Page last updated: 2024-12-06

magnesium hydroxide

Description Research Excerpts Clinical Trials Roles Classes Pathways Study Profile Bioassays Related Drugs Related Conditions Protein Interactions Research Growth

Description

hodgkinsine: structure given in first source; isolated from the tropical plant Psychotria oleoides [Medical Subject Headings (MeSH), National Library of Medicine, extracted Dec-2023]

Cross-References

ID SourceID
PubMed CID118701325
MeSH IDM0012887

Synonyms (4)

Synonym
C09211 ,
hodgkinsine
AC1L9C92 ,
surecn1006038
[information is derived through text-mining from research data collected from National Library of Medicine (NLM), extracted Dec-2023]

Research

Studies (7)

TimeframeStudies, This Drug (%)All Drugs %
pre-19900 (0.00)18.7374
1990's1 (14.29)18.2507
2000's3 (42.86)29.6817
2010's3 (42.86)24.3611
2020's0 (0.00)2.80
[information is prepared from research data collected from National Library of Medicine (NLM), extracted Dec-2023]

Study Types

Publication TypeThis drug (%)All Drugs (%)
Trials0 (0.00%)5.53%
Reviews0 (0.00%)6.00%
Case Studies0 (0.00%)4.05%
Observational0 (0.00%)0.25%
Other7 (100.00%)84.16%
[information is prepared from research data collected from National Library of Medicine (NLM), extracted Dec-2023]

Clinical Trials (18)

Trial Overview

TrialPhaseEnrollmentStudy TypeStart DateStatus
The Effects of Moviprep With Simethicone on Colonic Bubbles [NCT01209806]140 participants (Actual)Interventional2009-11-30Completed
Daily Mablet-treatment of Patients With COPD [NCT01118936]11 participants (Actual)Interventional2010-10-31Completed
A Phase 1, Open-label, Randomized, 3-Period, Relative Bioavailability Study Comparing the Pharmacokinetics of Granule and Tablet Formulations of Deferitazole (Disodium Salt) and a Capsule Formulation of Deferitazole (Magnesium Hydroxide Salt), Each Admini [NCT02065401]Phase 10 participants (Actual)Interventional2014-02-28Withdrawn(stopped due to This study was withdrawn until the evaluation of the nonclinical rat findings is complete.)
ERX1000 - A Phase I, Double-blind, Placebo-controlled, Single and Multiple Oral Dose, Safety, Tolerability, Pharmacokinetic, and Pharmacodynamic Study in Male and Female Subjects With Obesity [NCT04890873]Phase 148 participants (Actual)Interventional2019-10-17Completed
Pharmacokinetics and Metabolism of a Single Dose of [14C] BMS-986256 in Healthy Male Participants [NCT04269356]Phase 18 participants (Actual)Interventional2020-02-18Completed
Metacholine-provocation of Mablet-treated Asthmatics [NCT01118923]12 participants (Actual)Interventional2010-10-31Completed
A Phase 1, Open-Label, 3-Period Crossover Study Of The Effect Of An Antacid, A Proton Pump Inhibitor And An H2-Receptor Antagonist On Palbociclib (PD-0332991) Bioavailability Under Fed Conditions In Healthy Volunteers [NCT02097329]Phase 127 participants (Actual)Interventional2014-04-30Completed
OMAMA-study - Prevention of Opioid-induced Constipation in Patients With Advanced Cancer [NCT05216328]Phase 4330 participants (Anticipated)Interventional2022-12-02Recruiting
Magnesium Supplementation for Hypomagnesemia in Chronic Kidney Disease - A Dose-Finding Trial [NCT02216877]Phase 1/Phase 236 participants (Actual)Interventional2014-08-31Completed
RELISTOR's Effects on Opioid-Induced Constipation in Postoperative 1-2 Level Anterior Lumbar Interbody Fusion Patients: A Case-Control Study [NCT04930237]0 participants (Actual)Observational2021-07-01Withdrawn(stopped due to PI request to close study)
An Open-Label, 3-Period, Fixed-Sequence, Study to Examine the Effect of Aluminum Hydroxide/Magnesium Hydroxide/Simethicone and Omeprazole on the Single-Dose Pharmacokinetics of Tebipenem Pivoxil Hydrobromide (TBPM-PI-HBr) in Healthy Adult Subjects [NCT04368585]Phase 120 participants (Actual)Interventional2020-07-01Completed
The Impact of Air Travel on Passenger Cognitive Functions [NCT04802785]Phase 2/Phase 350 participants (Anticipated)Interventional2021-06-30Not yet recruiting
The Use of Methylnaltrexone to Reduce Post-operative Opioid-induced Constipation in the Pediatric Spinal Fusion Patient [NCT01773096]Phase 460 participants (Anticipated)Interventional2013-05-31Completed
Interventional, Randomized, Open-Label, Crossover, Single-Dose, Relative Bioavailability Study Comparing Two Pharmaceutical Formulations of Lu AG06466 and Investigating the Food Effect on Lu AG06466 in Healthy Subjects [NCT05028673]Phase 116 participants (Actual)Interventional2021-08-23Completed
A Single-Dose, Open-Label, Three-Period Crossover Study to Assess the Bioequivalence of Famotidine/Antacid Combination Tablets (FACT) Compared to Famotidine/Antacid EZ Chew Tablet Without Water and Famotidine/Antacid EZ Chew Tablet With Water [NCT00944671]Phase 124 participants (Actual)Interventional2008-02-29Completed
A Phase II, Randomized, Double-blind, Placebo-controlled, Parallel Group Proof-of-Concept Trial to Assess Relief of Meal Induced Heartburn by a Combination of Lansoprazole 15 mg and Antacid Versus Lansoprazole 15 mg and Antacid (Calcium Carbonate and Magn [NCT01037452]Phase 2120 participants (Actual)Interventional2009-12-31Completed
A Three-Part Phase 1 Study to Evaluate the Potential Drug Interaction Between ACH-0144471 and Cyclosporine, Tacrolimus, Antacids, and Omeprazole in Healthy Adult Subjects [NCT05109390]Phase 172 participants (Actual)Interventional2018-07-27Completed
Clinical Trial to Assess the Efficacy of Fixed Combination Product Tepilta® in the Treatment of Radiation-induced Oesophagitis Compared to Its Active Ingredients Oxetacaine and Antacids, and to Placebo [NCT01336530]Phase 340 participants (Actual)Interventional2011-04-30Terminated(stopped due to The study stopped prematurely due to and administrative reasons, not based on grounds of safety.)
[information is prepared from clinicaltrials.gov, extracted Sep-2024]

