Page last updated: 2024-10-29
ketoprofen and Pain
ketoprofen has been researched along with Pain in 168 studies
Ketoprofen: An IBUPROFEN-type anti-inflammatory analgesic and antipyretic. It is used in the treatment of rheumatoid arthritis and osteoarthritis.
ketoprofen : An oxo monocarboxylic acid that consists of propionic acid substituted by a 3-benzoylphenyl group at position 2.
Pain: An unpleasant sensation induced by noxious stimuli which are detected by NERVE ENDINGS of NOCICEPTIVE NEURONS.
Research Excerpts
| Excerpt | Relevance | Reference |
|---|---|---|
| "To compare the efficacy and safety of ketoprofen plasters and diclofenac plasters after 3 weeks of administration in patients with osteoarthritis-related knee pain." | 9.41 | Comparison of the Efficacy and Safety of Ketoprofen Plaster and Diclofenac Plaster for Osteoarthritis-Related Knee Pain: A Multicenter, Randomized, Active-Controlled, Open-Label, Parallel-Group, Phase III Clinical Trial. ( Cha, JE; Ershova, O; Hyun, BJ; Kastanayan, A; Krechikova, D; Nikulenkova, N; Polyakova, S; Shvarts, Y; Vinogradova, I; Yakushin, S, 2021) |
| " The eligible population (n = 200) with confirmed pharyngitis diagnosis on the Tonsillo Pharyngitis Assessment and moderate to severe sore throat was randomly divided into two cohorts to be administered with 50 mg of dexketoprofen (n = 98) or 1000-mg paracetamol (n = 102)." | 9.41 | Comparative evaluation of intravenous dexketoprofen and paracetamol in the management of pain induced by sore throat. ( Cimen, U; Cimen, YK; Erdur, B; Oncel, G; Ozen, M; Seyit, M; Turkcuer, I; Yilmaz, A, 2021) |
| "To compare the effects of IV paracetamol with dexketoprofen in patients presenting with primary dysmenorrhea to the emergency department." | 9.27 | Intravenous Dexketoprofen versus Intravenous Paracetamol for Dysmenorrhea: A Randomized Controlled Trial ( Eken, C; Karcıoğlu, Ö; Serinken, M, 2018) |
| "A significant pain reduction was observed following the use of ketoprofen when tested against a control gel (placebo)." | 9.22 | The effect of benzocaine and ketoprofen gels on pain during fixed orthodontic appliance treatment: a randomised, double-blind, crossover trial. ( Borzabadi-Farahani, A; Eslamian, L; Gholami, H, 2016) |
| "Ketoprofen has high analgesic efficacy against inflammatory and nociceptive pain." | 9.20 | Intravenous dexketoprofen induces less injection pain than racemic ketoprofen. ( Halinen, L; Kokki, H; Kokki, M; Nokela, A; Sjövall, S; Turunen, M, 2015) |
| "The results of our study showed that lidocaine puffs provided the best pain relief than the other analgesics used." | 9.20 | Effect of paracetamol, dexketoprofen trometamol, lidocaine spray, pethidine & diclofenac sodium application for pain relief during fractional curettage: A randomized controlled trial. ( Acmaz, G; Aksoy, H; Başer, M; Bayraktar, E; Müderris, İİ; Yilmaz, MO, 2015) |
| "A randomised controlled trial was conducted to investigate efficacy of paracetamol and dexketoprofen trometamol for perineal pain relief after perineal repair." | 9.19 | Paracetamol vs dexketoprofen for perineal pain relief after episiotomy or perineal tear. ( Akil, A; Api, O; Bektas, Y; Unal, O; Yalti, S; Yilmaz, AO, 2014) |
| ") injection of ketoprofen and castration technique on physiological and behavioral indicators of pain in beef calves." | 9.19 | Effects of castration method and frequency of intramuscular injections of ketoprofen on behavioral and physiological indicators of pain in beef cattle. ( Caulkett, NA; Fireheller, E; González, LA; Janzen, E; Moya, D; Schwartzkopf-Genswein, KS, 2014) |
| "To assess the efficacy and safety of 12-week treatment with ketoprofen in ultradeformable phospholipid vesicles in patients with OA knee pain and to compare the efficacy with that of ketoprofen-free vehicle and celecoxib." | 9.17 | A multicentre, randomized, placebo- and active-controlled trial comparing the efficacy and safety of topical ketoprofen in Transfersome gel (IDEA-033) with ketoprofen-free vehicle (TDT 064) and oral celecoxib for knee pain associated with osteoarthritis. ( Bolten, W; Cevc, G; Conaghan, PG; Dickson, J; Rother, M, 2013) |
| "This randomized, double-blind, phase III study evaluated the efficacy and safety of ketoprofen in an ultradeformable vesicle gel compared with ketoprofen-free gel in osteoarthritis (OA) knee pain." | 9.17 | A randomized, double-blind, phase III trial in moderate osteoarthritis knee pain comparing topical ketoprofen gel with ketoprofen-free gel. ( Conaghan, PG; Rother, M, 2013) |
| "5mg/ml oral suspension, compared to ketoprofen tablets in cats suffering from painful acute locomotor disorders." | 9.15 | Clinical evaluation of meloxicam versus ketoprofen in cats suffering from painful acute locomotor disorders. ( Grant, D; Johnston, L; Letellier, IM; Morton, CM; Narbe, R, 2011) |
| "A single oral dose of paracetamol or ketoprofen lysine salt are safe and effective analgesic treatments for children with sore throat in daily pediatric ambulatory care." | 9.15 | A randomized, double-blind, placebo-controlled trial of paracetamol and ketoprofren lysine salt for pain control in children with pharyngotonsillitis cared by family pediatricians. ( Carozzino, L; Del Vecchio, A; Della Casa Alberighi, O; Dionisio, P; Freschi, F; Jamone, R; Martini, A; Picollo, G; Ruperto, N; Salvatori, E; Zera, M, 2011) |
| "This study assessed the efficacy and safety of ketoprofen patch compared with placebo in patients who had rheumatoid arthritis and persistent wrist pain." | 9.14 | Efficacy and safety of ketoprofen patch in patients with rheumatoid arthritis: a randomized, double-blind, placebo-controlled study. ( Kawai, S; Kondo, M; Nagaya, I; Nawata, Y; Obata, J; Ohno, S; Oribe, M; Sugimoto, K; Uchida, E, 2010) |
| "Robenacoxib tablets administered once daily had noninferior efficacy and tolerability, and superior palatability, compared with the active control drug, ketoprofen, for the treatment of signs of acute pain and inflammation associated with musculoskeletal disorders in cats." | 9.14 | Evaluation of orally administered robenacoxib versus ketoprofen for treatment of acute pain and inflammation associated with musculoskeletal disorders in cats. ( Alexander, DG; Giraudel, JM; Gruet, P; King, JN; Seewald, W, 2010) |
| "To evaluate the efficacy and tolerability of ketoprofen patch in the treatment of tendinitis." | 9.11 | Topical ketoprofen patch in the treatment of tendinitis: a randomized, double blind, placebo controlled study. ( Guillon, Y; Mazières, B; Reiner, V; Rouanet, S; Scarsi, C, 2005) |
| "The efficacy and tolerability of aceclofenac, a new non-steroidal anti-inflammatory drug (NSAID) was compared to that of ketoprofen in a multicentre, double-blind, prospective, randomized study of 3-months duration in patients with rheumatoid arthritis." | 9.08 | Aceclofenac in comparison to ketoprofen in the treatment of rheumatoid arthritis. ( Ansoleaga, JJ; Gijón-Baños, J; Martín-Mola, E, 1995) |
| "The effectiveness of a balanced analgesia with buprenorphine ketoprofen-propacetamol for pain control during extracorporeal shock wave lithotripsy (ESWL) was evaluated in order to reduce the requirements for general anaesthesia." | 9.08 | Effect of balanced analgesia with buprenorphine on pain response and general anaesthesia requirement during lithotripsy procedures. ( Bannwarth, B; Delort-Laval, S; Krol-Houdek, MC; Maurette, P; Tauzin-Fin, P, 1998) |
| "A double-blind, double-dummy, crossover study was carried out in 8 centres to compare the efficacy and tolerability of 'controlled-release' ketoprofen tablets (200 mg) with that of indomethacin suppositories (100 mg) in out-patients with definite or classical rheumatoid arthritis." | 9.07 | A double-blind comparison of oral ketoprofen 'controlled release' and indomethacin suppository in the treatment of rheumatoid arthritis with special regard to morning stiffness and pain on awakening. ( Leden, I; Rubin, B; Uddenfeldt, P, 1993) |
| "Fifty-nine patients with acute gouty arthritis entered into a 7-day multicenter, double blind trial of ketoprofen versus indomethacin." | 9.06 | Ketoprofen versus indomethacin in patients with acute gouty arthritis: a multicenter, double blind comparative study. ( Altman, RD; Honig, S; Levin, JM; Lightfoot, RW, 1988) |
| "Under double-blind, crossover conditions, 43 women with primary dysmenorrhea received ketoprofen, ibuprofen, and placebo during three consecutive menstrual cycles." | 9.06 | Ketoprofen, ibuprofen, and placebo in the treatment of primary dysmenorrhea: a double-blind crossover comparison. ( Mehlisch, DR, 1988) |
| "The analgesic effects of single oral doses of ketoprofen 100 and 300 mg, the combination of aspirin 650 mg plus codeine 60 mg, and placebo were compared under double-blind conditions in 160 hospitalized patients with cancer pain." | 9.06 | A double-blind parallel evaluation of the efficacy and safety of a single dose of ketoprofen in cancer pain. ( Drew, J; Stambaugh, J, 1988) |
| "Forty women with moderate to severe primary dysmenorrhea participated in a two-month, double-blind, crossover trial comparing ketoprofen with mefenamic acid." | 9.06 | Double-blind comparison of ketoprofen and mefenamic acid in the treatment of primary dysmenorrhea. ( Bourgouin, J; Hébert, JG; Le Morvan, P, 1986) |
| "Thirty-six patients suffering from severe pain due to bone involvement from cancer participated in an analgesic study that compared single doses of ketoprofen 100 or 400 mg iv or injectable acetylsalicylic acid 1 g." | 9.05 | Injectable ketoprofen vs. acetylsalicylic acid for the relief of severe cancer pain: a double-blind, crossover trial. ( Bruni, G; Camera, P; Martoni, A; Pannuti, F; Rossi, AP; Sacchetti, G, 1984) |
| "Fourteen patients with acute lumbar pain and cervico-brachial radicular pain were treated with a single oral dose of 100 mg ketoprofen." | 9.05 | Correlation between ketoprofen plasma levels and analgesic effect in acute lumbar pain and radicular pain. ( Köhler, G; Morand, J; Primbs, P; Rübelt, C, 1985) |
| "In a double-blind trial 40 patients with ostheoarthritis were treated for relief of pain with ketoprofen or with the N-methyl-d-glucamine salt of indomethacin, both drugs being administered i." | 9.04 | Parenteral administration of ketoprofen in osteoarthritis: a double-blind trial versus the N-methyl-d-glucamine salt of indomethacin. ( Franchi, R; Liverta, C; Pollini, C; Pontiroli, AE, 1979) |
| "In a double-blind study of ketoprofen versus placebo in the treatment of osteoarthritis of the hip, it was shown by a sequential technique, that ketoprofen was significantly better than placebo." | 9.04 | A double-blind trial of ketoprofen in the treatment of osteoarthritis of the hip. ( Colinet, E; Famaey, JP, 1976) |
| "Dexketoprofen, an NSAID used in the management of acute and chronic pains, is licensed in several countries but has not previously been the subjected of a systematic review." | 8.84 | Systematic review of dexketoprofen in acute and chronic pain. ( Barden, J; Moore, RA, 2008) |
| " Supplementation with Casperome® 250 mg/day showed beneficial effects in the reduction of signs and symptoms of ankle sprains evaluated at day 3 and day 7, and was shown to induce measurable plasma level of boswellic acids." | 7.85 | Effectiveness of a novel boswellic acids delivery form (Casperome®) in the management of grade II ankle sprains due to sport trauma - a registry study. ( Abdel-Tawab, M; Belcaro, G; Cacchio, M; Cesarone, MR; Dugall, M; Eggenhoffner, R; Feragalli, B; Giacomelli, L; Ippolito, E; Riva, A; Togni, S, 2017) |
| " By the fourth week, pain was well controlled (NRS 0 to 2) in 80% of patients receiving ketoprofen compared with 46% of patients without ketoprofen (P<0." | 7.76 | Long-term continuous subcutaneous infusion of ketoprofen combined with morphine: a safe and effective approach to cancer pain. ( Cruto, M; Debernardi, F; Massucco, P; Moselli, NM; Savojardo, M, 2010) |
| "Ketoprofen was recently approved for use as an analgesic for treatment of mild to moderate pain in total daily doses up to 300 mg; the recommended initial dose is 25 to 50 mg every 6 to 8 hours as necessary." | 7.76 | Analgesic efficacy of ketoprofen in postpartum, general surgery, and chronic cancer pain. ( Olson, NZ; Sunshine, A, 1988) |
| " The safety profile of oral dexketoprofen trometamol for the treatment of acute mild to moderate pain of different causes in actual conditions of use in the primary care setting was assessed." | 7.75 | Postmarketing cohort study to assess the safety profile of oral dexketoprofen trometamol for mild to moderate acute pain treatment in primary care. ( Carne, X; Rios, J; Torres, F, 2009) |
