Adrenergic Uptake Inhibitors; alpha-Methyltyrosine; Animals; Dopamine; Enkephalin, D-Penicillamine ( | 2005 |
Involvement of 5-HT2 receptors in the antinociceptive effect of Uncaria tomentosa.
Topics: Acetic Acid; Analgesics; Animals; Arginine; Atropine; Behavior, Animal; Capsaicin; Cat's Claw; Dose- | 2005 |
Unexceptional seizure potential of tramadol or its enantiomers or metabolites in mice.
Topics: Analgesics, Opioid; Animals; Codeine; Cytochrome P-450 CYP2D6 Inhibitors; Drug Interactions; Hot Tem | 2008 |
Monoamines as mediators of the antinociceptive effect of baclofen.
Topics: alpha-Methyltyrosine; Analgesics; Animals; Baclofen; Biogenic Amines; Male; Methyltyrosines; Pain; R | 1983 |
[A new cyclohexylphenyl and cyclohexylphenylamine. Synthesis and pharmacological activity].
Topics: Aniline Compounds; Animals; Appetite; Benzene Derivatives; Blood Pressure; Cyclohexanes; Guinea Pigs | 1980 |
Neurochemical identification of fos-positive neurons using two-colour immunoperoxidase staining.
Topics: Animals; Biomarkers; Gene Expression Regulation; Hypothalamus; Immunoenzyme Techniques; Male; Medull | 1993 |
Sensitization of glutamate release and N-methyl-D-aspartate receptor response by transient dopamine pretreatment in prefrontal cortex of rats.
Topics: Animals; Avoidance Learning; Calcium Signaling; Dopamine; Dopamine Antagonists; Excitatory Amino Aci | 2002 |
Monoamines modulation of morphine action on pain threshold and cortical acetylcholine outflow.
Topics: Acetylcholine; Animals; Biogenic Amines; Cerebral Cortex; Dextroamphetamine; Female; Fenclonine; Gui | 1979 |
Hypothesis: migraine, a central biochemical dysnociception.
Topics: Adult; Animals; Apomorphine; Circadian Rhythm; Dopamine; Female; Fever; Headache; Humans; Levodopa; | 1976 |
The pain aggression induced by bronopol in the rat.
Topics: Aggression; Aging; Animals; Behavior, Animal; Drug Interactions; Female; Humans; Pain; Peritonitis; | 1975 |
Role of opioid receptors in self-aggression in rats.
Topics: Aggression; Amphetamine; Animals; Behavior, Animal; Male; Naloxone; Norepinephrine; Pain; Phenoxyben | 1991 |
Involvement of dopamine in the mechanism of action of FR64822, a novel non-opioid antinociceptive compound.
Topics: Acetates; Acetic Acid; Analgesics; Animals; Clonidine; Dopamine; Dopamine Antagonists; Male; Mice; M | 1991 |
[Intravenous sympatholysis in arterial occlusive diseases and acrosyndromes].
Topics: Arterial Occlusive Diseases; Bretylium Compounds; Guanethidine; Humans; Injections, Intravenous; Isc | 1990 |
[Effects of reserpine and 5-HT on analgesia induced by lappaconitine and N-deacetyllappaconitine].
Topics: Aconitine; Aconitum; Animals; Anti-Inflammatory Agents, Non-Steroidal; Female; Male; Morphine; Pain; | 1990 |
Analgesia in defeated mice: evidence for mediation via central rather than pituitary or adrenal endogenous opioid peptides.
Topics: Animals; beta-Endorphin; Central Nervous System; Dexamethasone; Endorphins; Enkephalins; Male; Mice; | 1988 |
[Site of analgesic action of aconitine and the relation between its action and the central noradrenergic system].
Topics: Aconitine; Aconitum; Analgesics; Animals; Female; Injections, Intraventricular; Injections, Spinal; | 1988 |
[Studies on factors affecting the actions of reserpine and pargyline on normal pain thresholds in mice and rats, and on the modification of morphine analgesia].
Topics: Animals; Female; Male; Mice; Morphine; Pain; Pargyline; Rats; Reserpine; Sensory Thresholds | 1986 |
[Studies on the analgesic action and physical dependence of bulleyaconitine A].
Topics: Aconitine; Aconitum; Analgesics; Animals; Drug Tolerance; Female; Male; Mice; Naloxone; Pain; Rats; | 1986 |
A comparative study of the effects of reserpine and p-chlorophenylalanine on morphine analgesia in mice.
Topics: 5-Hydroxytryptophan; Analgesia; Animals; Dihydroxyphenylalanine; Drug Synergism; Fenclonine; Male; M | 1973 |
Analgesic properties of phenylethylamine and phenylethanolamine in mice.
Topics: Animals; Disulfides; Ethanolamines; Fenclonine; Imidazoles; Injections, Intraperitoneal; Male; Metho | 1974 |
[Medial eminence of the neurohypophysis in extreme conditions].
Topics: Animals; Epinephrine; Inclusion Bodies; Male; Metyrapone; Microscopy, Electron; Nerve Endings; Pain; | 1972 |
Antagonism of morphine analgesia by reserpine and alpha-methyltyrosine and the role played by catecholamines in morphine analgesic action.
Topics: Analgesics; Animals; Brain; Catecholamines; Dental Pulp; Drug Antagonism; Electric Stimulation; Elec | 1967 |
The effect of reserpine and alpha-methyldopa on the analgesic action of morphine in the mouse.
Topics: Analgesia; Animals; Drug Antagonism; Drug Synergism; Hot Temperature; Male; Methyldopa; Mice; Morphi | 1967 |
7-Aminoheptanoic acid derivatives as potential neuropharmacological agents. I.
Topics: Analgesia; Animals; Appetite Regulation; Barbiturates; Cardiovascular System; Electroencephalography | 1972 |
Interaction of benactyzine with analgesics and prothiadene.
Topics: Aminopyrine; Animals; Benactyzine; Dibenzothiepins; Drug Synergism; Mice; Morphine; Pain; Reserpine | 1973 |
A gastrointestinal problem.
Topics: Abdomen; Humans; Hydrochlorothiazide; Hypertension; Ileum; Intestinal Diseases; Intestinal Obstructi | 1972 |
Antinociceptive activity of morphine after injection of biogenic amines in the cerebral ventricles of the conscious rat.
Topics: Animals; Cerebral Ventricles; Consciousness; Dihydroxyphenylalanine; Dopamine; Injections; Injection | 1971 |
[Reserpine therapy of periodic vomiting and abdominal pain in children].
Topics: Abdomen; Age Factors; Child; Humans; Pain; Phenobarbital; Reserpine; Vomiting | 1970 |
Effects of some psychoactive drugs on electroencephalogram and brain amines of immature rabbits.
Topics: Animals; Behavior, Animal; Brain; Brain Chemistry; Brain Stem; Cerebellum; Chlorpromazine; Electroen | 1965 |
The effect of psychopharmaca on exteroceptive blood pressure reflexes in non-anaesthetized cats.
Topics: Amphetamine; Animals; Autonomic Nervous System; Behavior, Animal; Blood Pressure; Capsicum; Cats; Ch | 1966 |