Page last updated: 2024-12-07

saclofen

Description Research Excerpts Clinical Trials Roles Classes Pathways Study Profile Bioassays Related Drugs Related Conditions Protein Interactions Research Growth Market Indicators

Description

saclofen: GABA-A receptor antagonist [Medical Subject Headings (MeSH), National Library of Medicine, extracted Dec-2023]

Cross-References

ID SourceID
PubMed CID122150
CHEMBL ID312403
CHEBI ID91596
SCHEMBL ID339757
MeSH IDM0215369

Synonyms (42)

Synonym
CHEMBL312403 ,
HMS3266E05
BRD-A24122750-001-01-1
gtpl1078
BPBIO1_000705
BIOMOL-NT_000242
saclofen
NCGC00024514-02
beta-(aminomethyl)-4-chlorobenzeneethanesulfonic acid
benzeneethanesulfonic acid, beta-(aminomethyl)-4-chloro-
3-amino-2-(4-chlorophenyl)-propane sulfonic acid
125464-42-8
L001268
FT-0692056
3-amino-2-(4-chlorophenyl)propane-1-sulfonic acid
3-amino-2-(4-chloro-phenyl)-propane-1-sulfonic acid
bdbm50286225
lrz36bcq1y ,
unii-lrz36bcq1y
AKOS015998998
c9h12clno3s
SCHEMBL339757
(rs)-3-amino-2-(4-chlorophenyl)propylsulfonic acid
HB0963
3-amino-2-(4-chlorophenyl)-1-propanesulfonic acid
AC-27755
J-005229
CHEBI:91596
saclofen, solid
BCP16740
DTXSID90903970
HMS3675C15
(+/-)-3-amino-2-( 4-chlorophenyl)propanesulfonic acid
DS-18252
sodiumpermanganate
HMS3411C15
Q7396879
BRD-A24122750-001-02-9
C72003
A846229
CS-0020455
HY-100813

Research Excerpts

Treatment

ExcerptReferenceRelevance
"Co-treatment with saclofen (25 μM) did not significantly affect LEV-induced NSCs proliferation and differentiation."( Levetiracetam promoted rat embryonic neurogenesis via NMDA receptor-mediated mechanism in vitro.
Alavi, MS; Ghorbani, A; Hosseini, A; Negah, SS; Sadeghnia, HR, 2021
)
0.94

Dosage Studied

ExcerptRelevanceReference
" In this report, we show that ATP elicits Ca(2+) responses producing a monophasic dose-response curve with an EC(50) value of 24."( GABAB receptor-mediated presynaptic potentiation of ATP ionotropic receptors in rat midbrain synaptosomes.
Gómez-Villafuertes, R; Gualix, J; Miras-Portugal, MT; Pintor, J, 2003
)
0.32
" We found that intrahippocampal application of 2-OH saclofen could significantly enhance the population spike (PS) amplitude with a dose-response relationship, and 20 μM 2-OH saclofen evidently facilitated the formation of behavioral LTP in the perforant pathway to the dentate gyrus (PP-DG) and led to an obvious improvement in maze learning performance."( Effects of intrahippocampal GABAB receptor antagonist treatment on the behavioral long-term potentiation and Y-maze learning performance.
Cai, ZL; Li, CH; Liu, QY; Liu, WX; Wang, CY; Xiao, P; Xu, ST, 2014
)
0.65
[information is derived through text-mining from research data collected from National Library of Medicine (NLM), extracted Dec-2023]

Drug Classes (1)

ClassDescription
organochlorine compoundAn organochlorine compound is a compound containing at least one carbon-chlorine bond.
[compound class information is derived from Chemical Entities of Biological Interest (ChEBI), Hastings J, Owen G, Dekker A, Ennis M, Kale N, Muthukrishnan V, Turner S, Swainston N, Mendes P, Steinbeck C. (2016). ChEBI in 2016: Improved services and an expanding collection of metabolites. Nucleic Acids Res]

Bioassays (3)

Assay IDTitleYearJournalArticle
AID1508630Primary qHTS for small molecule stabilizers of the endoplasmic reticulum resident proteome: Secreted ER Calcium Modulated Protein (SERCaMP) assay2021Cell reports, 04-27, Volume: 35, Issue:4
A target-agnostic screen identifies approved drugs to stabilize the endoplasmic reticulum-resident proteome.
AID1347154Primary screen GU AMC qHTS for Zika virus inhibitors2020Proceedings of the National Academy of Sciences of the United States of America, 12-08, Volume: 117, Issue:49
Therapeutic candidates for the Zika virus identified by a high-throughput screen for Zika protease inhibitors.
AID1346001Rat GABAB1 (GABAB receptors)1997Nature, Mar-20, Volume: 386, Issue:6622
Expression cloning of GABA(B) receptors uncovers similarity to metabotropic glutamate receptors.
[information is prepared from bioassay data collected from National Library of Medicine (NLM), extracted Dec-2023]

Research

Studies (103)

TimeframeStudies, This Drug (%)All Drugs %
pre-19900 (0.00)18.7374
1990's31 (30.10)18.2507
2000's50 (48.54)29.6817
2010's18 (17.48)24.3611
2020's4 (3.88)2.80
[information is prepared from research data collected from National Library of Medicine (NLM), extracted Dec-2023]

Market Indicators

Research Demand Index: 34.33

According to the monthly volume, diversity, and competition of internet searches for this compound, as well the volume and growth of publications, there is estimated to be moderate demand-to-supply ratio for research on this compound.

MetricThis Compound (vs All)
Research Demand Index34.33 (24.57)
Research Supply Index4.68 (2.92)
Research Growth Index4.42 (4.65)
Search Engine Demand Index44.79 (26.88)
Search Engine Supply Index2.00 (0.95)

This Compound (34.33)

All Compounds (24.57)

Study Types

Publication TypeThis drug (%)All Drugs (%)
Trials0 (0.00%)5.53%
Reviews0 (0.00%)6.00%
Case Studies0 (0.00%)4.05%
Observational0 (0.00%)0.25%
Other107 (100.00%)84.16%
[information is prepared from research data collected from National Library of Medicine (NLM), extracted Dec-2023]