| "The antinociceptive activity of dexketoprofen was studied in mice using the acetic acid writhing test (acute tonic pain), the tail flick test (acute phasic pain) and the formalin assay (inflammatory pain)." | 7.74 | Dexketoprofen-induced antinociception in animal models of acute pain: synergy with morphine and paracetamol. ( Dursteler, C; Miranda, HF; Pinardi, G; Prieto, JC; Puig, MM, 2007) |
| "We investigated the antinociceptive properties of dexketoprofen trometamol [S(+)-ketoprofen tromethamine salt; SKP], a new analgesic, antiinflammatory drug, using the pain-induced functional impairment model in the rat (PIFIR), an animal model of arthritic pain." | 7.70 | Antinociceptive effects of S(+)-ketoprofen and other analgesic drugs in a rat model of pain induced by uric acid. ( Cabré, F; Díaz, I; Fernández-Guasti, A; López-Muñoz, FJ; Mauleón, D; Tost, D; Ventura, R, 1998) |
| "Patients with renal lithiasis were included and were randomized to Group A (basal analgesia: midazolam (1 mg), fentanyl (0." | 7.11 | Value of Music and Nitrous Oxide for Pain Control during Extracorporeal Shock Wave Lithotripsy (ESWL). ( Alcoba-García, MP; Bueno-Serrano, G; González-Enguita, C; González-López, R; Llanos-Jiménez, L; Mahillo-Fernández, I; Tabares-Jiménez, J, 2022) |
| "To determine the efficacy and bioavailability of non-steroidal anti-inflammatory drugs (NSAIDs) when administered orally to sheep." | 6.80 | Randomised trial of the bioavailability and efficacy of orally administered flunixin, carprofen and ketoprofen in a pain model in sheep. ( Colditz, IG; Hinch, G; Lee, C; Marini, D; Petherick, JC; Pippia, J, 2015) |
| "The risk of oral NSAID including Cox-2 inhibitors to cause gastrointestinal, renal or cardiovascular adverse events related to systemic drug exposure could be reduced by local application." | 6.74 | A multiple-dose, open-label, safety, compliance, and usage evaluation study of epicutaneously applied Diractin (ketoprofen in Transfersome) in joint/musculoskeletal pain or soft tissue inflammation. ( Kneer, W; Rother, I; Rother, M; Seidel, E, 2009) |
| "ketorolac (10mg q." | 6.71 | Double-blind evaluation of short-term analgesic efficacy of orally administered dexketoprofen trometamol and ketorolac in bone cancer pain. ( Busquets, C; Camba, MA; Castro, A; Contreras, D; Gálvez, R; Herrera, J; Rodríguez, MJ, 2003) |
| "Oral ketoprofen (50 mg) was less effective and reduced the pain intensity by 45% (P<0." | 6.70 | Analgesic profile of peroral and topical ketoprofen upon low pH-induced muscle pain. ( Meller, ST; Steen, KH; Wegner, H, 2001) |
| "A double-blind randomized parallel-group trial was undertaken to evaluate the influence of the dosing time of sustained-release ketoprofen (SRK) on its acceptability and efficacy." | 6.67 | Dosing time optimizes sustained-release ketoprofen treatment of osteoarthritis. ( Buchmuller, A; Decousus, H; Hocquart, J; Mismetti, P; Perpoint, B; Queneau, P; Rambaud, C; Simitsidis, S, 1994) |
| "Carprofen is a propionic acid-derived NSAID that has anti-inflammatory, analgesic, and antipyretic activity." | 6.40 | Use of carprofen for the treatment of pain and inflammation in dogs. ( Fox, SM; Johnston, SA, 1997) |
| " This results in an increase in the rate of absorption of the active compound and, consequently, in an earlier onset of analgesic action." | 6.38 | Piroxicam-beta-cyclodextrin in the treatment of acute pain of rheumatic disease. ( Franchimont, P; Reginster, JY, 1993) |
| "There is a strong correlation between treatment resistant depression and increase in inflammatory cytokines in plasma and cerebrospinal fluid." | 5.48 | Population scale retrospective analysis reveals distinctive antidepressant and anxiolytic effects of diclofenac, ketoprofen and naproxen in patients with pain. ( Abagyan, R; Cohen, IV; Lee, KC; Makunts, T, 2018) |
| "Acute and chronic pain have an important socio-economical impact." | 5.46 | A "novel" association to treat pain: tramadol/dexketoprofen. The first drug of a "new pharmacological class". ( Allegri, M; Fanelli, G; Fornasari, D; Gerboni, S, 2017) |
| "To compare the efficacy and safety of ketoprofen plasters and diclofenac plasters after 3 weeks of administration in patients with osteoarthritis-related knee pain." | 5.41 | Comparison of the Efficacy and Safety of Ketoprofen Plaster and Diclofenac Plaster for Osteoarthritis-Related Knee Pain: A Multicenter, Randomized, Active-Controlled, Open-Label, Parallel-Group, Phase III Clinical Trial. ( Cha, JE; Ershova, O; Hyun, BJ; Kastanayan, A; Krechikova, D; Nikulenkova, N; Polyakova, S; Shvarts, Y; Vinogradova, I; Yakushin, S, 2021) |
| " The eligible population (n = 200) with confirmed pharyngitis diagnosis on the Tonsillo Pharyngitis Assessment and moderate to severe sore throat was randomly divided into two cohorts to be administered with 50 mg of dexketoprofen (n = 98) or 1000-mg paracetamol (n = 102)." | 5.41 | Comparative evaluation of intravenous dexketoprofen and paracetamol in the management of pain induced by sore throat. ( Cimen, U; Cimen, YK; Erdur, B; Oncel, G; Ozen, M; Seyit, M; Turkcuer, I; Yilmaz, A, 2021) |
| " Dose-response curves for DEX and TRM, individually and combined in a 1 : 1 proportion based on their potency were obtained, and the doses that produced a 50% inhibition calculated." | 5.38 | Antinociceptive and anti-exudative synergism between dexketoprofen and tramadol in a model of inflammatory pain in mice. ( Miranda, HF; Puig, MM; Romero, MA, 2012) |
| "Ankle sprains mainly caused by accidents or strenuous sport activities can often be quite painful and impair motility." | 5.35 | Management of uncomplicated ankle sprains with topical or oral ketoprofen treatment. A registry study. ( Belcaro, G; Cacchio, M; Cesarone, MR; Di Renzo, A; Dugall, M; Errichi, BM; Errichi, S; Fano, F; Gizzi, G; Grossi, MG; Ippolito, E; Ricci, A; Ruffini, I; Stuard, S; Vinciguerra, G, 2008) |
| "Analgesics are required to prevent and treat postpartum pain, but breast-feeding may be contraindicated, because data on milk transfer are very limited." | 5.34 | Excretion of ketoprofen and nalbuphine in human milk during treatment of maternal pain after delivery. ( Boissinot, C; Jacqz-Aigrain, E; Michel, J; Popon, M; Serreau, R; Sibony, O; Sobel, A, 2007) |
| " These data suggest that ketoprofen at the dosage rate of 1." | 5.29 | Effects of ketoprofen and phenylbutazone on chronic hoof pain and lameness in the horse. ( Kamerling, SG; Keowen, ML; Owens, JG; Stanton, SR, 1995) |
| "Ketoprofen was found to be significantly effective in all cases of non calcific rotator cuff tendinitis while no improvement was noted in calcific tendinitis." | 5.28 | [Ketoprofen efficacy and tolerance in simple painful shoulder]. ( Amanda Dal Pra, ML; Battisti, E; Cataldi, V; Cecconami, L; Franci, A; Gelli, R; Giordano, N; Marcolongo, R; Marcucci, P; Stuart, R, 1992) |
| "To compare the effects of IV paracetamol with dexketoprofen in patients presenting with primary dysmenorrhea to the emergency department." | 5.27 | Intravenous Dexketoprofen versus Intravenous Paracetamol for Dysmenorrhea: A Randomized Controlled Trial ( Eken, C; Karcıoğlu, Ö; Serinken, M, 2018) |
| "A significant pain reduction was observed following the use of ketoprofen when tested against a control gel (placebo)." | 5.22 | The effect of benzocaine and ketoprofen gels on pain during fixed orthodontic appliance treatment: a randomised, double-blind, crossover trial. ( Borzabadi-Farahani, A; Eslamian, L; Gholami, H, 2016) |
| "Ketoprofen has high analgesic efficacy against inflammatory and nociceptive pain." | 5.20 | Intravenous dexketoprofen induces less injection pain than racemic ketoprofen. ( Halinen, L; Kokki, H; Kokki, M; Nokela, A; Sjövall, S; Turunen, M, 2015) |
| "The results of our study showed that lidocaine puffs provided the best pain relief than the other analgesics used." | 5.20 | Effect of paracetamol, dexketoprofen trometamol, lidocaine spray, pethidine & diclofenac sodium application for pain relief during fractional curettage: A randomized controlled trial. ( Acmaz, G; Aksoy, H; Başer, M; Bayraktar, E; Müderris, İİ; Yilmaz, MO, 2015) |
| "Rocuronium is a non-depolarizing neuromuscular blocking agent which is associated with injection pain and induces withdrawal movement of the injected hand or arm or generalized movements of the body after intravenous injection." | 5.19 | Comparison of randomized preemptive dexketoprofen trometamol or placebo tablets to prevent withdrawal movement caused by rocuronium injection. ( Aydın, GB; Caparlar, CO; Ergil, J; Polat, R; Sayın, M, 2014) |
| "A randomised controlled trial was conducted to investigate efficacy of paracetamol and dexketoprofen trometamol for perineal pain relief after perineal repair." | 5.19 | Paracetamol vs dexketoprofen for perineal pain relief after episiotomy or perineal tear. ( Akil, A; Api, O; Bektas, Y; Unal, O; Yalti, S; Yilmaz, AO, 2014) |
| ") injection of ketoprofen and castration technique on physiological and behavioral indicators of pain in beef calves." | 5.19 | Effects of castration method and frequency of intramuscular injections of ketoprofen on behavioral and physiological indicators of pain in beef cattle. ( Caulkett, NA; Fireheller, E; González, LA; Janzen, E; Moya, D; Schwartzkopf-Genswein, KS, 2014) |
| "To assess the efficacy and safety of 12-week treatment with ketoprofen in ultradeformable phospholipid vesicles in patients with OA knee pain and to compare the efficacy with that of ketoprofen-free vehicle and celecoxib." | 5.17 | A multicentre, randomized, placebo- and active-controlled trial comparing the efficacy and safety of topical ketoprofen in Transfersome gel (IDEA-033) with ketoprofen-free vehicle (TDT 064) and oral celecoxib for knee pain associated with osteoarthritis. ( Bolten, W; Cevc, G; Conaghan, PG; Dickson, J; Rother, M, 2013) |
| "This randomized, double-blind, phase III study evaluated the efficacy and safety of ketoprofen in an ultradeformable vesicle gel compared with ketoprofen-free gel in osteoarthritis (OA) knee pain." | 5.17 | A randomized, double-blind, phase III trial in moderate osteoarthritis knee pain comparing topical ketoprofen gel with ketoprofen-free gel. ( Conaghan, PG; Rother, M, 2013) |
| "5mg/ml oral suspension, compared to ketoprofen tablets in cats suffering from painful acute locomotor disorders." | 5.15 | Clinical evaluation of meloxicam versus ketoprofen in cats suffering from painful acute locomotor disorders. ( Grant, D; Johnston, L; Letellier, IM; Morton, CM; Narbe, R, 2011) |
| "A single oral dose of paracetamol or ketoprofen lysine salt are safe and effective analgesic treatments for children with sore throat in daily pediatric ambulatory care." | 5.15 | A randomized, double-blind, placebo-controlled trial of paracetamol and ketoprofren lysine salt for pain control in children with pharyngotonsillitis cared by family pediatricians. ( Carozzino, L; Del Vecchio, A; Della Casa Alberighi, O; Dionisio, P; Freschi, F; Jamone, R; Martini, A; Picollo, G; Ruperto, N; Salvatori, E; Zera, M, 2011) |
| "This study assessed the efficacy and safety of ketoprofen patch compared with placebo in patients who had rheumatoid arthritis and persistent wrist pain." | 5.14 | Efficacy and safety of ketoprofen patch in patients with rheumatoid arthritis: a randomized, double-blind, placebo-controlled study. ( Kawai, S; Kondo, M; Nagaya, I; Nawata, Y; Obata, J; Ohno, S; Oribe, M; Sugimoto, K; Uchida, E, 2010) |
| "The severity of SWL-related pain was significantly better tolerated with dexketoprofen trometamol." | 5.14 | Comparison of the analgesic effects of dexketoprofen and diclofenac during shockwave lithotripsy: a randomized, double-blind clinical trial. ( Akduman, B; Erol, B; Hanci, V; Mungan, A; Tokgoz, H; Turksoy, O; Yurtlu, S, 2010) |
| "No statistically significant difference was found among the mean pain scores of women during the procedure in the dexketoprofen and saline, placebo and lidocaine, and dexketoprofen and lidocaine groups." | 5.14 | Comparison of oral nonsteroidal analgesic and intrauterine local anesthetic for pain relief in uterine fractional curettage: a randomized, double-blind, placebo-controlled trial. ( Api, M; Api, O; Emeksiz, MB; Ergen, B; Ugurel, V; Unal, O, 2010) |
