noroxymorphone

Description

noroxymorphone: an opioid for spinal analgesia; structure in first source [MeSH]

Noroxymorphone : no description available [CHeBI]

Cross-References

ID Source	ID
PubMed CID	5497189
SCHEMBL ID	136548
CHEBI ID	187724
MeSH ID	M0518445

Synonyms (28)

Synonym
morphinan-6-one, 4,5alpha-epoxy-3,14-dihydroxy- (8ci)
morphinan-6-one, 4,5-epoxy-3,14-dihydroxy-, (5alpha)- (9ci)
en 3169
7,8-dihydro-14-hydroxynormorphinone
morphinan-6-one, 4,5-epoxy-3,14-dihydroxy-, (5alpha)-
33522-95-1
14-hydroxydihydronormorphinone
(5alpha)-4,5-epoxy-3,14-dihydroxymorphinan-6-one
(5.alpha.)-4,5-epoxy-3,14-dihydroxymorphinan-6-one
nor oxymorphone
CHEBI:187724
(4r,4as,7ar,12bs)-4a,9-dihydroxy-1,2,3,4,5,6,7a,13-octahydro-4,12-methanobenzouro[3,2-e]isoquinolin-7-one
noroxymorphone
einecs 251-561-5
unii-9nz7111a9o
9nz7111a9o ,
SCHEMBL136548
en-3169
noroxymorphone [usp impurity]
noroxymorphone [who-dd]
naloxone hydrochloride dihydrate impurity a [ep impurity]
(-)-noroxymorphone
morphinan-6-one, 4,5-epoxy-3,14-dihydroxy-, (5.alpha.)-
HLMSIZPQBSYUNL-IPOQPSJVSA-N
4,5alpha-epoxy-3,14-dihydroxy morphinan-6-one
Q25102255
DTXSID80955145
(4R,4AS,7AR,12BS)-4A,9-DIHYDROXY-2,3,4,4A,5,6-HEXAHYDRO-1H-4,12-METHANOBENZOFURO[3,2-E]ISOQUINOLIN-7(7AH)-ONE

Drug Classes (1)

Class	Description
phenanthrenes	Any benzenoid aromatic compound that consists of a phenanthrene skeleton and its substituted derivatives thereof.

Research

Studies (22)

Timeframe	Studies, This Drug (%)	All Drugs %
pre-1990	2 (9.09)	18.7374
1990's	0 (0.00)	18.2507
2000's	5 (22.73)	29.6817
2010's	14 (63.64)	24.3611
2020's	1 (4.55)	2.80

Study Types

Publication Type	This drug (%)	All Drugs (%)
Trials	3 (12.50%)	5.53%
Reviews	0 (0.00%)	6.00%
Case Studies	1 (4.17%)	4.05%
Observational	0 (0.00%)	0.25%
Other	20 (83.33%)	84.16%

Substance	Classes	Roles	Relationship Strength
phenanthrene	ortho-fused polycyclic arene; ortho-fused tricyclic hydrocarbon; phenanthrenes	environmental contaminant; mouse metabolite	low
benzanthrone	phenanthrenes		low
9,10-phenanthrenequinone	phenanthrenes		low
dibenzo(aj)anthracene	phenanthrenes		low
7-hydroxymethyl-12-methylbenz(a)anthracene	phenanthrenes		low
1-methylphenanthrene	phenanthrenes	mutagen	low
dibenzo(a,e)fluoranthene	phenanthrenes		low
7-nitrobenzanthracene	phenanthrenes		low
halofantrine	phenanthrenes		low
3-nitroperylene	phenanthrenes		low
1-(2-phenanthrenyl)ethanone	phenanthrenes		low
benz(j)aceanthrylene	phenanthrenes		low
benz(l)aceanthrylene	phenanthrenes		low
norbuprenorphine	phenanthrenes		low
chrysene-1,4-dione	phenanthrenes		low
Hircinol	phenanthrenes		low
nitrobenzanthrone	phenanthrenes		low
7-benzylidenenaltrexone	phenanthrenes		low
methylnaltrexone	phenanthrenes		low
6 beta-hydroxynaltrexone	phenanthrenes		low
noroxycodone	phenanthrenes		low
(4R,4aS,7aR)-3-(cyclopropylmethyl)-4a,9-dihydroxy-2,4,5,6,7a,13-hexahydro-1H-4,12-methanobenzofuro[3,2-e]isoquinoline-7-one	phenanthrenes		low
trk 820	phenanthrenes		low
osu 03012	antibiotic antifungal drug; aromatic amide; glycine derivative; organofluorine compound; phenanthrenes; pyrazoles	antineoplastic agent; apoptosis inducer; EC 2.7.11.1 (non-specific serine/threonine protein kinase) inhibitor	low

