amobarbital and Pain
amobarbital has been researched along with Pain in 26 studies
Amobarbital: A barbiturate with hypnotic and sedative properties (but not antianxiety). Adverse effects are mainly a consequence of dose-related CNS depression and the risk of dependence with continued use is high. (From Martindale, The Extra Pharmacopoeia, 30th ed, p565)
amobarbital : A member of the class of barbiturates that is pyrimidine-2,4,6(1H,3H,5H)-trione substituted by a 3-methylbutyl and an ethyl group at position 5. Amobarbital has been shown to exhibit sedative and hypnotic properties.
Pain: An unpleasant sensation induced by noxious stimuli which are detected by NERVE ENDINGS of NOCICEPTIVE NEURONS.
Research Excerpts
| Excerpt | Relevance | Reference |
|---|---|---|
| "Sodium amobarbital decreased spontaneous pain by 73% (vs 46% with lidocaine) and normalized sensory abnormalities at or above the level of injury in 3 patients (as compared to just 1 patient with lidocaine), 2 of whom had transitional zone allodynia/hyperalgesia." | 9.14 | Effects of intravenous sodium amobarbital vs lidocaine on pain and sensory abnormalities in patients with spinal cord injury. ( Bharatwal, B; Krassioukov, AV; Mailis-Gagnon, A; Yegneswaran, B, 2009) |
| "A mitochondrial electron transport chain member complex I inhibitor, amobarbital, can reduce oxidative damage and chondrocyte death, eventually preventing post-traumatic osteoarthritis (PTOA)." | 8.12 | HPLC-UV Method Validation for Amobarbital and Pharmaceutical Stability Evaluation When Dispersed in a Hyaluronic Acid Hydrogel: A New Concept for Post-Traumatic Osteoarthritis Prevention. ( Chakka, JL; Martin, JA; Naguib, YW; Quarterman, JC; Salem, AK; Seol, D, 2022) |
| "Sodium amobarbital decreased spontaneous pain by 73% (vs 46% with lidocaine) and normalized sensory abnormalities at or above the level of injury in 3 patients (as compared to just 1 patient with lidocaine), 2 of whom had transitional zone allodynia/hyperalgesia." | 5.14 | Effects of intravenous sodium amobarbital vs lidocaine on pain and sensory abnormalities in patients with spinal cord injury. ( Bharatwal, B; Krassioukov, AV; Mailis-Gagnon, A; Yegneswaran, B, 2009) |
| "A mitochondrial electron transport chain member complex I inhibitor, amobarbital, can reduce oxidative damage and chondrocyte death, eventually preventing post-traumatic osteoarthritis (PTOA)." | 4.12 | HPLC-UV Method Validation for Amobarbital and Pharmaceutical Stability Evaluation When Dispersed in a Hyaluronic Acid Hydrogel: A New Concept for Post-Traumatic Osteoarthritis Prevention. ( Chakka, JL; Martin, JA; Naguib, YW; Quarterman, JC; Salem, AK; Seol, D, 2022) |
Research
Studies (26)
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 21 (80.77) | 18.7374 |
| 1990's | 2 (7.69) | 18.2507 |
| 2000's | 2 (7.69) | 29.6817 |
| 2010's | 0 (0.00) | 24.3611 |
| 2020's | 1 (3.85) | 2.80 |
Authors
| Authors | Studies |
|---|---|
| Quarterman, JC | 1 |
| Naguib, YW | 1 |
| Chakka, JL | 1 |
| Seol, D | 1 |
| Martin, JA | 1 |
| Salem, AK | 1 |
| Mailis-Gagnon, A | 2 |
| Yegneswaran, B | 1 |
| Bharatwal, B | 1 |