| "Robenacoxib tablets administered once daily had noninferior efficacy and tolerability, and superior palatability, compared with the active control drug, ketoprofen, for the treatment of signs of acute pain and inflammation associated with musculoskeletal disorders in cats." | 5.14 | Evaluation of orally administered robenacoxib versus ketoprofen for treatment of acute pain and inflammation associated with musculoskeletal disorders in cats. ( Alexander, DG; Giraudel, JM; Gruet, P; King, JN; Seewald, W, 2010) |
| "To compare the ketoprofen TDS patch with diclofenac gel in the treatment of traumatic acute pain in benign sport-related soft-tissue injuries." | 5.12 | Topical ketoprofen TDS patch versus diclofenac gel: efficacy and tolerability in benign sport related soft-tissue injuries. ( Cobián, C; Esparza, F; García-Cota, JJ; Jiménez, JF; Maestro, A; Sánchez, C, 2007) |
| "The optimum doses of carprofen, flunixin, ketoprofen and sodium salicylate for the treatment of inflammatory pain were determined in domestic fowl using the microcrystalline sodium urate model of articular pain." | 5.11 | Effects of non-steroidal anti-inflammatory drugs on pain-related behaviour in a model of articular pain in the domestic fowl. ( Gentle, MJ; Hocking, PM; Robertson, GW, 2005) |
| "After 1 week of treatment, the decrease in spontaneous pain was -50+/-20 mm for ketoprofen and -38+/-24 mm for the placebo, showing a statistically significant intergroup difference (P=." | 5.11 | Topical ketoprofen patch (100 mg) for the treatment of ankle sprain: a randomized, double-blind, placebo-controlled study. ( Mazières, B; Reiner, V; Rouanet, S; Scarsi, C; Velicy, J, 2005) |
| "To evaluate the efficacy and tolerability of ketoprofen patch in the treatment of tendinitis." | 5.11 | Topical ketoprofen patch in the treatment of tendinitis: a randomized, double blind, placebo controlled study. ( Guillon, Y; Mazières, B; Reiner, V; Rouanet, S; Scarsi, C, 2005) |
| "Patients who fitted the study criteria were given either 25 mg oral dexketoprofen trometamol or 50 mg sodium diclofenac immediately after triage; baseline and 15 minute pain scores were then recorded for one hour." | 5.10 | Randomised controlled trial of the onset of analgesic efficacy of dexketoprofen and diclofenac in lower limb injury. ( Herington, J; Kapadia, Y; Leman, P, 2003) |
| "The efficacy and tolerability of aceclofenac, a new non-steroidal anti-inflammatory drug (NSAID) was compared to that of ketoprofen in a multicentre, double-blind, prospective, randomized study of 3-months duration in patients with rheumatoid arthritis." | 5.08 | Aceclofenac in comparison to ketoprofen in the treatment of rheumatoid arthritis. ( Ansoleaga, JJ; Gijón-Baños, J; Martín-Mola, E, 1995) |
| "The clinical efficacy of the two topical analgesics, ketoprofen hydroalcoholic gel (Fastum gel) and diclofenac emulgel, for osteoarthritis of the knee was studied." | 5.08 | Topical analgesics for knee arthrosis: a parallel study of ketoprofen gel and diclofenac emulgel. ( Boonsanong, W; Penkitti, P; Soparat, K; Waikakul, S, 1997) |
| "The effectiveness of a balanced analgesia with buprenorphine ketoprofen-propacetamol for pain control during extracorporeal shock wave lithotripsy (ESWL) was evaluated in order to reduce the requirements for general anaesthesia." | 5.08 | Effect of balanced analgesia with buprenorphine on pain response and general anaesthesia requirement during lithotripsy procedures. ( Bannwarth, B; Delort-Laval, S; Krol-Houdek, MC; Maurette, P; Tauzin-Fin, P, 1998) |
| "A double-blind, double-dummy, crossover study was carried out in 8 centres to compare the efficacy and tolerability of 'controlled-release' ketoprofen tablets (200 mg) with that of indomethacin suppositories (100 mg) in out-patients with definite or classical rheumatoid arthritis." | 5.07 | A double-blind comparison of oral ketoprofen 'controlled release' and indomethacin suppository in the treatment of rheumatoid arthritis with special regard to morning stiffness and pain on awakening. ( Leden, I; Rubin, B; Uddenfeldt, P, 1993) |
| "Three groups of 20 patients, who suffered of acute pain (dental or low back or menorrhalgia) have been randomized and treated, obtained their informed consent, with meclofenamic acid 100 mg or ketoprofene 50 mg by oral route." | 5.07 | [Analgesic effect of sodium meclofenamate on several painful symptoms]. ( Castellari, A, 1993) |
| "Fifty-nine patients with acute gouty arthritis entered into a 7-day multicenter, double blind trial of ketoprofen versus indomethacin." | 5.06 | Ketoprofen versus indomethacin in patients with acute gouty arthritis: a multicenter, double blind comparative study. ( Altman, RD; Honig, S; Levin, JM; Lightfoot, RW, 1988) |
| "Under double-blind, crossover conditions, 43 women with primary dysmenorrhea received ketoprofen, ibuprofen, and placebo during three consecutive menstrual cycles." | 5.06 | Ketoprofen, ibuprofen, and placebo in the treatment of primary dysmenorrhea: a double-blind crossover comparison. ( Mehlisch, DR, 1988) |
| "The analgesic effects of single oral doses of ketoprofen 100 and 300 mg, the combination of aspirin 650 mg plus codeine 60 mg, and placebo were compared under double-blind conditions in 160 hospitalized patients with cancer pain." | 5.06 | A double-blind parallel evaluation of the efficacy and safety of a single dose of ketoprofen in cancer pain. ( Drew, J; Stambaugh, J, 1988) |
| "Forty women with moderate to severe primary dysmenorrhea participated in a two-month, double-blind, crossover trial comparing ketoprofen with mefenamic acid." | 5.06 | Double-blind comparison of ketoprofen and mefenamic acid in the treatment of primary dysmenorrhea. ( Bourgouin, J; Hébert, JG; Le Morvan, P, 1986) |
| " Effectiveness of the two forms of ketoprofen on morning stiffness and pain scale was found to be comparable." | 5.05 | [Double-blind comparative study of Bi-Profenid tablets and Profenid capsules in inflammatory rheumatism]. ( Ayrolles, C; Camus, JP; Fournie, A; Koeger, AC; Prier, A, 1983) |
| "Thirty-six patients suffering from severe pain due to bone involvement from cancer participated in an analgesic study that compared single doses of ketoprofen 100 or 400 mg iv or injectable acetylsalicylic acid 1 g." | 5.05 | Injectable ketoprofen vs. acetylsalicylic acid for the relief of severe cancer pain: a double-blind, crossover trial. ( Bruni, G; Camera, P; Martoni, A; Pannuti, F; Rossi, AP; Sacchetti, G, 1984) |
| "Fourteen patients with acute lumbar pain and cervico-brachial radicular pain were treated with a single oral dose of 100 mg ketoprofen." | 5.05 | Correlation between ketoprofen plasma levels and analgesic effect in acute lumbar pain and radicular pain. ( Köhler, G; Morand, J; Primbs, P; Rübelt, C, 1985) |
| "In a double-blind trial 40 patients with ostheoarthritis were treated for relief of pain with ketoprofen or with the N-methyl-d-glucamine salt of indomethacin, both drugs being administered i." | 5.04 | Parenteral administration of ketoprofen in osteoarthritis: a double-blind trial versus the N-methyl-d-glucamine salt of indomethacin. ( Franchi, R; Liverta, C; Pollini, C; Pontiroli, AE, 1979) |
| "Ninety patients with rheumatoid arthritis completed a double-blind crossover trial comparing fenoprofen, ibuprofen, ketoprofen, and naproxen." | 5.04 | Four new anti-inflammatory drugs: responses and variations. ( Balme, HW; Franklin, S; Huskisson, EC; Scott, J; Woolf, DL, 1976) |
| "In a double-blind study of ketoprofen versus placebo in the treatment of osteoarthritis of the hip, it was shown by a sequential technique, that ketoprofen was significantly better than placebo." | 5.04 | A double-blind trial of ketoprofen in the treatment of osteoarthritis of the hip. ( Colinet, E; Famaey, JP, 1976) |
| " Data from randomized, phase III studies in OA knee pain in which TDT 064 was used as the drug-free vehicle control for IDEA-033 (ketoprofen in ultra-deformable phospholipid vesicles) demonstrate a marked and consistent response to TDT 064 in terms of pain, stiffness, and function." | 4.90 | Drug-free gel containing ultra-deformable phospholipid vesicles (TDT 064) as topical therapy for the treatment of pain associated with osteoarthritis: a review of clinical efficacy and safety. ( Bijlsma, JW; Conaghan, PG; Kneer, W; Kvien, TK; Rother, M; Wise, E, 2014) |
| "Dexketoprofen, an NSAID used in the management of acute and chronic pains, is licensed in several countries but has not previously been the subjected of a systematic review." | 4.84 | Systematic review of dexketoprofen in acute and chronic pain. ( Barden, J; Moore, RA, 2008) |
| " Supplementation with Casperome® 250 mg/day showed beneficial effects in the reduction of signs and symptoms of ankle sprains evaluated at day 3 and day 7, and was shown to induce measurable plasma level of boswellic acids." | 3.85 | Effectiveness of a novel boswellic acids delivery form (Casperome®) in the management of grade II ankle sprains due to sport trauma - a registry study. ( Abdel-Tawab, M; Belcaro, G; Cacchio, M; Cesarone, MR; Dugall, M; Eggenhoffner, R; Feragalli, B; Giacomelli, L; Ippolito, E; Riva, A; Togni, S, 2017) |
| "The combination of pomegranate seed oil and ketoprofen in nanoemulsions aiming to improve the antinociceptive effect was evaluated according to the writhing test and Complete Freud's Adjuvant induced paw inflammation in mice." | 3.83 | Pomegranate seed oil nanoemulsions improve the photostability and in vivo antinociceptive effect of a non-steroidal anti-inflammatory drug. ( Barbieri, AV; Beck, RCR; Cervi, VF; Cruz, L; Ferreira, LM; Gehrcke, M; Nogueira, CW; Sari, MHM; Zborowski, VA, 2016) |
| "The median pain reduction in ketoprofen and placebo groups at 15 minutes was 27 (19." | 3.83 | Topical Ketoprofen Versus Placebo in Treatment of Acute Ankle Sprain in the Emergency Department. ( Eken, C; Elicabuk, H; Serinken, M, 2016) |
| " The present study used assays of pain-related stimulation and depression of behavior in rats to compare effects of 1) two peripherally restricted κ agonists [the tetrapeptide D-Phe-D-Phe-D-Ile-D-Arg-NH(2) (ffir) and the nonpeptidic compound ((R,S)-N-[2-(N-methyl-3,4-dichlorophenylacetamido)-2-(3-carboxyphenyl)-ethyl]pyrrolidine hydrochloride (ICI204448)], 2) a centrally penetrating κ agonist (salvinorin A), and 3) several reference drugs, including a nonsteroidal anti-inflammatory drug (NSAID; ketoprofen)." | 3.78 | Effects of peripherally restricted κ opioid receptor agonists on pain-related stimulation and depression of behavior in rats. ( Cheng, K; Morrissey, E; Negus, SS; O'Connell, R; Rice, KC, 2012) |
| "Topical ketoprofen patches are widely used in the treatment of musculoskeletal pain, but the pharmacokinetics of ketoprofen following topical application remain unclear." | 3.76 | Ketoprofen absorption by muscle and tendon after topical or oral administration in patients undergoing anterior cruciate ligament reconstruction. ( Hara, K; Ju, YJ; Mochizuki, T; Morito, T; Muneta, T; Sekiya, I; Tsuji, K; Yagishita, K; Yamazaki, J, 2010) |
| " By the fourth week, pain was well controlled (NRS 0 to 2) in 80% of patients receiving ketoprofen compared with 46% of patients without ketoprofen (P<0." | 3.76 | Long-term continuous subcutaneous infusion of ketoprofen combined with morphine: a safe and effective approach to cancer pain. ( Cruto, M; Debernardi, F; Massucco, P; Moselli, NM; Savojardo, M, 2010) |
| " The animal was administered multiple nonsteroidal anti-inflammatory drugs (NSAIDs), including meloxicam, flunixin meglumine, and ketoprofen for pain management." | 3.76 | Nonsteroidal anti-inflammatory drug-associated renal papillary necrosis in a white-tailed deer (Odocoileus virginianus). ( Genova, SG; Hall, B; Ketz-Riley, CJ; Ritchey, JW; Stern, AW, 2010) |
| "Ketoprofen is a potent non-steroidal anti-inflammatory drug has been used in the treatment of various kinds of pains, inflammation and arthritis." | 3.76 | Anti-inflammatory and analgesic effects of ketoprofen in palm oil esters nanoemulsion. ( Azmin, MN; Elrashid, SM; Munavvar, AS; Sakeena, MH; Yam, MF, 2010) |
| "Ketoprofen was recently approved for use as an analgesic for treatment of mild to moderate pain in total daily doses up to 300 mg; the recommended initial dose is 25 to 50 mg every 6 to 8 hours as necessary." | 3.76 | Analgesic efficacy of ketoprofen in postpartum, general surgery, and chronic cancer pain. ( Olson, NZ; Sunshine, A, 1988) |
