Page last updated: 2024-11-06

reserpine and Pain

reserpine has been researched along with Pain in 63 studies

Reserpine: An alkaloid found in the roots of Rauwolfia serpentina and R. vomitoria. Reserpine inhibits the uptake of norepinephrine into storage vesicles resulting in depletion of catecholamines and serotonin from central and peripheral axon terminals. It has been used as an antihypertensive and an antipsychotic as well as a research tool, but its adverse effects limit its clinical use.
reserpine : An alkaloid found in the roots of Rauwolfia serpentina and R. vomitoria.

Pain: An unpleasant sensation induced by noxious stimuli which are detected by NERVE ENDINGS of NOCICEPTIVE NEURONS.

Research Excerpts

ExcerptRelevanceReference
"Both regional intravenous guanethidine and reserpine have been reported as effective in the treatment of reflex sympathetic dystrophy."9.06A comparison of regional intravenous guanethidine and reserpine in reflex sympathetic dystrophy. A controlled, randomized, double-blind crossover study. ( Gallo, JP; Kaul, AF; Lief, PA; Reisman, RM; Rocco, AG, 1989)
" Recently, a rat reserpine-induced pain model showing exaggerated pain-related behaviors to mechanical and thermal stimuli has been used in FM research."8.12Nociceptive chemical hypersensitivity in the spinal cord of a rat reserpine-induced fibromyalgia model. ( Ejiri, Y; Mizumura, K; Ota, H; Taguchi, T; Uta, D, 2022)
"This study is to offer a clinical pain-depression dyad therapy of ferulic acid, the pain-depression dyad induced by reserpine was established and the dose-effect relationship of ferulic acid on ameliorating pain-depression dyad was explored."7.79[Influence of ferulic acid on the pain-depression dyad induced by reserpine]. ( Pan, JC; Shi, HM; Wang, QD; Zhang, L, 2013)
"Pain and depression are often co-existing pathological states that promote mutual severity resulting in limited efficacy of current treatment strategies."5.62Skimmetin/osthole mitigates pain-depression dyad via inhibiting inflammatory and oxidative stress-mediated neurotransmitter dysregulation. ( Bhatti, R; Garg, S; Kaur, A; Singh, L, 2021)
"Chronic pain has consistently been correlated with depression."5.43Echinocystic acid reduces reserpine-induced pain/depression dyad in mice. ( Deng, YT; Feng, B; Han, J; Li, S; Wang, DS; Wang, XS; Yang, Q; Zhao, MG, 2016)
"The activated microglia and behavioral hyperalgesia were significantly tranquilized by intraperitoneal injection of minocycline."5.42Peripheral and spinal mechanisms of nociception in a rat reserpine-induced pain model. ( Hayashi, K; Katanosaka, K; Kiyama, H; Mizumura, K; Taguchi, T; Wakatsuki, K; Yamanaka, A; Yamashita, M; Yasui, M, 2015)
"Gentiopicroside (Gent) is a secoiridoid compound isolated from Gentiana lutea that exhibits analgesic properties and inhibits the expression of GluN2B-containing N-methyl-D-aspartate (NMDA) receptors in the anterior cingulate cortex of mice."5.40Attenuation of reserpine-induced pain/depression dyad by gentiopicroside through downregulation of GluN2B receptors in the amygdala of mice. ( Gao, GD; Guo, HJ; Li, XS; Liu, SB; Tian, Z; Zhang, N; Zhao, MG; Zhao, R, 2014)
"Depression and pain are often diagnosed in the same patients."5.37Curcumin ameliorates reserpine-induced pain-depression dyad: behavioural, biochemical, neurochemical and molecular evidences. ( Arora, V; Chopra, K; Kuhad, A; Tiwari, V, 2011)
"Both regional intravenous guanethidine and reserpine have been reported as effective in the treatment of reflex sympathetic dystrophy."5.06A comparison of regional intravenous guanethidine and reserpine in reflex sympathetic dystrophy. A controlled, randomized, double-blind crossover study. ( Gallo, JP; Kaul, AF; Lief, PA; Reisman, RM; Rocco, AG, 1989)
" Recently, a rat reserpine-induced pain model showing exaggerated pain-related behaviors to mechanical and thermal stimuli has been used in FM research."4.12Nociceptive chemical hypersensitivity in the spinal cord of a rat reserpine-induced fibromyalgia model. ( Ejiri, Y; Mizumura, K; Ota, H; Taguchi, T; Uta, D, 2022)
" Fibromyalgia was induced by three injections once a day of reserpine at the dose of 1 mg/kg."4.12Role of Etanercept and Infliximab on Nociceptive Changes Induced by the Experimental Model of Fibromyalgia. ( Cordaro, M; Cuzzocrea, S; D'Amico, R; Di Paola, D; Di Paola, R; Franco, G; Fusco, R; Genovese, T; Impellizzeri, D; Marino, Y; Siracusa, R, 2022)
"The present study investigated the efficacy of cationic liposome-encapsulated carotenoids (lutein or beta-carotene) as a treatment in an animal model of fibromyalgia (FM)."4.02Cationic liposome-encapsulated carotenoids as a potential treatment for fibromyalgia in an animal model. ( Elkholy, NS; Mohammed, HS; Shafaa, MW, 2021)
