theobromine has been researched along with Pain in 12 studies
Theobromine: 3,7-Dimethylxanthine. The principle alkaloid in Theobroma cacao (the cacao bean) and other plants. A xanthine alkaloid that is used as a bronchodilator and as a vasodilator. It has a weaker diuretic activity than THEOPHYLLINE and is also a less powerful stimulant of smooth muscle. It has practically no stimulant effect on the central nervous system. It was formerly used as a diuretic and in the treatment of angina pectoris and hypertension. (From Martindale, The Extra Pharmacopoeia, 30th ed, pp1318-9)
theobromine : A dimethylxanthine having the two methyl groups located at positions 3 and 7. A purine alkaloid derived from the cacao plant, it is found in chocolate, as well as in a number of other foods, and is a vasodilator, diuretic and heart stimulator.
Pain: An unpleasant sensation induced by noxious stimuli which are detected by NERVE ENDINGS of NOCICEPTIVE NEURONS.
| Excerpt | Relevance | Reference |
|---|---|---|
| "Twenty patients with ischemic rest pain were treated with intravenous pentoxifylline, 1,200 mg daily, for up to three weeks." | 7.67 | Intravenous pentoxifylline in the treatment of rest pain: a preliminary report. ( Carey, D; Kent, P; McCollum, PT; Moore, DJ; O'Driscoll, K; Shanik, DG; Stanley, ST; Weil von der Ahe, CA, 1989) |
| " In the present study, we examined the antinociceptive and anti-inflammatory effects produced by the peripheral (intraplantar) administration of 5'-amino-5'-deoxyadenosine (an adenosine kinase inhibitor), 2'-deoxycoformycin (an adenosine deaminase inhibitor), and combinations of both agents in the carrageenan-induced thermal hyperalgesia and paw oedema model in the rat." | 3.70 | Antinociceptive and anti-inflammatory properties of an adenosine kinase inhibitor and an adenosine deaminase inhibitor. ( Poon, A; Sawynok, J, 1999) |
| "Twenty patients with ischemic rest pain were treated with intravenous pentoxifylline, 1,200 mg daily, for up to three weeks." | 3.67 | Intravenous pentoxifylline in the treatment of rest pain: a preliminary report. ( Carey, D; Kent, P; McCollum, PT; Moore, DJ; O'Driscoll, K; Shanik, DG; Stanley, ST; Weil von der Ahe, CA, 1989) |
| " infusion of pentoxifylline, administering 1,200 mg/24 hours through 15 days, was studied in 22 patients (19 m, 3 f) with arteriographically confirmed extensive occlusion in the femoro-popliteal segment, associated with marked intermittent claudication and rest pain of varying severity." | 3.67 | Continuous infusion treatment with pentoxifylline in patients with severe peripheral vascular occlusive disease. ( Angelides, NS, 1986) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 8 (66.67) | 18.7374 |
| 1990's | 2 (16.67) | 18.2507 |
| 2000's | 2 (16.67) | 29.6817 |
| 2010's | 0 (0.00) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Choi, SS | 1 |
| Han, KJ | 1 |
| Lee, JK | 1 |
| Lee, HK | 1 |
| Han, EJ | 1 |
| Kim, DH | 1 |
| Suh, HW | 1 |
| Malec, D | 1 |
| Poleszak, E | 1 |
| Khosla, AA | 1 |
| Chintu, C | 1 |
| Sawynok, J | 2 |
| Zarrindast, MR | 1 |
| Reid, AR | 1 |
| Doak, GJ | 1 |
| Poon, A | 1 |
| Teuscher, T | 1 |
| Von Der Ahe, CW | 1 |
| Baillod, P | 1 |
| Holzer, B | 1 |
| McCollum, PT | 1 |
| Kent, P | 1 |
| O'Driscoll, K | 1 |
| Carey, D | 1 |
| Stanley, ST | 1 |
| Weil von der Ahe, CA | 1 |
| Moore, DJ | 1 |
| Shanik, DG | 1 |
| Manrique, RV | 1 |
| Thomas, JH | 1 |
| Swannack, CJ | 1 |
| McAnaw, M | 1 |
| Klein, S | 1 |
| Kinnaman, ML | 1 |
| Iliopoulos, JI | 1 |
| Hermreck, AS | 1 |
| Pierce, GE | 1 |
| Pichard, E | 1 |
| Duflo, B | 1 |
| Coulibaly, S | 1 |
| Mariko, B | 1 |
| Monsempes, JL | 1 |
| Traore, HA | 1 |
| Diallo, AD | 1 |
| Angelides, NS | 1 |
| Menozzi, D | 1 |
| Frigerio, G | 1 |
5 trials available for theobromine and Pain
| Article | Year |
|---|---|
A pilot study: an open clinical trial of pentoxiphylline in patients with painful sickle cell crises.