| "The antinociceptive activity of dexketoprofen was studied in mice using the formalin assay for orofacial pain." | 3.75 | The effect of opioid antagonists on synergism between dexketoprofen and tramadol. ( Gonzalez, C; Miranda, HF; Pinardi, G; Zegpi, C, 2009) |
| " The safety profile of oral dexketoprofen trometamol for the treatment of acute mild to moderate pain of different causes in actual conditions of use in the primary care setting was assessed." | 3.75 | Postmarketing cohort study to assess the safety profile of oral dexketoprofen trometamol for mild to moderate acute pain treatment in primary care. ( Carne, X; Rios, J; Torres, F, 2009) |
| " The size of the udder, the signs of pain and the concentrations of thromboxane B2, especially in plasma, were also reduced, and the appearance of their milk was almost normal." | 3.74 | Efficacy of oral and parenteral ketoprofen in lactating cows with endotoxin-induced acute mastitis. ( Banting, A; Banting, S; Heinonen, K; Mustonen, K, 2008) |
| "The antinociceptive activity of dexketoprofen was studied in mice using the acetic acid writhing test (acute tonic pain), the tail flick test (acute phasic pain) and the formalin assay (inflammatory pain)." | 3.74 | Dexketoprofen-induced antinociception in animal models of acute pain: synergy with morphine and paracetamol. ( Dursteler, C; Miranda, HF; Pinardi, G; Prieto, JC; Puig, MM, 2007) |
| "Pain threshold increased after treatment, and was significantly increased in the loxoprofen-Na group compared with the control group (p < 0." | 3.74 | Analgesic effect of percutaneously absorbed non-steroidal anti-inflammatory drugs: an experimental study in a rat acute inflammation model. ( Kikuchi, S; Konno, S; Sekiguchi, M; Shirasaka, M, 2008) |
| "The aim of this study was to validate a model of postfracture pain in mice, which was evaluated in the presence and the absence of morphine and ketoprofen." | 3.74 | Mouse model of fracture pain. ( Fourcade, O; Girolami, JP; Laffosse, JM; Minville, V; Tack, I, 2008) |
| " Based on a clinical observation of synergism between nefopam, a centrally acting non-opioid that inhibits monoamines reuptake, and ketoprofen, a non-steroidal anti-inflammatory drug, the objective of this study was to further explore this antinociceptive synergy in four distinct animal models of pain (both drugs were administered subcutaneously)." | 3.74 | Nefopam and ketoprofen synergy in rodent models of antinociception. ( Coppé, MC; Gillardin, JM; Girard, P; Pansart, Y; Verniers, D, 2008) |
| " Physical therapy intervention consisted of 6 visits over a 3-week period with traditional interventions (including rest, discontinuation of activities that aggravate the condition, hot and cold packs, heel lifts, calf stretching, and strengthening) and the addition of ketoprofen gel to reduce local inflammation and relieve pain." | 3.73 | Ketoprofen gel as an adjunct to physical therapist management of a child with Sever disease. ( White, RL, 2006) |
| "Despite ketoprofen infusion and free access to a patient-controlled pump with fentanyl citrate for rescue analgesia, inadequate pain relief was common both after uvulopalatoplasty (35%) and after tonsillectomy (28%) during the first 24 hours after surgery." | 3.72 | Pain intensity after laseruvulopalatoplasty and tonsillectomy. ( Aho, M; Kokki, H; Nikanne, E; Virtaniemi, J, 2003) |
| "We investigated the antinociceptive properties of dexketoprofen trometamol [S(+)-ketoprofen tromethamine salt; SKP], a new analgesic, antiinflammatory drug, using the pain-induced functional impairment model in the rat (PIFIR), an animal model of arthritic pain." | 3.70 | Antinociceptive effects of S(+)-ketoprofen and other analgesic drugs in a rat model of pain induced by uric acid. ( Cabré, F; Díaz, I; Fernández-Guasti, A; López-Muñoz, FJ; Mauleón, D; Tost, D; Ventura, R, 1998) |
| " Both etodolac and bromelain inhibited the inflammatory pain in concanavalin A-treated paws of rats in a dose-dependent manner, but indomethacin did not." | 3.69 | Effect of etodolac on prostaglandin E2 biosynthesis, active oxygen generation and bradykinin formation. ( Dainaka, J; Hashii, H; Inoue, K; Kimura, K; Motonaga, A; Nishimura, T; Ueda, F; Yamate, K, 1994) |
| "Evidence for the effectiveness of ketoprofen in animal models of inflammation and its antipyretic effect is reviewed." | 3.65 | Some pharmacological and toxicological studies on ketoprofen. ( Ducrot, R; Guyonnet, JC; Julou, L; Pasquet, J, 1976) |
| "Patients with renal lithiasis were included and were randomized to Group A (basal analgesia: midazolam (1 mg), fentanyl (0." | 3.11 | Value of Music and Nitrous Oxide for Pain Control during Extracorporeal Shock Wave Lithotripsy (ESWL). ( Alcoba-García, MP; Bueno-Serrano, G; González-Enguita, C; González-López, R; Llanos-Jiménez, L; Mahillo-Fernández, I; Tabares-Jiménez, J, 2022) |
| "Pain has a negative impact on life satisfaction (LS)." | 2.87 | Life satisfaction and pain interference in spine surgery patients before and after surgery: comparison between on-opioid and opioid-naïve patients. ( Kokki, H; Kokki, M; Kuronen, M; Nyyssönen, T; Savolainen, S, 2018) |
| " Adverse drug reactions may be renal, gastrointestinal, hematological, or immunologic." | 2.82 | Efficacy and Safety of NSAIDs in Infants: A Comprehensive Review of the Literature of the Past 20 Years. ( Gorenflo, M; Saur, P; van den Anker, JN; van Dyk, M; Welzel, T; Ziesenitz, VC, 2022) |
| "Pain was assessed by a visual analogue scale (VAS) during and after the HSG procedure." | 2.80 | Factors influencing the severity of pain during hysterosalpingography. ( Grzechocińska, B; Kaczyński, B; Marianowski, P; Szymusik, I; Wielgoś, M, 2015) |
| "To determine the efficacy and bioavailability of non-steroidal anti-inflammatory drugs (NSAIDs) when administered orally to sheep." | 2.80 | Randomised trial of the bioavailability and efficacy of orally administered flunixin, carprofen and ketoprofen in a pain model in sheep. ( Colditz, IG; Hinch, G; Lee, C; Marini, D; Petherick, JC; Pippia, J, 2015) |
| "Oral ketoprofen was well tolerated and no adverse events were observed." | 2.76 | Oral ketoprofen is effective in the treatment of non-infectious lameness in sows. ( Ala-Kurikka, E; Heinonen, M; Mustonen, K; Orro, T; Peltoniemi, O; Raekallio, M; Vainio, O, 2011) |
| "The risk of oral NSAID including Cox-2 inhibitors to cause gastrointestinal, renal or cardiovascular adverse events related to systemic drug exposure could be reduced by local application." | 2.74 | A multiple-dose, open-label, safety, compliance, and usage evaluation study of epicutaneously applied Diractin (ketoprofen in Transfersome) in joint/musculoskeletal pain or soft tissue inflammation. ( Kneer, W; Rother, I; Rother, M; Seidel, E, 2009) |
| "ketoprofen was prevented by i." | 2.72 | Involvement of opioidergic and alpha2-adrenergic mechanisms in the central analgesic effects of non-steroidal anti-inflammatory drugs in sheep. ( Chambers, JP; Lizarraga, I, 2006) |
| "ketorolac (10mg q." | 2.71 | Double-blind evaluation of short-term analgesic efficacy of orally administered dexketoprofen trometamol and ketorolac in bone cancer pain. ( Busquets, C; Camba, MA; Castro, A; Contreras, D; Gálvez, R; Herrera, J; Rodríguez, MJ, 2003) |
| "Ketoprofen treatment after muscle damaging exercise reduces muscle soreness and improves force recovery." | 2.70 | Effect of ketoprofen on muscle function and sEMG activity after eccentric exercise. ( Clarkson, PM; Kamen, G; Knight, CA; Sayers, SP; Van Wegen, EH, 2001) |
| "Oral ketoprofen (50 mg) was less effective and reduced the pain intensity by 45% (P<0." | 2.70 | Analgesic profile of peroral and topical ketoprofen upon low pH-induced muscle pain. ( Meller, ST; Steen, KH; Wegner, H, 2001) |
| "A double-blind randomized parallel-group trial was undertaken to evaluate the influence of the dosing time of sustained-release ketoprofen (SRK) on its acceptability and efficacy." | 2.67 | Dosing time optimizes sustained-release ketoprofen treatment of osteoarthritis. ( Buchmuller, A; Decousus, H; Hocquart, J; Mismetti, P; Perpoint, B; Queneau, P; Rambaud, C; Simitsidis, S, 1994) |
| "Diclofenac was preferred to naproxen, aspirin and indomethacin, while piroxicam and placebo were preferred only to aspirin." | 2.66 | Double-blind preference and compliance multicentre study in osteoarthritis: once-a-day treatment. ( Bassi, GP; Borghi, C; Camarri, E; Cocco, F; Francucci, BM; Giannini, R; Giordano, N; Marcolongo, R; Mordini, M; Neri, D, 1985) |
| "Osteoarthritis is a good indication for these medications whose effectiveness is well documented." | 2.65 | [Comparative double-blind study of ketoprofen slow-release tablets and indomethacin in coxarthrosis and gonarthrosis]. ( Gougeon, J, 1983) |
| " Pharmacokinetic data indicate that although plasma levels of ketoprofen are higher when the drug is administered as a patch versus a gel, the total systemic bioavailability of ketoprofen 100 mg administered via a patch is no more than 10% of that reported for ketoprofen 100 mg administered orally." | 2.43 | Topical ketoprofen patch. ( Mazières, B, 2005) |
| "Carprofen is a propionic acid-derived NSAID that has anti-inflammatory, analgesic, and antipyretic activity." | 2.40 | Use of carprofen for the treatment of pain and inflammation in dogs. ( Fox, SM; Johnston, SA, 1997) |
| "Dexketoprofen trometamol is a water-soluble salt of the dextrorotatory enantiomer of the nonsteroidal anti-inflammatory drug (NSAID) ketoprofen." | 2.39 | Preclinical and clinical development of dexketoprofen. ( Artigas, R; Carganico, G; García, ML; Mauleón, D, 1996) |
| " This results in an increase in the rate of absorption of the active compound and, consequently, in an earlier onset of analgesic action." | 2.38 | Piroxicam-beta-cyclodextrin in the treatment of acute pain of rheumatic disease. ( Franchimont, P; Reginster, JY, 1993) |
| "Ketoprofen is clinically used to treat osteoporotic pain, while long-term oral administration of ketoprofen can cause some side effects." | 1.62 | An Mg-MOFs based multifunctional medicine for the treatment of osteoporotic pain. ( Ge, Y; Li, H; Lin, Y; Lin, Z; Tang, B; Tian, Y; Wang, K; Wang, Y; Wu, Y; Zhang, J, 2021) |
| "Mechanical allodynia, heat hyperalgesia, biased weight-bearing, and hindpaw thickness were assessed 0." | 1.62 | Antinociception produced by nonsteroidal anti-inflammatory drugs in female vs male rats. ( Britch, SC; Craft, RM; Hewitt, KA, 2021) |
| "Pain is a significant public health problem, and assessment of pain-related impairment of behavior is a key clinical indicator and treatment target." | 1.51 | Effects of monoamine uptake inhibitors on pain-related depression of nesting in mice. ( Alexander, KS; Miller, LL; Patton, TB; Rodriguez, TR; Sarfo, AN, 2019) |
| "There is a strong correlation between treatment resistant depression and increase in inflammatory cytokines in plasma and cerebrospinal fluid." | 1.48 | Population scale retrospective analysis reveals distinctive antidepressant and anxiolytic effects of diclofenac, ketoprofen and naproxen in patients with pain. ( Abagyan, R; Cohen, IV; Lee, KC; Makunts, T, 2018) |
| "Acute and chronic pain have an important socio-economical impact." | 1.46 | A "novel" association to treat pain: tramadol/dexketoprofen. The first drug of a "new pharmacological class". ( Allegri, M; Fanelli, G; Fornasari, D; Gerboni, S, 2017) |
| "With a suspected diagnosis of dystonia, biperiden lactate 5 mg/ml was administered via the intramuscular route and the contractions abated within 30 seconds of the injection." | 1.42 | Acute dystonic reaction due to dexketoprofen trometamol. ( Giray, TA; Kavalci, C; Kayipmaz, AE; Kocalar, UG; Tasci, SS, 2015) |
| "Pain is often associated with depression of behavior and mood, and relief of pain-related depression is a common goal of treatment." | 1.40 | Pain-related depression of the mesolimbic dopamine system in rats: expression, blockade by analgesics, and role of endogenous κ-opioids. ( Banks, ML; Bowers, MS; Carlezon, WA; Cheng, K; Leitl, MD; Negus, SS; Onvani, S; Rice, KC, 2014) |
| " Dose-response curves for DEX and TRM, individually and combined in a 1 : 1 proportion based on their potency were obtained, and the doses that produced a 50% inhibition calculated." | 1.38 | Antinociceptive and anti-exudative synergism between dexketoprofen and tramadol in a model of inflammatory pain in mice. ( Miranda, HF; Puig, MM; Romero, MA, 2012) |