| Krassioukov, AV | 1 |
| DIONESOV, SM | 1 |
| TOLOKOVA, NA | 1 |
| DAVIS, JD | 1 |
| MILLER, NE | 1 |
| ZEPPENFELD, I | 1 |
| Sa, DS | 1 |
| Nicholson, K | 1 |
| Lang, AE | 1 |
| Peck, RE | 2 |
| Mettler, L | 1 |
| Sadighi, R | 1 |
| Mailis, A | 2 |
| Plapler, P | 1 |
| Ashby, P | 1 |
| Shoichet, R | 1 |
| Roe, S | 2 |
| Amani, N | 1 |
| Umana, M | 1 |
| Basur, R | 1 |
| Shoichet, RP | 1 |
| Hartmann, G | 1 |
| Ravry, MJ | 1 |
| Borlich, DR | 1 |
| Knoll, J | 1 |
| Fürst, S | 1 |
| Mészáros, Z | 1 |
| Grayson, MF | 1 |
| Huskisson, EC | 1 |
| Schiller, U | 1 |
| Holsten, E | 1 |
| Raymann, F | 1 |
| Faust, B | 1 |
| Arnemann, W | 1 |
| Beecher, HK | 1 |
| Melikoglu, S | 1 |
| Timar, M | 1 |
| Sauvard, L | 1 |
| Botez, A | 1 |
| Simionovici, M | 1 |
| Winter, D | 1 |
| Georgescu, CM | 1 |
| Cristescu, C | 1 |
| Panaitescu, T | 1 |
| Schleith, K | 1 |
Trials
6 trials available for amobarbital and Pain
| Article | Year |
|---|---|
Effects of intravenous sodium amobarbital vs lidocaine on pain and sensory abnormalities in patients with spinal cord injury.
Topics: Adult; Amobarbital; Anesthetics, Local; Female; Humans; Hypnotics and Sedatives; Injections, Intrave | 2009 |
Effect of intravenous sodium amytal on cutaneous limb temperatures and sympathetic skin responses in normal subjects and pain patients with and without Complex Regional Pain Syndromes (type I and II). I.
Topics: Adult; Aged; Amobarbital; Body Temperature; Causalgia; Extremities; Female; Galvanic Skin Response; | 1997 |
Effect of intravenous sodium amytal on cutaneous sensory abnormalities, spontaneous pain and algometric pain pressure thresholds in neuropathic pain patients: a placebo-controlled study. II.
Topics: Adult; Amobarbital; Female; Humans; Hypnotics and Sedatives; Injections, Intravenous; Male; Middle A | 1997 |
A sequential trial of indomethacin and sodium amylobarbitone at night in rheumatoid arthritis, with comments on the statistical method.
Topics: Amobarbital; Arthritis, Rheumatoid; Clinical Trials as Topic; Drug Therapy, Combination; Humans; Ind | 1974 |
[Therapeutic findings with a new, both sedative and spasmolytically-active analgesic].
Topics: Aminopyrine; Amobarbital; Clinical Trials as Topic; Codeine; Humans; Pain; Scopolamine | 1965 |
[On analgesic therapy in a surgical patient register].
Topics: Aminopyrine; Amobarbital; Clinical Trials as Topic; Codeine; Humans; Pain; Postoperative Care; Scopo | 1965 |
Other Studies
20 other studies available for amobarbital and Pain
| Article | Year |
|---|---|
HPLC-UV Method Validation for Amobarbital and Pharmaceutical Stability Evaluation When Dispersed in a Hyaluronic Acid Hydrogel: A New Concept for Post-Traumatic Osteoarthritis Prevention.
Topics: Amobarbital; Chromatography, High Pressure Liquid; Humans; Hyaluronic Acid; Hydrogels; Osteoarthriti | 2022 |
[Peculiarities of activity of narcotics following nociceptive irritation in hypothyroidism in animals].
Topics: Amobarbital; Animals; Chloral Hydrate; Hypothyroidism; Narcotics; Pain; Skin Diseases; Thiouracil | 1958 |
FEAR AND PAIN: THEIR EFFECT ON SELF-INJECTION OF AMOBARBITAL SODIUM BY RATS.