"This study investigated the effects of Phα1β, pregabalin and diclofenac using an animal model of fibromyalgia (FM)."3.80The effects of Phα1β, a spider toxin, calcium channel blocker, in a mouse fibromyalgia model. ( Castro, CJ; da Costa Lopes, AM; da Silva, CA; da Silva, JF; de Souza, AH; Ferreira, J; Gomez, MV; Klein, CP; Pereira, EM, 2014)
"This study is to offer a clinical pain-depression dyad therapy of ferulic acid, the pain-depression dyad induced by reserpine was established and the dose-effect relationship of ferulic acid on ameliorating pain-depression dyad was explored."3.79[Influence of ferulic acid on the pain-depression dyad induced by reserpine]. ( Pan, JC; Shi, HM; Wang, QD; Zhang, L, 2013)
"More studies are still warranted in similar rodent models of pain and depression, so, that the present findings can be further substantiated to establish the clinical effectiveness of berberine in a subset of patients suffering from pain as well as depression."3.79Possible involvement of oxido-nitrosative stress induced neuro-inflammatory cascade and monoaminergic pathway: underpinning the correlation between nociceptive and depressive behaviour in a rodent model. ( Arora, V; Chopra, K, 2013)
" The SD50 (estimated dose required to induce seizures in 50% of test group) of tramadol to antinociceptive ED50 ratio was almost identical to that of codeine."3.74Unexceptional seizure potential of tramadol or its enantiomers or metabolites in mice. ( Raffa, RB; Stone, DJ, 2008)
"Pain and depression are often co-existing pathological states that promote mutual severity resulting in limited efficacy of current treatment strategies."1.62Skimmetin/osthole mitigates pain-depression dyad via inhibiting inflammatory and oxidative stress-mediated neurotransmitter dysregulation. ( Bhatti, R; Garg, S; Kaur, A; Singh, L, 2021)
"Fibromyalgia is a disease characterised as generalised chronic primary pain that causes functional disability and a reduction in patients' quality of life, without specific pathophysiology or appropriate treatment."1.51Kinins and their B ( Brusco, I; Cunha, TM; Ferreira, J; Fischer, S; Justino, AB; Machado-de-Ávila, RA; Oliveira, SM; Scussel, R; Silva, CR, 2019)
"Chronic pain has consistently been correlated with depression."1.43Echinocystic acid reduces reserpine-induced pain/depression dyad in mice. ( Deng, YT; Feng, B; Han, J; Li, S; Wang, DS; Wang, XS; Yang, Q; Zhao, MG, 2016)
"The activated microglia and behavioral hyperalgesia were significantly tranquilized by intraperitoneal injection of minocycline."1.42Peripheral and spinal mechanisms of nociception in a rat reserpine-induced pain model. ( Hayashi, K; Katanosaka, K; Kiyama, H; Mizumura, K; Taguchi, T; Wakatsuki, K; Yamanaka, A; Yamashita, M; Yasui, M, 2015)
"Gentiopicroside (Gent) is a secoiridoid compound isolated from Gentiana lutea that exhibits analgesic properties and inhibits the expression of GluN2B-containing N-methyl-D-aspartate (NMDA) receptors in the anterior cingulate cortex of mice."1.40Attenuation of reserpine-induced pain/depression dyad by gentiopicroside through downregulation of GluN2B receptors in the amygdala of mice. ( Gao, GD; Guo, HJ; Li, XS; Liu, SB; Tian, Z; Zhang, N; Zhao, MG; Zhao, R, 2014)
"Depression and pain are often diagnosed in the same patients."1.37Curcumin ameliorates reserpine-induced pain-depression dyad: behavioural, biochemical, neurochemical and molecular evidences. ( Arora, V; Chopra, K; Kuhad, A; Tiwari, V, 2011)
"Berberine at lower dose did not affect the locomotor activity and barbiturate-induced sleep time."1.35On the mechanism of antidepressant-like action of berberine chloride. ( Dhir, A; Kulkarni, SK, 2008)
"To develop better treatments for pain-centered fibromyalgia symptoms, there is still a need for animal models which mimic the features of fibromyalgia patients."1.35Biogenic amine depletion causes chronic muscular pain and tactile allodynia accompanied by depression: A putative animal model of fibromyalgia. ( Aoki, T; Matsuoka, N; Nagakura, Y; Oe, T, 2009)
"Pretreatment with reserpine (2 mg/kg) significantly reduced the antinociceptive activity of FR64822, when tested against acetic acid writhing."1.28Involvement of dopamine in the mechanism of action of FR64822, a novel non-opioid antinociceptive compound. ( Nomura, K; Ohkubo, Y; Yamaguchi, I, 1991)
"When baclofen was administered intraperitoneally, pretreatment with depletors of monoamines and catecholamines (reserpine, alpha-MPT) produced a marked increase in antinociceptive activity in both tests."1.27Monoamines as mediators of the antinociceptive effect of baclofen. ( Sawynok, J, 1983)
"Reserpine pretreatment antagonized the antinociceptive effect of morphine; this effect was reversed by intraventricular injection of 5-HT."1.25Antinociceptive activity of morphine after injection of biogenic amines in the cerebral ventricles of the conscious rat. ( Sparkes, CG; Spencer, PS, 1971)

