1h-(1,2,4)oxadiazolo(4,3-a)quinoxalin-1-one has been researched along with Pain in 16 studies
1H-(1,2,4)oxadiazolo(4,3-a)quinoxalin-1-one: structure given in first source; inhibits guanylyl cyclase
1H-[1,2,4]oxadiazolo[4,3-a]quinoxalin-1-one : A member of the class of oxadiazoloquinoxalines that is 1H-[1,2,4]oxadiazolo[4,3-a]quinoxaline substituted at position 1 by an oxo group.
Pain: An unpleasant sensation induced by noxious stimuli which are detected by NERVE ENDINGS of NOCICEPTIVE NEURONS.
| Excerpt | Relevance | Reference |
|---|---|---|
| "Zaprinast is a phosphodiesterase inhibitor that is active in various models of pain when administered locally." | 3.73 | Lack of the nitric oxide-cyclic GMP-potassium channel pathway for the antinociceptive effect of intrathecal zaprinast in a rat formalin test. ( Bae, HB; Choi, JI; Chung, SS; Chung, ST; Jeong, CY; Jeong, SW; Kim, CM; Kim, SJ; Yoo, KY; Yoon, MH, 2005) |
| " This pharmacodynamic phenomenon is referred to in the present work as "teleantagonism"." | 1.35 | Teleantagonism: A pharmacodynamic property of the primary nociceptive neuron. ( Cunha, FQ; Duarte, DB; Ferrari, LF; Ferreira, SH; Funez, MI; Lorenzetti, BB; Parada, CA; Sachs, D, 2008) |
| "Pinacidil activity was not blocked by L-NAME, D-NAME, 7-nitroindazole, ODQ, KT-5823 or okadaic acid." | 1.33 | The nitric oxide-cyclic GMP-protein kinase G-K+ channel pathway participates in the antiallodynic effect of spinal gabapentin. ( Flores-Murrieta, FJ; Granados-Soto, V; Mixcoatl-Zecuatl, T, 2006) |
| "L-NMA was also able to reverse that hyperalgesia." | 1.30 | Nitric oxide signaling in pain and nociceptor sensitization in the rat. ( Aley, KO; Levine, JD; McCarter, G, 1998) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 2 (12.50) | 18.2507 |
| 2000's | 13 (81.25) | 29.6817 |
| 2010's | 1 (6.25) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Funez, MI | 1 |
| Ferrari, LF | 1 |
| Duarte, DB | 1 |
| Sachs, D | 2 |
| Cunha, FQ | 2 |
| Lorenzetti, BB | 1 |
| Parada, CA | 2 |
| Ferreira, SH | 2 |
| Clemente-Napimoga, JT | 1 |
| Pellegrini-da-Silva, A | 1 |
| Ferreira, VH | 1 |
| Napimoga, MH | 1 |
| Tambeli, CH | 1 |
| Romero, TR | 1 |
| Galdino, GS | 1 |
| Silva, GC | 1 |
| Resende, LC | 1 |
| Perez, AC | 1 |
| Côrtes, SF | 1 |
| Duarte, ID | 1 |
| Déciga-Campos, M | 1 |
| López-Muñoz, FJ | 1 |
| Ambriz-Tututi, M | 1 |
| Velázquez-Zamora, DA | 1 |
| Urquiza-Marín, H | 1 |
| Granados-Soto, V | 7 |
| Lozano-Cuenca, J | 1 |
| Castañeda-Hernández, G | 1 |
| Kamei, J | 1 |
| Tamura, N | 1 |
| Saitoh, A | 1 |
| Torres-López, JE | 2 |
| Yoon, MH | 1 |
| Choi, JI | 1 |
| Bae, HB | 1 |
| Jeong, SW | 1 |
| Chung, SS | 1 |
| Yoo, KY | 1 |
| Jeong, CY | 1 |
| Kim, SJ | 1 |
| Chung, ST | 1 |
| Kim, CM | 1 |
| Araiza-Saldaña, CI | 1 |
| Reyes-García, G | 1 |
| Bermúdez-Ocaña, DY | 1 |
| Pérez-Severiano, F | 1 |
| Mixcoatl-Zecuatl, T | 1 |
| Flores-Murrieta, FJ | 1 |
| Brito, GA | 1 |
| Vale, ML | 1 |
| Lotufo, CM | 1 |
| Ribeiro, RA | 1 |
| Aley, KO | 1 |
| McCarter, G | 1 |
| Levine, JD | 1 |
| Kawamata, T | 1 |
| Omote, K | 1 |
| Aguirre-Bañuelos, P | 1 |
| Lázaro-Ibáñez, GG | 1 |
16 other studies available for 1h-(1,2,4)oxadiazolo(4,3-a)quinoxalin-1-one and Pain
| Article | Year |
|---|---|
Teleantagonism: A pharmacodynamic property of the primary nociceptive neuron.
