Compounds > cm 40907
Page last updated: 2024-09-23

cm 40907

Description

CM 40907: structure given in first source [Medical Subject Headings (MeSH), National Library of Medicine, extracted Dec-2023]

Cross-References

ID SourceID
PubMed CID65835
CHEMBL ID122135
SCHEMBL ID2109167
MeSH IDM0131987

Synonyms (26)

Synonym
cm-40907
lodaxaprine
4-piperidinol, 1-(6-(2-chlorophenyl)-3-pyridazinyl)-
cm 40907
lodaxaprine [inn]
1-(6-(o-chlorophenyl)-3-pyridazinyl)-4-piperidinol
3-(4-hydroxypiperidino)-6-(4-chlorophenyl)pyridazine
1-(6-(2-chlorophenyl)-3-pyridazinyl)-4-piperidinol
lodaxaprina [spanish]
lodaxaprium [latin]
1-[6-(2-chlorophenyl)pyridazin-3-yl]piperidin-4-ol
CHEMBL122135
93181-81-8
unii-d59zq3vvmv
lodaxaprium
3-(4-hydroxypiperidyl)-6-(2'-chlorophenyl)pyridazine
d59zq3vvmv ,
lodaxaprina
USEZRIFSJXAMJD-UHFFFAOYSA-N
3-(4-hydroxy-piperidino)-6-(2-chlorophenyl)pyridazine
SCHEMBL2109167
DTXSID50239308
AKOS030218732
1-[6-(2-chlorophenyl)-3-pyridazinyl]-4-piperidinol
Q27276115
Z2681891706

Bioassays (8)

Assay IDTitleYearJournalArticle
AID114801Anticonvulsant activity in Clonic seizures when administered orally in mice1986Journal of medicinal chemistry, Mar, Volume: 29, Issue:3
Synthesis and activity of 6-aryl-3-(hydroxypolymethyleneamino)pyridazines in animal models of epilepsy.
AID40039Antagonist activity to generalized seizures Photically induced seizures in senegalese Papio papio baboons1986Journal of medicinal chemistry, Mar, Volume: 29, Issue:3
Synthesis and activity of 6-aryl-3-(hydroxypolymethyleneamino)pyridazines in animal models of epilepsy.
AID190465Antagonist activity to generalized seizures kindled amygdaloid seizures in rats1986Journal of medicinal chemistry, Mar, Volume: 29, Issue:3
Synthesis and activity of 6-aryl-3-(hydroxypolymethyleneamino)pyridazines in animal models of epilepsy.
AID114802Anticonvulsant activity in tonic seizures when administered orally in mice1986Journal of medicinal chemistry, Mar, Volume: 29, Issue:3
Synthesis and activity of 6-aryl-3-(hydroxypolymethyleneamino)pyridazines in animal models of epilepsy.
AID114817Sedative properties by the rotarod test1986Journal of medicinal chemistry, Mar, Volume: 29, Issue:3
Synthesis and activity of 6-aryl-3-(hydroxypolymethyleneamino)pyridazines in animal models of epilepsy.
AID114634Anticonvulsant activity in Maximal electroshock (MES) when administered orally in mice1986Journal of medicinal chemistry, Mar, Volume: 29, Issue:3
Synthesis and activity of 6-aryl-3-(hydroxypolymethyleneamino)pyridazines in animal models of epilepsy.
AID114623Evaluated for Bicuculline-induced seizures (anticonvulsant activity) when administered orally in mice.1986Journal of medicinal chemistry, Mar, Volume: 29, Issue:3
Synthesis and activity of 6-aryl-3-(hydroxypolymethyleneamino)pyridazines in animal models of epilepsy.
AID114622Evaluated for Bicuculline-induced lethality (anticonvulsant activity) when administered orally in mice.1986Journal of medicinal chemistry, Mar, Volume: 29, Issue:3
Synthesis and activity of 6-aryl-3-(hydroxypolymethyleneamino)pyridazines in animal models of epilepsy.
[information is prepared from bioassay data collected from National Library of Medicine (NLM), extracted Dec-2023]

Research

Studies (5)

TimeframeStudies, This Drug (%)All Drugs %
pre-19902 (40.00)18.7374
1990's3 (60.00)18.2507
2000's0 (0.00)29.6817
2010's0 (0.00)24.3611
2020's0 (0.00)2.80
[information is prepared from research data collected from National Library of Medicine (NLM), extracted Dec-2023]