Research

Studies (63)

TimeframeStudies, this research(%)All Research%
pre-199033 (52.38)18.7374
1990's5 (7.94)18.2507
2000's7 (11.11)29.6817
2010's13 (20.63)24.3611
2020's5 (7.94)2.80

Authors

AuthorsStudies
Ejiri, Y1
Uta, D1
Ota, H1
Mizumura, K2
Taguchi, T2
Cordaro, M1
Siracusa, R1
D'Amico, R1
Genovese, T1
Franco, G1
Marino, Y1
Di Paola, D1
Cuzzocrea, S1
Impellizzeri, D1
Di Paola, R1
Fusco, R1
Ikeda, N1
Kawasaki, M1
Baba, K1
Nishimura, H1
Fujitani, T1
Suzuki, H1
Matsuura, T1
Ohnishi, H1
Shimizu, M1
Sanada, K1
Nishimura, K1
Yoshimura, M1
Maruyama, T1
Conway-Campbell, BL1
Onaka, T1
Teranishi, H1
Hanada, R1
Ueta, Y1
Sakai, A1
Nagakura, Y2
Miwa, M1
Yoshida, M1
Miura, R1
Tanei, S1
Tsuji, M1
Takeda, H1
Singh, L1
Kaur, A1
Garg, S1
Bhatti, R1
Elkholy, NS1
Shafaa, MW1
Mohammed, HS1
Hernandez-Leon, A1
Fernández-Guasti, A1
Martínez, A1
Pellicer, F1
González-Trujano, ME1
Siemian, JN1
Shang, L1
Seaman, RW1
Zhu, Q1
Zhang, Y1
Li, JX1
De la Luz-Cuellar, YE1
Rodríguez-Palma, EJ1
Franco-Enzástiga, Ú1
Salinas-Abarca, AB1
Delgado-Lezama, R1
Granados-Soto, V1
Brusco, I1
Justino, AB1
Silva, CR1
Fischer, S1
Cunha, TM1
Scussel, R1
Machado-de-Ávila, RA1
Ferreira, J2
Oliveira, SM1
Xu, Y1
Zhang, L2
Shao, T1
Ruan, L1
Wang, L1
Sun, J1
Li, J1
Zhu, X1
O'Donnell, JM1
Pan, J1
Wang, QD1
Shi, HM1
Pan, JC1
Arora, V2
Chopra, K2
de Souza, AH1
da Costa Lopes, AM1
Castro, CJ1
Pereira, EM1
Klein, CP1
da Silva, CA1
da Silva, JF1
Gomez, MV1
Liu, SB1
Zhao, R1
Li, XS1
Guo, HJ1
Tian, Z1
Zhang, N1
Gao, GD1
Zhao, MG2
Katanosaka, K1
Yasui, M1
Hayashi, K1
Yamashita, M1
Wakatsuki, K1
Kiyama, H1
Yamanaka, A1
Li, S1
Han, J1
Wang, DS1
Feng, B1
Deng, YT1
Wang, XS1
Yang, Q1
Kulkarni, SK1
Dhir, A1
Oe, T1
Aoki, T1
Matsuoka, N1
Kuhad, A1
Tiwari, V1
SCHNEIDER, JA2
SIGG, EB1
CAPRIO, G1
KOISS, G1
MILETITS, I1
Jain, S1
Sharma, R2
TONKIKH, AV1
IL'INA, AI1
TEPLOV, SI1
TSOU, K1
TU, ZH1
MEDAKOVIC, M1
BANIC, B1
TAKAGI, H1
TAKASHIMA, T1
KIMURA, K1
GASCON, A1
NOCETI, D1
NASTA, AG1
Fusa, K1
Takahashi, I1
Watanabe, S1
Aono, Y1
Ikeda, H1
Saigusa, T1
Nagase, H1
Suzuki, T1
Koshikawa, N1
Cools, AR1
Jürgensen, S1
Dalbó, S1
Angers, P1
Santos, AR1
Ribeiro-do-Valle, RM1
Raffa, RB1
Stone, DJ1
Sawynok, J1
de Meglio, P1
Carissimi, M1
Ravenna, F1
Gentili, P1
Smith, DW1
Day, TA1
Takita, M1
Kawashima, T1
Kaneko, H1
Suzuki, SS1
Yokoi, H1
Beani, L1
Siniscalchi, A1
Sarto, G1
Sicuteri, F1
Nieminen, L1
Möttönen, M1
Manchanda, SK1
Nayar, U1
Ohkubo, Y1
Nomura, K1
Yamaguchi, I1
Muller, A1
Sudbrack, G1
Guo, X1
Tang, XC2
Rocco, AG1
Kaul, AF1
Reisman, RM1
Gallo, JP1
Lief, PA1
Thompson, ML1
Miczek, KA1
Noda, K1
Shuster, L1
Kumar, MS1
Bragin, EO1
Zheng, P1
Yang, YR1
Hong, GX1
Wei, BW1
Yang, JG1
Qin, WC1
Teng, Z1
Liu, XJ1
Lu, WH1
Wang, MD1
Li, AL1
Chase, TN1
Murphy, DL1
Contreras, E1
Quijada, L1
Tamayo, L1
Giardina, WJ1
Dedov, II1
Verri, RA1
Graeff, FG1
Corrado, AP1
Ross, JW1
Ashford, A1
Malen, CE1
Poignant, JC1
Zàbojnìkovà, M1
Kovalcìk, V1
Jiràskovà, M1
Wilkinson, B1
Williams, JA1
Sparkes, CG1
Spencer, PS1
Solc, J1
Sauerová, Z1
Pscheidt, GR1
Schweigerdt, A1
Himwich, HE1
Thuránszky, K1