Topics: Amobarbital; Fear; Injections; Pain; Rats; Reinforcement, Psychology; Research | 1963 |
[PAIN EXPERIENCE AND ITS CONTROL BY DRUGS].
Topics: Amobarbital; Codeine; Dimenhydrinate; Drug Therapy; Humans; Pain; Scopolamine | 1965 |
Posttraumatic painful torticollis.
Topics: Adolescent; Adult; Amobarbital; Female; Humans; Hypnotics and Sedatives; Injections, Intravenous; Ma | 2003 |
A precise technique for the measurement of pain.
Topics: Adult; Amobarbital; Female; Humans; Male; Pain | 1967 |
[Gynecologic-obstetric pain therapy. Use of Lonarid N].
Topics: Acetaminophen; Adolescent; Adult; Amobarbital; Caffeine; Codeine; Drug Combinations; Dysmenorrhea; E | 1980 |
Sodium amytal in the diagnosis of chronic pain.
Topics: Adult; Amobarbital; Chronic Disease; Female; Humans; Infusions, Parenteral; Male; Malingering; Middl | 1978 |
[Initial treatment of colics and spastic pain].
Topics: Amobarbital; Butylscopolammonium Bromide; Codeine; Colic; Drug Combinations; Pain; Spasm | 1977 |
Dexamyl, abdominal angina, and celiac-artery compression.
Topics: Abdomen; Amobarbital; Celiac Artery; Dextroamphetamine; Drug Combinations; Female; Humans; Middle Ag | 1977 |
[Rational and risk-free treatment of internal-medicine emergencies].
Topics: Ambulatory Care; Amobarbital; Codeine; Dipyrone; Drug Combinations; Emergencies; Gastrointestinal Di | 1977 |
The pharmacology of 1,6-dimethyl-3-carbethoxy-4-oxo-6,7,8,9-tetrahydrohomopyrimidazol-methylsulphate (MZ-144), a new, potent, non-narcotic analgesic. II. Toxicity and analgetic effect of MZ-144 compared to narcotic and non-narcotic analgesics.
Topics: Aminopyrine; Amobarbital; Analgesics; Animals; Aspirin; Blood; Cats; Codeine; Diazepam; Dogs; Drug A | 1971 |
The application of thymometry to the measurement of anxiety.
Topics: Amobarbital; Anxiety; Audiometry; Carbon Dioxide; Emotions; Humans; Nystagmus, Pathologic; Pain; Pro | 1966 |
[Pain from the viewpoint of the general practitioner. Experiences with a new analgesic].
Topics: Adolescent; Adult; Aged; Amobarbital; Analgesics; Antipyrine; Caffeine; Family Practice; Humans; Mid | 1969 |
[Ambulatory experiences with a new analgesic].
Topics: Adult; Aged; Ambulatory Care; Aminopyrine; Amobarbital; Analgesics; Antipyrine; Caffeine; Female; Hu | 1969 |
[Comments on analgetic therapy in urology].
Topics: Adolescent; Adult; Aged; Amobarbital; Analgesics; Codeine; Dimenhydrinate; Female; Humans; Male; Mid | 1968 |
Anxiety and pain.
Topics: Amobarbital; Anxiety; Fear; Humans; Hysteria; Male; Military Medicine; Morphine; Pain; Time Factors; | 1969 |
[Clinical experiences with a new morphine-sparing analgesic].
Topics: Aminopyrine; Amobarbital; Codeine; Humans; Pain; Scopolamine | 1965 |
Pharmacological effects of some 6-azauracil derivatives.
Topics: Amobarbital; Animals; Blood Pressure; Body Temperature; Carotid Sinus; Diuresis; Dogs; Electroconvul | 1966 |
[Drug therapy in control of pains in gynecology].
Topics: Amobarbital; Codeine; Dysmenorrhea; Female; Genital Diseases, Female; Humans; Pain; Postoperative Co | 1966 |