Study Types

Publication TypeThis drug (%)All Drugs (%)
Trials2 (40.00%)5.53%
Reviews0 (0.00%)6.00%
Case Studies0 (0.00%)4.05%
Observational0 (0.00%)0.25%
Other3 (60.00%)84.16%
[information is prepared from research data collected from National Library of Medicine (NLM), extracted Dec-2023]
SubstanceDescriptionRelationhip StrengthStudiesTrialsClassesRoles
phenytoin[no description available]medium10imidazolidine-2,4-dioneanticonvulsant;
drug allergen;
sodium channel blocker;
teratogenic agent
carbamazepine[no description available]medium10dibenzoazepine;
ureas		analgesic;
anticonvulsant;
antimanic drug;
drug allergen;
EC 3.5.1.98 (histone deacetylase) inhibitor;
environmental contaminant;
glutamate transporter activator;
mitogen;
non-narcotic analgesic;
sodium channel blocker;
xenobiotic
phenobarbital[no description available]medium10barbituratesanticonvulsant;
drug allergen;
excitatory amino acid antagonist;
sedative
valproate sodium[no description available]medium10organic sodium saltgeroprotector
pentylenetetrazole[no description available]medium10organic heterobicyclic compound;
organonitrogen heterocyclic compound
dimethyl sulfoxide[no description available]medium10sulfoxide;
volatile organic compound		alkylating agent;
antidote;
Escherichia coli metabolite;
geroprotector;
MRI contrast agent;
non-narcotic analgesic;
polar aprotic solvent;
radical scavenger
aspirin[no description available]medium11benzoic acids;
phenyl acetates;
salicylates		anticoagulant;
antipyretic;
cyclooxygenase 1 inhibitor;
cyclooxygenase 2 inhibitor;
drug allergen;
EC 1.1.1.188 (prostaglandin-F synthase) inhibitor;
geroprotector;
non-narcotic analgesic;
non-steroidal anti-inflammatory drug;
plant activator;
platelet aggregation inhibitor;
prostaglandin antagonist;
teratogenic agent
flunitrazepam[no description available]medium101,4-benzodiazepinone;
C-nitro compound;
monofluorobenzenes		anxiolytic drug;
GABAA receptor agonist;
sedative
gamma-aminobutyric acid[no description available]medium10amino acid zwitterion;
gamma-amino acid;
monocarboxylic acid		human metabolite;
neurotransmitter;
Saccharomyces cerevisiae metabolite;
signalling molecule
ConditionIndicatedRelationship StrengthStudiesTrials
Absence Seizure0low20
Absence Seizures0low20
Ache0medium11
Atonic Absence Seizure0low20
Atonic Absence Seizures0low20
Atonic Seizure0low20
Atonic Seizures0low20
Aura0medium21
Awakening Epilepsy0medium21
Clonic Seizure0low20
Clonic Seizures0low20
Complex Partial Seizure0low20
Complex Partial Seizures0low20
Convulsion0low20
Convulsion, Non-Epileptic0low20
Convulsions0low20
Convulsive Seizure0low20
Convulsive Seizures0low20
Disease Models, Animal0low10
Epilepsy0medium21
Epilepsy, Cryptogenic0medium21
Epileptic Seizure0low20
Epileptic Seizures0low20
Generalized Absence Seizure0low20
Generalized Absence Seizures0low20
Generalized Tonic-Clonic Seizures0low20
Jacksonian Seizure0low20
Myoclonic Seizure0low20
Myoclonic Seizures0low20
Non-Epileptic Seizure0low20
Non-Epileptic Seizures0low20
Nonepileptic Seizure0low20
Nonepileptic Seizures0low20
Pain0medium11
Pain, Burning0medium11
Pain, Crushing0medium11
Pain, Migratory0medium11
Pain, Radiating0medium11
Pain, Splitting0medium11
Partial Seizure0low20
Partial Seizures0low20
Petit Mal Convulsion0low20
Seizure0low20
Seizure Disorder0medium21
Seizures0low20
Seizures, Auditory0low20
Seizures, Clonic0low20
Seizures, Convulsive0low20
Seizures, Epileptic0low20
Seizures, Focal0low20
Seizures, Generalized0low20
Seizures, Gustatory0low20
Seizures, Motor0low20
Seizures, Olfactory0low20
Seizures, Sensory0low20
Seizures, Somatosensory0low20
Seizures, Tonic0low20
Seizures, Tonic-Clonic0low20
Seizures, Vertiginous0low20
Seizures, Vestibular0low20
Seizures, Visual0low20
Single Seizure0low20
Suffering, Physical0medium11
Tonic Clonic Seizure0low20
Tonic Seizure0low20
Tonic Seizures0low20
Tonic-Clonic Seizure0low20
Tonic-Clonic Seizures0low20

Research Highlights

Dosage (1)

ArticleYear
Analgesic potency of a new anticonvulsant drug versus acetylsalicylic acid via laser somatosensory evoked potentials. Randomized placebo-controlled double-blind (5-way) crossover study.
Arzneimittel-Forschung, Volume: 41, Issue: 4		1991
[information is derived through text-mining from research data collected from National Library of Medicine (NLM), extracted Dec-2023]