Clinical Trials (1)

Trial Overview

TrialPhaseEnrollmentStudy TypeStart DateStatus
A Double-blind, Randomized, Placebo-controlled Trial of Berberine as an Adjuvant to Treat Antipsychotic-induced Metabolic Syndrome in Patients With Schizophrenia Spectrum Disorders[NCT02983188]Phase 2/Phase 3113 participants (Actual)Interventional2018-04-25Completed
[information is prepared from clinicaltrials.gov, extracted Sep-2024]

Reviews

2 reviews available for reserpine and Pain

ArticleYear
Opioid and catecholaminergic mechanisms of different types of analgesia.
    Annals of the New York Academy of Sciences, 1986, Volume: 467

    Topics: Acetates; Acetic Acid; Acupuncture Therapy; Analgesia; Animals; Electric Stimulation; Electroshock;

1986
Serotonin and central nervous system function.
    Annual review of pharmacology, 1973, Volume: 13

    Topics: Affective Symptoms; Aggression; Animals; Body Temperature Regulation; Cats; Cattle; Central Nervous

1973

Trials

1 trial available for reserpine and Pain

ArticleYear
A comparison of regional intravenous guanethidine and reserpine in reflex sympathetic dystrophy. A controlled, randomized, double-blind crossover study.
    The Clinical journal of pain, 1989, Volume: 5, Issue:3

    Topics: Adult; Body Temperature; Double-Blind Method; Female; Guanethidine; Humans; Injections, Intravenous;

1989

Other Studies

60 other studies available for reserpine and Pain

ArticleYear
Nociceptive chemical hypersensitivity in the spinal cord of a rat reserpine-induced fibromyalgia model.
    Neuroscience research, 2022, Volume: 181

    Topics: Animals; Fibromyalgia; Formaldehyde; Nociception; Pain; Proto-Oncogene Proteins c-fos; Rats; Rats, S

2022
Role of Etanercept and Infliximab on Nociceptive Changes Induced by the Experimental Model of Fibromyalgia.
    International journal of molecular sciences, 2022, May-30, Volume: 23, Issue:11

    Topics: Animals; Etanercept; Fibromyalgia; Hyperalgesia; Infliximab; Models, Theoretical; Nociception; p38 M

2022
Chemogenetic Activation of Oxytocin Neurons Improves Pain in a Reserpine-induced Fibromyalgia Rat Model.
    Neuroscience, 2023, 09-15, Volume: 528

    Topics: Animals; Fibromyalgia; Humans; Luminescent Proteins; Neurons; Oxytocin; Pain; Rats; Rats, Transgenic

