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sanshool

Description

sanshool: isolated from the stem bark of Zanthoxylum liebmannianum; RN given for (E,E,Z,E)-isomer; structure in first source [MeSH]

alpha-Sanshool : no description available [CHeBI]

Cross-References

ID Source	ID
PubMed CID	6440935
SCHEMBL ID	1030320
CHEBI ID	80920
MeSH ID	M0263941

Synonyms (26)

Synonym
alpha-sanshool
sanshool
504-97-2
C17091
(2e,6z,8e,10e)-n-(2-methylpropyl)dodeca-2,6,8,10-tetraenamide
2,6,8,10-dodecatetraenamide, n-(2-methylpropyl)-, (e,e,z,e)-
unii-yb7lbg97px
(e,e,z,e)-n-(2-methylpropyl)-2,6,8,10-dodecatetraenamide
yb7lbg97px ,
SCHEMBL1030320
CHEBI:80920
echinacein
Q2839529
HY-N2527
CS-0022798
(2e,6z,8e,10e)-n-(2-methylpropyl)-2,6,8,10-dodecatetraenamide
DTXSID601319143
EN300-21953183
alpha-sanshooel
echinaceine
n-isobutyl-trans-2,cis-6,trans-8,trans-10-dodecatetraenamide
neoherculine
2e,6z,8e,10e-dodecatetraenoic acid n-(2-methylpropyl)amide
n-(2-methylpropyl)-2e,6z,8e,10e-dodecatetraenamide
2,6,8,10-dodecatetraenamide, n-(2-methylpropyl)-, (2e,6z,8e,10e)-
AKOS040744365

Drug Classes (1)

Class	Description
fatty amide	A monocarboxylic acid amide derived from a fatty acid.

Research

Studies (46)

Timeframe	Studies, This Drug (%)	All Drugs %
pre-1990	0 (0.00)	18.7374
1990's	1 (2.17)	18.2507
2000's	12 (26.09)	29.6817
2010's	20 (43.48)	24.3611
2020's	13 (28.26)	2.80

Study Types

Publication Type	This drug (%)	All Drugs (%)
Trials	0 (0.00%)	5.53%
Reviews	2 (4.35%)	6.00%
Case Studies	0 (0.00%)	4.05%
Observational	0 (0.00%)	0.25%
Other	44 (95.65%)	84.16%

Substance	Classes	Roles	Relationship Strength
1-phenyl-2-palmitoylamino-3-morpholino-1-propanol	benzyl alcohols; fatty amide; morpholines; secondary alcohol; tertiary amino compound		low
lauric acid diethanolamide	fatty amide		low
valnoctamide	fatty amide		low
diethylallylacetamide	fatty amide		low
dipropylacetamide	fatty amide	geroprotector; metabolite; teratogenic agent	low
n-myristoylglycine	fatty amide; N-acylglycine	human blood serum metabolite; human urinary metabolite	low
n,n'-diallyltartardiamide	fatty amide		low
ici 162846	fatty amide		low
n-palmitoylglycine	fatty amide; N-acylglycine 16:0	human metabolite; marine metabolite	low
3-methyl-N-(2-phenylethyl)-2-butenamide	fatty amide		low
N-[[(5-chloro-2-pyridinyl)amino]-sulfanylidenemethyl]-3-methylbutanamide	fatty amide		low
N-[(2-adamantylamino)-sulfanylidenemethyl]hexanamide	fatty amide		low
N-[[(1-oxo-3-phenylpropyl)hydrazo]-sulfanylidenemethyl]pentanamide	fatty amide		low
N,N'-bis(3-phenylpropyl)butanediamide	fatty amide		low
3-(2-furanyl)-N-[3-(2-furanyl)-4-methylpentyl]-4-phenylbutanamide	fatty amide		low
arachidonyl dopamine	catechols; fatty amide; N-(fatty acyl)-dopamine; secondary carboxamide		low
n-oleoyldopamine	catechols; fatty amide; N-(fatty acyl)-dopamine; secondary carboxamide	TRPV1 agonist	low
n-arachidonylglycine	fatty amide; N-acylglycine		low
arachidonyl-2-chloroethylamide	fatty amide; organochlorine compound; secondary carboxamide; synthetic cannabinoid	CB1 receptor agonist; CB2 receptor agonist; neuroprotective agent	low
pellitorine	fatty amide	metabolite	low
oleoylanilide	anilide; fatty amide		low
am-356	fatty amide		low
n-oleoylglycine	fatty amide; N-acylglycine 18:1	metabolite	low
linoleylanilide	anilide; fatty amide		low
(2E,4E)-N-isobutyl-2,4-dodecadienamide	fatty amide	metabolite	low
kalkitoxin	fatty amide		low
barbamide	fatty amide		low