Topics: Adolescent; Adult; Anemia, Sickle Cell; Child; Child, Preschool; Clinical Trials as Topic; Female; H | 1984 |
Double-blind randomised clinical trial of pentoxiphyllin in vaso-occlusive sickle cell crisis.
Topics: Acute Disease; Adolescent; Analgesics; Anemia, Sickle Cell; Child; Double-Blind Method; Female; Huma | 1989 |
Placebo controlled double-blind study of pentoxifylline in sickle cell disease patients.
Topics: Adolescent; Anemia, Sickle Cell; Clinical Trials as Topic; Double-Blind Method; Erythrocyte Count; F | 1987 |
[Effectiveness of treatment during osteoarticular pain crises in drepanocytosis; based on the example of pentoxifylline].
Topics: Adult; Anemia, Sickle Cell; Double-Blind Method; Drug Evaluation; Erythrocyte Deformability; Female; | 1987 |
A controlled study of dextropropoxyphene 1-carboxymethyl-3,7-dimethylxanthine (Z867) IN POSt-operative pain.
Topics: Dextropropoxyphene; Drug Combinations; Humans; Pain; Placebos; Surgical Procedures, Operative; Theob | 1973 |
7 other studies available for theobromine and Pain
| Article | Year |
|---|---|
Antinociceptive mechanisms of orally administered decursinol in the mouse.
Topics: Administration, Oral; Adrenergic alpha-Antagonists; Analgesics; Animals; Benzopyrans; Butyrates; Cyp | 2003 |
Adenosine receptor ligands and dizocilpine-induced antinociception in mice.
Topics: Acetic Acid; Animals; Behavior, Animal; Dizocilpine Maleate; Excitatory Amino Acid Antagonists; Male | 2005 |
Adenosine A3 receptor activation produces nociceptive behaviour and edema by release of histamine and 5-hydroxytryptamine.
Topics: Animals; Behavior, Animal; Body Temperature; Edema; Histamine Release; Injections, Subcutaneous; Mal | 1997 |
Antinociceptive and anti-inflammatory properties of an adenosine kinase inhibitor and an adenosine deaminase inhibitor.
Topics: Adenosine Deaminase; Adenosine Deaminase Inhibitors; Adenosine Kinase; Analgesics; Animals; Anti-Inf | 1999 |
Intravenous pentoxifylline in the treatment of rest pain: a preliminary report.
Topics: Aged; Female; Humans; Injections, Intravenous; Ischemia; Leg; Male; Pain; Pentoxifylline; Pilot Proj | 1989 |
Determinants of response to pentoxifylline therapy in patients with intermittent claudication.
Topics: Adult; Aged; Blood Pressure; Female; Humans; Intermittent Claudication; Locomotion; Male; Middle Age | 1987 |
Continuous infusion treatment with pentoxifylline in patients with severe peripheral vascular occlusive disease.
Topics: Arterial Occlusive Diseases; Blood Pressure; Female; Femoral Artery; Humans; Infusions, Parenteral; | 1986 |