2023
Spontaneous pain-associated facial expression and efficacy of clinically used drugs in the reserpine-induced rat model of fibromyalgia.
    European journal of pharmacology, 2019, Dec-01, Volume: 864

    Topics: Analgesics; Animals; Disease Models, Animal; Facial Expression; Fibromyalgia; Male; Pain; Rats; Rats

2019
Skimmetin/osthole mitigates pain-depression dyad via inhibiting inflammatory and oxidative stress-mediated neurotransmitter dysregulation.
    Metabolic brain disease, 2021, Volume: 36, Issue:1

    Topics: Animals; Behavior, Animal; Brain; Coumarins; Cytokines; Depression; Drug Therapy, Combination; Femal

2021
Cationic liposome-encapsulated carotenoids as a potential treatment for fibromyalgia in an animal model.
    Biochimica et biophysica acta. Molecular basis of disease, 2021, 07-01, Volume: 1867, Issue:7

    Topics: Animals; Antioxidants; Carotenoids; Female; Fibromyalgia; Liposomes; Lutein; Pain; Rats; Reserpine

2021
Sleep architecture is altered in the reserpine-induced fibromyalgia model in ovariectomized rats.
    Behavioural brain research, 2019, 05-17, Volume: 364

    Topics: Animals; Disease Models, Animal; Female; Fibromyalgia; Fluoxetine; Hyperalgesia; Ovariectomy; Pain;

2019
Effects of imidazoline I2 receptor agonists on reserpine-induced hyperalgesia and depressive-like behavior in rats.
    Behavioural pharmacology, 2019, Volume: 30, Issue:5

    Topics: Analgesics; Animals; Benzofurans; Depression; Disease Models, Animal; Fibromyalgia; Hyperalgesia; Id

2019
Blockade of spinal α
    European journal of pharmacology, 2019, Sep-05, Volume: 858

    Topics: Animals; Astrocytes; Female; Fibromyalgia; Ganglia, Spinal; Gene Expression Regulation; Hyperalgesia

2019
Kinins and their B
    Biochemical pharmacology, 2019, Volume: 168

    Topics: Animals; Behavior, Animal; Bradykinin; Disease Models, Animal; Fibromyalgia; Gene Knockout Technique

2019
Ferulic acid increases pain threshold and ameliorates depression-like behaviors in reserpine-treated mice: behavioral and neurobiological analyses.
    Metabolic brain disease, 2013, Volume: 28, Issue:4

    Topics: Animals; Behavior, Animal; Brain; Coumaric Acids; Depression; Disease Models, Animal; Dopamine; Mice

2013
[Influence of ferulic acid on the pain-depression dyad induced by reserpine].
    Yao xue xue bao = Acta pharmaceutica Sinica, 2013, Volume: 48, Issue:1

    Topics: Animals; Antidepressive Agents; Coumaric Acids; Depression; Dopamine; Dose-Response Relationship, Dr

2013
Possible involvement of oxido-nitrosative stress induced neuro-inflammatory cascade and monoaminergic pathway: underpinning the correlation between nociceptive and depressive behaviour in a rodent model.
    Journal of affective disorders, 2013, Volume: 151, Issue:3

    Topics: Animals; Berberine; Caspase 3; Cerebral Cortex; Depression; Disease Models, Animal; Dopamine; Hippoc

2013
The effects of Phα1β, a spider toxin, calcium channel blocker, in a mouse fibromyalgia model.
    Toxicon : official journal of the International Society on Toxinology, 2014, Volume: 81

    Topics: Animals; Brain; Calcium Channel Blockers; Diclofenac; Disease Models, Animal; Dopamine; Fibromyalgia

2014
Attenuation of reserpine-induced pain/depression dyad by gentiopicroside through downregulation of GluN2B receptors in the amygdala of mice.
    Neuromolecular medicine, 2014, Volume: 16, Issue:2

    Topics: Amygdala; Analgesics; Animals; Biogenic Amines; Brain Chemistry; Caspase 3; Chronic Pain; Depression

2014
Peripheral and spinal mechanisms of nociception in a rat reserpine-induced pain model.
    Pain, 2015, Volume: 156, Issue:3

    Topics: Acid Sensing Ion Channels; Action Potentials; Analysis of Variance; Animals; Antihypertensive Agents

2015
Echinocystic acid reduces reserpine-induced pain/depression dyad in mice.
    Metabolic brain disease, 2016, Volume: 31, Issue:2

    Topics: Analgesics; Animals; Behavior, Animal; Brain; Depression; Depressive Disorder; Disease Models, Anima

2016
On the mechanism of antidepressant-like action of berberine chloride.
    European journal of pharmacology, 2008, Jul-28, Volume: 589, Issue:1-3

    Topics: Analgesics; Animals; Antidepressive Agents; Behavior, Animal; Berberine; Body Temperature; Brain; De

