A ceramide glucosyltransferase that is encoded in the genome of human. [PRO:DNx, UniProtKB:Q16739]
EC 2.4.1.80;
GLCT-1;
Glucosylceramide synthase;
GCS;
UDP-glucose ceramide glucosyltransferase;
UDP-glucose:N-acylsphingosine D-glucosyltransferase
| Timeframe | Studies on this Protein(%) | All Drugs % |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 0 (0.00) | 18.2507 |
| 2000's | 0 (0.00) | 29.6817 |
| 2010's | 4 (100.00) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Drug | Taxonomy | Measurement | Average (mM) | Bioassay(s) | Publication(s) |
|---|---|---|---|---|---|
| 1-deoxynojirimycin | Homo sapiens (human) | IC50 | 100.0000 | 1 | 1 |
| miglustat | Homo sapiens (human) | IC50 | 29.7500 | 4 | 4 |
| migalastat | Homo sapiens (human) | IC50 | 100.0000 | 1 | 1 |
| miglitol | Homo sapiens (human) | IC50 | 1,000.0000 | 1 | 1 |
| n-(5-adamantane-1-yl-methoxy-pentyl)deoxynojirimycin | Homo sapiens (human) | IC50 | 5.5883 | 6 | 6 |
| l-altro-1-deoxynojirimycin | Homo sapiens (human) | IC50 | 100.0000 | 1 | 1 |
This protein enables 3 target(s):
| Target | Category | Definition |
|---|---|---|
| protein binding | molecular function | Binding to a protein. [GOC:go_curators] |
| ceramide glucosyltransferase activity | molecular function | Catalysis of the reaction: UDP-glucose + N-acylsphingosine = UDP + D-glucosyl-N-acylsphingosine. [EC:2.4.1.80] |
| dihydroceramide glucosyltransferase activity | molecular function | Catalysis of the reaction: UDP-alpha-D-glucose + a dihydroceramide = UDP + H+ + a D-glucosyl-N-acylsphinganine. [EC:2.4.1.80, GOC:pz] |
This protein is located in 1 target(s):
| Target | Category | Definition |
|---|---|---|
| Golgi membrane | cellular component | The lipid bilayer surrounding any of the compartments of the Golgi apparatus. [GOC:mah] |
This protein is active in 1 target(s):
| Target | Category | Definition |
|---|---|---|
| membrane | cellular component | A lipid bilayer along with all the proteins and protein complexes embedded in it and attached to it. [GOC:dos, GOC:mah, ISBN:0815316194] |
This protein is involved in 12 target(s):
| Target | Category | Definition |
|---|---|---|
| protein lipidation | biological process | The covalent attachment of lipid groups to an amino acid in a protein. [GOC:jl] |
| glucosylceramide biosynthetic process | biological process | The chemical reactions and pathways resulting in the formation of glucosylceramides, any compound formed by the replacement of the glycosidic hydroxyl group of a cyclic form of glucose by a ceramide group. [GOC:ai] |
| glycosphingolipid biosynthetic process | biological process | The chemical reactions and pathways resulting in the formation of glycosphingolipid, a compound with residues of sphingoid and at least one monosaccharide. [GOC:go_curators] |
| epidermis development | biological process | The process whose specific outcome is the progression of the epidermis over time, from its formation to the mature structure. The epidermis is the outer epithelial layer of an animal, it may be a single layer that produces an extracellular material (e.g. the cuticle of arthropods) or a complex stratified squamous epithelium, as in the case of many vertebrate species. [GOC:go_curators, UBERON:0001003] |
| regulation of signal transduction | biological process | Any process that modulates the frequency, rate or extent of signal transduction. [GOC:sm] |
| cell differentiation | biological process | The cellular developmental process in which a relatively unspecialized cell, e.g. embryonic or regenerative cell, acquires specialized structural and/or functional features that characterize a specific cell. Differentiation includes the processes involved in commitment of a cell to a specific fate and its subsequent development to the mature state. [ISBN:0198506732] |
| keratinocyte differentiation | biological process | The process in which a relatively unspecialized cell acquires specialized features of a keratinocyte. [GOC:dph, GOC:mah, GOC:sdb_2009, GOC:tb] |
| leptin-mediated signaling pathway | biological process | The series of molecular signals initiated by leptin binding to its receptor on the surface of a cell, and ending with the regulation of a downstream cellular process, e.g. transcription. Leptin is a hormone manufactured primarily in the adipocytes of white adipose tissue, and the level of circulating leptin is directly proportional to the total amount of fat in the body. [GOC:mah, GOC:signaling, GOC:yaf] |
| neuron development | biological process | The process whose specific outcome is the progression of a neuron over time, from initial commitment of the cell to a specific fate, to the fully functional differentiated cell. [GOC:dph] |
| establishment of skin barrier | biological process | Establishment of the epithelial barrier, the functional barrier in the skin that limits its permeability. [GOC:dph] |
| intestinal lipid absorption | biological process | A process in which lipids are taken up from the contents of the intestine. [GOC:dos, GOC:sl, PMID:18768481] |
| cornified envelope assembly | biological process | The aggregation, arrangement and bonding together of a set of components to form a cornified envelope. [GO_REF:0000079, GOC:pm, GOC:TermGenie, PMID:22226963, PMID:24794495] |