Substance	Studies	Classes	Roles	First Year	Last Year	Average Age	Relationship Strength	Trials	pre-1990	2000's	2010's
acetic acid	1	monocarboxylic acid	antimicrobial food preservative; Daphnia magna metabolite; food acidity regulator; protic solvent	2008	2008	16.0	low	0	0	1	0
cyclopropane	1	cycloalkane; cyclopropanes	inhalation anaesthetic	2008	2008	16.0	low	0	0	1	0
oxazoles	1	1,3-oxazoles; mancude organic heteromonocyclic parent; monocyclic heteroarene		2016	2016	8.0	low	0	0	0	1
palladium	1	metal allergen; nickel group element atom; platinum group metal atom		2016	2016	8.0	low	0	0	0	1
atropine	1			1964	1964	60.0	low	0	1	0	0
oxazolidine	1	oxazolidine		2016	2016	8.0	low	0	0	0	1
buprenorphine	2	morphinane alkaloid	delta-opioid receptor antagonist; kappa-opioid receptor antagonist; mu-opioid receptor agonist; opioid analgesic	2009	2009	15.0	low	0	0	2	0
nadp	1			2020	2020	4.0	low	0	0	0	1
naloxone	4	morphinane alkaloid; organic heteropentacyclic compound; tertiary alcohol	antidote to opioid poisoning; central nervous system depressant; mu-opioid receptor antagonist	2008	2019	12.8	low	1	0	3	1
oxycodone	14	organic heteropentacyclic compound; semisynthetic derivative	antitussive; mu-opioid receptor agonist; opioid analgesic	2008	2020	10.4	medium	3	0	3	11
oxymorphone	13	morphinane alkaloid		1964	2020	14.0	medium	2	1	2	10
morphine	1	morphinane alkaloid; organic heteropentacyclic compound; tertiary amino compound	anaesthetic; drug allergen; environmental contaminant; geroprotector; mu-opioid receptor agonist; opioid analgesic; plant metabolite; vasodilator agent; xenobiotic	2015	2015	9.0	low	0	0	0	1
naltrexone	2	cyclopropanes; morphinane-like compound; organic heteropentacyclic compound	antidote to opioid poisoning; central nervous system depressant; environmental contaminant; mu-opioid receptor antagonist; xenobiotic	2008	2015	12.5	low	0	0	1	1
noroxycodone	10	phenanthrenes		2008	2020	9.8	high	3	0	2	8
morphinans	22	isoquinoline alkaloid fundamental parent; morphinane alkaloid		1963	2020	15.4	high	3	2	6	14

Condition	Studies	First Year	Last Year	Average Age	Relationship Strength	Trials	2000's	2010's
Ache	1	2014	2014	10.0	low	0	0	1
Acute Post-operative Pain	1	2011	2011	13.0	low	1	0	1
Benign Neoplasms	1	2012	2012	12.0	low	0	0	1
Chronic Disease	1	2017	2017	7.0	low	0	0	1
Chronic Illness	1	2017	2017	7.0	low	0	0	1
Chronic Kidney Failure	2	2017	2019	6.0	medium	1	0	2
Chronic Pain	2	2012	2017	9.5	medium	0	0	2
Kidney Failure, Chronic	2	2017	2019	6.0	medium	1	0	2
Neoplasms	1	2012	2012	12.0	low	0	0	1
Pain	1	2014	2014	10.0	low	0	0	1
Pain, Chronic	2	2012	2017	9.5	medium	0	0	2
Pain, Postoperative	1	2011	2011	13.0	low	1	0	1
Sensitivity and Specificity	1	2010	2010	14.0	low	0	1	0

Pharmacokinetics (4)

Article	Year
Pharmacokinetics of oxycodone/naloxone and its metabolites in patients with end-stage renal disease during and between haemodialysis sessions. Nephrology, dialysis, transplantation : official publication of the European Dialysis and Transplant Association - European Renal Association, , 04-01, Volume: 34, Issue:4	2019
Maturation of oxycodone pharmacokinetics in neonates and infants: Oxycodone and its metabolites in plasma and urine. British journal of clinical pharmacology, , Volume: 83, Issue:4	2017
Pharmacokinetics of oxycodone hydrochloride and three of its metabolites after intravenous administration in Chinese patients with pain. Pharmacological reports : PR, , Volume: 66, Issue:1	2014
Elimination of intravenous oxycodone in the elderly: a pharmacokinetic study in postoperative orthopaedic patients of different age groups. Drugs & aging, , Jan-01, Volume: 28, Issue:1	2011

Dosage (1)

Article	Year
Pharmacokinetics of oxycodone/naloxone and its metabolites in patients with end-stage renal disease during and between haemodialysis sessions. Nephrology, dialysis, transplantation : official publication of the European Dialysis and Transplant Association - European Renal Association, , 04-01, Volume: 34, Issue:4	2019

noroxymorphone

Description

Cross-References

Synonyms (28)

Drug Classes (1)

Research

Studies (22)

Study Types

Related Drugs (38)

Drugs in this Class (24)

Drugs Researched Together (15)

Related Conditions (13)

Pharmacokinetics (4)

Dosage (1)