2008
Biogenic amine depletion causes chronic muscular pain and tactile allodynia accompanied by depression: A putative animal model of fibromyalgia.
    Pain, 2009, Volume: 146, Issue:1-2

    Topics: Adrenergic Uptake Inhibitors; Animals; Biogenic Amines; Central Nervous System; Depressive Disorder;

2009
Curcumin ameliorates reserpine-induced pain-depression dyad: behavioural, biochemical, neurochemical and molecular evidences.
    Psychoneuroendocrinology, 2011, Volume: 36, Issue:10

    Topics: Adrenergic Uptake Inhibitors; Animals; Antidepressive Agents; Behavior, Animal; Biomarkers; Curcumin

2011
Reserpine antagonism of morphine analgesia in mice.
    Proceedings of the Society for Experimental Biology and Medicine. Society for Experimental Biology and Medicine (New York, N.Y.), 1954, Volume: 87, Issue:3

    Topics: Analgesia; Anesthesia; Anesthesia and Analgesia; Animals; Mice; Morphine; Pain; Pain Management; Rau

1954
Synergism of amines and antagonism of reserpine to morphine analgesia.
    Proceedings of the Society for Experimental Biology and Medicine. Society for Experimental Biology and Medicine (New York, N.Y.), 1958, Volume: 97, Issue:1

    Topics: Amines; Analgesia; Drug Interactions; Morphine; Mycobacterium; Pain; Pain Management; Reserpine

1958
[Surgical anesthesia in jaundice patients].
    Magyar sebeszet, 1959, Volume: 12, Issue:1

    Topics: Analgesia; Anesthesia; Anesthesia and Analgesia; Jaundice; Pain; Procaine; Reserpine

1959
Analgesia in phasic and tonic pain tests in a pharmacological model of autotomy.
    Indian journal of experimental biology, 2002, Volume: 40, Issue:11

    Topics: Adrenergic alpha-Antagonists; Adrenergic Uptake Inhibitors; Amphetamine; Analgesia; Animals; Behavio

2002
[Pharmacological analysis of the mechanism of change in the blood pressure and coronary circulation after pain stimulation].
    Fiziologicheskii zhurnal SSSR imeni I. M. Sechenova, 1960, Volume: 46

    Topics: Blood Pressure; Blood Pressure Determination; Chlorpromazine; Coronary Circulation; Coronary Vessels

1960
[EFFECTS OF RESERPINE, ALPHA-METHYL-DOPA AND THEIR INTERACTIONS ON MORPHINE ANALGESIA].
    Sheng li xue bao : [Acta physiologica Sinica], 1963, Volume: 26

    Topics: Analgesia; Animals; Antihypertensive Agents; Catecholamines; Dihydroxyphenylalanine; Electricity; Ho

1963
THE ACTION OF RESERPINE AND ALPHA-METHYL-M-TYROSINE ON THE ANALGESIC EFFECT OF MORPHINE IN RATS AND MICE.
    The Journal of pharmacy and pharmacology, 1964, Volume: 16

    Topics: Analgesia; Analgesics; Animals; Iproniazid; Methyltyrosines; Mice; Morphine; Pain; Pain Management;

1964
ANTAGONISM OF THE ANALGETIC EFFECT OF MORPHINE IN MICE BY TETRABENAZINE AND RESERPINE.
    Archives internationales de pharmacodynamie et de therapie, 1964, Jun-01, Volume: 149

    Topics: Analgesia; Animals; Mice; Morphine; Pain; Pain Management; Pharmacology; Research; Reserpine; Tetrab

1964
[ROLE OF SEVERAL SEROTONIN AND CATECHOLAMINE LIBERATORS IN THE PHENOMENON OF PAIN IN THE RAT].
    Revue canadienne de biologie, 1964, Volume: 23

    Topics: Bretylium Compounds; Carboxy-Lyases; Catecholamines; Enzyme Inhibitors; Guanethidine; Morphine; Pain

1964
[Combined serpasil and doriden in the treatment of pain in chronic peripheral arterial diseases and in preoperative and postoperative sedation].
    Gazzetta medica italiana, 1955, Volume: 114, Issue:4

    Topics: Anticonvulsants; Antihypertensive Agents; Glutethimide; Humans; Pain; Peripheral Arterial Disease; P

1955
The non-peptidic delta opioid receptor agonist TAN-67 enhances dopamine efflux in the nucleus accumbens of freely moving rats via a mechanism that involves both glutamate and free radicals.
    Neuroscience, 2005, Volume: 130, Issue:3

    Topics: Adrenergic Uptake Inhibitors; alpha-Methyltyrosine; Animals; Dopamine; Enkephalin, D-Penicillamine (