Substance	Studies	Classes	Roles	First Year	Last Year	Average Age	Relationship Strength	2000's	2010's	post-2020
gamma-aminobutyric acid	1	amino acid zwitterion; gamma-amino acid; monocarboxylic acid	human metabolite; neurotransmitter; Saccharomyces cerevisiae metabolite; signalling molecule	2010	2010	14.0	low	1	0	0
citric acid, anhydrous	1	tricarboxylic acid	antimicrobial agent; chelator; food acidity regulator; fundamental metabolite	2011	2011	13.0	low	0	1	0
coumarin	1	coumarins	fluorescent dye; human metabolite; plant metabolite	2017	2017	7.0	low	0	1	0
guaiacol	1	guaiacols	disinfectant; EC 1.1.1.25 (shikimate dehydrogenase) inhibitor; expectorant; plant metabolite	2009	2009	15.0	low	1	0	0
urea	1	isourea; monocarboxylic acid amide; one-carbon compound	Daphnia magna metabolite; Escherichia coli metabolite; fertilizer; flour treatment agent; human metabolite; mouse metabolite; Saccharomyces cerevisiae metabolite	2010	2010	14.0	low	1	0	0
menthol	2	p-menthane monoterpenoid; secondary alcohol	volatile oil component	2009	2011	14.0	low	1	1	0
metolachlor	1	aromatic amide; benzenes; ether; organochlorine compound		2014	2014	10.0	low	0	1	0
potassium chloride	1	inorganic chloride; inorganic potassium salt; potassium salt	fertilizer	2008	2008	16.0	low	1	0	0
allyl isothiocyanate	1	alkenyl isothiocyanate; isothiocyanate	antimicrobial agent; antineoplastic agent; apoptosis inducer; lachrymator; metabolite	2013	2013	11.0	low	0	1	0
sucrose	1	glycosyl glycoside	algal metabolite; Escherichia coli metabolite; human metabolite; mouse metabolite; osmolyte; Saccharomyces cerevisiae metabolite; sweetening agent	2017	2017	7.0	low	0	1	0
acrolein	3	enal	herbicide; human xenobiotic metabolite; toxin	2011	2016	10.7	low	0	3	0
ethyl acetate	1	acetate ester; ethyl ester; volatile organic compound	EC 3.4.19.3 (pyroglutamyl-peptidase I) inhibitor; metabolite; polar aprotic solvent; Saccharomyces cerevisiae metabolite	2023	2023	1.0	low	0	0	1
catechin	1	catechin	antioxidant; plant metabolite	2017	2017	7.0	low	0	1	0
hesperidin	1	3'-hydroxyflavanones; 4'-methoxyflavanones; dihydroxyflavanone; disaccharide derivative; flavanone glycoside; monomethoxyflavanone; rutinoside	mutagen	2017	2017	7.0	low	0	1	0
trinitrobenzenesulfonic acid	1	arenesulfonic acid; C-nitro compound	epitope; explosive; reagent	2011	2011	13.0	low	0	1	0
sesamin	1	benzodioxoles; furofuran; lignan	antineoplastic agent; neuroprotective agent; plant metabolite	2017	2017	7.0	low	0	1	0
6-paradol	1	ketone; monomethoxybenzene; phenols		2009	2009	15.0	low	1	0	0
planinin	1	lignan		2017	2017	7.0	low	0	1	0
isovitexin	1	C-glycosyl compound; trihydroxyflavone	EC 3.2.1.20 (alpha-glucosidase) inhibitor; metabolite	2017	2017	7.0	low	0	1	0
kobusin	1	benzodioxoles; dimethoxybenzene; furofuran; lignan	plant metabolite	2017	2017	7.0	medium	0	1	0
eudesmin	1			2017	2017	7.0	low	0	1	0
gingerol	1	beta-hydroxy ketone; guaiacols	antineoplastic agent; plant metabolite	2011	2011	13.0	low	0	1	0
lignans	1			2017	2017	7.0	low	0	1	0
betadex	1	cyclodextrin		2018	2018	6.0	low	0	1	0
oleic acid	1	octadec-9-enoic acid	antioxidant; Daphnia galeata metabolite; EC 3.1.1.1 (carboxylesterase) inhibitor; Escherichia coli metabolite; mouse metabolite; plant metabolite; solvent	2022	2022	2.0	low	0	0	1
cinnamaldehyde	3	3-phenylprop-2-enal; cinnamaldehydes	antifungal agent; EC 4.3.1.24 (phenylalanine ammonia-lyase) inhibitor; flavouring agent; hypoglycemic agent; plant metabolite; sensitiser; vasodilator agent	2011	2016	10.7	low	0	3	0
piperine	1	benzodioxoles; N-acylpiperidine; piperidine alkaloid; tertiary carboxamide	food component; human blood serum metabolite; NF-kappaB inhibitor; plant metabolite	2013	2013	11.0	low	0	1	0
capsaicin	8	capsaicinoid	non-narcotic analgesic; TRPV1 agonist; voltage-gated sodium channel blocker	2007	2023	13.1	medium	6	1	1
capsazepine	1	benzazepine; catechols; monochlorobenzenes; thioureas	capsaicin receptor antagonist	2007	2007	17.0	low	1	0	0
2,3,4-tri-o-acetylarabinopyranosyl isothiocyanate	1			2009	2009	15.0	low	1	0	0
naphthoquinones	1			2016	2016	8.0	low	0	1	0
vitexin	1	C-glycosyl compound; trihydroxyflavone	antineoplastic agent; EC 3.2.1.20 (alpha-glucosidase) inhibitor; plant metabolite; platelet aggregation inhibitor	2017	2017	7.0	low	0	1	0
apigenin	1	trihydroxyflavone	antineoplastic agent; metabolite	2017	2017	7.0	low	0	1	0
shogaol	1	enone; monomethoxybenzene; phenols		2009	2009	15.0	low	1	0	0
cysteine	1	cysteinium	fundamental metabolite	2023	2023	1.0	low	0	0	1
lavandulol	1	lavandulol		2013	2013	11.0	low	0	1	0
1-isoquinolin-5-yl-3-(4-trifluoromethyl-benzyl)-urea	1			2010	2010	14.0	low	1	0	0
acebutolol	1	alpha-D-glucosyl-(1->4)-D-mannopyranose		2007	2007	17.0	low	1	0	0
chlorophyll b	1	chlorophyll	cofactor	2014	2014	10.0	low	0	1	0
chlorophyll a	1	chlorophyll; methyl ester	cofactor	2014	2014	10.0	low	0	1	0
sodium glutamate	1	monosodium glutamate	flavouring agent	2017	2017	7.0	low	0	1	0
piperidines	1			2013	2013	11.0	low	0	1	0
warfarin	1	benzenes; hydroxycoumarin; methyl ketone		2017	2017	7.0	low	0	1	0
adrenomedullin	1			2011	2011	13.0	low	0	1	0
pheophytin a	1			2014	2014	10.0	low	0	1	0