| "We evaluated the modulatory role of the groundwater contaminant arsenic on the pharmacodynamic responses of the nonsteroidal analgesic-antipyretic drug ketoprofen and the major pro-inflammatory mediators linked to the mechanism of ketoprofen's therapeutic effects." | 1.38 | Subacute arsenic exposure through drinking water reduces the pharmacodynamic effects of ketoprofen in male rats. ( Ahmad, W; Chanderashekara, HH; Prawez, S; Sankar, P; Sarkar, SN; Tandan, SK, 2012) |
| "Ketoprofen treatment significantly reduced the rectal temperature and total clinical scores, and lowered blood thromboxane B(2) concentrations when compared with the control group." | 1.38 | Dose-response investigation of oral ketoprofen in pigs challenged with Escherichia coli endotoxin. ( Banting, A; Heinonen, M; Mustonen, K; Peltoniemi, OA; Raekallio, M; Vainio, O, 2012) |
| "Ankle sprains mainly caused by accidents or strenuous sport activities can often be quite painful and impair motility." | 1.35 | Management of uncomplicated ankle sprains with topical or oral ketoprofen treatment. A registry study. ( Belcaro, G; Cacchio, M; Cesarone, MR; Di Renzo, A; Dugall, M; Errichi, BM; Errichi, S; Fano, F; Gizzi, G; Grossi, MG; Ippolito, E; Ricci, A; Ruffini, I; Stuard, S; Vinciguerra, G, 2008) |
| "Analgesics are required to prevent and treat postpartum pain, but breast-feeding may be contraindicated, because data on milk transfer are very limited." | 1.34 | Excretion of ketoprofen and nalbuphine in human milk during treatment of maternal pain after delivery. ( Boissinot, C; Jacqz-Aigrain, E; Michel, J; Popon, M; Serreau, R; Sibony, O; Sobel, A, 2007) |
| "Muscle hyperalgesia (post-operative decrease in threshold with respect to pre-stone implantation) was significantly reduced in extent and duration in ketoprofen with respect to saline-injected animals but no difference was found between the pre- and post-operative treatment." | 1.31 | Pre-emptive analgesia in rats with artificial ureteric calculosis. Effects on visceral pain behavior in the post-operative period. ( Affaitati, G; Giamberardino, MA; Lerza, R; Vecchiet, L, 2000) |
| " These data suggest that ketoprofen at the dosage rate of 1." | 1.29 | Effects of ketoprofen and phenylbutazone on chronic hoof pain and lameness in the horse. ( Kamerling, SG; Keowen, ML; Owens, JG; Stanton, SR, 1995) |
| "Ketoprofen was found to be significantly effective in all cases of non calcific rotator cuff tendinitis while no improvement was noted in calcific tendinitis." | 1.28 | [Ketoprofen efficacy and tolerance in simple painful shoulder]. ( Amanda Dal Pra, ML; Battisti, E; Cataldi, V; Cecconami, L; Franci, A; Gelli, R; Giordano, N; Marcolongo, R; Marcucci, P; Stuart, R, 1992) |
| " In 6 patients the "therapeutic follow-up test" allowed to decrease dosage to one tablet a day." | 1.27 | [Long-term study of 150 mg. Bi-Profenid in patients followed at the Department of Rheumatology of Cochin Hospital]. ( Amor, B; Dougados, M; Harrewyn, JM, 1983) |
| " The mean (+/- SD) values of clinical parameters were as follows: distribution half-life = 0." | 1.27 | Clinical pharmacokinetics of ketoprofen after single intravenous administration as a bolus or infusion. ( Albessard, F; Debruyne, D; Hurault de Ligny, B; Moulin, M; Ryckelynck, JP, 1987) |
Research
Studies (168)
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 35 (20.83) | 18.7374 |
| 1990's | 25 (14.88) | 18.2507 |
| 2000's | 41 (24.40) | 29.6817 |
| 2010's | 54 (32.14) | 24.3611 |
| 2020's | 13 (7.74) | 2.80 |
Authors
| Authors | Studies |
|---|---|
| Bonacorso, HG | 1 |
| Rosa, WC | 1 |
| Oliveira, SM | 1 |
| Brusco, I | 1 |
| Brum, ES | 1 |
| Rodrigues, MB | 1 |
| Frizzo, CP | 1 |
| Zanatta, N | 1 |
| Chłoń-Rzepa, G | 1 |
| Ślusarczyk, M | 1 |
| Jankowska, A | 1 |
| Gawalska, A | 1 |
| Bucki, A | 1 |
| Kołaczkowski, M | 1 |
| Świerczek, A | 1 |
| Pociecha, K | 1 |
| Wyska, E | 1 |
| Zygmunt, M | 1 |
| Kazek, G | 1 |
| Sałat, K | 1 |
| Pawłowski, M | 1 |
| Bua, S | 1 |
| Lucarini, L | 1 |
| Micheli, L | 1 |
| Menicatti, M | 1 |
| Bartolucci, G | 1 |
| Selleri, S | 1 |
| Di Cesare Mannelli, L | 1 |
| Ghelardini, C | 1 |
| Masini, E | 1 |
| Carta, F | 1 |
| Gratteri, P | 1 |
| Nocentini, A | 1 |
| Supuran, CT | 1 |
| Yakushin, S | 1 |
| Polyakova, S | 1 |
| Shvarts, Y | 1 |
| Kastanayan, A | 1 |
| Krechikova, D | 1 |
| Ershova, O | 1 |
| Nikulenkova, N | 1 |
| Vinogradova, I | 1 |
| Hyun, BJ | 1 |
| Cha, JE | 1 |
| Ge, Y | 1 |
| Wang, K | 1 |
| Li, H | 1 |
| Tian, Y | 1 |
| Wu, Y | 1 |
| Lin, Z | 1 |
| Lin, Y | 1 |
| Wang, Y | 1 |
| Zhang, J | 1 |
| Tang, B | 1 |
| Nixon, E | 2 |
| Carlson, AR | 1 |
| Routh, PA | 1 |
| Hernandez, L | 1 |
| Almond, GW | 1 |
| Baynes, RE | 2 |
| Messenger, KM | 2 |
| Meunier, V | 1 |
| Mares, O | 1 |
| Gricourt, Y | 1 |
| Simon, N | 1 |
| Kouyoumdjian, P | 1 |
| Cuvillon, P | 1 |
| Chittenden, JT | 1 |
| Ziesenitz, VC | 1 |
| Welzel, T | 1 |
| van Dyk, M | 1 |
| Saur, P | 1 |
| Gorenflo, M | 1 |
| van den Anker, JN | 1 |
| Bueno-Serrano, G | 1 |
| Alcoba-García, MP | 1 |
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| Lobo, S | 1 |
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| Miranda, HF | 7 |
| Noriega, V | 1 |
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| Poblete, P | 1 |
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| Prieto, JC | 4 |
| Araujo, MAR | 1 |
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| Hewitt, KA | 1 |
| Britch, SC | 1 |
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| Negus, SS | 5 |
| Cimen, U | 1 |
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| Cimen, YK | 1 |
| Seyit, M | 1 |
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| Erdur, B | 1 |
| Turkcuer, I | 1 |
| Oncel, G | 1 |
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| Kokki, H | 3 |
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| Kokki, M | 2 |
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| Mauleón, D | 2 |
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Clinical Trials (10)
Trial Overview
| Trial | Phase | Enrollment | Study Type | Start Date | Status | ||
|---|---|---|---|---|---|---|---|
| Opioid Induced Bowel Dysfunction in Patients Undergoing Spinal Surgery[NCT02573922] | Phase 4 | 180 participants (Actual) | Interventional | 2012-05-31 | Completed | ||
| A Randomised, Double-blind, Placebo Controlled Study of Topical FLEXISEQ® for the Treatment of Osteoarthritis of the Knee in Patients Contraindicated for or With Clinical Intolerance to NSAIDs[NCT02594176] | 600 participants (Anticipated) | Interventional | 2015-10-31 | Recruiting | |||
| Multicenter, Randomized, Double-blind, Placebo- and Active-controlled Study of Safety and Efficacy of Two Dosages of Epicutaneously Applied Diractin® (Ketoprofen in Transfersome® Gel) for the Treatment of Osteoarthritis of the Knee[NCT00716547] | Phase 3 | 1,399 participants (Actual) | Interventional | 2008-05-31 | Completed | ||
| Multicentre, Randomized, Double-blind, Placebo-controlled Study of Safety and Efficacy of Epicutaneously Applied Diractin® (Ketoprofen in Transfersome® Gel) for the Treatment of Osteoarthritis of the Knee[NCT00722852] | Phase 3 | 555 participants (Actual) | Interventional | 2008-06-30 | Completed | ||
| The Effect of Intracervical Lidocaine Versus Intramuscular Diclofenac for Pain Relief During Hysterosalpingography Among Infertile Women In A Tertiary Hospital In Kano: A Randomized Controlled Trial[NCT02918812] | Phase 4 | 140 participants (Anticipated) | Interventional | 2016-09-30 | Recruiting | ||
| [NCT01947205] | 111 participants (Actual) | Interventional | 2012-11-30 | Completed | |||
| Safety and Efficacy of Sonohysterosalpingography for the Evaluation of Infertility[NCT03234569] | 27 participants (Actual) | Interventional | 2018-01-31 | Completed | |||
| [NCT01993589] | 144 participants (Actual) | Interventional | 2012-11-30 | Completed | |||
| Analgesic Efficacy of Preoperative Oral Administration of Dexketoprofen Trometamol in Third Molar Surgery, Compared to Postoperative Administration[NCT02380001] | Phase 4 | 60 participants (Actual) | Interventional | 2015-01-31 | Completed | ||
| Double-blind Randomized Clinical Study on Topical Diclofenac Efficacy in Symptomatic Relief of Temporomandibular Degenerative Joint Disease in Women.[NCT00471393] | 28 participants (Actual) | Interventional | 2006-05-31 | Completed | |||
| [information is prepared from clinicaltrials.gov, extracted Sep-2024] | |||||||
Reviews
11 reviews available for ketoprofen and Pain
| Article | Year |
|---|---|
Efficacy and Safety of NSAIDs in Infants: A Comprehensive Review of the Literature of the Past 20 Years.
Topics: Adolescent; Anti-Inflammatory Agents; Anti-Inflammatory Agents, Non-Steroidal; Aspirin; Celecoxib; C | 2022 |
Drug-free gel containing ultra-deformable phospholipid vesicles (TDT 064) as topical therapy for the treatment of pain associated with osteoarthritis: a review of clinical efficacy and safety.
Topics: Administration, Topical; Anti-Inflammatory Agents, Non-Steroidal; Gels; Humans; Ketoprofen; Lipid Bi | 2014 |
Systematic review of dexketoprofen in acute and chronic pain.
Topics: Acute Disease; Anti-Inflammatory Agents, Non-Steroidal; Chronic Disease; Dose-Response Relationship, | 2008 |
Dexketoprofen trometamol: clinical evidence supporting its role as a painkiller.
Topics: Animals; Anti-Inflammatory Agents, Non-Steroidal; Clinical Trials as Topic; Humans; Ketoprofen; Pain | 2008 |
Topical NSAIDs for acute pain: a meta-analysis.
Topics: Acute Disease; Administration, Topical; Adult; Anti-Inflammatory Agents, Non-Steroidal; Double-Blind | 2004 |
The welfare significance of the castration of cattle: a review.
Topics: Anesthetics, Local; Animal Welfare; Animals; Anti-Inflammatory Agents, Non-Steroidal; Cattle; Hydroc | 2005 |
Topical ketoprofen patch.
Topics: Administration, Cutaneous; Anti-Inflammatory Agents, Non-Steroidal; Humans; Ketoprofen; Pain | 2005 |
Piroxicam-beta-cyclodextrin in the treatment of acute pain of rheumatic disease.
Topics: Acute Disease; Adult; beta-Cyclodextrins; Controlled Clinical Trials as Topic; Cyclodextrins; Diclof | 1993 |
Preclinical and clinical development of dexketoprofen.
Topics: Analgesia; Animals; Anti-Inflammatory Agents, Non-Steroidal; Benzoquinones; Cyclooxygenase Inhibitor | 1996 |
Use of carprofen for the treatment of pain and inflammation in dogs.
Topics: Acetaminophen; Analgesics, Non-Narcotic; Animals; Anti-Inflammatory Agents, Non-Steroidal; Aspirin; | 1997 |
Analgesic efficacy of ketoprofen in postpartum, general surgery, and chronic cancer pain.
Topics: Female; Humans; Ketoprofen; Neoplasms; Pain; Pain, Postoperative; Phenylpropionates; Postpartum Peri | 1988 |
Trials
76 trials available for ketoprofen and Pain
| Article | Year |
|---|---|
Comparison of the Efficacy and Safety of Ketoprofen Plaster and Diclofenac Plaster for Osteoarthritis-Related Knee Pain: A Multicenter, Randomized, Active-Controlled, Open-Label, Parallel-Group, Phase III Clinical Trial.
Topics: Adult; Anti-Inflammatory Agents, Non-Steroidal; Diclofenac; Double-Blind Method; Humans; Ketoprofen; | 2021 |
Value of Music and Nitrous Oxide for Pain Control during Extracorporeal Shock Wave Lithotripsy (ESWL).
Topics: Analgesics; Fentanyl; Humans; Ketoprofen; Lithiasis; Lithotripsy; Midazolam; Music; Nitrous Oxide; P | 2022 |
Comparative evaluation of intravenous dexketoprofen and paracetamol in the management of pain induced by sore throat.
Topics: Acetaminophen; Anti-Inflammatory Agents, Non-Steroidal; Double-Blind Method; Humans; Ketoprofen; Pai | 2021 |
Intravenous Dexketoprofen versus Intravenous Paracetamol for Dysmenorrhea: A Randomized Controlled Trial
Topics: Acetaminophen; Anti-Inflammatory Agents, Non-Steroidal; Double-Blind Method; Dysmenorrhea; Female; H | 2018 |
Life satisfaction and pain interference in spine surgery patients before and after surgery: comparison between on-opioid and opioid-naïve patients.
Topics: Acetaminophen; Adult; Aged; Analgesics, Opioid; Drug Combinations; Elective Surgical Procedures; Fem | 2018 |
[Evaluation of protocols on the use of analgesics for pain management in patients with extracorporeal shock wave lithotripsy (ESWL)].
Topics: Adult; Aged; Aged, 80 and over; Analgesics; Anesthetics, Local; Anti-Inflammatory Agents, Non-Steroi | 2019 |
A multicentre, randomized, placebo- and active-controlled trial comparing the efficacy and safety of topical ketoprofen in Transfersome gel (IDEA-033) with ketoprofen-free vehicle (TDT 064) and oral celecoxib for knee pain associated with osteoarthritis.
