Page last updated: 2024-12-08
dioclein
Description
Research Excerpts
Clinical Trials
Roles
Classes
Pathways
Study Profile
Bioassays
Related Drugs
Related Conditions
Protein Interactions
Research Growth
Market Indicators
Description
dioclein: isolated from the plant Dioclea grandiflora [Medical Subject Headings (MeSH), National Library of Medicine, extracted Dec-2023]
Related Flora
Flora | Rank | Flora Definition | Family | Family Definition |
---|---|---|---|---|
Dioclea | genus | A plant genus of the family FABACEAE. Members contain MANNOSE-BINDING LECTINS and dioclein.[MeSH] | Fabaceae | The large family of plants characterized by pods. Some are edible and some cause LATHYRISM or FAVISM and other forms of poisoning. Other species yield useful materials like gums from ACACIA and various LECTINS like PHYTOHEMAGGLUTININS from PHASEOLUS. Many of them harbor NITROGEN FIXATION bacteria on their roots. Many but not all species of beans belong to this family.[MeSH] |
Cross-References
ID Source | ID |
---|---|
PubMed CID | 178055 |
SCHEMBL ID | 782044 |
MeSH ID | M0249605 |
Synonyms (10)
Synonym |
---|
5,2',5'-trihydroxy-6,7-dimethoxyflavanone |
dioclein |
LMPK12140604 |
(2s)-2-(2,5-dihydroxyphenyl)-5-hydroxy-6,7-dimethoxy-2,3-dihydrochromen-4-one |
161748-44-3 |
4h-1-benzopyran-4-one, 2-(2,5-dihydroxyphenyl)-2,3-dihydro-5-hydroxy-6,7-dimethoxy-, (s)- |
SCHEMBL782044 |
c17h16o7 |
2-(2,5-dihydroxyphenyl)-5-hydroxy-6,7-dimethoxy-2,3-dihydro-4h-1-benzopyran-4-one |
DTXSID00936592 |
Research Excerpts
Overview
Dioclein is a flavonoid reported to have many beneficial effects on the cardiovascular system such as vasorelaxant, hypotensive, antioxidant and antiarrythmogenic activities.
Excerpt | Reference | Relevance |
---|---|---|
"Dioclein is a flavonoid reported to have many beneficial effects on the cardiovascular system such as vasorelaxant, hypotensive, antioxidant and antiarrythmogenic activities. " | ( Complexation with beta-cyclodextrin confers oral activity on the flavonoid dioclein. Cortes, SF; De Sousa, FB; Lemos, VS; Lula, IS; Rezende, BA; Schmitt, M; Sinisterra, RD, 2009) | 2.03 |
Bioavailability
Excerpt | Reference | Relevance |
---|---|---|
" In conclusion, our results show that the new complex prepared by inclusion of dioclein in beta-CD improves the hypotensive effect of the flavonoid by increasing its bioavailability and enables dioclein to be effective after oral administration." | ( Complexation with beta-cyclodextrin confers oral activity on the flavonoid dioclein. Cortes, SF; De Sousa, FB; Lemos, VS; Lula, IS; Rezende, BA; Schmitt, M; Sinisterra, RD, 2009) | 0.81 |
[information is derived through text-mining from research data collected from National Library of Medicine (NLM), extracted Dec-2023]
Research
Studies (10)
Timeframe | Studies, This Drug (%) | All Drugs % |
---|---|---|
pre-1990 | 0 (0.00) | 18.7374 |
1990's | 2 (20.00) | 18.2507 |
2000's | 6 (60.00) | 29.6817 |
2010's | 2 (20.00) | 24.3611 |
2020's | 0 (0.00) | 2.80 |
[information is prepared from research data collected from National Library of Medicine (NLM), extracted Dec-2023] |
Market Indicators
Research Demand Index: 17.25
According to the monthly volume, diversity, and competition of internet searches for this compound, as well the volume and growth of publications, there is estimated to be moderate demand-to-supply ratio for research on this compound.
| This Compound (17.25) All Compounds (24.57) |
Study Types
Publication Type | This drug (%) | All Drugs (%) |
---|---|---|
Trials | 0 (0.00%) | 5.53% |
Reviews | 0 (0.00%) | 6.00% |
Case Studies | 0 (0.00%) | 4.05% |
Observational | 0 (0.00%) | 0.25% |
Other | 10 (100.00%) | 84.16% |
[information is prepared from research data collected from National Library of Medicine (NLM), extracted Dec-2023] |