Trial Outcomes

TrialOutcome
NCT00944671 (4) [back to overview]Area Under the Curve (AUC(0 to Infinity)) Following Single Dose Administration of Famotidine/Antacid Combination EZ Chew With Water and Famotidine/Antacid Tablet With Water
NCT00944671 (4) [back to overview]Area Under the Curve (AUC(0 to Infinity)) Following Single Dose Administration of Famotidine/Antacid Combination EZ Chew Without Water and Famotidine/Antacid Tablet With Water
NCT00944671 (4) [back to overview]Peak Plasma Concentration (Cmax) of Famotidine Following Single Dose Administration of Famotidine/Antacid Combination EZ Chew With Water and Famotidine/Antacid Tablet With Water
NCT00944671 (4) [back to overview]Peak Plasma Concentration (Cmax) of Famotidine Following Single Dose Administration of Famotidine/Antacid Combination EZ Chew Without Water and Famotidine/Antacid Tablet With Water
NCT01037452 (4) [back to overview]Measure: Maximum Heartburn Intensity for Those Participants Who Experience Any Heartburn After the Heartburn-inducing Meals
NCT01037452 (4) [back to overview]Measure: Maximum Heartburn Intensity for Those Participants Who Experience Any Nighttime Heartburn
NCT01037452 (4) [back to overview]Measure: Number of Participants That Reported an Adverse Event for the Combination Product, PPI Alone, Antacid Alone and Placebo.
NCT01037452 (4) [back to overview]Measure: Number of Participants With no Heartburn (Post Treatment) Following Consumption of Heartburn-inducing Meal