Topics: Analgesics, Opioid; Animals; Anti-Inflammatory Agents, Non-Steroidal; Dinoprostone; Dopamine; Drug I | 2008 |
Gonadal hormones decrease temporomandibular joint kappa-mediated antinociception through a down-regulation in the expression of kappa opioid receptors in the trigeminal ganglia.
Topics: Analgesics; Animals; Arginine; Cyclic GMP; Down-Regulation; Female; Gonadal Hormones; Humans; Male; | 2009 |
Ketamine activates the L-arginine/Nitric oxide/cyclic guanosine monophosphate pathway to induce peripheral antinociception in rats.
Topics: Analgesia; Anesthetics, Dissociative; Animals; Arginine; Cyclic AMP; Dinoprostone; Drug Synergism; E | 2011 |
Participation of the NO-cyclic GMP pathway in rofecoxib-induced antinociception.
Topics: Animals; Anti-Inflammatory Agents, Non-Steroidal; Arginine; Cyclic GMP; Cyclooxygenase 2; Cyclooxyge | 2003 |
Analysis of the mechanism underlying the peripheral antinociceptive action of sildenafil in the formalin test.
Topics: Analgesics; Animals; Apamin; Charybdotoxin; Cyclic GMP-Dependent Protein Kinases; Dose-Response Rela | 2005 |
Peripheral and spinal mechanisms of antinociceptive action of lumiracoxib.
Topics: Analgesics; Animals; Apamin; Behavior, Animal; Charybdotoxin; Diclofenac; Dose-Response Relationship | 2005 |
Possible involvement of the spinal nitric oxide/cGMP pathway in vincristine-induced painful neuropathy in mice.
Topics: Analysis of Variance; Animals; Arginine; Blotting, Western; Cyclic GMP; Dose-Response Relationship, | 2005 |
Peripheral participation of the phosphodiesterase 3 on formalin-evoked nociception.
Topics: 3',5'-Cyclic-AMP Phosphodiesterases; Animals; Cyclic Nucleotide Phosphodiesterases, Type 3; Dose-Res | 2005 |
Lack of the nitric oxide-cyclic GMP-potassium channel pathway for the antinociceptive effect of intrathecal zaprinast in a rat formalin test.
Topics: 3',5'-Cyclic-GMP Phosphodiesterases; Analgesics; Animals; Cyclic GMP; Formaldehyde; Glyburide; Injec | 2005 |
Effect of diabetes on the mechanisms of intrathecal antinociception of sildenafil in rats.
Topics: Analgesia; Animals; Blood Glucose; Body Weight; Carbazoles; Cyclic GMP-Dependent Protein Kinases; Di | 2005 |
The nitric oxide-cyclic GMP-protein kinase G-K+ channel pathway participates in the antiallodynic effect of spinal gabapentin.
Topics: Amines; Analgesics; Animals; Apamin; Carbazoles; Charybdotoxin; Cyclic GMP; Cyclic GMP-Dependent Pro | 2006 |
Peripheral antinociceptive effect of pertussis toxin: activation of the arginine/NO/cGMP/PKG/ ATP-sensitive K channel pathway.
Topics: Adenosine Triphosphate; Analgesia; Analgesics; Animals; Arginine; Bucladesine; Carbazoles; Cells, Cu | 2006 |
Nitric oxide signaling in pain and nociceptor sensitization in the rat.
Topics: Animals; Dinoprostone; Enzyme Inhibitors; Guanylate Cyclase; Hyperalgesia; Male; Nitric Oxide; Nitri | 1998 |
Activation of spinal N-methyl-D-aspartate receptors stimulates a nitric oxide/cyclic guanosine 3,5-monophosphate/glutamate release cascade in nociceptive signaling.
Topics: 2-Amino-5-phosphonovalerate; Animals; Behavior, Animal; Cyclic GMP; Enzyme Inhibitors; Excitatory Am | 1999 |
Evidence for the participation of the nitric oxide-cyclic GMP pathway in the antinociceptive action of meloxicam in the formalin test.
Topics: Analgesics, Non-Narcotic; Animals; Cyclic GMP; Dose-Response Relationship, Drug; Enzyme Inhibitors; | 2000 |
Participation of the nitric oxide-cyclic GMP-ATP-sensitive K(+) channel pathway in the antinociceptive action of ketorolac.
Topics: Adenosine Triphosphate; Analgesics; Animals; Behavior, Animal; Cyclic AMP; Dose-Response Relationshi | 2001 |