Topics: Administration, Oral; Administration, Topical; Adult; Aged; Aged, 80 and over; Anti-Inflammatory Age | 2013 |
A multicentre, randomized, placebo- and active-controlled trial comparing the efficacy and safety of topical ketoprofen in Transfersome gel (IDEA-033) with ketoprofen-free vehicle (TDT 064) and oral celecoxib for knee pain associated with osteoarthritis.
Topics: Administration, Oral; Administration, Topical; Adult; Aged; Aged, 80 and over; Anti-Inflammatory Age | 2013 |
A multicentre, randomized, placebo- and active-controlled trial comparing the efficacy and safety of topical ketoprofen in Transfersome gel (IDEA-033) with ketoprofen-free vehicle (TDT 064) and oral celecoxib for knee pain associated with osteoarthritis.
Topics: Administration, Oral; Administration, Topical; Adult; Aged; Aged, 80 and over; Anti-Inflammatory Age | 2013 |
A multicentre, randomized, placebo- and active-controlled trial comparing the efficacy and safety of topical ketoprofen in Transfersome gel (IDEA-033) with ketoprofen-free vehicle (TDT 064) and oral celecoxib for knee pain associated with osteoarthritis.
Topics: Administration, Oral; Administration, Topical; Adult; Aged; Aged, 80 and over; Anti-Inflammatory Age | 2013 |
A randomized, double-blind, phase III trial in moderate osteoarthritis knee pain comparing topical ketoprofen gel with ketoprofen-free gel.
Topics: Administration, Cutaneous; Aged; Anti-Inflammatory Agents, Non-Steroidal; Double-Blind Method; Femal | 2013 |
A randomized, double-blind, phase III trial in moderate osteoarthritis knee pain comparing topical ketoprofen gel with ketoprofen-free gel.
Topics: Administration, Cutaneous; Aged; Anti-Inflammatory Agents, Non-Steroidal; Double-Blind Method; Femal | 2013 |
A randomized, double-blind, phase III trial in moderate osteoarthritis knee pain comparing topical ketoprofen gel with ketoprofen-free gel.
Topics: Administration, Cutaneous; Aged; Anti-Inflammatory Agents, Non-Steroidal; Double-Blind Method; Femal | 2013 |
A randomized, double-blind, phase III trial in moderate osteoarthritis knee pain comparing topical ketoprofen gel with ketoprofen-free gel.
Topics: Administration, Cutaneous; Aged; Anti-Inflammatory Agents, Non-Steroidal; Double-Blind Method; Femal | 2013 |
Comparison of randomized preemptive dexketoprofen trometamol or placebo tablets to prevent withdrawal movement caused by rocuronium injection.
Topics: Adult; Aged; Aged, 80 and over; Androstanols; Anti-Inflammatory Agents, Non-Steroidal; Elective Surg | 2014 |
Paracetamol vs dexketoprofen for perineal pain relief after episiotomy or perineal tear.
Topics: Acetaminophen; Adult; Analgesics, Non-Narcotic; Anti-Inflammatory Agents, Non-Steroidal; Double-Blin | 2014 |
Can the addition of a paracervical block to systemic or local analgesics improve the pain perceived by the patient during hysterosalpingography?
Topics: Adolescent; Adult; Anesthesia, Local; Anesthesia, Obstetrical; Anesthetics, Local; Double-Blind Meth | 2014 |
Effect of paracetamol, dexketoprofen trometamol, lidocaine spray, and paracervical block application for pain relief during suction termination of first-trimester pregnancy.
Topics: Abortion, Induced; Acetaminophen; Administration, Intravenous; Administration, Oral; Adult; Anesthes | 2013 |
Effects of castration method and frequency of intramuscular injections of ketoprofen on behavioral and physiological indicators of pain in beef cattle.
Topics: Animals; Anti-Inflammatory Agents, Non-Steroidal; Behavior, Animal; Cattle; Cattle Diseases; Drug Ad | 2014 |
Factors influencing the severity of pain during hysterosalpingography.
Topics: Adult; Analgesics; Anti-Inflammatory Agents, Non-Steroidal; Dipyrone; Fallopian Tubes; Female; Human | 2015 |
Intravenous dexketoprofen induces less injection pain than racemic ketoprofen.
Topics: Adult; Aged; Aged, 80 and over; Anti-Inflammatory Agents, Non-Steroidal; Cross-Over Studies; Double- | 2015 |
Randomised trial of the bioavailability and efficacy of orally administered flunixin, carprofen and ketoprofen in a pain model in sheep.
Topics: Administration, Oral; Animals; Anti-Inflammatory Agents, Non-Steroidal; Biological Availability; Car | 2015 |
Effect of paracetamol, dexketoprofen trometamol, lidocaine spray, pethidine & diclofenac sodium application for pain relief during fractional curettage: A randomized controlled trial.
Topics: Acetaminophen; Adult; Aged; Analgesia; Curettage; Diclofenac; Female; Gynecologic Surgical Procedure | 2015 |
The effect of benzocaine and ketoprofen gels on pain during fixed orthodontic appliance treatment: a randomised, double-blind, crossover trial.
Topics: Adolescent; Adult; Anesthetics, Local; Anti-Inflammatory Agents, Non-Steroidal; Benzocaine; Cross-Ov | 2016 |
A multiple-dose, open-label, safety, compliance, and usage evaluation study of epicutaneously applied Diractin (ketoprofen in Transfersome) in joint/musculoskeletal pain or soft tissue inflammation.
Topics: Administration, Cutaneous; Aged; Anti-Inflammatory Agents, Non-Steroidal; Arthralgia; Drug Carriers; | 2009 |
A randomized, controlled clinical trial of ketoprofen for sickle-cell disease vaso-occlusive crises in adults.
Topics: Analgesics, Opioid; Anemia, Sickle Cell; Cyclooxygenase Inhibitors; Double-Blind Method; Female; Hos | 2009 |
Efficacy and safety of ketoprofen patch in patients with rheumatoid arthritis: a randomized, double-blind, placebo-controlled study.
Topics: Administration, Cutaneous; Anti-Inflammatory Agents, Non-Steroidal; Arthritis, Rheumatoid; Double-Bl | 2010 |
Comparison of the analgesic effects of dexketoprofen and diclofenac during shockwave lithotripsy: a randomized, double-blind clinical trial.
Topics: Adult; Aged; Analgesics; Diclofenac; Double-Blind Method; Humans; Ketoprofen; Lithotripsy; Male; Mid | 2010 |
Comparison of oral nonsteroidal analgesic and intrauterine local anesthetic for pain relief in uterine fractional curettage: a randomized, double-blind, placebo-controlled trial.
Topics: Administration, Intravaginal; Administration, Oral; Adult; Anesthesia, Local; Anesthesia, Obstetrica | 2010 |
Evaluation of orally administered robenacoxib versus ketoprofen for treatment of acute pain and inflammation associated with musculoskeletal disorders in cats.
Topics: Alanine Transaminase; Alkaline Phosphatase; Animals; Appetite; Aspartate Aminotransferases; Behavior | 2010 |
Ketoprofen in piglets: enantioselective pharmacokinetics, pharmacodynamics and PK/PD modelling.
Topics: Animals; Anti-Inflammatory Agents, Non-Steroidal; Body Temperature; Female; Fever; Inflammation; Kao | 2011 |
Oral ketoprofen is effective in the treatment of non-infectious lameness in sows.
Topics: Administration, Oral; Animals; Anti-Inflammatory Agents, Non-Steroidal; Double-Blind Method; Female; | 2011 |
Clinical evaluation of meloxicam versus ketoprofen in cats suffering from painful acute locomotor disorders.
Topics: Administration, Oral; Animals; Anti-Inflammatory Agents, Non-Steroidal; Cat Diseases; Cats; Female; | 2011 |
A randomized, double-blind, placebo-controlled trial of paracetamol and ketoprofren lysine salt for pain control in children with pharyngotonsillitis cared by family pediatricians.
Topics: Acetaminophen; Acute Disease; Administration, Oral; Ambulatory Care; Analgesics, Non-Narcotic; Anti- | 2011 |
Comparison of two doses of ketoprofen to treat pain: a double-blind, randomized, noninferiority trial.
Topics: Adult; Analgesics; Anti-Inflammatory Agents, Non-Steroidal; Double-Blind Method; Female; Humans; Ket | 2014 |
Effects of local anaesthesia or local anaesthesia plus a non-steroidal anti-inflammatory drug on the acute cortisol response of calves to five different methods of castration.
Topics: Anesthetics, Local; Animals; Anti-Inflammatory Agents, Non-Steroidal; Body Weight; Cattle; Hydrocort | 2002 |
Double-blind evaluation of short-term analgesic efficacy of orally administered dexketoprofen trometamol and ketorolac in bone cancer pain.
Topics: Administration, Oral; Adult; Aged; Aged, 80 and over; Analgesics; Anti-Inflammatory Agents, Non-Ster | 2003 |
Efficacy of transdermal ketoprofen for delayed onset muscle soreness.
Topics: Administration, Cutaneous; Adolescent; Adult; Anti-Inflammatory Agents, Non-Steroidal; Double-Blind | 2003 |
Randomised controlled trial of the onset of analgesic efficacy of dexketoprofen and diclofenac in lower limb injury.
Topics: Acute Disease; Administration, Oral; Adult; Analgesics; Diclofenac; Double-Blind Method; Female; Hum | 2003 |
Effects of non-steroidal anti-inflammatory drugs on pain-related behaviour in a model of articular pain in the domestic fowl.
Topics: Animals; Anti-Inflammatory Agents, Non-Steroidal; Carbazoles; Chickens; Clonixin; Dose-Response Rela | 2005 |
Topical ketoprofen patch (100 mg) for the treatment of ankle sprain: a randomized, double-blind, placebo-controlled study.
Topics: Administration, Topical; Adolescent; Adult; Aged; Ankle Injuries; Anti-Inflammatory Agents, Non-Ster | 2005 |
Paravertebral block with ropivacaine 0.5% versus systemic analgesia for pain relief after thoracotomy.
Topics: Acetaminophen; Adult; Aged; Amides; Analgesia, Patient-Controlled; Analgesics, Opioid; Anesthetics, | 2005 |
Topical ketoprofen patch in the treatment of tendinitis: a randomized, double blind, placebo controlled study.
Topics: Administration, Topical; Adult; Anti-Inflammatory Agents, Non-Steroidal; Female; Humans; Ketoprofen; | 2005 |
Involvement of opioidergic and alpha2-adrenergic mechanisms in the central analgesic effects of non-steroidal anti-inflammatory drugs in sheep.
Topics: Adrenergic alpha-Antagonists; Animals; Anti-Inflammatory Agents, Non-Steroidal; Dose-Response Relati | 2006 |
Topical ketoprofen TDS patch versus diclofenac gel: efficacy and tolerability in benign sport related soft-tissue injuries.
Topics: Administration, Topical; Adolescent; Adult; Anti-Inflammatory Agents, Non-Steroidal; Athletic Injuri | 2007 |
[Double-blind comparative study of Bi-Profenid tablets and Profenid capsules in inflammatory rheumatism].
Topics: Adolescent; Adult; Aged; Arthritis, Rheumatoid; Capsules; Child; Clinical Trials as Topic; Delayed-A | 1983 |
[Bi-Profenid in rheumatologic practice].
Topics: Adult; Aged; Clinical Trials as Topic; Delayed-Action Preparations; Female; Humans; Ketoprofen; Male | 1983 |
[Comparative double-blind study of ketoprofen slow-release tablets and indomethacin in coxarthrosis and gonarthrosis].
Topics: Aged; Clinical Trials as Topic; Delayed-Action Preparations; Double-Blind Method; Female; Hip Joint; | 1983 |
[Comparative double-blind study of Bi-Profenid and oxyphenbutazone in sports pathology].
Topics: Adolescent; Adult; Ankle Injuries; Athletic Injuries; Clinical Trials as Topic; Double-Blind Method; | 1983 |
Injectable ketoprofen vs. acetylsalicylic acid for the relief of severe cancer pain: a double-blind, crossover trial.
Topics: Adult; Aged; Aspirin; Clinical Trials as Topic; Double-Blind Method; Female; Humans; Injections, Int | 1984 |
[Controlled clinical experiment with the topical use of 2-(3-benzoyl-phenyl) propionic acid at 3 different concentrations].
Topics: Administration, Topical; Adolescent; Adult; Aged; Child; Clinical Trials as Topic; Dose-Response Rel | 1980 |
Tolerability of nimesulide and ketoprofen in paediatric patients with traumatic or surgical fractures.
Topics: Adolescent; Anti-Inflammatory Agents, Non-Steroidal; Child; Female; Fractures, Bone; Humans; Ketopro | 1993 |
Dosing time optimizes sustained-release ketoprofen treatment of osteoarthritis.
Topics: Adult; Chronobiology Phenomena; Delayed-Action Preparations; Double-Blind Method; Drug Administratio | 1994 |
A double-blind comparison of oral ketoprofen 'controlled release' and indomethacin suppository in the treatment of rheumatoid arthritis with special regard to morning stiffness and pain on awakening.
Topics: Administration, Rectal; Adult; Aged; Ambulatory Care; Arthritis, Rheumatoid; Central Nervous System | 1993 |
[Analgesic effect of sodium meclofenamate on several painful symptoms].
Topics: Analgesia; Double-Blind Method; Humans; Ketoprofen; Meclofenamic Acid; Pain; Pain Measurement; Time | 1993 |
Ketoprofen 2.5% gel versus placebo gel in the treatment of acute soft tissue injuries.
Topics: Administration, Topical; Double-Blind Method; Female; Gels; Humans; Ketoprofen; Male; Pain; Pain Thr | 1993 |
Aceclofenac in comparison to ketoprofen in the treatment of rheumatoid arthritis.