2005
Involvement of 5-HT2 receptors in the antinociceptive effect of Uncaria tomentosa.
    Pharmacology, biochemistry, and behavior, 2005, Volume: 81, Issue:3

    Topics: Acetic Acid; Analgesics; Animals; Arginine; Atropine; Behavior, Animal; Capsaicin; Cat's Claw; Dose-

2005
Unexceptional seizure potential of tramadol or its enantiomers or metabolites in mice.
    The Journal of pharmacology and experimental therapeutics, 2008, Volume: 325, Issue:2

    Topics: Analgesics, Opioid; Animals; Codeine; Cytochrome P-450 CYP2D6 Inhibitors; Drug Interactions; Hot Tem

2008
Monoamines as mediators of the antinociceptive effect of baclofen.
    Naunyn-Schmiedeberg's archives of pharmacology, 1983, Volume: 323, Issue:1

    Topics: alpha-Methyltyrosine; Analgesics; Animals; Baclofen; Biogenic Amines; Male; Methyltyrosines; Pain; R

1983
[A new cyclohexylphenyl and cyclohexylphenylamine. Synthesis and pharmacological activity].
    Il Farmaco; edizione scientifica, 1980, Volume: 35, Issue:3

    Topics: Aniline Compounds; Animals; Appetite; Benzene Derivatives; Blood Pressure; Cyclohexanes; Guinea Pigs

1980
Neurochemical identification of fos-positive neurons using two-colour immunoperoxidase staining.
    Journal of neuroscience methods, 1993, Volume: 47, Issue:1-2

    Topics: Animals; Biomarkers; Gene Expression Regulation; Hypothalamus; Immunoenzyme Techniques; Male; Medull

1993
Sensitization of glutamate release and N-methyl-D-aspartate receptor response by transient dopamine pretreatment in prefrontal cortex of rats.
    Neuroscience letters, 2002, Jan-11, Volume: 317, Issue:2

    Topics: Animals; Avoidance Learning; Calcium Signaling; Dopamine; Dopamine Antagonists; Excitatory Amino Aci

2002
Monoamines modulation of morphine action on pain threshold and cortical acetylcholine outflow.
    Pharmacological research communications, 1979, Volume: 11, Issue:8

    Topics: Acetylcholine; Animals; Biogenic Amines; Cerebral Cortex; Dextroamphetamine; Female; Fenclonine; Gui

1979
Hypothesis: migraine, a central biochemical dysnociception.
    Headache, 1976, Volume: 16, Issue:4

    Topics: Adult; Animals; Apomorphine; Circadian Rhythm; Dopamine; Female; Fever; Headache; Humans; Levodopa;

1976
The pain aggression induced by bronopol in the rat.
    Acta pharmacologica et toxicologica, 1975, Volume: 37, Issue:3

    Topics: Aggression; Aging; Animals; Behavior, Animal; Drug Interactions; Female; Humans; Pain; Peritonitis;

1975
Role of opioid receptors in self-aggression in rats.
    Indian journal of physiology and pharmacology, 1991, Volume: 35, Issue:3

    Topics: Aggression; Amphetamine; Animals; Behavior, Animal; Male; Naloxone; Norepinephrine; Pain; Phenoxyben

1991
Involvement of dopamine in the mechanism of action of FR64822, a novel non-opioid antinociceptive compound.
    European journal of pharmacology, 1991, Nov-05, Volume: 204, Issue:2

    Topics: Acetates; Acetic Acid; Analgesics; Animals; Clonidine; Dopamine; Dopamine Antagonists; Male; Mice; M

1991
[Intravenous sympatholysis in arterial occlusive diseases and acrosyndromes].
    Agressologie: revue internationale de physio-biologie et de pharmacologie appliquees aux effets de l'agression, 1990, Volume: 31, Issue:4

    Topics: Arterial Occlusive Diseases; Bretylium Compounds; Guanethidine; Humans; Injections, Intravenous; Isc

1990
[Effects of reserpine and 5-HT on analgesia induced by lappaconitine and N-deacetyllappaconitine].
    Zhongguo yao li xue bao = Acta pharmacologica Sinica, 1990, Volume: 11, Issue:1

    Topics: Aconitine; Aconitum; Animals; Anti-Inflammatory Agents, Non-Steroidal; Female; Male; Morphine; Pain;

1990
Analgesia in defeated mice: evidence for mediation via central rather than pituitary or adrenal endogenous opioid peptides.
    Pharmacology, biochemistry, and behavior, 1988, Volume: 29, Issue:3

    Topics: Animals; beta-Endorphin; Central Nervous System; Dexamethasone; Endorphins; Enkephalins; Male; Mice;