Area Under the Curve (AUC(0 to Infinity)) Following Single Dose Administration of Famotidine/Antacid Combination EZ Chew With Water and Famotidine/Antacid Tablet With Water

(NCT00944671)
Timeframe: Through 24 hours post-dose (½, 1, 1 ½, 2, 2 ½, 3, 4, 6, 8, 10, 12, 14, 24 hours post-dose)

Interventionng*h/mL (Geometric Mean)
Famotidine/Antacid Combination EZ Chew Tablet With Water260.1
Famotidine/Antacid Combination Tablet With Water248.0

[back to top]

Area Under the Curve (AUC(0 to Infinity)) Following Single Dose Administration of Famotidine/Antacid Combination EZ Chew Without Water and Famotidine/Antacid Tablet With Water

(NCT00944671)
Timeframe: Through 24 hours post-dose (½, 1, 1 ½, 2, 2 ½, 3, 4, 6, 8, 10, 12, 14, 24 hours post-dose)

Interventionng*hr/mL (Geometric Mean)
Famotidine/Antacid Combination EZ Chew Tablet Without Water261.2
Famotidine/Antacid Combination Tablet With Water248.0

[back to top]

Peak Plasma Concentration (Cmax) of Famotidine Following Single Dose Administration of Famotidine/Antacid Combination EZ Chew With Water and Famotidine/Antacid Tablet With Water

(NCT00944671)
Timeframe: Through 24 hours post-dose (½, 1, 1 ½, 2, 2 ½, 3, 4, 6, 8, 10, 12, 14, 24 hours post-dose)

Interventionng/mL (Geometric Mean)
Famotidine/Antacid Combination EZ Chew Tablet With Water45.9
Famotidine/Antacid Combination Tablet With Water44.4

[back to top]

Peak Plasma Concentration (Cmax) of Famotidine Following Single Dose Administration of Famotidine/Antacid Combination EZ Chew Without Water and Famotidine/Antacid Tablet With Water

(NCT00944671)
Timeframe: Through 24 hours post-dose (½, 1, 1 ½, 2, 2 ½, 3, 4, 6, 8, 10, 12, 14, 24 hours post-dose)

Interventionng/mL (Geometric Mean)
Famotidine/Antacid Combination EZ Chew Tablet Without Water45.5
Famotidine/Antacid Combination Tablet With Water44.4

[back to top]

Measure: Maximum Heartburn Intensity for Those Participants Who Experience Any Heartburn After the Heartburn-inducing Meals

"Heartburn severity was measured using a Visual Analog Scale, which was 100 milliimeters long.~0 millimeters: None (no heartburn) 100 millimeters: Most severe" (NCT01037452)
Timeframe: 1 day

Interventionmillimeters (Mean)
Combination Product69.3
PPI Alone61.2
Antacid Alone59.1
Placebo56.9

[back to top]

Measure: Maximum Heartburn Intensity for Those Participants Who Experience Any Nighttime Heartburn

"Heartburn severity was measured using a Visual Analog Scale, which was 100 milliimeters long.~0 millimeters: None (no heartburn) 100 millimeters: Most severe" (NCT01037452)
Timeframe: 1 day

Interventionmillimeters (Mean)
Combination Product8.2
PPI Alone7.0
Antacid Alone4.7
Placebo4.0

[back to top]

Measure: Number of Participants That Reported an Adverse Event for the Combination Product, PPI Alone, Antacid Alone and Placebo.

(NCT01037452)
Timeframe: 1 day

Interventionparticipants (Number)
Combination Product0
PPI Alone1
Antacid Alone0
Placebo0

[back to top]

Measure: Number of Participants With no Heartburn (Post Treatment) Following Consumption of Heartburn-inducing Meal

Participant reported severity of heartburn using a Visual Analog Scale (VAS)directly on CRF every 15 minutes until no heartburn reported or up to 5 hours after 1st heartburn-inducing meal, whichever occurred first. At this point in time, a diary was provided to participants to record any changes in severity of heartburn for 28 hours post treatment. (NCT01037452)
Timeframe: 1 day

Interventionparticipants (Number)
Combination Product0
PPI Alone2
Antacid Alone1
Placebo0

[back to top]