Topics: Adolescent; Adult; Aged; Anti-Inflammatory Agents, Non-Steroidal; Arthritis, Rheumatoid; Diclofenac; | 1995 |
Tonic versus phasic pain: dose-related effects of ketoprofen.
Topics: Adult; Anti-Inflammatory Agents, Non-Steroidal; Carbon Dioxide; Cross-Over Studies; Dose-Response Re | 1995 |
Topical analgesics for knee arthrosis: a parallel study of ketoprofen gel and diclofenac emulgel.
Topics: Anti-Inflammatory Agents, Non-Steroidal; Arthritis; Chi-Square Distribution; Diclofenac; Female; Gel | 1997 |
Effect of balanced analgesia with buprenorphine on pain response and general anaesthesia requirement during lithotripsy procedures.
Topics: Acetaminophen; Adolescent; Adult; Aged; Aged, 80 and over; Analgesics, Non-Narcotic; Analgesics, Opi | 1998 |
Effect of ketoprofen on muscle function and sEMG activity after eccentric exercise.
Topics: Adult; Anti-Inflammatory Agents, Non-Steroidal; Electromyography; Exercise; Female; Humans; Ketoprof | 2001 |
Analgesic profile of peroral and topical ketoprofen upon low pH-induced muscle pain.
Topics: Administration, Oral; Administration, Topical; Adult; Analgesics; Buffers; Double-Blind Method; Fema | 2001 |
Evaluation of the clinical efficacy of meloxicam in cats with painful locomotor disorders.
Topics: Administration, Oral; Animals; Anti-Inflammatory Agents, Non-Steroidal; Cat Diseases; Cats; Female; | 2001 |
Evaluation of analgesic action and efficacy of antirheumatic drugs. Study of 10 drugs in 684 patients with rheumatoid arthritis.
Topics: Acetaminophen; Anti-Inflammatory Agents, Non-Steroidal; Arthritis, Rheumatoid; Aspirin; Clinical Tri | 1976 |
Parenteral administration of ketoprofen in osteoarthritis: a double-blind trial versus the N-methyl-d-glucamine salt of indomethacin.
Topics: Clinical Trials as Topic; Double-Blind Method; Drug Evaluation; Female; Gait; Humans; Indomethacin; | 1979 |
Four new anti-inflammatory drugs: responses and variations.
Topics: Anti-Inflammatory Agents; Arthritis, Rheumatoid; Clinical Trials as Topic; Fenoprofen; Gastrointesti | 1976 |
A double-blind trial of ketoprofen in the treatment of osteoarthritis of the hip.
Topics: Analgesics; Benzophenones; Clinical Trials as Topic; Digestive System; Drug Evaluation; Female; Hip | 1976 |
Results of the rectal administration of ketoprofen in fifty-two patients.
Topics: Adult; Aged; Anti-Inflammatory Agents; Arthritis; Arthritis, Rheumatoid; Benzophenones; Clinical Tri | 1976 |
[A double blind clinical trial of ketoprofen in rectal presentation in the treatment of painful shoulder (author's transl)].
Topics: Adult; Aged; Clinical Trials as Topic; Double-Blind Method; Female; Humans; Ketoprofen; Male; Middle | 1976 |
[Clinical evaluation of pain. Value of a 2-dimensional index of pain].
Topics: Arthritis, Rheumatoid; Clinical Trials as Topic; Humans; Ketoprofen; Pain; Phenylpropionates | 1989 |
Central analgesic effect of ketoprofen in humans: electrophysiological evidence for a supraspinal mechanism in a double-blind and cross-over study.
Topics: Adult; Analgesics; Brain; Double-Blind Method; Female; Humans; Ketoprofen; Male; Pain; Paraplegia; P | 1989 |
Ketoprofen vs etofenamate in a controlled double-blind study: evidence of topical effectiveness in soft tissue rheumatic pain.
Topics: Adult; Aged; Aged, 80 and over; Anti-Inflammatory Agents, Non-Steroidal; Clinical Trials as Topic; D | 1988 |
Ketoprofen versus indomethacin in patients with acute gouty arthritis: a multicenter, double blind comparative study.
Topics: Administration, Oral; Adult; Aged; Aged, 80 and over; Arthritis, Gouty; Clinical Trials as Topic; Do | 1988 |
Ketoprofen, ibuprofen, and placebo in the treatment of primary dysmenorrhea: a double-blind crossover comparison.
Topics: Adult; Clinical Trials as Topic; Double-Blind Method; Dysmenorrhea; Female; Humans; Ibuprofen; Ketop | 1988 |
A double-blind parallel evaluation of the efficacy and safety of a single dose of ketoprofen in cancer pain.
Topics: Adult; Aged; Aged, 80 and over; Clinical Trials as Topic; Double-Blind Method; Female; Humans; Ketop | 1988 |
Analgesic efficacy of ketoprofen in postpartum, general surgery, and chronic cancer pain.
Topics: Female; Humans; Ketoprofen; Neoplasms; Pain; Pain, Postoperative; Phenylpropionates; Postpartum Peri | 1988 |
Double-blind comparison of ketoprofen and mefenamic acid in the treatment of primary dysmenorrhea.
Topics: Adolescent; Adult; Clinical Trials as Topic; Double-Blind Method; Dysmenorrhea; Female; Humans; Keto | 1986 |
Double-blind comparison of ketoprofen and placebo in the treatment of sprains and strains.
Topics: Acetaminophen; Adolescent; Adult; Cryotherapy; Double-Blind Method; Female; Humans; Immobilization; | 1986 |
Double-blind preference and compliance multicentre study in osteoarthritis: once-a-day treatment.
Topics: Adult; Aged; Aspirin; Clinical Trials as Topic; Diclofenac; Double-Blind Method; Drug Administration | 1985 |
Correlation between ketoprofen plasma levels and analgesic effect in acute lumbar pain and radicular pain.
Topics: Acute Disease; Analgesia; Brachial Plexus Neuritis; Clinical Trials as Topic; Female; Humans; Ketopr | 1985 |
Successful treatment of biliary colic with intravenous ketoprofen or lysine acetylsalicylate.
Topics: Adult; Aged; Analgesics; Aspirin; Biliary Tract Diseases; Clinical Trials as Topic; Colic; Double-Bl | 1985 |
Administration of ketoprofen suppositories for out-patient post-operative analgesia.
Topics: Adenofibroma; Adolescent; Adult; Ambulatory Care; Breast Neoplasms; Double-Blind Method; Female; Hum | 1985 |
Other Studies
82 other studies available for ketoprofen and Pain
| Article | Year |
|---|---|
Synthesis of novel trifluoromethyl-substituted spiro-[chromeno[4,3-d]pyrimidine-5,1'-cycloalkanes], and evaluation of their analgesic effects in a mouse pain model.
Topics: Animals; Anti-Inflammatory Agents, Non-Steroidal; Arthritis; Benzopyrans; Capsaicin; Heterocyclic Co | 2017 |
Novel amide derivatives of 1,3-dimethyl-2,6-dioxopurin-7-yl-alkylcarboxylic acids as multifunctional TRPA1 antagonists and PDE4/7 inhibitors: A new approach for the treatment of pain.
Topics: Amides; Analgesics; Animals; Cyclic Nucleotide Phosphodiesterases, Type 4; Cyclic Nucleotide Phospho | 2018 |
Bioisosteric Development of Multitarget Nonsteroidal Anti-Inflammatory Drug-Carbonic Anhydrases Inhibitor Hybrids for the Management of Rheumatoid Arthritis.
Topics: Animals; Anti-Inflammatory Agents, Non-Steroidal; Arthritis, Rheumatoid; Carbonic Anhydrase Inhibito | 2020 |
An Mg-MOFs based multifunctional medicine for the treatment of osteoporotic pain.
Topics: Anti-Inflammatory Agents, Non-Steroidal; Drug Liberation; Humans; Ketoprofen; Pain; Pharmaceutical P | 2021 |
Comparative effects of nonsteroidal anti-inflammatory drugs at castration and tail-docking in neonatal piglets.
Topics: Animal Husbandry; Animals; Animals, Newborn; Anti-Inflammatory Agents, Non-Steroidal; Castration; Cl | 2021 |
Patient satisfaction after distal upper limb surgery under WALANT versus axillary block: A propensity-matched comparative cohort study.
Topics: Acetaminophen; Analgesics; Analgesics, Opioid; Cohort Studies; Humans; Ketoprofen; Pain; Patient Sat | 2022 |
Pharmacokinetic/pharmacodynamic modeling of ketoprofen and flunixin at piglet castration and tail-docking.
Topics: Animals; Anti-Inflammatory Agents, Non-Steroidal; Clonixin; Dinoprostone; Hydrocortisone; Ketoprofen | 2022 |
Evaluation iontophoretic delivery of a cationic ketoprofen prodrug for treating nociceptive symptoms in monosodium iodoacetate induced osteoarthritic rat model.
Topics: Animals; Anti-Inflammatory Agents, Non-Steroidal; Disease Models, Animal; Female; Iodoacetates; Iont | 2019 |
Nitric Oxide and Opioids Involvement in Isobolographic Nsaids Antinociception.
Topics: Acetaminophen; Analgesics, Opioid; Animals; Anti-Inflammatory Agents, Non-Steroidal; Cyclooxygenase | 2019 |
Ketoprofen hypersensibility and idiosyncratic response - a case report.
Topics: Adult; Anti-Inflammatory Agents, Non-Steroidal; Drug Hypersensitivity; Humans; Hypersensitivity, Imm | 2020 |
[The chemoreactomic analysis of the central mechanisms of action of non-steroidal anti-inflammatory drugs].
Topics: Anti-Inflammatory Agents, Non-Steroidal; Diclofenac; Humans; Ketoprofen; Opiate Alkaloids; Pain; Pir | 2020 |
Antinociception produced by nonsteroidal anti-inflammatory drugs in female vs male rats.
Topics: Analgesics; Animals; Anti-Inflammatory Agents, Non-Steroidal; Celecoxib; Disease Models, Animal; Dos | 2021 |
Behavioral Battery for Testing Candidate Analgesics in Mice. I. Validation with Positive and Negative Controls.
Topics: Amphetamine; Analgesics; Animals; Behavior, Animal; Diazepam; Drug Evaluation, Preclinical; False Ne | 2021 |
A "novel" association to treat pain: tramadol/dexketoprofen. The first drug of a "new pharmacological class".
Topics: Analgesics, Opioid; Anti-Inflammatory Agents, Non-Steroidal; Drug Combinations; Humans; Ketoprofen; | 2017 |
Effectiveness of a novel boswellic acids delivery form (Casperome®) in the management of grade II ankle sprains due to sport trauma - a registry study.
Topics: Adult; Ankle Injuries; Drug Carriers; Female; Hematoma; Humans; Ketoprofen; Male; Pain; Pilot Projec | 2017 |
Population scale retrospective analysis reveals distinctive antidepressant and anxiolytic effects of diclofenac, ketoprofen and naproxen in patients with pain.
Topics: Anti-Anxiety Agents; Anti-Inflammatory Agents, Non-Steroidal; Antidepressive Agents; Anxiety; Cohort | 2018 |
What place is there for tramadol/dexketoprofen?
Topics: Analgesics; Analgesics, Opioid; Anti-Inflammatory Agents, Non-Steroidal; Drug Combinations; Humans; | 2018 |
Effects of monoamine uptake inhibitors on pain-related depression of nesting in mice.
Topics: Analgesics, Opioid; Animals; Behavior, Animal; Bupropion; Citalopram; Conditioning, Operant; Dopamin | 2019 |
Use of validated objective methods of locomotion characteristics and weight distribution for evaluating the efficacy of ketoprofen for alleviating pain in cows with limb pathologies.
Topics: Analysis of Variance; Animals; Cattle; Cattle Diseases; Disease Management; Extremities; Gait; Ketop | 2019 |
Novel ketoprofen-antioxidants mutual codrugs as safer nonsteroidal anti-inflammatory drugs: Synthesis, kinetic and pharmacological evaluation.
Topics: Analgesics; Animals; Anti-Inflammatory Agents, Non-Steroidal; Anti-Ulcer Agents; Antioxidants; Biphe | 2019 |
Pain-related depression of the mesolimbic dopamine system in rats: expression, blockade by analgesics, and role of endogenous κ-opioids.
Topics: Analgesics, Opioid; Animals; Benzeneacetamides; Depression; Disease Models, Animal; Dopamine; Gene E | 2014 |
Comparison of the effects of dexketoprofen trometamol, meloxicam and diclofenac sodium on fibular fracture healing, kidney and liver: an experimental rat model.
Topics: Animals; Anti-Inflammatory Agents, Non-Steroidal; Biomechanical Phenomena; Diclofenac; Fibula; Fract | 2014 |
Effects of ketoprofen, morphine, and kappa opioids on pain-related depression of nesting in mice.
Topics: Analgesics, Opioid; Analysis of Variance; Animals; Anti-Inflammatory Agents, Non-Steroidal; Benzenea | 2015 |
Acute dystonic reaction due to dexketoprofen trometamol.
Topics: Anti-Inflammatory Agents, Non-Steroidal; Dystonia; Humans; Ketoprofen; Male; Pain; Tromethamine; You | 2015 |
Pomegranate seed oil nanoemulsions improve the photostability and in vivo antinociceptive effect of a non-steroidal anti-inflammatory drug.
Topics: Abdomen; Acetic Acid; Analgesics; Animals; Anti-Inflammatory Agents, Non-Steroidal; Constriction, Pa | 2016 |
Topical Ketoprofen Versus Placebo in Treatment of Acute Ankle Sprain in the Emergency Department.