1988
[Site of analgesic action of aconitine and the relation between its action and the central noradrenergic system].
    Zhongguo yao li xue bao = Acta pharmacologica Sinica, 1988, Volume: 9, Issue:6

    Topics: Aconitine; Aconitum; Analgesics; Animals; Female; Injections, Intraventricular; Injections, Spinal;

1988
[Studies on factors affecting the actions of reserpine and pargyline on normal pain thresholds in mice and rats, and on the modification of morphine analgesia].
    Yao xue xue bao = Acta pharmaceutica Sinica, 1986, Volume: 21, Issue:11

    Topics: Animals; Female; Male; Mice; Morphine; Pain; Pargyline; Rats; Reserpine; Sensory Thresholds

1986
[Studies on the analgesic action and physical dependence of bulleyaconitine A].
    Yao xue xue bao = Acta pharmaceutica Sinica, 1986, Volume: 21, Issue:12

    Topics: Aconitine; Aconitum; Analgesics; Animals; Drug Tolerance; Female; Male; Mice; Naloxone; Pain; Rats;

1986
A comparative study of the effects of reserpine and p-chlorophenylalanine on morphine analgesia in mice.
    Psychopharmacologia, 1973, Feb-20, Volume: 28, Issue:4

    Topics: 5-Hydroxytryptophan; Analgesia; Animals; Dihydroxyphenylalanine; Drug Synergism; Fenclonine; Male; M

1973
Analgesic properties of phenylethylamine and phenylethanolamine in mice.
    Pharmacology, 1974, Volume: 12, Issue:1

    Topics: Animals; Disulfides; Ethanolamines; Fenclonine; Imidazoles; Injections, Intraperitoneal; Male; Metho

1974
[Medial eminence of the neurohypophysis in extreme conditions].
    Doklady Akademii nauk SSSR, 1972, Jun-21, Volume: 204, Issue:6

    Topics: Animals; Epinephrine; Inclusion Bodies; Male; Metyrapone; Microscopy, Electron; Nerve Endings; Pain;

1972
Antagonism of morphine analgesia by reserpine and alpha-methyltyrosine and the role played by catecholamines in morphine analgesic action.
    The Journal of pharmacy and pharmacology, 1967, Volume: 19, Issue:4

    Topics: Analgesics; Animals; Brain; Catecholamines; Dental Pulp; Drug Antagonism; Electric Stimulation; Elec

1967
The effect of reserpine and alpha-methyldopa on the analgesic action of morphine in the mouse.
    The Journal of pharmacy and pharmacology, 1967, Volume: 19, Issue:11

    Topics: Analgesia; Animals; Drug Antagonism; Drug Synergism; Hot Temperature; Male; Methyldopa; Mice; Morphi

1967
7-Aminoheptanoic acid derivatives as potential neuropharmacological agents. I.
    Experientia, 1972, Jul-15, Volume: 28, Issue:7

    Topics: Analgesia; Animals; Appetite Regulation; Barbiturates; Cardiovascular System; Electroencephalography

1972
Interaction of benactyzine with analgesics and prothiadene.
    Activitas nervosa superior, 1973, Volume: 15, Issue:2

    Topics: Aminopyrine; Animals; Benactyzine; Dibenzothiepins; Drug Synergism; Mice; Morphine; Pain; Reserpine

1973
A gastrointestinal problem.
    British medical journal, 1972, Mar-25, Volume: 1, Issue:5803

    Topics: Abdomen; Humans; Hydrochlorothiazide; Hypertension; Ileum; Intestinal Diseases; Intestinal Obstructi

1972
Antinociceptive activity of morphine after injection of biogenic amines in the cerebral ventricles of the conscious rat.
    British journal of pharmacology, 1971, Volume: 42, Issue:2

    Topics: Animals; Cerebral Ventricles; Consciousness; Dihydroxyphenylalanine; Dopamine; Injections; Injection

1971
[Reserpine therapy of periodic vomiting and abdominal pain in children].
    Ceskoslovenska pediatrie, 1970, Volume: 25, Issue:4

    Topics: Abdomen; Age Factors; Child; Humans; Pain; Phenobarbital; Reserpine; Vomiting

1970
Effects of some psychoactive drugs on electroencephalogram and brain amines of immature rabbits.
    Life sciences, 1965, Volume: 4, Issue:13

    Topics: Animals; Behavior, Animal; Brain; Brain Chemistry; Brain Stem; Cerebellum; Chlorpromazine; Electroen

1965
The effect of psychopharmaca on exteroceptive blood pressure reflexes in non-anaesthetized cats.
    Archives internationales de pharmacodynamie et de therapie, 1966, Volume: 159, Issue:1

    Topics: Amphetamine; Animals; Autonomic Nervous System; Behavior, Animal; Blood Pressure; Capsicum; Cats; Ch

1966