Proteins > Arginase-1
Page last updated: 2024-08-07 18:28:40

Arginase-1

An arginase-1 that is encoded in the genome of human. [PRO:WCB, UniProtKB:P05089]

Synonyms

EC 3.5.3.1;
Liver-type arginase;
Type I arginase

Research

Bioassay Publications (11)

TimeframeStudies on this Protein(%)All Drugs %
pre-19900 (0.00)18.7374
1990's0 (0.00)18.2507
2000's0 (0.00)29.6817
2010's6 (54.55)24.3611
2020's5 (45.45)2.80

Compounds (6)

Drugs with Inhibition Measurements

DrugTaxonomyMeasurementAverage (mM)Bioassay(s)Publication(s)
2-aminoimidazoleHomo sapiens (human)Ki3,600.000011
Nomega-hydroxy-nor-l-arginineHomo sapiens (human)IC503.680022
3,3',4,5'-tetrahydroxystilbeneHomo sapiens (human)IC50622.500022
(S)-2-amino-6-boronohexanoic acidHomo sapiens (human)IC503.606566
2-amino-6-boronohexanoic acidHomo sapiens (human)IC501.125022

Drugs with Activation Measurements

DrugTaxonomyMeasurementAverage (mM)Bioassay(s)Publication(s)
n(omega)-hydroxyarginineHomo sapiens (human)Kd3.600011
Nomega-hydroxy-nor-l-arginineHomo sapiens (human)Kd0.282022
(S)-2-amino-6-boronohexanoic acidHomo sapiens (human)Kd0.009333

Enables

This protein enables 3 target(s):

TargetCategoryDefinition
protein bindingmolecular functionBinding to a protein. [GOC:go_curators]
arginase activitymolecular functionCatalysis of the reaction: L-arginine + H2O = L-ornithine + urea. [EC:3.5.3.1]
manganese ion bindingmolecular functionBinding to a manganese ion (Mn). [GOC:ai]

Located In

This protein is located in 6 target(s):

TargetCategoryDefinition
extracellular regioncellular componentThe space external to the outermost structure of a cell. For cells without external protective or external encapsulating structures this refers to space outside of the plasma membrane. This term covers the host cell environment outside an intracellular parasite. [GOC:go_curators]
extracellular spacecellular componentThat part of a multicellular organism outside the cells proper, usually taken to be outside the plasma membranes, and occupied by fluid. [ISBN:0198547684]
nucleuscellular componentA membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent. [GOC:go_curators]
cytosolcellular componentThe part of the cytoplasm that does not contain organelles but which does contain other particulate matter, such as protein complexes. [GOC:hjd, GOC:jl]
azurophil granule lumencellular componentThe volume enclosed by the membrane of an azurophil granule, a primary lysosomal granule found in neutrophil granulocytes that contains a wide range of hydrolytic enzymes and is released into the extracellular fluid. [GOC:bf, PMID:17152095]
specific granule lumencellular componentThe volume enclosed by the membrane of a specific granule, a granule with a membranous, tubular internal structure, found primarily in mature neutrophil cells. Most are released into the extracellular fluid. Specific granules contain lactoferrin, lysozyme, vitamin B12 binding protein and elastase. [GOC:bf, PMID:7334549]

Active In

This protein is active in 2 target(s):

TargetCategoryDefinition
cytosolcellular componentThe part of the cytoplasm that does not contain organelles but which does contain other particulate matter, such as protein complexes. [GOC:hjd, GOC:jl]
cytoplasmcellular componentThe contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures. [ISBN:0198547684]

Involved In

This protein is involved in 11 target(s):

TargetCategoryDefinition
urea cyclebiological processThe sequence of reactions by which arginine is synthesized from ornithine, then cleaved to yield urea and regenerate ornithine. The overall reaction equation is NH3 + CO2 + aspartate + 3 ATP + 2 H2O = urea + fumarate + 2 ADP + 2 phosphate + AMP + diphosphate. [GOC:pde, GOC:vw, ISBN:0198506732]
adaptive immune responsebiological processAn immune response mediated by cells expressing specific receptors for antigens produced through a somatic diversification process, and allowing for an enhanced secondary response to subsequent exposures to the same antigen (immunological memory). [GO_REF:0000022, GOC:add, ISBN:0781735149]
arginine catabolic processbiological processThe chemical reactions and pathways resulting in the breakdown of arginine, 2-amino-5-(carbamimidamido)pentanoic acid. [GOC:go_curators]
negative regulation of T cell proliferationbiological processAny process that stops, prevents or reduces the rate or extent of T cell proliferation. [GOC:jl]
defense response to protozoanbiological processReactions triggered in response to the presence of a protozoan that act to protect the cell or organism. [GOC:jl]
innate immune responsebiological processInnate immune responses are defense responses mediated by germline encoded components that directly recognize components of potential pathogens. [GO_REF:0000022, GOC:add, GOC:ebc, GOC:mtg_sensu]
negative regulation of activated T cell proliferationbiological processAny process that stops, prevents or reduces the rate or extent of activated T cell proliferation. [GOC:go_curators]
negative regulation of type II interferon-mediated signaling pathwaybiological processAny process that decreases the rate, frequency or extent of an interferon-gamma-mediated signaling pathway. [GOC:dph]
positive regulation of neutrophil mediated killing of fungusbiological processAny process that increases the frequency, rate or extent of the directed killing of a fungal cell by a neutrophil. [GOC:add, GOC:mah]
negative regulation of T-helper 2 cell cytokine productionbiological processAny process that stops, prevents or reduces the frequency, rate or extent of T-helper 2 cell cytokine production. [GOC:obol]
arginine catabolic process to ornithinebiological processThe chemical reactions and pathways resulting in the breakdown of arginine into other compounds, including ornithine. [GOC:go_curators]