Topics: Ankle Injuries; Anti-Inflammatory Agents, Non-Steroidal; Double-Blind Method; Emergency Service, Hos | 2016 |
Pain alleviation during castration of piglets: a comparative study of different farm options.
Topics: Anesthesia, Local; Animal Husbandry; Animals; Anti-Inflammatory Agents, Non-Steroidal; Behavior, Ani | 2016 |
Efficacy of oral and parenteral ketoprofen in lactating cows with endotoxin-induced acute mastitis.
Topics: Administration, Oral; Animals; Anti-Inflammatory Agents, Non-Steroidal; Body Temperature; Cattle; En | 2008 |
Prevention of N-methyl-D-aspartate-induced mechanical nociception by intrathecal administration of ketoprofen and ketamine in sheep.
Topics: Animals; Anti-Inflammatory Agents, Non-Steroidal; Female; Injections, Spinal; Ketamine; Ketoprofen; | 2008 |
Effects of tramadol and dexketoprofen on analgesia and gastrointestinal transit in mice.
Topics: Analgesics, Opioid; Animals; Anti-Inflammatory Agents, Non-Steroidal; Charcoal; Disease Models, Anim | 2009 |
The effect of opioid antagonists on synergism between dexketoprofen and tramadol.
Topics: Analgesics; Animals; Drug Synergism; Ketoprofen; Male; Mice; Narcotic Antagonists; Pain; Tramadol | 2009 |
Management of uncomplicated ankle sprains with topical or oral ketoprofen treatment. A registry study.
Topics: Administration, Cutaneous; Administration, Oral; Adult; Ankle Injuries; Anti-Inflammatory Agents, No | 2008 |
Postmarketing cohort study to assess the safety profile of oral dexketoprofen trometamol for mild to moderate acute pain treatment in primary care.
Topics: Acute Disease; Adult; Anti-Inflammatory Agents, Non-Steroidal; Cohort Studies; Female; Humans; Ketop | 2009 |
Ketoprofen absorption by muscle and tendon after topical or oral administration in patients undergoing anterior cruciate ligament reconstruction.
Topics: Absorption; Administration, Cutaneous; Administration, Oral; Administration, Topical; Adolescent; Ad | 2010 |
Long-term continuous subcutaneous infusion of ketoprofen combined with morphine: a safe and effective approach to cancer pain.
Topics: Aged; Anti-Inflammatory Agents, Non-Steroidal; Dose-Response Relationship, Drug; Drug Therapy, Combi | 2010 |
Nonsteroidal anti-inflammatory drug-associated renal papillary necrosis in a white-tailed deer (Odocoileus virginianus).
Topics: Animals; Anti-Inflammatory Agents, Non-Steroidal; Connective Tissue; Deer; Fatal Outcome; Female; Ho | 2010 |
Anti-inflammatory and analgesic effects of ketoprofen in palm oil esters nanoemulsion.
Topics: Analgesics; Animals; Anti-Inflammatory Agents, Non-Steroidal; Carrageenan; Edema; Emulsions; Esters; | 2010 |
Antinociceptive and anti-exudative synergism between dexketoprofen and tramadol in a model of inflammatory pain in mice.
Topics: Analgesics, Opioid; Animals; Anti-Inflammatory Agents, Non-Steroidal; Disease Models, Animal; Drug C | 2012 |
Effects of peripherally restricted κ opioid receptor agonists on pain-related stimulation and depression of behavior in rats.
Topics: Animals; Behavior, Animal; Cocaine; Diterpenes, Clerodane; Flupenthixol; Ketoprofen; Male; Oligopept | 2012 |
Subacute arsenic exposure through drinking water reduces the pharmacodynamic effects of ketoprofen in male rats.
Topics: Administration, Oral; Animals; Anti-Inflammatory Agents, Non-Steroidal; Arsenites; Carrageenan; Cycl | 2012 |
Dose-response investigation of oral ketoprofen in pigs challenged with Escherichia coli endotoxin.
Topics: Administration, Oral; Animals; Anti-Inflammatory Agents, Non-Steroidal; Dose-Response Relationship, | 2012 |
Ketoprofen-liposomes formulation for clinical therapy.
Topics: Animals; Anti-Inflammatory Agents, Non-Steroidal; Ketoprofen; Liposomes; Mice; Pain | 2012 |
Dissociable effects of the cannabinoid receptor agonists Δ9-tetrahydrocannabinol and CP55940 on pain-stimulated versus pain-depressed behavior in rats.
Topics: Analgesics; Animals; Anti-Inflammatory Agents, Non-Steroidal; Behavior, Animal; Brain; Cannabinoid R | 2012 |
Local tolerability and effectiveness of Ketospray® 10% cutaneous spray solution.
Topics: Administration, Topical; Adolescent; Adult; Aged; Aged, 80 and over; Anti-Inflammatory Agents, Non-S | 2012 |
Pain intensity after laseruvulopalatoplasty and tonsillectomy.
Topics: Adult; Analgesics, Opioid; Anti-Inflammatory Agents, Non-Steroidal; Female; Fentanyl; Follow-Up Stud | 2003 |
Antinociceptive synergy, additivity, and subadditivity with combinations of oral glucosamine plus nonopioid analgesics in mice.
Topics: Acetaminophen; Administration, Oral; Analgesics, Non-Narcotic; Animals; Anti-Inflammatory Agents, No | 2003 |
Analgesic effects of intra-nasal enkephalins.
Topics: Acetic Acid; Administration, Intranasal; Analgesics; Animals; Dicarboxylic Acids; Drug Synergism; Ed | 2003 |
Ketoprofen gel as an adjunct to physical therapist management of a child with Sever disease.
Topics: Administration, Topical; Anti-Inflammatory Agents, Non-Steroidal; Calcaneus; Child; Combined Modalit | 2006 |
Depression of NMDA-receptor-mediated segmental transmission by ketamine and ketoprofen, but not L-NAME, on the in vitro neonatal rat spinal cord preparation.
Topics: Afferent Pathways; Animals; Animals, Newborn; Cyclooxygenase Inhibitors; Dose-Response Relationship, | 2006 |
Dexketoprofen-induced antinociception in animal models of acute pain: synergy with morphine and paracetamol.
Topics: Acetaminophen; Acute Disease; Analgesics; Analysis of Variance; Animals; Anti-Inflammatory Agents, N | 2007 |
Isobolographic analysis of multimodal analgesia in an animal model of visceral acute pain.
Topics: Acetaminophen; Acute Disease; Adrenergic alpha-Antagonists; Analgesics; Analgesics, Non-Narcotic; An | 2008 |
Excretion of ketoprofen and nalbuphine in human milk during treatment of maternal pain after delivery.
Topics: Adult; Analgesics, Opioid; Anti-Inflammatory Agents, Non-Steroidal; Female; Humans; Ketoprofen; Milk | 2007 |
Analgesic effect of percutaneously absorbed non-steroidal anti-inflammatory drugs: an experimental study in a rat acute inflammation model.
Topics: Acute Disease; Administration, Topical; Animals; Anti-Inflammatory Agents, Non-Steroidal; Contusions | 2008 |
Mouse model of fracture pain.
Topics: Animals; Disease Models, Animal; Fractures, Bone; Hot Temperature; Ketoprofen; Male; Mice; Mice, Inb | 2008 |
Nefopam and ketoprofen synergy in rodent models of antinociception.
Topics: Acetic Acid; Analgesics, Non-Narcotic; Animals; Anti-Inflammatory Agents, Non-Steroidal; Behavior, A | 2008 |
[Clinical study of Bi-Profenid in rheumatologic practice].
Topics: Adult; Aged; Arthritis, Rheumatoid; Delayed-Action Preparations; Female; Humans; Ketoprofen; Male; M | 1983 |
[Long-term study of 150 mg. Bi-Profenid in patients followed at the Department of Rheumatology of Cochin Hospital].
Topics: Adult; Aged; Delayed-Action Preparations; Female; Humans; Ketoprofen; Male; Middle Aged; Pain; Pheny | 1983 |
[Ketoprofen in cervicofacial oncology].
Topics: Head and Neck Neoplasms; Humans; Injections, Intramuscular; Ketoprofen; Pain; Phenylpropionates; Sup | 1980 |
[Controlled study of the analgesic action of Profenid in severe pain].
Topics: Adult; Aged; Analgesics; Double-Blind Method; Drug Evaluation; Female; Humans; Ketoprofen; Male; Mid | 1983 |
Effect of etodolac on prostaglandin E2 biosynthesis, active oxygen generation and bradykinin formation.
Topics: Animals; Aspirin; Bradykinin; Bromelains; Cartilage, Articular; Cell Line; Concanavalin A; Depressio | 1994 |
Ketoprofen in Pain. Proceedings of Actron International Experts Meeting. Interlaken, Switzerland, 20-23 March 1994.
Topics: Humans; Ketoprofen; Pain | 1994 |
Effects of ketoprofen and phenylbutazone on chronic hoof pain and lameness in the horse.
Topics: Analgesia; Animals; Anti-Inflammatory Agents, Non-Steroidal; Chronic Disease; Female; Foot Diseases; | 1995 |
Ketoprofen and carotico-cavernous fistula.
Topics: Adult; Arteriovenous Fistula; Carotid Artery Injuries; Cavernous Sinus; Cyclooxygenase Inhibitors; H | 1997 |
Assessing pain in animals.
Topics: Analgesics, Opioid; Animals; Anti-Inflammatory Agents, Non-Steroidal; Butorphanol; Dog Diseases; Dog | 1997 |
The NSAID dexketoprofen trometamol is as potent as mu-opioids in the depression of wind-up and spinal cord nociceptive reflexes in normal rats.
Topics: Animals; Anti-Inflammatory Agents, Non-Steroidal; Blood-Brain Barrier; Depression, Chemical; Electri | 1999 |
Antinociceptive effects of S(+)-ketoprofen and other analgesic drugs in a rat model of pain induced by uric acid.
Topics: Administration, Oral; Analgesics, Non-Narcotic; Analgesics, Opioid; Animals; Biotransformation; Dise | 1998 |
Limiting sensitivity after quadrant scaling and root planing.
Topics: Anesthesia, Dental; Anti-Inflammatory Agents, Non-Steroidal; Dental Scaling; Fluorides, Topical; Hum | 2000 |
Pre-emptive analgesia in rats with artificial ureteric calculosis. Effects on visceral pain behavior in the post-operative period.
Topics: Analgesia; Analgesics; Analgesics, Opioid; Animals; Behavior, Animal; Electric Stimulation; Female; | 2000 |
Neostigmine interactions with non steroidal anti-inflammatory drugs.
Topics: Animals; Anti-Inflammatory Agents, Non-Steroidal; Cholinesterase Inhibitors; Diclofenac; Disease Mod | 2002 |
Assessment of the analgesic effects of ketoprofen in ducks anesthetized with isoflurane.
Topics: Anesthetics, Inhalation; Animals; Anti-Inflammatory Agents, Non-Steroidal; Cross-Over Studies; Ducks | 2002 |
Some pharmacological and toxicological studies on ketoprofen.
Topics: Analgesics; Animals; Anti-Inflammatory Agents; Aspirin; Benzophenones; Fever; Guinea Pigs; Indometha | 1976 |
Pure enantiomers of 2-arylpropionic acids: tools in pain research and improved drugs in rheumatology.
Topics: Animals; Humans; Ibuprofen; Ketoprofen; Pain; Propionates; Research; Rheumatic Diseases; Stereoisome | 1992 |
[Ketoprofen efficacy and tolerance in simple painful shoulder].
Topics: Adult; Aged; Drug Evaluation; Drug Tolerance; Female; Humans; Ketoprofen; Male; Middle Aged; Pain; P | 1992 |
[Evaluation of the analgesic activity of a new ketoprofen-sucralfate combination].
Topics: Adolescent; Adult; Aged; Analgesics; Drug Combinations; Female; Humans; Ketoprofen; Male; Middle Age | 1991 |
Ketoprofen in the treatment of scleritis.
Topics: Female; Humans; Ketoprofen; Male; Middle Aged; Pain; Scleritis | 1991 |
Ketoprofen: i.c.v. injection and electrophysiological aspects of antinociceptive effect.
Topics: Animals; Arthritis, Experimental; Brain; Electrodes; Evoked Potentials; Injections, Intraventricular | 1990 |
Anatomical mapping of brain sites involved in the antinociceptive effects of ketoprofen.
Topics: Animals; Brain Mapping; Ketoprofen; Male; Motor Activity; Pain; Rats; Rats, Inbred Strains; Reaction | 1990 |
[Ketoprofen lysine treatment of painful manifestations of spinal osteoarthrosis].
Topics: Adult; Aged; Anti-Inflammatory Agents, Non-Steroidal; Drug Evaluation; Female; Humans; Ketoprofen; L | 1988 |
Ketoprofen: a new nonsteroidal anti-inflammatory analgesic.
Topics: Anti-Inflammatory Agents, Non-Steroidal; Humans; Ketoprofen; Pain; Phenylpropionates; United States; | 1988 |
Ketoprofen (Orudis): U.S. and European experience in arthritis and pain.
Topics: Arthritis; Humans; Ketoprofen; Pain; Phenylpropionates | 1988 |
Clinical pharmacokinetics of ketoprofen after single intravenous administration as a bolus or infusion.
Topics: Adult; Colic; Female; Humans; Infusions, Intravenous; Injections, Intravenous; Ketoprofen; Kidney Di | 1987 |
Diclofenac in the treatment of painful joints and traumatic tendinitis (including strains and sprains): a brief review.
Topics: Diclofenac; Flufenamic Acid; Humans; Ibuprofen; Indomethacin; Joint Diseases; Ketoprofen; Naproxen; | 1985 |