Condition	Studies	First Year	Last Year	Average Age	Relationship Strength	1990's	2000's	2010's	post-2020
Ache	2	2005	2013	15.0	low	0	1	1	0
Acute Confusional Senile Dementia	1	2022	2022	2.0	low	0	0	0	1
Adhesions, Tissue	1	2007	2007	17.0	low	0	1	0	0
Alzheimer Disease	1	2022	2022	2.0	low	0	0	0	1
Autoimmune Diabetes	1	2013	2013	11.0	low	0	0	1	0
Colitis	1	2011	2011	13.0	low	0	0	1	0
Colitis, Granulomatous	1	2011	2011	13.0	low	0	0	1	0
Complication, Postoperative	1	2007	2007	17.0	low	0	1	0	0
Crohn Disease	1	2011	2011	13.0	low	0	0	1	0
Dermatitis, Radiation-Induced	1	2019	2019	5.0	low	0	0	1	0
Diabetes Mellitus, Type 1	1	2013	2013	11.0	low	0	0	1	0
Disease Models, Animal	3	2007	2016	12.7	medium	0	1	2	0
Dysesthesia	1	2010	2010	14.0	low	0	1	0	0
Erythema	1	2019	2019	5.0	low	0	0	1	0
Hypesthesia	1	2005	2005	19.0	low	0	1	0	0
Ileus	1	2016	2016	8.0	low	0	0	1	0
Infections, Nematode	1	1996	1996	28.0	low	1	0	0	0
Intestinal Obstruction	1	2007	2007	17.0	low	0	1	0	0
Muscle Contraction	2	2001	2007	20.0	low	0	2	0	0
Obesity	1	2023	2023	1.0	low	0	0	0	1
Ovine Diseases	1	1996	1996	28.0	low	1	0	0	0
Pain	2	2005	2013	15.0	low	0	1	1	0
Postoperative Complications	1	2007	2007	17.0	low	0	1	0	0
Radiodermatitis	1	2019	2019	5.0	low	0	0	1	0

Pharmacokinetics (1)

Article	Year
Anesthetic constituents of Zanthoxylum bungeanum Maxim.: A pharmacokinetic study. Journal of separation science, , Volume: 39, Issue:14	2016

Bioavailability (1)

Article	Year
Quantitative structure-pungency landscape of sanshool dietary components from Zanthoxylum species. Food chemistry, , Nov-30, Volume: 363	2021